Abstract:
:The I-J subregion of the mouse major histocompatibility complex has been reported to encode antigenic determinants expressed by suppressor T cells. Previously, cosmid clones were obtained from mouse sperm DNA that contain all of the sequences between the I-A and I-E subregions, where I-J has been mapped genetically. However, hybridization of these sequences to RNA prepared from several I-J-positive suppressor T-cell hybridomas did not reveal the presence of a transcript. In addition, no rearrangements in this DNA were detected in the suppressor T cells that we have analyzed. Our results indicate that the I-J polypeptides are not encoded between the I-A and I-E subregions of the major histocompatibility complex. We discuss several hypotheses concerning the possible location and expression of I-J genes.
journal_name
Proc Natl Acad Sci U S Aauthors
Kronenberg M,Steinmetz M,Kobori J,Kraig E,Kapp JA,Pierce CW,Sorensen CM,Suzuki G,Tada T,Hood Ldoi
10.1073/pnas.80.18.5704subject
Has Abstractpub_date
1983-09-01 00:00:00pages
5704-8issue
18eissn
0027-8424issn
1091-6490journal_volume
80pub_type
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