当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Second type of criticality in the brain uncovers rich multiple-neuron dynamics.

Second type of criticality in the brain uncovers rich multiple-neuron dynamics.

Abstract：

:Cortical networks that have been found to operate close to a critical point exhibit joint activations of large numbers of neurons. However, in motor cortex of the awake macaque monkey, we observe very different dynamics: massively parallel recordings of 155 single-neuron spiking activities show weak fluctuations on the population level. This a priori suggests that motor cortex operates in a noncritical regime, which in models, has been found to be suboptimal for computational performance. However, here, we show the opposite: The large dispersion of correlations across neurons is the signature of a second critical regime. This regime exhibits a rich dynamical repertoire hidden from macroscopic brain signals but essential for high performance in such concepts as reservoir computing. An analytical link between the eigenvalue spectrum of the dynamics, the heterogeneity of connectivity, and the dispersion of correlations allows us to assess the closeness to the critical point.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Dahmen D,Grün S,Diesmann M,Helias M

doi

10.1073/pnas.1818972116

subject

Has Abstract

pub_date

2019-06-25 00:00:00

pages

13051-13060

issue

26

eissn

0027-8424

issn

1091-6490

pii

1818972116

journal_volume

116

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

    abstract：:The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines. In the present investigation we have studied the expression of these genes in biopsy specimens from human glioblastomas. Hyperplasia of the vascular endothelium is a pro...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.20.7748

    authors： Hermansson M,Nistér M,Betsholtz C,Heldin CH,Westermark B,Funa K

    更新日期：1988-10-01 00:00:00

  • Two forms of yeast glycogen synthetase and their role in glycogen accumulation.

    abstract：:The glycogen content of yeast rises dramatically just before the onset of the stationary phase of growth. Concomitantly, a rapid increase was found in the glucose 6-phosphate-independent (I) activity of glycogen synthetase, as well as in the total amount of enzyme. A mutant (GS 1-36) was obtained, which did not accumu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.66.3.967

    authors： Rothman-Denes LB,Cabib E

    更新日期：1970-07-01 00:00:00

  • Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.

    abstract：:Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307813100

    authors： Lee SY,Wenk MR,Kim Y,Nairn AC,De Camilli P

    更新日期：2004-01-13 00:00:00

  • Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

    abstract：:The effect of Zn2+ on a voltage-dependent, transient potassium current (IA) in acutely dissociated neurons from the suprachiasmatic nucleus was studied with the whole-cell patch-clamp technique. At micromolar concentrations, Zn2+ markedly potentiated IA activated from a holding potential of -60 mV, which is the restin...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.24.11806

    authors： Huang RC,Peng YW,Yau KW

    更新日期：1993-12-15 00:00:00

  • The Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcription.

    abstract：:The importance of core histones in the regulation of DNA function by chromatin is clear. However, little is known about the role of the linker histone. We investigated the role of H1 in Saccharomyces cerevisiae during extensive transcriptional reprogramming in stationary phase. Although the levels of linker histone Hh...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0806337105

    authors： Schäfer G,McEvoy CR,Patterton HG

    更新日期：2008-09-30 00:00:00

  • Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation.

    abstract：:Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor 4 (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we repo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212769110

    authors： Wang G,Guo X,Hong W,Liu Q,Wei T,Lu C,Gao L,Ye D,Zhou Y,Chen J,Wang J,Wu M,Liu H,Kang J

    更新日期：2013-02-19 00:00:00

  • A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.

    abstract：:Developing tissues contain motile populations of cells that can self-organize into spatially ordered tissues based on differences in their interfacial surface energies. However, it is unclear how self-organization by this mechanism remains robust when interfacial energies become heterogeneous in either time or space. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1410776112

    authors： Cerchiari AE,Garbe JC,Jee NY,Todhunter ME,Broaders KE,Peehl DM,Desai TA,LaBarge MA,Thomson M,Gartner ZJ

    更新日期：2015-02-17 00:00:00

  • Rates of change in natural and anthropogenic radiative forcing over the past 20,000 years.

    abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0707386105

    authors： Joos F,Spahni R

    更新日期：2008-02-05 00:00:00

  • Nucleosomes associated with newly replicated DNA have an altered conformation.

    abstract：:In vitro DNA synthesis was studied in HeLa cell nuclei, with emphasis on the question of whether newly replicated DNA is associated with nucleosomes. The newly replicated DNA was twice as sensitive to digestion by micrococcal nuclease as mature chromatin DNA, reaching a limit digest at 20-25% acid-insoluble product. E...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.6.2717

    authors： Seale RL

    更新日期：1978-06-01 00:00:00

  • Ultrasensitivity of the Bacillus subtilis sporulation decision.

    abstract：:Starving Bacillus subtilis cells execute a gene expression program resulting in the formation of stress-resistant spores. Sporulation master regulator, Spo0A, is activated by a phosphorelay and controls the expression of a multitude of genes, including the forespore-specific sigma factor σ(F) and the mother cell-speci...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1213974109

    authors： Narula J,Devi SN,Fujita M,Igoshin OA

    更新日期：2012-12-11 00:00:00

  • Isolation and identification of a biologically active peptide derived from the CH3 domain of human IgG1.

