Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.

abstract：:Viral hepatitis is a disease of antiquity, but evidence for more than one etiologic agent has been recognized only since the 1940s, when two viruses (hepatitis A virus and hepatitis B virus) were thought to account for all disease. In the past 20 years, three additional hepatitis agents (hepatitis C virus, hepatitis D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell RH

更新日期：1994-03-29 00:00:00

abstract：:Recombinant human migration inhibitory factor (MIF), isolated through functional expression cloning in COS-1 cells, up-regulates expression of genes encoding HLA-DR and interleukin 1 beta (IL-1 beta) and elaboration of IL-1 beta by human monocyte-derived macrophages. Administration of soluble bovine serum albumin or h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiser WY,Pozzi LM,Titus RG,David JR

更新日期：1992-09-01 00:00:00

abstract：:The ability to dynamically organize functional nanoparticles (NPs) via the use of environmental triggers (temperature, pH, light, or solvent polarity) opens up important perspectives for rapid and convenient construction of a rich variety of complex assemblies and materials with new structures and functionalities. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Wang Z,He Y,Yoon YJ,Jung J,Zhang G,Lin Z

更新日期：2018-02-13 00:00:00

abstract：:Previous studies have provided evidence that IL-15 expression within human tumors is crucial for optimal antitumor responses; however, the regulation of IL-15 within the tumor microenvironment (TME) is unclear. We report herein, in analyses of mice implanted with various tumor cell lines, soluble IL-15/IL-15Rα complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santana Carrero RM,Beceren-Braun F,Rivas SC,Hegde SM,Gangadharan A,Plote D,Pham G,Anthony SM,Schluns KS

更新日期：2019-01-08 00:00:00

abstract：:Based on the cell surface expression of CD4 and CD8 molecules, murine thymocytes can be divided into four populations: these include CD4-, CD8- double-negative and CD4+, CD8+ double-positive subpopulations, both of which consist largely of immature cells, and the single positive, CD4+ or CD8+, subsets that contain fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikolić-Zugić J,Bevan MJ

更新日期：1988-11-01 00:00:00

abstract：:The p6 domain of HIV-1 Gag contains highly conserved peptide motifs that recruit host machinery to sites of virus assembly, thereby promoting particle release from the infected cell. We previously reported that mutations in the YPXnL motif of p6, which binds the host protein Alix, severely impair HIV-1 replication. Pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Duyne R,Kuo LS,Pham P,Fujii K,Freed EO

更新日期：2019-04-30 00:00:00

abstract：:This paper reports that there are major differences between mammalian cell lines in the propensity to progress into subsequent cell cycles when mitosis is inhibited with agents that disrupt the assembly of the mitotic spindle apparatus (Colcemid, nocodazole, and taxol). Human HeLa S3 cells, which represent one extreme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kung AL,Sherwood SW,Schimke RT

更新日期：1990-12-01 00:00:00

abstract：:Mechanisms of bacterial pathogenesis have become an increasingly important subject as pathogens have become increasingly resistant to current antibiotics. The adhesion of microorganisms to the surface of host tissue is often a first step in pathogenesis and is a plausible target for new antiinfective agents. Examinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang MN,Smith SP,Metallo SJ,Choi IS,Prentiss M,Whitesides GM

更新日期：2000-11-21 00:00:00

abstract：:The I-J subregion of the mouse major histocompatibility complex has been reported to encode antigenic determinants expressed by suppressor T cells. Previously, cosmid clones were obtained from mouse sperm DNA that contain all of the sequences between the I-A and I-E subregions, where I-J has been mapped genetically. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronenberg M,Steinmetz M,Kobori J,Kraig E,Kapp JA,Pierce CW,Sorensen CM,Suzuki G,Tada T,Hood L

更新日期：1983-09-01 00:00:00

abstract：:The generation of high-titer, helper-free retroviruses by transient transfection has been achieved by using the highly transfectable 293T cell line into which are stably introduced constructs that express retroviral packaging functions. The resulting ecotropic virus packaging cell line BOSC 23 produces infectious retr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pear WS,Nolan GP,Scott ML,Baltimore D

