The carboxy-terminal domain of complexin I stimulates liposome fusion.

abstract：:Spreading depression (SD), a slow diffusion-mediated self-sustained wave of depolarization that severely disrupts neuronal function, has been implicated as a cause of cellular injury in a number of central nervous system pathologies, including blind spots in the retina. Here we show that in the hypoglycemic chicken re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Y,Santos LM,Mattiace LA,Costa ML,Ferreira LC,Benabou K,Kim AH,Abrahams J,Bennett MV,Rozental R

更新日期：2012-02-14 00:00:00

abstract：:The physiological significance of multiple G-protein-coupled receptor subtypes, such as the beta-adrenergic receptors (beta ARs), remains obscure, since in many cases several subtypes activate the same effector and utilize the same physiological agonists. We inspected the deduced amino acid sequences of the beta AR su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liggett SB,Freedman NJ,Schwinn DA,Lefkowitz RJ

更新日期：1993-04-15 00:00:00

abstract：:Small solutes affect protein and nucleic acid processes because of favorable or unfavorable chemical interactions of the solute with the biopolymer surface exposed or buried in the process. Large solutes also exclude volume and affect processes where biopolymer molecularity and/or shape changes. Here, we develop an an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles DB,LaCroix AS,Deines NF,Shkel I,Record MT Jr

更新日期：2011-08-02 00:00:00

abstract：:The chromatin core particle DNA conformation deduced in broad outline by Finch et al. [Finch, J. T., Lutter, L. C., Rhodes, D., Brown, R. S., Rushton, B., Levitt, M. & Klug, A. (1977) Nature 269, 29-36] can be described in detail using other available experimental results. Histone binding sites compatible with the pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carter CW Jr

更新日期：1978-08-01 00:00:00

abstract：:The data reported here demonstrate that a preparation extracted from nonpathogenic mycobacteria such as Mycobacterium smegmatis and hereafter referred to as interphase material protected mice against Ehrlich ascitic carcinoma, L-1210 leukemia, and another syngeneic lymphoid leukemia. Furthermore, mice treated by this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamensans A,Chedid L,Lederer E,Rosselet JP,Gustafson RH,Spencer HJ,Ludwig B,Berger FM

更新日期：1975-09-01 00:00:00

abstract：:Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strittmatter WJ,Roses AD

更新日期：1995-05-23 00:00:00

abstract：:Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roselli-Rehfuss L,Mountjoy KG,Robbins LS,Mortrud MT,Low MJ,Tatro JB,Entwistle ML,Simerly RB,Cone RD

更新日期：1993-10-01 00:00:00

abstract：:The majority of familial Alzheimer disease mutations are linked to the recently cloned presenilin (PS) genes, which encode two highly homologous proteins (PS-1 and PS-2). It was shown that the full-length PS-2 protein is phosphorylated constitutively within its N-terminal domain by casein kinases, whereas the PS-1 pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter J,Grünberg J,Capell A,Pesold B,Schindzielorz A,Citron M,Mendla K,George-Hyslop PS,Multhaup G,Selkoe DJ,Haass C

更新日期：1997-05-13 00:00:00

abstract：:We showed previously that rrn P1 promoters require unusually high concentrations of the initiating nucleoside triphosphates (ATP or GTP, depending on the promoter) for maximal transcription in vitro. We proposed that this requirement for high initiating NTP concentrations contributes to control of the rrn P1 promoters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider DA,Gaal T,Gourse RL

更新日期：2002-06-25 00:00:00

abstract：:A major goal of tumor immunotherapy is the effective eradication of established metastases associated with the induction of a T cell-mediated protective immunity. We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion protein that assures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Dreier T,Xiang R,Varki NM,Kang AS,Reisfeld RA

更新日期：1998-03-03 00:00:00

abstract：:Biological membranes are complex, self-organized structures that define boundaries and compartmentalize space in living matter. Composed of a wide variety of lipid and protein molecules, these responsive surfaces mediate transmembrane signaling and material transport within the cell and with its environment. It is wel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watkins EB,Miller CE,Majewski J,Kuhl TL

更新日期：2011-04-26 00:00:00

abstract：:Climate change is expected to alter the distribution and abundance of many species. Predictions of climate-induced population extinctions are supported by geographic range shifts that correspond to climatic warming, but few extinctions have been linked mechanistically to climate change. Here we show that extinctions o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLaughlin JF,Hellmann JJ,Boggs CL,Ehrlich PR

更新日期：2002-04-30 00:00:00

abstract：:Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and embryonic and pupal diapauses have been extensively studied in mostly holometabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miki T,Shinohara T,Chafino S,Noji S,Tomioka K

更新日期：2020-03-10 00:00:00

abstract：:Purified dihydropyridine-sensitive calcium channels from rabbit skeletal muscle were reconstituted into phosphatidylcholine vesicles to evaluate the effect of phosphorylation by cyclic AMP-dependent protein kinase (PK-A) on their function. Both the rate and extent of 45Ca2+ uptake into vesicles containing reconstitute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nunoki K,Florio V,Catterall WA