    abstract：:A 24-amino acid residue peptide has been isolated from the Fc region of a human IgG1 myeloma protein. The peptide has associated with it the same ability to induce murine B cells to polyclonally secrete antibody as does the intact Fc fragment. Amino acid composition of the peptide indicates that on a mole/mole basis t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.17.5388

    authors： Morgan EL,Hugli TE,Weigle WO

    更新日期：1982-09-01 00:00:00

  • The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

    abstract：:Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha(4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor. We find that alpha(4)beta(7)(high) C...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0911796106

    authors： Cicala C,Martinelli E,McNally JP,Goode DJ,Gopaul R,Hiatt J,Jelicic K,Kottilil S,Macleod K,O'Shea A,Patel N,Van Ryk D,Wei D,Pascuccio M,Yi L,McKinnon L,Izulla P,Kimani J,Kaul R,Fauci AS,Arthos J

    更新日期：2009-12-08 00:00:00

  • Surveillance mechanism linking Bub1 loss to the p53 pathway.

    abstract：:Bub1 is a kinase believed to function primarily in the mitotic spindle checkpoint. Mutation or aberrant Bub1 expression is associated with chromosomal instability, aneuploidy, and human cancer. We now find that targeting Bub1 by RNAi or simian virus 40 (SV40) large T antigen in normal human diploid fibroblasts results...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0703164104

    authors： Gjoerup OV,Wu J,Chandler-Militello D,Williams GL,Zhao J,Schaffhausen B,Jat PS,Roberts TM

    更新日期：2007-05-15 00:00:00

  • High-affinity binding of Escherichia coli SecB to the signal sequence region of a presecretory protein.

    abstract：:The Escherichia coli cytosolic homotetrameric protein SecB is known to be involved in protein export across the plasma membrane. A currently prevalent view holds that SecB functions exclusively as a chaperone interacting nonspecifically with unfolded proteins, not necessarily exported proteins, whereas a contrary view...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.22.10133

    authors： Watanabe M,Blobel G

    更新日期：1995-10-24 00:00:00

  • Superfamily Gondwanatherioidea: a previously unrecognized radiation of multituberculate mammals in South America.

    abstract：:Multituberculates were the longest-lived order of the Class Mammalia and, during the Mesozoic and early Cenozoic, were among the most diverse and abundant representatives of the class. However, until the recent discovery of two Cretaceous teeth, one from South America and one from Africa, they were known only from nor...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.90.20.9379

    authors： Krause DW,Bonaparte JF

    更新日期：1993-10-15 00:00:00

  • Activation of purified calcium channels by stoichiometric protein phosphorylation.

    abstract：:Purified dihydropyridine-sensitive calcium channels from rabbit skeletal muscle were reconstituted into phosphatidylcholine vesicles to evaluate the effect of phosphorylation by cyclic AMP-dependent protein kinase (PK-A) on their function. Both the rate and extent of 45Ca2+ uptake into vesicles containing reconstitute...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.17.6816

    authors： Nunoki K,Florio V,Catterall WA

    更新日期：1989-09-01 00:00:00

  • Abrupt tectonics and rapid slab detachment with grain damage.

    abstract：:A simple model for necking and detachment of subducting slabs is developed to include the coupling between grain-sensitive rheology and grain-size evolution with damage. Necking is triggered by thickened buoyant crust entrained into a subduction zone, in which case grain damage accelerates necking and allows for relat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1415473112

    authors： Bercovici D,Schubert G,Ricard Y

    更新日期：2015-02-03 00:00:00

  • Radiocarbon-based approach capable of subannual precision resolves the origins of the site of Por-Bajin.

    abstract：:Inadequate resolution is the principal limitation of radiocarbon dating. However, recent work has shown that exact-year precision is attainable if use can be made of past increases in atmospheric radiocarbon concentration or so-called Miyake events. Here, this nascent method is applied to an archaeological site of pre...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1921301117

    authors： Kuitems M,Panin A,Scifo A,Arzhantseva I,Kononov Y,Doeve P,Neocleous A,Dee M

    更新日期：2020-06-23 00:00:00

  • The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments.

    abstract：:Our recent studies have shown that deregulated expression of R2, the rate-limiting component of ribonucleotide reductase, enhances transformation and malignant potential by cooperating with activated oncogenes. We now demonstrate that the R1 component of ribonucleotide reductase has tumor-suppressing activity. Stable ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.24.13181

    authors： Fan H,Huang A,Villegas C,Wright JA

    更新日期：1997-11-25 00:00:00

  • Primary photochemical event in vision: proton translocation.