更新日期：1993-09-15 00:00:00

abstract：:Protein functions require conformational motions. We show here that the dominant conformational motions are slaved by the hydration shell and the bulk solvent. The protein contributes the structure necessary for function. We formulate a model that is based on experiments, insights from the physics of glass-forming liq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frauenfelder H,Chen G,Berendzen J,Fenimore PW,Jansson H,McMahon BH,Stroe IR,Swenson J,Young RD

更新日期：2009-03-31 00:00:00

abstract：:F(o)F(1)-ATP synthase manufactures the energy "currency," ATP, of living cells. The soluble F(1) portion, called F(1)-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the gamma-subunit. A coarse-grained plastic network model is used to show at a residue level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pu J,Karplus M

更新日期：2008-01-29 00:00:00

abstract：:The distribution of dopamine-containing processes in the striatum of fetal and neonatal cats was studied by immunohistochemical and glyoxylic acid histofluorescence methods and compared to the distribution of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) observed by thiocholine histochemistry in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graybiel AM,Pickel VM,Joh TH,Reis DJ,Ragsdale CW Jr

更新日期：1981-09-01 00:00:00

abstract：:Regulated exocytosis requires tight coupling of the membrane fusion machinery to a triggering signal and a fast response time. Complexins are part of this regulation and, together with synaptotagmins, control calcium-dependent exocytosis. Stimulatory and inhibitory functions have been reported for complexins. To test ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malsam J,Seiler F,Schollmeier Y,Rusu P,Krause JM,Söllner TH

更新日期：2009-02-10 00:00:00

abstract：:Irrigation of the dog's oxyntic glandular mucosa contained in a chronically prepared, vagally denervated, separated pouch of the dog's stomach with a solution (0.5 mg ml-1) of lyophilized venom of the hooded cobra (Naja naja) increases the permeability of the mucosa. If irrigation with venom solution is repeated at we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davenport HW

更新日期：1976-03-01 00:00:00

abstract：:In Drosophila, heterochromatin protein 1 (HP1) suppresses the expression of euchromatic genes that are artificially translocated adjacent to heterochromatin by expanding heterochromatin structure into neighboring euchromatin. The purpose of this study was to determine whether HP1 functions as a transcriptional repress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang KK,Eissenberg JC,Worman HJ

更新日期：2001-09-25 00:00:00

abstract：:Developing tools for investigating the cellular activity of glycans will help to delineate the molecular basis for aberrant glycosylation in pathological processes such as cancer. Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu TL,Hanson SR,Kishikawa K,Wang SK,Sawa M,Wong CH

更新日期：2007-02-20 00:00:00

abstract：:Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poët M,Kornak U,Schweizer M,Zdebik AA,Scheel O,Hoelter S,Wurst W,Schmitt A,Fuhrmann JC,Planells-Cases R,Mole SE,Hübner CA,Jentsch TJ

更新日期：2006-09-12 00:00:00

abstract：:Population outbreaks in tundra rodents have intrigued scientists for a century as a result of their spectacular appearances and their general lessons in ecology. One outstanding question that has led to competing hypotheses is why sympatric lemmings and voles differ in regularity and shape of their outbreaks. Lemming ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ims RA,Yoccoz NG,Killengreen ST

更新日期：2011-02-01 00:00:00

abstract：:In FRTL5 rat thyroid cells, norepinephrine, by interacting with alpha 1-adrenergic receptors, stimulates inositol phosphate formation, through activation of phospholipase C, and arachidonic acid release. Recent studies have shown that GTP-binding proteins couple several types of receptors to phospholipase C activation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burch RM,Luini A,Axelrod J

更新日期：1986-10-01 00:00:00

abstract：:Ras CAAX (C = cysteine, A = aliphatic amino acid, and X = any amino acid) peptidomimetic inhibitors of farnesyl protein transferase suppress Ras-dependent cell transformation by preventing farnesylation of the Ras oncoprotein. These compounds are potential anticancer agents for tumors associated with Ras mutations. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kauffmann RC,Qian Y,Vogt A,Sebti SM,Hamilton AD,Carthew RW

