当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Thermodynamic aspects of the linkage between binding of chloride and oxygen to human hemoglobin.

Thermodynamic aspects of the linkage between binding of chloride and oxygen to human hemoglobin.

Abstract：

:Oxygen isotherms of human hemoglobin measured in distilled water and in solutions of sodium chloride in the concentration range from 0.02 to 3.0 M indicate that the oxygen affinity decreases up to about 1 M salt and then begins to increase. The isotherms obtained in the range from 0.02 to 0.6 M sodium chloride, at 37 degrees and pH 7.4, have been analyzed in terms of changes in Gibbs free energy of heme ligation, resulting from the differential interaction between the chloride ion and the two forms of hemoglobin. The maximal theoretical change in Gibbs free energy that chloride ion can exert on the oxygen binding of hemoglobin amounts to 4.9 +/- 0.2 kcal/mol (21 +/- 0.8 kJ/mol) of hemoglobin tetramer. A plot of the logarithm of oxygen concentration at half saturation versus the logarithm of the chloride concentration has a slope of 0.40, suggesting 1.6 apparent chloride sites per hemoglobin tetramer. Because the interaction between chloride and hemoglobin is dependent on pH, the apparent thermodynamic linkage between chloride and oxygen binding will also include the salt dependence of the Bohr effect at pH 7.4. The fractional change in Gibbs free energy, measured as a function of the chloride concentration, can be approximated by the binding isotherm between a protein and a ligand, using an association constant of 11 M(-1). Thus, if the number of oxygen-linked chloride sites is more than one per hemoglobin tetramer, these sites must be considered independent.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Haire RN,Hedlund BE

doi

10.1073/pnas.74.10.4135

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

4135-8

issue

10

eissn

0027-8424

issn

1091-6490

journal_volume

74

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.

    abstract：:Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0400930101

    authors： Castilla LH,Perrat P,Martinez NJ,Landrette SF,Keys R,Oikemus S,Flanegan J,Heilman S,Garrett L,Dutra A,Anderson S,Pihan GA,Wolff L,Liu PP

    更新日期：2004-04-06 00:00:00

  • Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis.

    abstract：:In translation, elongation factor Tu (EF-Tu) molecules deliver aminoacyl-tRNAs to the mRNA-programmed ribosome. The GTPase activity of EF-Tu is triggered by ribosome-induced conformational changes of the factor that play a pivotal role in the selection of the cognate aminoacyl-tRNAs. We present a 6.7-A cryo-electron m...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0811370106

    authors： Villa E,Sengupta J,Trabuco LG,LeBarron J,Baxter WT,Shaikh TR,Grassucci RA,Nissen P,Ehrenberg M,Schulten K,Frank J

    更新日期：2009-01-27 00:00:00

  • Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

    abstract：:We have characterized seven murine retinoic acid receptor gamma cDNA isoforms (mRAR-gamma 1 to -gamma 7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-gamma 1 and -gamma 2) differ in their N-terminal A region, wh...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.7.2700

    authors： Kastner P,Krust A,Mendelsohn C,Garnier JM,Zelent A,Leroy P,Staub A,Chambon P

    更新日期：1990-04-01 00:00:00

  • Quorum decision-making facilitates information transfer in fish shoals.

    abstract：:Despite the growing interest in collective phenomena such as "swarm intelligence" and "wisdom of the crowds," little is known about the mechanisms underlying decision-making in vertebrate animal groups. How do animals use the behavior of others to make more accurate decisions, especially when it is not possible to ide...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0710344105

    authors： Ward AJ,Sumpter DJ,Couzin ID,Hart PJ,Krause J

    更新日期：2008-05-13 00:00:00

  • Climatic shifts drove major contractions in avian latitudinal distributions throughout the Cenozoic.

    abstract：:Many higher level avian clades are restricted to Earth's lower latitudes, leading to historical biogeographic reconstructions favoring a Gondwanan origin of crown birds and numerous deep subclades. However, several such "tropical-restricted" clades (TRCs) are represented by stem-lineage fossils well outside the ranges...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1903866116

    authors： Saupe EE,Farnsworth A,Lunt DJ,Sagoo N,Pham KV,Field DJ

    更新日期：2019-06-25 00:00:00

  • Isolation and characterization of the human uracil DNA glycosylase gene.

    abstract：:A series of anti-human placental uracil DNA glycosylase monoclonal antibodies was used to screen a human placental cDNA library in phage lambda gt11. Twenty-seven immunopositive plaques were detected and purified. One clone containing a 1.2-kilobase (kb) human cDNA insert was chosen for further study by insertion into...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.22.8693

    authors： Vollberg TM,Siegler KM,Cool BL,Sirover MA

    更新日期：1989-11-01 00:00:00

  • Contingent gene regulatory networks and B cell fate specification.

    abstract：:The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components incl...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,评审

    doi：10.1073/pnas.0500480102

    authors： Singh H,Medina KL,Pongubala JM

    更新日期：2005-04-05 00:00:00

  • Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray.

