Immunity to commensal skin fungi promotes psoriasiform skin inflammation.

abstract：:To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Patel MR,Prescher JA,Patsialou A,Qian D,Lin J,Wen S,Chang YF,Bachmann MH,Shimono Y,Dalerba P,Adorno M,Lobo N,Bueno J,Dirbas FM,Goswami S,Somlo G,Condeelis J,Contag CH,Gambhir SS,Clarke MF

更新日期：2010-10-19 00:00:00

abstract：:The claudin-low subtype is a recently identified rare molecular subtype of human breast cancer that expresses low levels of tight and adherens junction genes and shows high expression of epithelial-to-mesenchymal transition (EMT) genes. These tumors are enriched in gene expression signatures derived from human tumor-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herschkowitz JI,Zhao W,Zhang M,Usary J,Murrow G,Edwards D,Knezevic J,Greene SB,Darr D,Troester MA,Hilsenbeck SG,Medina D,Perou CM,Rosen JM

更新日期：2012-02-21 00:00:00

abstract：:In order to retain in an in situ system the control mechanisms involved in synthesis of bacteriophage T4 DNA, infected cells were made permeable to nucleotides by plasmolysis with concentrated sucrose. Such preparations use exogenous deoxyribonucleotides to synthesize T4 phage DNA. As has been observed with in vivo st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wovcha MG,Tomich PK,Chiu CS,Greenberg GR

更新日期：1973-08-01 00:00:00

abstract：:Previous work on perceptual decision making in the sensorimotor system has shown population dynamics in the beta band, corresponding to the encoding of stimulus properties and the final decision outcome. Here, we asked how oscillatory dynamics in the medial premotor cortex (MPC) contribute to supramodal perceptual dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haegens S,Vergara J,Rossi-Pool R,Lemus L,Romo R

更新日期：2017-12-26 00:00:00

abstract：:The high resolution 1H and 31P NMR spectra of the (dG-dC)8 duplex have been recorded in low- and high-salt solutions in order to evaluate the structural aspects of the salt-induced transition of oligo(dG-dC) in solution [Pohl, F. M. & Jovin, T. M. (1972) J. Mol. Biol. 67, 375-396]. The NMR data require that the (dG-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Canuel LL,Pohl FM

更新日期：1979-06-01 00:00:00

abstract：:Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naeve GS,Ramakrishnan M,Kramer R,Hevroni D,Citri Y,Theill LE

更新日期：1997-03-18 00:00:00

abstract：:Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lengsfeld AM,Löw I,Wieland T,Dancker P,Hasselbach W

更新日期：1974-07-01 00:00:00

abstract：:In an unprecedented finding, Davis et al. [Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N. & Parker, W. D., Jr. (1997) Proc. Natl. Acad. Sci. USA 94, 4526-4531] used an unusual DNA isolation method to show that healthy adults harbor a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano M,Shtilbans A,Mayeux R,Davidson MM,DiMauro S,Knowles JA,Schon EA

更新日期：1997-12-23 00:00:00

abstract：:25-Hydroxycholesterol is produced in mammalian tissues. The function of this oxysterol is unknown. Here we describe a central role for 25-hydroxycholesterol in regulating the immune system. In initial experiments, we found that stimulation of macrophage Toll-like receptors (TLR) induced expression of cholesterol 25-hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauman DR,Bitmansour AD,McDonald JG,Thompson BM,Liang G,Russell DW

更新日期：2009-09-29 00:00:00

abstract：:Host cell binding is an essential step in colonization by many bacterial pathogens, and the Lyme disease agent, Borrelia burgdorferi, which colonizes multiple tissues, is capable of attachment to diverse cell types. Glycosaminoglycans (GAGs) are ubiquitously expressed on mammalian cells and are recognized by multiple ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer JR,Parveen N,Magoun L,Leong JM

