Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.

abstract：:Immunoreactive and bioreactive corticotropin (ACTH-like) activities have been detected in the median eminence and remaining medial basal hypothalamus of both normal and hypophysectomized adult male rats: bioreactive ACTH (pg/100 mug of protein) 1028 in median eminence and 1289 in medial basal hypothalamus; immunoreact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger DT,Liotta A,Brownstein MJ

更新日期：1977-02-01 00:00:00

abstract：:Monoclonal antibodies have been obtained that recognize either the A or B chain of human urinary urokinase. These antibodies identify human urokinase-producing cells and the product of urokinase mRNA. Anti-urokinase monoclonal antibodies precipitate an approximately equal to 54,000-dalton protein synthesized in vitro ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salerno G,Verde P,Nolli ML,Corti A,Szöts H,Meo T,Johnson J,Bullock S,Cassani G,Blasi F

更新日期：1984-01-01 00:00:00

abstract：:Despite enormous body plan variation, genes regulating embryonic development are highly conserved. Here, we probe the mechanisms that predispose ancient regulatory genes to reutilization and diversification rather than evolutionary loss. The Hox gene fushi tarazu (ftz) arose as a homeotic gene but functions as a pair-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffer A,Xiang J,Pick L

更新日期：2013-02-05 00:00:00

abstract：:A mitochondrial gene from Saccharomyces cerevisiae encoding a hydrophobic membrane protein, subunit 8 of the F0/F1-type mitochondrial ATPase complex, has been functionally replaced by an artificial nuclear gene specifying an imported version of this protein. The experiments reported here utilized a multicopy expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagley P,Farrell LB,Gearing DP,Nero D,Meltzer S,Devenish RJ

更新日期：1988-04-01 00:00:00

abstract：:Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype, is considered to play a causative role in the etiology of ischemic stroke and several neurodegenerative diseases. The NMDA receptor is therefore a target for the development of neuroprotective agents....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tai KK,Blondelle SE,Ostresh JM,Houghten RA,Montal M

更新日期：2001-03-13 00:00:00

abstract：:Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis. We aimed to identify molecular mediators of these effects, focusing on long-lasting epigenetic changes. In a hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provençal N,Arloth J,Cattaneo A,Anacker C,Cattane N,Wiechmann T,Röh S,Ködel M,Klengel T,Czamara D,Müller NS,Lahti J,PREDO team.,Räikkönen K,Pariante CM,Binder EB

更新日期：2020-09-22 00:00:00

abstract：:We report a general mass spectrometric approach for the rapid identification and characterization of proteins isolated by preparative two-dimensional polyacrylamide gel electrophoresis. This method possesses the inherent power to detect and structurally characterize covalent modifications. Absolute sensitivities of ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clauser KR,Hall SC,Smith DM,Webb JW,Andrews LE,Tran HM,Epstein LB,Burlingame AL

更新日期：1995-05-23 00:00:00

abstract：:H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and Mycobacteria, respectively, that play an important role in the silencing of horizontally acquired foreign DNA that is more AT-rich than the resident genome. Despite the fact that Lsr2 and H-NS proteins are dissimilar in sequence and structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon BR,Li Y,Cote A,Weirauch MT,Ding P,Hughes TR,Navarre WW,Xia B,Liu J

更新日期：2011-06-28 00:00:00

abstract：:In this study we examine how the introduction of a reference lottery with nonrandom outcomes alters the way in which choices among pairs of lotteries are made, even if it does not alter the choices. We use different domains (some of the lotteries produce gains, other losses) and different contexts (one member of the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickhaut J,McCabe K,Nagode JC,Rustichini A,Smith K,Pardo JV

更新日期：2003-03-18 00:00:00

abstract：:Phage phi 29 DNA cannot be phosphorylated with polynucleotide kinase and [gamma-32P]ATP because of the presence of a viral protein covalently linked to the 5' termini. The 5' ends can, however, be made susceptible to phosphorylation by treatment with alkali and alkaline phosphatase. Restriction fragments Hpa II C and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escarmís C,Salas M

更新日期：1981-03-01 00:00:00

abstract：:Human diploid fibroblasts (HDFs) possess Ca(2+)-dependent membrane currents. These currents were suppressed in late-passage normal (senescent) HDFs and prematurely senescent HDFs derived from a subject with Werner syndrome (WS), compared with early-passage normal (young) HDFs. When young HDFs were microinjected with m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Thweatt R,Lumpkin CK Jr,Goldstein S

更新日期：1994-03-15 00:00:00

abstract：:Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human preterm birth, we show here that uterine decidual senescence early in pregnancy via heightened mammalian target of rapamycin complex 1 (mTORC1) signaling is a sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirota Y,Cha J,Yoshie M,Daikoku T,Dey SK

更新日期：2011-11-01 00:00:00

abstract：:A fundamental question in the study of human language acquisition centers around apportioning explanatory force between the experience of the learner and the core knowledge that allows learners to represent that experience. We provide a previously unidentified kind of data identifying children's contribution to langua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han CH,Musolino J,Lidz J

更新日期：2016-01-26 00:00:00

abstract：:Kampo formulations are traditional herbal medications used in China and Japan for many centuries to treat diarrheal diseases such as cholera. Our studies were undertaken to identify and verify by chemical synthesis the active components that inhibited cholera toxin (CT), the virulence factor secreted by Vibrio cholera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oi H,Matsuura D,Miyake M,Ueno M,Takai I,Yamamoto T,Kubo M,Moss J,Noda M

