Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy.

abstract：:Photonic materials with positionally ordered structure can interact strongly with light to produce brilliant structural colors. Here, we found that the nonperiodic nematic liquid crystals of nanoplates can also display structural color with only significant orientational order. Owing to the loose stacking of the nemat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng M,King D,Huang D,Do C,Wang L,Chen M,Lei S,Lin P,Chen Y,Cheng Z

更新日期：2019-09-10 00:00:00

abstract：:Listeria monocytogenes is an intracellular parasite that can readily infect the macrophage-like cell line J774 and the kidney epithelial cell PtK2. After being ingested, the organism escapes from the phagolysosome into the host-cell cytoplasm. N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)-phallacidin, a specific stain for act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabiri GA,Sanger JM,Portnoy DA,Southwick FS

更新日期：1990-08-01 00:00:00

abstract：:We have studied androgen binding characteristics of cells for androgen insensitivity from an obligate heterozygote, who is the mother of three male pseudohermaphrodites with dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) receptor deficiency. Specific dihydrotestosterone binding by skin fibroblasts from he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer WJ 3rd,Migeon BR,Migeon CJ

更新日期：1975-04-01 00:00:00

abstract：:The drought of progress in clinical brain tumor therapy provides an impetus for developing new treatments as well as methods for testing therapeutics in animal models. The inability of traditional assays to simultaneously measure tumor size, location, growth kinetics, and cell kill achieved by a treatment complicates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross BD,Zhao YJ,Neal ER,Stegman LD,Ercolani M,Ben-Yoseph O,Chenevert TL

更新日期：1998-06-09 00:00:00

abstract：:We have expressed a male-specific, pheromone-sensitive odorant receptor (OR), BmorOR1, from the silkworm moth Bombyx mori in an "empty neuron" housed in the ab3 sensilla of a Drosophila Deltahalo mutant. Single-sensillum recordings showed that the BmorOR1-expressing neurons in the transgenic flies responded to the B. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syed Z,Ishida Y,Taylor K,Kimbrell DA,Leal WS

更新日期：2006-10-31 00:00:00

abstract：:We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

更新日期：1999-04-27 00:00:00

abstract：:The murine mast cell line PB-3c is dependent on interleukin 3 (IL-3) with respect to survival and proliferation. These cells also require IL-3 to display antigen-mediated serotonin release, which is coupled to a transient increase of cytosolic free calcium ([Ca2+]i). The antigen-mediated exocytosis is inhibited by pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazurek N,Regazzi R,Borner C,Wyss R,Conscience JF,Erne P,Eppenberger U,Fabbro D

更新日期：1987-03-01 00:00:00

abstract：:The fossil record of land plants is an obvious source of information on the dynamics of mass extinctions in the geological past. In conjunction with the end-Permian ecological crisis, approximately 250 million years ago, palynological data from East Greenland reveal some unanticipated patterns. We document the signifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Looy CV,Twitchett RJ,Dilcher DL,Van Konijnenburg-Van Cittert JH,Visscher H

更新日期：2001-07-03 00:00:00

abstract：:Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased brain. To probe the dynamics of blood flow at this level, we used two-photon laser scanning microscopy to image the motion of red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinfeld D,Mitra PP,Helmchen F,Denk W

更新日期：1998-12-22 00:00:00

abstract：:A Chinese hamster ovary cell (CHO) mutant (strain 58), defective in CDP-choline synthetase (cholinephosphate cytidylyltransferase; CTP:cholinephosphate cytidylyltransferase, EC 2.7.7.15), is temperature sensitive for growth and contains less than half of the normal amount of phosphatidylcholine under nonpermissive con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esko JD,Nishijima M,Raetz CR

更新日期：1982-03-01 00:00:00

abstract：:Huntington's disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dargaei Z,Bang JY,Mahadevan V,Khademullah CS,Bedard S,Parfitt GM,Kim JC,Woodin MA

更新日期：2018-02-13 00:00:00

abstract：:Marine ecosystems are in decline. New transformational changes in governance are urgently required to cope with overfishing, pollution, global changes, and other drivers of degradation. Here we explore social, political, and ecological aspects of a transformation in governance of Chile's coastal marine resources, from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Hughes TP,Olsson P,Folke C,Defeo O,Fernández M,Foale S,Gunderson LH,Rodríguez-Sickert C,Scheffer M,Steneck RS,Castilla JC

更新日期：2010-09-28 00:00:00

abstract：:The posteromedial barrel subfield of the somatosensory cortex of mice was examined histochemically for cytochrome oxidase activity (cytochrome c oxidase; ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1). In normal mice a high enzymatic activity was found within the barrel hollows, rather than in the sides and sept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong-Riley MT,Welt C

更新日期：1980-04-01 00:00:00

abstract：:Summertime Arctic shipboard observations of oxygenated volatile organic compounds (OVOCs) such as organic acids, key precursors of climatically active secondary organic aerosol (SOA), are consistent with a novel source of OVOCs to the marine boundary layer via chemistry at the sea surface microlayer. Although this sou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mungall EL,Abbatt JPD,Wentzell JJB,Lee AKY,Thomas JL,Blais M,Gosselin M,Miller LA,Papakyriakou T,Willis MD,Liggio J