更新日期：2003-06-10 00:00:00

abstract：:Operating rooms (ORs) are inhabited by hierarchical, mixed-gender clinical teams that are often prone to conflict. In evolutionary terms, one expects more within- than between-gender rivalries, especially since the OR is a place where all sorts of social interactions occur, not merely technical communications. To docu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones LK,Jennings BM,Higgins MK,de Waal FBM

更新日期：2018-07-17 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup) with A+T-rich coding sequences. In this paper, we show that cells productively infected with HVS contain high concentrations of a virus-specified thymidylate synthase (5,10-methylenetetrahydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honess RW,Bodemer W,Cameron KR,Niller HH,Fleckenstein B,Randall RE

更新日期：1986-06-01 00:00:00

abstract：:Effects of temperature on biological processes are complex. Diffusion is less affected than the diverse enzymatic reactions that have distinct individual temperature profiles. Hence thermal fluctuations pose a formidable challenge to ectothermic organisms in which body temperature is largely dictated by the ambient te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radermacher PT,Myachina F,Bosshardt F,Pandey R,Mariappa D,Müller HA,Lehner CF

更新日期：2014-04-15 00:00:00

abstract：:Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugaiyan G,Mittal A,Weiner HL

更新日期：2010-06-22 00:00:00

abstract：:We previously have identified a subpopulation of contact-insensitive (CS-) cells which lacks density-dependent inhibition of cell division in primary and low-passage cultures of Syrian hamster embryonic (SHE) fibroblastic cells. Further, we have shown that the proportion of these CS- cells declines as a result of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano S,Ueo H,Bruce SA,Ts'o PO

更新日期：1985-08-01 00:00:00

abstract：:Sinorhizobium meliloti is an alpha-proteobacterium that forms agronomically important N(2)-fixing root nodules in legumes. We report here the complete sequence of the largest constituent of its genome, a 62.7% GC-rich 3,654,135-bp circular chromosome. Annotation allowed assignment of a function to 59% of the 3,341 pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capela D,Barloy-Hubler F,Gouzy J,Bothe G,Ampe F,Batut J,Boistard P,Becker A,Boutry M,Cadieu E,Dréano S,Gloux S,Godrie T,Goffeau A,Kahn D,Kiss E,Lelaure V,Masuy D,Pohl T,Portetelle D,Pühler A,Purnelle B,Ramsper

更新日期：2001-08-14 00:00:00

abstract：:Symbiotic microbes impact the severity of a variety of diseases through regulation of T-cell development. However, little is known regarding the molecular mechanisms by which this is accomplished. Here we report that a secreted factor, Erdr1, is regulated by the microbiota to control T-cell apoptosis. Erdr1 expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soto R,Petersen C,Novis CL,Kubinak JL,Bell R,Stephens WZ,Lane TE,Fujinami RS,Bosque A,O'Connell RM,Round JL

更新日期：2017-05-23 00:00:00

abstract：:BDF1 [(C57BL/6 X DBA/2)F1] mice were primed with alum-absorbed ovalbumin, and their spleen cells were cultured with ovalbumin to activate antigen-primed T cells. The activated T cells were then propagated in interleukin 2-containing medium in the presence or absence of affinity-purified glycosylation-inhibiting factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwata M,Ishizaka K

更新日期：1987-04-01 00:00:00

abstract：:The numbers and proportion of neurons in areas and regions of cortex were determined for a single cortical hemisphere from two prosimian galagos, one New World owl monkey, one Old World macaque monkey, and one baboon. The results suggest that there is a common plan of cortical organization across the species examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins CE,Airey DC,Young NA,Leitch DB,Kaas JH

更新日期：2010-09-07 00:00:00

abstract：:An essential element in the web-trap architecture, the capture silk spun by ecribellate orb spiders consists of glue droplets sitting astride a silk filament. Mechanically this thread presents a mixed solid-liquid behavior unknown to date. Under extension, capture silk behaves as a particularly stretchy solid, owing t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elettro H,Neukirch S,Vollrath F,Antkowiak A