更新日期：1989-09-01 00:00:00

abstract：:How granzymes gain entry into the cytosol of target cells during killer cell attack has been the subject of several studies in the past, but the effective delivery mechanism during target cell encounter has not been clarified. Here we show that granzyme B (GzmB) mutants lacking binding to negatively charged, essential...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurschus FC,Fellows E,Stegmann E,Jenne DE

更新日期：2008-09-16 00:00:00

abstract：:Sialyl Lewis x (sLe(x)) and sialyl Lewis a (sLe(a)) glycans are expressed on highly metastatic colon cancer cells. They promote extravasation of cancer cells and tumor angiogenesis via interacting with E-selectin on endothelial cells. Recently, epithelial-mesenchymal transition (EMT) has been noted as a critical pheno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakuma K,Aoki M,Kannagi R

更新日期：2012-05-15 00:00:00

abstract：:Two-dimensional gel electrophoresis of immunoprecipitated human HLA-DR antigens from cells expressing the HLA-DR4 haplotype shows distinct clustering of beta-chain patterns. Six unique electrophoretic variants were observed among 17 HLA-DR4 homozygous cell lines (HCL) analyzed. These patterns correlate precisely with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepom BS,Nepom GT,Mickelson E,Antonelli P,Hansen JA

更新日期：1983-11-01 00:00:00

abstract：:The complete coding region of maize transposable element Ac and truncated but active derivatives of it were placed under the control of promoters of different strength and tested for the ability to excise transposable element Ds from a beta-glucuronidase reporter gene in a cotransfection assay in Petunia protoplasts. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker D,Lütticke R,Li M,Starlinger P

更新日期：1992-06-15 00:00:00

abstract：:Circulating peripheral blood cells and disaggregated yolk sac cells were obtained from normal mouse embryos as early as day 9 of gestation, prior to the formation of the fetal liver. These were cultured in vitro in plasma clots or methylcellulose, in the presence of either embryonic fluid or adult spleen cell-conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong PM,Clarke BJ,Carr DH,Chui DH

更新日期：1982-05-01 00:00:00

abstract：:The measurement of any nonchromosomal genetic contribution to the heritability of a trait is often confounded by the inability to control both the chromosomal and nonchromosomal information in a population. We have designed a unique system in yeast where we can control both sources of information so that the phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards MD,Symbor-Nagrabska A,Dollard L,Gifford DK,Fink GR

更新日期：2014-05-27 00:00:00

abstract：:Platelets are best known for their vasoprotective responses to injury and inflammation. Here, we have asked whether they also support vascular integrity when neither injury nor inflammation is present. Changes in vascular barrier function in dermal and meningeal vessels were measured in real time in mouse models using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Konradt C,Corken A,Ware J,Nieswandt B,Di Paola J,Yu M,Wang D,Nieman MT,Whiteheart SW,Brass LF

更新日期：2020-09-29 00:00:00

abstract：:Autocatalytic chemical reactions are widely studied as models of biological processes and to better understand the origins of life on Earth. Minimal self-reproducing amphiphiles have been developed in this context and as an approach to de novo "bottom-up" synthetic protocells. How chemicals come together to produce li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortega-Arroyo J,Bissette AJ,Kukura P,Fletcher SP

更新日期：2016-10-04 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:Antigen-independent cell lines were derived from mouse helper T-cell clones by culture in autologous supernatant obtained after stimulation with concanavalin A. A factor, termed P40, supporting the growth of these lines was purified and characterized as a basic 32- to 39-kDa single-chain glycoprotein functionally dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uyttenhove C,Simpson RJ,Van Snick J

更新日期：1988-09-01 00:00:00

abstract：:After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effect of ascorbate appears to be unrelated to its cofactor function in collagen hydroxylation. The collagenous protein secret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murad S,Grove D,Lindberg KA,Reynolds G,Sivarajah A,Pinnell SR

更新日期：1981-05-01 00:00:00

abstract：:Mutations in sequences at the C terminus of the capsid precursor protein of human immunodeficiency virus type 1 that affect the viral p6 protein prevent release of budded virus particles from the cell surface. The experiments reported here define an important step in the life cycle of the virus, the release of the bud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Göttlinger HG,Dorfman T,Sodroski JG,Haseltine WA

更新日期：1991-04-15 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive phenotype consistent with impaired transport of cationic amino acids at the basolateral membrane of intestinal and renal epithelia. On the assumption that the basolateral membrane of epithelial cells and plasma membrane of parenchymal cells are functional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DW,Scriver CR,Tenenhouse HS,Simell O

更新日期：1987-11-01 00:00:00

abstract：:In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forget BG,Marotta CA,Weissman SM,Cohen-Solal M

更新日期：1975-09-01 00:00:00

abstract：:The cingulate gyri in 37 subjects with and without early dementia of the Alzheimer type (DAT) were studied by using MRI at 1.0 mm3 isotropic resolution. Groups were segregated into young controls (n = 10), age-matched normal controls (n = 10), very mild DAT (n = 8), and mild DAT (n = 9). By using automated Bayesian se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MI,Hosakere M,Barker AR,Priebe CE,Lee N,Ratnanather JT,Wang L,Gado M,Morris JC,Csernansky JG

更新日期：2003-12-09 00:00:00