更新日期：1995-11-21 00:00:00

abstract：:Networks are widely used in the biological, physical, and social sciences as a concise mathematical representation of the topology of systems of interacting components. Understanding the structure of these networks is one of the outstanding challenges in the study of complex systems. Here we describe a general techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman ME,Leicht EA

更新日期：2007-06-05 00:00:00

abstract：:The concentration of urea in renal medullary cells is high enough to affect enzymes seriously by reducing Vmax or raising Km, yet the cells survive and function. The usual explanation is that the methylamines found in the renal medulla, namely glycerophosphocholine and betaine, have actions opposite to those of urea a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burg MB,Peters EM,Bohren KM,Gabbay KH

更新日期：1999-05-25 00:00:00

abstract：:Phagocytosis is a primary defense program orchestrated by monocytes/macrophages. Unregulated phagocytosis can lead to pathological conditions. In the current study we have demonstrated that Wnt5a stimulates phagocytosis through PI3 kinase-Rac1 and lipid-raft-dependent processes. Wnt5a-mediated augmentation in phagocyt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maiti G,Naskar D,Sen M

更新日期：2012-10-09 00:00:00

abstract：:We explored the conformational landscape of the proteinogenic amino acid serine [CH(2)OH CH(NH(2)) COOH] in the gas phase. Solid serine was vaporized by laser ablation, expanded in a supersonic jet, and characterized by Fourier transform microwave spectroscopy. In the isolation conditions of the jet there have been di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanco S,Sanz ME,López JC,Alonso JL

更新日期：2007-12-18 00:00:00

abstract：:Fetal cerebral neurons at the initiation of active neurite outgrowth in culture incorporate 4-fold more [3H]glucosamine into glycoproteins than into the cellular lipid fraction. After 8 days or longer, when a well-developed fiber network is apparent, lipids are labeled more extensively than the glycoproteins. Labeling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yavin E,Richter-Landsberg C,Duksin D,Yavin Z

更新日期：1984-09-01 00:00:00

abstract：:Primitive cells capable of generating small resistance arterioles and capillary structures in the injured myocardium have been identified repeatedly. However, these cells do not form large conductive coronary arteries that would have important implications in the management of the ischemic heart. In the current study,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bearzi C,Leri A,Lo Monaco F,Rota M,Gonzalez A,Hosoda T,Pepe M,Qanud K,Ojaimi C,Bardelli S,D'Amario D,D'Alessandro DA,Michler RE,Dimmeler S,Zeiher AM,Urbanek K,Hintze TH,Kajstura J,Anversa P

更新日期：2009-09-15 00:00:00

abstract：:Incubation of chicken embryo fibroblasts with mitogenic concentrations of insulin for 24 hr or with the tumor promoter phorbol 12-myristate 13-acetate for 6 hr stimulated lactate release and 3-O-methylglucose uptake. Insulin also increased the Vmax of 6-phosphofructo-1-kinase (ATP:D-fructose-6-phosphate 1-phosphotrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosca L,Rousseau GG,Hue L

更新日期：1985-10-01 00:00:00

abstract：:Sonic hedgehog (Shh) plays an integral role in both the anterior-posterior (A-P) patterning and expansion of developing vertebrate limbs through a feedback loop involving Fgfs, Bmps, and Gremlin. In bat limbs A-P patterning and the size of the digital field are unique. The posterior digits of the forelimb are elongate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hockman D,Cretekos CJ,Mason MK,Behringer RR,Jacobs DS,Illing N

更新日期：2008-11-04 00:00:00

abstract：:Mutations in WNK1 and WNK4 lead to familial hyperkalemic hypertension (FHHt). Because FHHt associates net positive Na(+) balance together with K(+) and H(+) renal retention, the identification of WNK1 and WNK4 led to a new paradigm to explain how aldosterone can promote either Na(+) reabsorption or K(+) secretion in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadchouel J,Soukaseum C,Büsst C,Zhou XO,Baudrie V,Zürrer T,Cambillau M,Elghozi JL,Lifton RP,Loffing J,Jeunemaitre X

更新日期：2010-10-19 00:00:00