更新日期：2017-06-13 00:00:00

abstract：:Seed germination is a complex trait of key ecological and agronomic significance. Few genetic factors regulating germination have been identified, and the means by which their concerted action controls this developmental process remains largely unknown. Using publicly available gene expression data from Arabidopsis th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassel GW,Lan H,Glaab E,Gibbs DJ,Gerjets T,Krasnogor N,Bonner AJ,Holdsworth MJ,Provart NJ

更新日期：2011-06-07 00:00:00

abstract：:Echoviruses have been implicated in multiple human disease syndromes, including aseptic meningitis, paralysis, and heart disease, but no animal model is available for studying the pathogenesis of infection. Production of human integrin very late antigen 2, a receptor for echovirus type 1, in transgenic mice conferred ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SA,Thaker HM,Racaniello VR

更新日期：2003-12-23 00:00:00

abstract：:Accumulation of (45)Ca(++) was found to occur in membrane vesicles of E. coli prepared by lysis with a French pressure cell. The uptake occurs by active transport, requiring an energy source. Substrates of the electron transport chain, including D-lactate, reduced phenazine methosulfate, and NADH, stimulated accumulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen BP,McClees JS

更新日期：1974-12-01 00:00:00

abstract：:The lacY gene of Escherichia coli was cut into two approximately equal-size fragments with Afl II and subcloned individually or together under separate lac operator/promoters in plasmid pT7-5. Under these conditions, lac permease is expressed in two portions: (i) the N-terminal portion (the N terminus, the first six p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi E,Kaback HR

更新日期：1990-06-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major complication of chronic inflammation and one of the most common human systemic amyloid diseases worldwide. Most circulating SAA is protected f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman S,Gantz DL,Haupt C,Gursky O

更新日期：2017-08-08 00:00:00

abstract：:A fundamental issue in human development concerns how the young infant's ability to recognize emotional signals is acquired through both biological programming and learning factors. This issue is extremely difficult to investigate because of the variety of sensory experiences to which humans are exposed immediately af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollak SD,Kistler DJ

更新日期：2002-06-25 00:00:00

abstract：:During neurogenesis of the mammalian neocortex, neural progenitor cells divide to generate daughter cells that either become neurons or remain as progenitor cells. The mouse numb (m-numb) gene encodes a membrane-associated protein that is asymmetrically localized to the apical cell membrane of dividing cortical progen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong W,Jiang MM,Schonemann MD,Meneses JJ,Pedersen RA,Jan LY,Jan YN

更新日期：2000-06-06 00:00:00

abstract：:Retroviruses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, and subsequently reinvaded host genomes. Together, endogenous retroviruses and LTR retrotransposons represent major components of animal, plant, and fungal genomes. Sequences from these elements have been exapte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodonova SO,Prinz S,Bilanchone V,Sandmeyer S,Briggs JAG

更新日期：2019-05-14 00:00:00

abstract：:A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Skofitsch G,Bannon MJ,Jacobowitz DM

更新日期：1986-03-01 00:00:00

abstract：:Cortical networks that have been found to operate close to a critical point exhibit joint activations of large numbers of neurons. However, in motor cortex of the awake macaque monkey, we observe very different dynamics: massively parallel recordings of 155 single-neuron spiking activities show weak fluctuations on th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahmen D,Grün S,Diesmann M,Helias M

更新日期：2019-06-25 00:00:00

abstract：:Recombinant plasmids containing mutant or wild-type adenovirus serotype 2 EIa genes that produce the 12S mRNA alone, the 13S mRNA alone, or both mRNAs were cotransfected into HeLa cells with plasmids containing the viral EIIa or EIII transcription units. The amount of RNA produced from the EIIa and EIII promoters was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leff T,Elkaim R,Goding CR,Jalinot P,Sassone-Corsi P,Perricaudet M,Kédinger C,Chambon P

更新日期：1984-07-01 00:00:00

abstract：:In this study, we quantified 249 mature micro-RNA (miRNA) transcripts in estrogen receptor-positive (ER(+)) primary breast tumors of patients with lymph node-negative (LNN) disease to identify miRNAs associated with metastatic capability. In addition, the prognostic value of the candidate miRNAs was determined in ER(-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foekens JA,Sieuwerts AM,Smid M,Look MP,de Weerd V,Boersma AW,Klijn JG,Wiemer EA,Martens JW

更新日期：2008-09-02 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own components, although critically important, are largely unknown. Ub, a principal component of the system, must be maintained at adequate levels to support cellular homeostasis under basal and stressed conditions. It was suggested that Ub is degrade...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabek N,Herman-Bachinsky Y,Ciechanover A

更新日期：2009-07-21 00:00:00

abstract：:Rabbit chondrocyte cultures on plastic dishes are capable of depositing a cartilaginous matrix, although the matrix does not calcify unless high levels of phosphate are added to the medium. In the present study, we cultivated a pelleted mass of rabbit growth-plate chondrocytes in the presence of Eagle's minimum essent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato Y,Iwamoto M,Koike T,Suzuki F,Takano Y

更新日期：1988-12-01 00:00:00

abstract：:We investigated the influence of interareal distance on connectivity patterns in a database obtained from the injection of retrograde tracers in 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third of the 1,615 pathways projecting to the 29 target areas were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markov NT,Ercsey-Ravasz M,Lamy C,Ribeiro Gomes AR,Magrou L,Misery P,Giroud P,Barone P,Dehay C,Toroczkai Z,Knoblauch K,Van Essen DC,Kennedy H

更新日期：2013-03-26 00:00:00