Antiviral effect on MS-2 coliphage obtained with a synthetic antigen.

abstract：:The nonlinear nature of integration among cortical brain areas renders the effective connectivity between them inherently dynamic and context-sensitive. One emerging architectural principle of functional brain organization, which rests explicitly on these nonlinear interactions, is that neuronal responses expressed at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friston KJ,Büchel C

更新日期：2000-06-20 00:00:00

abstract：:Circadian rhythms in metazoan eukaryotes are controlled by an endogenous molecular clock. It functions in many locations, including subsets of brain neurons (clock neurons) within the central nervous system. Although the molecular clock relies on transcription/translation feedback loops, posttranscriptional regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Rosbash M

更新日期：2016-05-24 00:00:00

abstract：:We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root ganglion neurons from mice were exposed to various pharmacological agents (challenge compounds), while ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teichert RW,Smith NJ,Raghuraman S,Yoshikami D,Light AR,Olivera BM

更新日期：2012-01-31 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of the beta-globin cluster depend on sequences located at a considerable d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liebhaber SA,Griese EU,Weiss I,Cash FE,Ayyub H,Higgs DR,Horst J

更新日期：1990-12-01 00:00:00

abstract：:Diversity in 39 HLA-A, -B, and -C molecules is derived from 20 amino acid positions of high variability and 71 positions of low variability. Variation in the structurally homologous alpha 1 and alpha 2 domains is distinct and may correlate with partial segregation of peptide and T-cell receptor binding functions. Comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parham P,Lomen CE,Lawlor DA,Ways JP,Holmes N,Coppin HL,Salter RD,Wan AM,Ennis PD

更新日期：1988-06-01 00:00:00

abstract：:RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit responsible for transcribing the general stress response genes when environmental stress is imposed on Bacillus subtilis. The C-terminal domain of RsbR and its paralogues is a substrate for the kinase function of another sigma(B) regulator, RsbT,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray JW,Delumeau O,Lewis RJ

更新日期：2005-11-29 00:00:00

abstract：:We developed two solid-phase reagent systems for microscopic visualization and characterization of melanocyte-stimulating hormone (MSH) receptors of melanoma cells. Multiple copies of [Nle-4,D-Phe-7]-alpha-MSH, a potent analog of alpha-MSH, were conjugated to microspheres (latex beads) or macrospheres (polyamide beads...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SD,Jiang J,Hadley ME,Bentley DL,Hruby VJ

更新日期：1996-11-26 00:00:00

abstract：:Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurabielle C,Link VM,Bouladoux N,Han SJ,Merrill ED,Lightfoot YL,Seto N,Bleck CKE,Smelkinson M,Harrison OJ,Linehan JL,Tamoutounour S,Lionakis MS,Kaplan MJ,Nakajima S,Belkaid Y

更新日期：2020-07-14 00:00:00

abstract：:We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser MB,Moser EI,Forrest E,Andersen P,Morris RG

更新日期：1995-10-10 00:00:00

abstract：:ATP is copackaged and coreleased with adrenergic, serotonergic, and cholinergic neurotransmitters, suggesting a possible interaction between the signaling pathways for ATP and these coreleased neurotransmitters. Muscarinic m2 and m4, alpha 2-adrenergic, and D2-dopaminergic neurotransmitter receptors, which have in com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felder CC,Williams HL,Axelrod J

更新日期：1991-08-01 00:00:00

abstract：:Losses are a possibility in many risky decisions, and organisms have evolved mechanisms to evaluate and avoid them. Laboratory and field evidence suggests that people often avoid risks with losses even when they might earn a substantially larger gain, a behavioral preference termed "loss aversion." The cautionary brak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Martino B,Camerer CF,Adolphs R

更新日期：2010-02-23 00:00:00

abstract：:Antigen-induced activation of T cells can be specifically inhibited by antigen analogs that have been termed T-cell receptor peptide antagonists. These antagonists appear to act by inducing the formation of nonstimulatory or partially stimulatory complexes between T-cell receptors and the major histocompatibility comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Page DM,Alexander J,Snoke K,Appella E,Sette A,Hedrick SM,Grey HM

更新日期：1994-04-26 00:00:00

abstract：:To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

更新日期：1989-12-01 00:00:00

abstract：:In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response to conserved pathogen-associated molecular patterns. In addition, immunity can be induced in tissues remote from infection sites by system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truman W,Bennett MH,Kubigsteltig I,Turnbull C,Grant M

更新日期：2007-01-16 00:00:00

abstract：:The downstream box (DB) is a sequence element that enhances translation of several bacterial and phage mRNAs. It has been proposed that the DB enhances translation by base pairing transiently to bases 1469-1483 of 16S rRNA, the so-called anti-DB, during the initiation phase of translation. We have tested this model of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Connor M,Asai T,Squires CL,Dahlberg AE