    abstract：:Picosecond studies of rhodopsin in low-temperature glasses have been carried out in order to observe directly the risetime of prelumirhodopsin, the first intermediate in the visual pathway. Only at 20 K or below can the risetime of this intermediate be resolved and even at 4 K it is astoundingly rapid, about 36 psec. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.8.3119

    authors： Peters K,Applebury ML,Rentzepis PM

    更新日期：1977-08-01 00:00:00

  • Spiral structure of Escherichia coli HUalphabeta provides foundation for DNA supercoiling.

    abstract：:We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special imp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0611686104

    authors： Guo F,Adhya S

    更新日期：2007-03-13 00:00:00

  • Self-referential phase reset based on inferior olive oscillator dynamics.

    abstract：:The olivo-cerebellar network is a key neuronal circuit that provides high-level motor control in the vertebrate CNS. Functionally, its network dynamics is organized around the oscillatory membrane potential properties of inferior olive (IO) neurons and their electrotonic connectivity. Because IO action potentials are ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0407900101

    authors： Kazantsev VB,Nekorkin VI,Makarenko VI,Llinás R

    更新日期：2004-12-28 00:00:00

  • Structure of an endogenous yeast 26S proteasome reveals two major conformational states.

    abstract：:The eukaryotic proteasome mediates degradation of polyubiquitinated proteins. Here we report the single-particle cryoelectron microscopy (cryo-EM) structures of the endogenous 26S proteasome from Saccharomyces cerevisiae at 4.6- to 6.3-Å resolution. The fine features of the cryo-EM maps allow modeling of 18 subunits i...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1601561113

    authors： Luan B,Huang X,Wu J,Mei Z,Wang Y,Xue X,Yan C,Wang J,Finley DJ,Shi Y,Wang F

    更新日期：2016-03-08 00:00:00

  • The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion.

    abstract：:Deletion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia coli has no significant effect on expression or activity, whereas Delta12 leads to increased rates of permease turnover after membrane insertion and decreased transport activity, and Delta20 abolishes insertion and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.140224497

    authors： Weinglass AB,Kaback HR

    更新日期：2000-08-01 00:00:00

  • Spectroscopic elucidation of energy transfer in hybrid inorganic-biological organisms for solar-to-chemical production.

    abstract：:The rise of inorganic-biological hybrid organisms for solar-to-chemical production has spurred mechanistic investigations into the dynamics of the biotic-abiotic interface to drive the development of next-generation systems. The model system, Moorella thermoacetica-cadmium sulfide (CdS), combines an inorganic semicond...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1610554113

    authors： Kornienko N,Sakimoto KK,Herlihy DM,Nguyen SC,Alivisatos AP,Harris CB,Schwartzberg A,Yang P

    更新日期：2016-10-18 00:00:00

  • Spectral evidence for a new photoreactive component of the oxygen-evolving system in photosynthesis.

    abstract：:On illuminating chloroplasts with "short-wavelength" monochromatic light that supports oxygen evolution, spectral evidence was obtained for a new photoreactive chloroplast component, provisionally designated C550, which shows a reversible decrease of absorbance with a maximum at 550 mmu. The light-induced absorbance c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.63.3.963

    authors： Knaff DB,Arnon DI

    更新日期：1969-07-01 00:00:00

  • Replication initiator protein of plasmid R6K autoregulates its own synthesis at the transcriptional step.

    abstract：:The replication initiator protein of plasmid R6K preferentially repressed transcription initiated in vitro from the promoter of the initiator protein cistron. DNase I protection experiments revealed that the sequences in the region of the promoter recognized by the initiator protein partially overlapped the sequences ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.9.2574

    authors： Kelley W,Bastia D

    更新日期：1985-05-01 00:00:00

  • Transport properties of glass-forming liquids suggest that dynamic crossover temperature is as important as the glass transition temperature.

    abstract：:It is becoming common practice to partition glass-forming liquids into two classes based on the dependence of the shear viscosity η on temperature T. In an Arrhenius plot, ln η vs 1/T, a strong liquid shows linear behavior whereas a fragile liquid exhibits an upward curvature [super-Arrhenius (SA) behavior], a situati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1015340107

    authors： Mallamace F,Branca C,Corsaro C,Leone N,Spooren J,Chen SH,Stanley HE

    更新日期：2010-12-28 00:00:00

  • The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells.

    abstract：:Erythroid Krüppel-like factor (EKLF), which binds to the CACCC box in the beta-globin promoter, is required for the expression of the beta-globin gene in adult erythroid cells. It was recently demonstrated that EKLF is also required for the activity of the beta-globin locus control region (LCR) 5'HS3. Some evidence su...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.18.10051

    authors： Lee JS,Lee CH,Chung JH

    更新日期：1999-08-31 00:00:00

  • Predicting free choices for abstract intentions.

    abstract：:Unconscious neural activity has been repeatedly shown to precede and potentially even influence subsequent free decisions. However, to date, such findings have been mostly restricted to simple motor choices, and despite considerable debate, there is no evidence that the outcome of more complex free decisions can be pr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212218110

    authors： Soon CS,He AH,Bode S,Haynes JD

    更新日期：2013-04-09 00:00:00