Abstract:
:We have characterized seven murine retinoic acid receptor gamma cDNA isoforms (mRAR-gamma 1 to -gamma 7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-gamma 1 and -gamma 2) differ in their N-terminal A region, which is known to be important for differential transactivation by other nuclear receptors. mRAR-gamma 1 and -gamma 2, the predominant isoforms, are differentially expressed in adult tissues and during embryogenesis. Most notably, skin contains almost exclusively mRAR-gamma 1 transcripts. The conservation of the RAR-gamma isoforms from mouse to human together with their patterns of expression suggests that they perform specific functions, which may account for the pleiotropic effect of retinoic acid in embryogenesis and development.
journal_name
Proc Natl Acad Sci U S Aauthors
Kastner P,Krust A,Mendelsohn C,Garnier JM,Zelent A,Leroy P,Staub A,Chambon Pdoi
10.1073/pnas.87.7.2700subject
Has Abstractpub_date
1990-04-01 00:00:00pages
2700-4issue
7eissn
0027-8424issn
1091-6490journal_volume
87pub_type
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