更新日期：1999-08-03 00:00:00

abstract：:We have shown that a scanning transmission electron microscope with a high brightness field emission source is capable of obtaining better than 3 A resolution using 30 to 40 keV electrons. Elastic dark field images of single atoms of uranium and mercury are shown which demonstrate this fact as determined by a modified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall J,Langmore J,Isaacson M,Crewe AV

更新日期：1974-01-01 00:00:00

abstract：:One of the ultimate objectives of de novo protein design is to realize systems capable of catalyzing redox reactions on substrates. This goal is challenging as redox-active proteins require design considerations for both the reduced and oxidized states of the protein. In this paper, we describe the spectroscopic chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tegoni M,Yu F,Bersellini M,Penner-Hahn JE,Pecoraro VL

更新日期：2012-12-26 00:00:00

abstract：:A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averyhart-Fullard V,Datta K,Marcus A

更新日期：1988-02-01 00:00:00

abstract：:Despite the promise of immune checkpoint blockade (ICB) therapy against cancer, challenges associated with low objective response rates and severe systemic side effects still remain and limit its clinical applications. Here, we described a cold atmospheric plasma (CAP)-mediated ICB therapy integrated with microneedles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen G,Chen Z,Wen D,Wang Z,Li H,Zeng Y,Dotti G,Wirz RE,Gu Z

更新日期：2020-02-18 00:00:00

abstract：:Standard economic and evolutionary models assume that humans are fundamentally selfish. On this view, any acts of prosociality--such as cooperation, giving, and other forms of altruism--result from covert attempts to avoid social injunctions against selfishness. However, even in the absence of social pressure, individ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaki J,Mitchell JP

更新日期：2011-12-06 00:00:00

abstract：:Metabolic, infectious, and tumor cell-intrinsic noxae can all evoke the endoplasmic reticulum (ER) stress response in tumor cells, which is critical for tumor cell growth and cancer progression. Evidence exists that the ER stress response can drive a proinflammatory program in tumor cells and macrophages but, to our k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahadevan NR,Rodvold J,Sepulveda H,Rossi S,Drew AF,Zanetti M

更新日期：2011-04-19 00:00:00

abstract：:Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodelin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czéh B,Michaelis T,Watanabe T,Frahm J,de Biurrun G,van Kampen M,Bartolomucci A,Fuchs E

更新日期：2001-10-23 00:00:00

abstract：:The matrix of second derivatives of 21 apparent local energy minima of deca-L-alanine has been computed. The results show that all these conformations are true local energy minima and, therefore, potentially stable conformations for this peptide. Calculations of the relative statistical weights of these conformations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibson KD,Scheraga HA

更新日期：1969-06-01 00:00:00

abstract：:Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the cell surface. The experiments reported here define an important step in the life cycle of the virus, the release of the bud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Göttlinger HG,Dorfman T,Sodroski JG,Haseltine WA

更新日期：1991-04-15 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00

abstract：:Embryonic pluripotency in the mouse is established and maintained by a gene-regulatory network under the control of a core set of transcription factors that include octamer-binding protein 4 (Oct4; official name POU domain, class 5, transcription factor 1, Pou5f1), sex-determining region Y (SRY)-box containing gene 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Tresguerres B,Cañon S,Rayon T,Pernaute B,Crespo M,Torroja C,Manzanares M

更新日期：2010-11-16 00:00:00

abstract：:L-type Ca(2+) currents conducted by CaV1.2 channels initiate excitation-contraction coupling in the heart. Their activity is increased by β-adrenergic/cAMP signaling via phosphorylation by PKA in the fight-or-flight response, but the sites of regulation are unknown. We describe the functional role of phosphorylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Y,Westenbroek RE,Scheuer T,Catterall WA

更新日期：2013-11-26 00:00:00

abstract：:Chromosome rearrangements, such as large deletions, inversions, or translocations, mediate migration of large DNA segments within or between chromosomes, which can have major effects on cellular genetic control. A method for chromosome manipulation would be very useful for studying the consequences of large-scale DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Deursen J,Fornerod M,Van Rees B,Grosveld G

更新日期：1995-08-01 00:00:00

abstract：:A hybrid bacteriophage, P420, was constructed in vitro; it contains part of bacteriophage P4 and a 3.6-kilobase derivative of plasmid ColE1. In Escherichia coli, the plasmid-phage hybrid can exist as a stable plasmid or can be packaged into infective bacteriophage particles. Replication of P420, directed by the ColE1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn M,Helinski DR

更新日期：1978-05-01 00:00:00