更新日期：2016-05-31 00:00:00

abstract：:It is widely accepted that the heavily glycosylated glycoprotein gp120 on the surface of HIV-1 shields peptide epitopes from recognition by the immune system and may promote infection in vivo by interaction with dendritic cells and transport to tissue rich in CD4(+) T cells such as lymph nodes. A conserved cluster of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang SK,Liang PH,Astronomo RD,Hsu TL,Hsieh SL,Burton DR,Wong CH

更新日期：2008-03-11 00:00:00

abstract：:The efficacy of active immunization with the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administration reinstatement was assessed in rats. An animal model of relapse was used where rats were trained to self-administer cocaine, subjected to a period of extinction by substituting th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrera MR,Ashley JA,Zhou B,Wirsching P,Koob GF,Janda KD

更新日期：2000-05-23 00:00:00

abstract：:Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin S,Liu M,Niu W,Zhang CL

更新日期：2011-12-27 00:00:00

abstract：:Previous studies of legume nodules have indicated that formation of the heme moiety of leghemoglobin is a function of the bacterial symbiont. We now show that a hemA mutant of Bradyrhizobium japonicum that cannot carry out the first step in heme biosynthesis forms fully effective nodules on soybeans. The bacterial mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerinot ML,Chelm BK

更新日期：1986-03-01 00:00:00

abstract：:Inhibitory postsynaptic currents occurring spontaneously in the teleost Mauthner cell were analyzed with the single-electrode voltage-clamp technique. They were collected during depolarizing steps and were outward-going; this procedure allowed them to be isolated from possible excitatory currents flowing in the opposi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korn H,Burnod Y,Faber DS

更新日期：1987-08-01 00:00:00

abstract：:OLE (ornate, large, extremophilic) RNAs comprise a class of structured noncoding RNAs (ncRNAs) found in many extremophilic bacteria species. OLE RNAs constitute one of the longest and most widespread bacterial ncRNA classes whose major biochemical function remains unknown. In the Gram-positive alkaliphile Bacillus hal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris KA,Zhou Z,Peters ML,Wilkins SG,Breaker RR

更新日期：2018-07-03 00:00:00

abstract：:It is well-established morphologically that bipolar cells, the second-order neurons in the vertebrate retina, make reciprocal synapses with amacrine cells in the inner plexiform layer. However, neither the property nor the physiological function of the feedback synapse is understood. Autoradiographic and immunohistoch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachibana M,Kaneko A

更新日期：1987-05-01 00:00:00

abstract：:We present a method for studying RNA processing and ribonucleoprotein assembly in vivo, by using RNA synthesized in vitro. SP6-transcribed 32P-labeled U2 small nuclear RNA precursor molecules were introduced into cultured human 293 cells by calcium phosphate-mediated uptake, as in standard DNA transfection experiments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinschmidt AM,Pederson T

更新日期：1990-02-01 00:00:00

abstract：:The lack of genetic means has been a serious limitation in studying mosquito immunity. We generated Relish-mediated immune deficiency (RMID) by transforming Aedes aegypti with the Delta Rel transgene driven by the vitellogenin (Vg) promoter using the pBac[3xP3-EGFP, afm] vector. A stable transformed line had a single ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shin SW,Kokoza V,Lobkov I,Raikhel AS

更新日期：2003-03-04 00:00:00

abstract：:The Ca(2+) channel alpha(1A)-subunit is a voltage-gated, pore-forming membrane protein positioned at the intersection of two important lines of research: one exploring the diversity of Ca(2+) channels and their physiological roles, and the other pursuing mechanisms of ataxia, dystonia, epilepsy, and migraine. alpha(1A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jun K,Piedras-Rentería ES,Smith SM,Wheeler DB,Lee SB,Lee TG,Chin H,Adams ME,Scheller RH,Tsien RW,Shin HS

更新日期：1999-12-21 00:00:00