    abstract：:High-resolution single nucleotide polymorphism genomic microarray (SNP-chip) is a useful tool to define gene dosage levels over the whole genome, allowing precise detection of deletions and duplications/amplifications of chromosomes in cancer cells. We found that this new technology can also identify breakpoints of ch...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0711039105

    authors： Kawamata N,Ogawa S,Zimmermann M,Niebuhr B,Stocking C,Sanada M,Hemminki K,Yamatomo G,Nannya Y,Koehler R,Flohr T,Miller CW,Harbott J,Ludwig WD,Stanulla M,Schrappe M,Bartram CR,Koeffler HP

    更新日期：2008-08-19 00:00:00

  • Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).

    abstract：:Hypothesis directed proteomics offers higher throughput over global analyses. We show that immunoprecipitation (IP)-tandem mass spectrometry (LC-MS/MS) in H929 multiple myeloma (MM) cancer cells led to the discovery of a rare and unexpected BCR-ABL fusion, informing a therapeutic intervention using imatinib (Gleevec)....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212759109

    authors： Breitkopf SB,Yuan M,Pihan GA,Asara JM

    更新日期：2012-10-02 00:00:00

  • Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.

    abstract：:The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We presen...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.15.5697

    authors： Reed SI,Wittenberg C

    更新日期：1990-08-01 00:00:00

  • Synergistic myelopoietic actions in vivo after administration to mice of combinations of purified natural murine colony-stimulating factor 1, recombinant murine interleukin 3, and recombinant murine granulocyte/macrophage colony-stimulating factor.

    abstract：:Combinations of low dosages of purified murine hematopoietic colony-stimulating factors (CSFs)--L-cell CSF type 1 (CSF-1), recombinant interleukin 3 (IL-3), and recombinant granulocyte/macrophage CSF (GM-CSF)--were compared with single CSFs for their influence on the cycling rates and numbers of bone marrow granulocyt...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.11.3871

    authors： Broxmeyer HE,Williams DE,Hangoc G,Cooper S,Gillis S,Shadduck RK,Bicknell DC

    更新日期：1987-06-01 00:00:00

  • Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes.

    abstract：:Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequest...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.16.5075

    authors： David PH,Hommel M,Miller LH,Udeinya IJ,Oligino LD

    更新日期：1983-08-01 00:00:00

  • Kinetic diversity of amyloid oligomers.

    abstract：:The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many increasingly common and currently incurable human disorders, including Alzheimer's and Parkinson's diseases. Oligomeric species form transiently during this process and not only act as essential intermediates in the assembly of n...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1922267117

    authors： Dear AJ,Michaels TCT,Meisl G,Klenerman D,Wu S,Perrett S,Linse S,Dobson CM,Knowles TPJ

    更新日期：2020-06-02 00:00:00

  • A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: importance for the Q-cycle and superoxide production.

    abstract：:The cytochrome bc1 and related complexes are essential energy-conserving components of mitochondrial and bacterial electron transport chains. They orchestrate a complex sequence of electron and proton transfer reactions resulting in the oxidation of quinol, the reduction of a mobile electron carrier, and the transloca...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0702621104

    authors： Cape JL,Bowman MK,Kramer DM

    更新日期：2007-05-08 00:00:00

  • Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

    abstract：:Previous studies have established that incubation of low density lipoprotein (LDL) with cultured endothelial cells (EC) converts it to a new form (EC-modified LDL) that is now recognized by a specific receptor on macrophages (the acetyl LDL receptor) and is taken up and degraded 3-10 times more rapidly than native LDL...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.9.3000

    authors： Parthasarathy S,Steinbrecher UP,Barnett J,Witztum JL,Steinberg D

    更新日期：1985-05-01 00:00:00

  • The deep, hot biosphere: Twenty-five years of retrospection.

    abstract：:Twenty-five years ago this month, Thomas Gold published a seminal manuscript suggesting the presence of a "deep, hot biosphere" in the Earth's crust. Since this publication, a considerable amount of attention has been given to the study of deep biospheres, their role in geochemical cycles, and their potential to infor...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1701266114

    authors： Colman DR,Poudel S,Stamps BW,Boyd ES,Spear JR

    更新日期：2017-07-03 00:00:00

  • Global view of the protein universe.

    abstract：:To explore protein space from a global perspective, we consider 9,710 SCOP (Structural Classification of Proteins) domains with up to 70% sequence identity and present all similarities among them as networks: In the "domain network," nodes represent domains, and edges connect domains that share "motifs," i.e., signifi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1403395111

    authors： Nepomnyachiy S,Ben-Tal N,Kolodny R

    更新日期：2014-08-12 00:00:00

  • A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.

    abstract：:We have isolated two genes, Hox-2.8 and Hox-2.9, from the mouse homeobox cluster Hox-2, located on chromosome 11. A 120-kilobase yeast artificial chromosome (YAC) containing a large region of the murine Hox-2 cluster, including 45 kilobases of sequence upstream of the most 5' gene, was cloned. The DNA sequence of the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.12.4751

    authors： Rubock MJ,Larin Z,Cook M,Papalopulu N,Krumlauf R,Lehrach H

    更新日期：1990-06-01 00:00:00

  • Coherent phonon dynamics in spatially separated graphene mechanical resonators.

