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Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

Abstract：

:Representational difference analysis was used to search for pathogens in multiple sclerosis brains. We detected a 341-nucleotide fragment that was 99.4% identical to the major DNA binding protein gene of human herpesvirus 6 (HHV-6). Examination of 86 brain specimens by PCR demonstrated that HHV-6 was present in > 70% of MS cases and controls and is thus a commensal virus of the human brain. By DNA sequencing, 36/37 viruses from MS cases and controls were typed as HHV-6 variant B group 2. Other herpesviruses, retroviruses, and measles virus were detected infrequently or not at all. HHV-6 expression was examined by immunocytochemistry with monoclonal antibodies against HHV-6 virion protein 101K and DNA binding protein p41. Nuclear staining of oligodendrocytes was observed in MS cases but not in controls, and in MS cases it was observed around plaques more frequently than in uninvolved white matter. MS cases showed prominent cytoplasmic staining of neurons in gray matter adjacent to plaques, although neurons expressing HHV-6 were also found in certain controls. Since destruction of oligodendrocytes is a hallmark of MS, these studies suggest an association of HHV-6 with the etiology or pathogenesis of MS.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Challoner PB,Smith KT,Parker JD,MacLeod DL,Coulter SN,Rose TM,Schultz ER,Bennett JL,Garber RL,Chang M

doi

10.1073/pnas.92.16.7440

subject

Has Abstract,Author List Incomplete

pub_date

1995-08-01 00:00:00

pages

7440-4

issue

16

eissn

0027-8424

issn

1091-6490

journal_volume

92

pub_type

临床试验,杂志文章

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