更新日期：2002-03-05 00:00:00

abstract：:Despite high predation pressure, planktonic copepods remain one of the most abundant groups on the planet. Their escape response provides one of most effective mechanisms to maximize evolutionary fitness. Owing to their small size (100 µm) compared with their predators (>1 mm), increasing viscosity is believed to have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gemmell BJ,Sheng J,Buskey EJ

更新日期：2013-03-19 00:00:00

abstract：:Let t --> gamma(t) be a homogeneous curve in R(n). For suitable f, define [unk](f)(x) = sup(h > 0)|(1/h) [unk](0) (h)f(x - gamma(t)) dt|. Then parallel[unk](f) parallel(p)

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM

更新日期：1976-07-01 00:00:00

abstract：:T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory signal IL-4 and depends only on T cell receptor stimulation. Here, we show that in the course of Th2 cell differentiation in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Löhning M,Richter A,Stamm T,Hu-Li J,Assenmacher M,Paul WE,Radbruch A

更新日期：2003-10-14 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:We have studied hepatic uptake of chylomicron retinyl ester. Chylomicrons were obtained from intestinal lymph of rats that were given retinol in groundnut oil by intraduodenal injection. When lymph was injected intravenously into normal rats, the radioactivity was cleared from blood with t1/2 approximately equal to 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blomhoff R,Helgerud P,Rasmussen M,Berg T,Norum KR

更新日期：1982-12-01 00:00:00

abstract：:Thiol-dependent redox regulation allows the rapid adaptation of chloroplast function to unpredictable changes in light intensity. Traditionally, it has been considered that chloroplast redox regulation relies on photosynthetically reduced ferredoxin (Fd), thioredoxins (Trxs), and an Fd-dependent Trx reductase (FTR), t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Ruiz JM,Naranjo B,Ojeda V,Guinea M,Cejudo FJ

更新日期：2017-11-07 00:00:00

abstract：:Prey in natural communities are usually shared by many predator species. How predators coexist while competing for the same prey is one of the fundamental questions in ecology. Here, we show that competing predator species may not only coexist on a single prey but even help each other to persist if they specialize on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Roos AM,Schellekens T,Van Kooten T,Persson L

更新日期：2008-09-16 00:00:00

abstract：:The central questions of bacterial ecology and evolution require a method to consistently demarcate, from the vast and diverse set of bacterial cells within a natural community, the groups playing ecologically distinct roles (ecotypes). Because of a lack of theory-based guidelines, current methods in bacterial systema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koeppel A,Perry EB,Sikorski J,Krizanc D,Warner A,Ward DM,Rooney AP,Brambilla E,Connor N,Ratcliff RM,Nevo E,Cohan FM

更新日期：2008-02-19 00:00:00

abstract：:The coat protein of bacteriophage MS-2 was cleaved with cyanogen bromide to yield three fragments, possessing the sequence 1-88 (P1), 89-108 (P2), and 109-129 (P3), respectively. The mixture of peptides P2 and P3, which could not be separated, was found capable of inhibiting the neutralization of the phage by antiseru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langbeheim H,Arnon R,Sela M

更新日期：1976-12-01 00:00:00

abstract：:Ninety kilobase pairs (kb) of DNA have been isolated from the 3B region of the X chromosome of Drosophila melanogaster. Previous cytogenetic analyses have placed a gene required for rhythmic behavior (per) in this chromosomal interval. Physical characterization of a series of chromosomal rearrangements altering per lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bargiello TA,Young MW

更新日期：1984-04-01 00:00:00

abstract：:The lamB protein, the receptor for phage lambda, was purified from the outer membrane of Escherichia coli K-12 by extraction with Triton X-100 and EDTA, chromatography on DEAE-Sephacel in Triton X-100, exchange of Triton for cholate by gel filtration, and chromatography on Sephacryl S-200 in cholate, NaCl, and EDTA. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckey M,Nikaido H

更新日期：1980-01-01 00:00:00

abstract：:For study of the basis of an X-linked form of gout in man, several clonal lines deficient in hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) were selected from the human lymphoblast line WI-L2 by spontaneous and mutagen-induced resistance to 10 muM 8-azaguanine. Three groups could be defined: (1) clones wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever JE,Nuki G,Seegmiller JE

更新日期：1974-07-01 00:00:00

abstract：:The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhao D,Horie T,Chen G,Bao H,Chen S,Liu W,Horie R,Liang T,Dong B,Feng Q,Tao Q,Liu X

更新日期：2017-08-01 00:00:00

abstract：:The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with low concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giannakakou P,Nakano M,Nicolaou KC,O'Brate A,Yu J,Blagosklonny MV,Greber UF,Fojo T

更新日期：2002-08-06 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:The inward Na+ current underlying the action potential in nerve is terminated by inactivation. The preceding report shows that deletions within the intracellular linker between domains III and IV remove inactivation, but mutation of conserved basic and paired acidic amino acids has little effect. Here we show that sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： West JW,Patton DE,Scheuer T,Wang Y,Goldin AL,Catterall WA

更新日期：1992-11-15 00:00:00