    abstract：:Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step toward scalable phonon-based applications. Here we report tunable coherent phonon dynamics...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1916978117

    authors： Zhang ZZ,Song XX,Luo G,Su ZJ,Wang KL,Cao G,Li HO,Xiao M,Guo GC,Tian L,Deng GW,Guo GP

    更新日期：2020-03-17 00:00:00

  • Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

    abstract：:Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization of G-protein-coupled receptors. Herein we describe the generation of monoclonal antibodies (mAbs) t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.15.7649

    authors： Oppermann M,Diversé-Pierluissi M,Drazner MH,Dyer SL,Freedman NJ,Peppel KC,Lefkowitz RJ

    更新日期：1996-07-23 00:00:00

  • Metal-induced sensor mobilization turns on affinity to activate regulator for metal detoxification in live bacteria.

    abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1919816117

    authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

    更新日期：2020-06-16 00:00:00

  • Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.

    abstract：:Prey shifts in carnivorous predators are events that can initiate the accelerated generation of new biodiversity. However, it is seldom possible to reconstruct how the change in prey preference occurred. Here we describe an evolutionary "smoking gun" that illuminates the transition from worm hunting to fish hunting am...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1424435112

    authors： Aman JW,Imperial JS,Ueberheide B,Zhang MM,Aguilar M,Taylor D,Watkins M,Yoshikami D,Showers-Corneli P,Safavi-Hemami H,Biggs J,Teichert RW,Olivera BM

    更新日期：2015-04-21 00:00:00

  • ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells.

    abstract：:Endothelial cells (EC) play a central role in inflammatory immune responses and efficiently induce effector functions in T cells, despite lacking the classical costimulatory ligands CD80 and CD86. By using the mAb HIL-131 we now demonstrate that human inducible costimulator-ligand (ICOS-L), a molecule related to CD80/...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.092576699

    authors： Khayyamian S,Hutloff A,Büchner K,Gräfe M,Henn V,Kroczek RA,Mages HW

    更新日期：2002-04-30 00:00:00

  • cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

    abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.252782799

    authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

    更新日期：2003-02-18 00:00:00

  • Selective loss of polymorphic mating types is associated with rapid phenotypic evolution during morphic speciation.

    abstract：:Polymorphism may play an important role in speciation because new species could originate from the distinctive morphs observed in polymorphic populations. However, much remains to be understood about the process by which morphs found new species. To detail the steps of this mode of speciation, we studied the geographi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0909480107

    authors： Corl A,Davis AR,Kuchta SR,Sinervo B

    更新日期：2010-03-02 00:00:00

  • Combined transcriptome analysis of fetal human and mouse cerebral cortex exposed to alcohol.

    abstract：:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms obse...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1100903108

    authors： Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic P

    更新日期：2011-03-08 00:00:00

  • Transformation of the cryobehavior of rye protoplasts by modification of the plasma membrane lipid composition.

    abstract：:The freezing tolerance of protoplasts isolated from nonacclimated rye leaves (Secale cereale L. cv Puma) was significantly altered by using a pH-induced protoplastliposome fusion technique to modify the lipid composition of the plasma membrane. The increase in freezing tolerance was elicited by fusion with liposomes c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.23.9026

    authors： Steponkus PL,Uemura M,Balsamo RA,Arvinte T,Lynch DV

    更新日期：1988-12-01 00:00:00

  • The point of no return in vetoing self-initiated movements.

    abstract：:In humans, spontaneous movements are often preceded by early brain signals. One such signal is the readiness potential (RP) that gradually arises within the last second preceding a movement. An important question is whether people are able to cancel movements after the elicitation of such RPs, and if so until which po...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1513569112

    authors： Schultze-Kraft M,Birman D,Rusconi M,Allefeld C,Görgen K,Dähne S,Blankertz B,Haynes JD

    更新日期：2016-01-26 00:00:00

  • Localization of calmodulin in rat tissues.

    abstract：:The localization of calmodulin, a calcium-dependent modulator of many enzymes, was studied in rat liver, skeletal muscle, and adrenal slices. Calmodulin is found in liver cytoplasm, nucleus, and plasma membrane. Much of the cytoplasmic calmodulin is associated with glycogen particles presumably bound to enzymes involv...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.1.366

    authors： Harper JF,Cheung WY,Wallace RW,Huang HL,Levine SN,Steiner AL

    更新日期：1980-01-01 00:00:00

  • Alpha-helical stabilization by side chain shielding of backbone hydrogen bonds.

    abstract：:We study atomic models of the thermodynamics of the structural transition of peptides that form alpha-helices. The effect of sequence variation on alpha-helix formation for alanine-rich peptides, Ac-Ala21-methyl amide (A21) and Ac-A5 (AAARA)3A-methyl amide (Fs peptide), is investigated by atomic simulation studies of ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.042496899

    authors： García AE,Sanbonmatsu KY

    更新日期：2002-03-05 00:00:00