Predicting free choices for abstract intentions.

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:The functional groups found among the RNA bases and in the phosphoribose backbone represent a limited repertoire from which to construct a ribozyme active site. This work investigates the possibility that simple RNA phosphodiester and hydroxyl functional groups could catalyze amide bond synthesis. Reaction of amine gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chamberlin SI,Merino EJ,Weeks KM

更新日期：2002-11-12 00:00:00

abstract：:Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miao RQ,Gao Y,Harrison KD,Prendergast J,Acevedo LM,Yu J,Hu F,Strittmatter SM,Sessa WC

更新日期：2006-07-18 00:00:00

abstract：:Membrane lipids were once thought to be homogenously distributed in the 2D surface of a membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition away from other membrane lipids. Lipid raft theory further implicates these cholesterol-rich domains in many processes such as signaling and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foster LJ,De Hoog CL,Mann M

更新日期：2003-05-13 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:Rodless retina (gene symbol, r) was discovered in mice by Keeler 70 years ago and was first described in this journal as an autosomal recessive mutation leading to "the absence of the visual cells (rods), the external nuclear layer, and the external molecular layer" [Keeler, C. E. (1924) Proc. Natl. Acad. Sci. USA 10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pittler SJ,Keeler CE,Sidman RL,Baehr W

更新日期：1993-10-15 00:00:00

abstract：:Markov chain Monte Carlo (MCMC) or the Metropolis-Hastings algorithm is a simulation algorithm that has made modern Bayesian statistical inference possible. Nevertheless, the efficiency of different Metropolis-Hastings proposal kernels has rarely been studied except for the Gaussian proposal. Here we propose a unique ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Rodríguez CE

更新日期：2013-11-26 00:00:00

abstract：:We explore the interactions of CYT-19, a DExD/H-box protein that functions in folding of group I RNAs, with a well characterized misfolded species of the Tetrahymena ribozyme. Consistent with its function, CYT-19 accelerates refolding of the misfolded RNA to its native state. Unexpectedly, CYT-19 performs another reac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tijerina P,Bhaskaran H,Russell R

更新日期：2006-11-07 00:00:00

abstract：:The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon assembly of the alpha/beta-tubulin heterodimer, GTP bound to beta-tubulin is hydrolyzed to GDP reaching a steady-state equilibrium between free tubulin dimers and microtubules. The binding of Ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao H,Verdier-Pinard P,Fernandez-Fuentes N,Burd B,Angeletti R,Fiser A,Horwitz SB,Orr GA

更新日期：2006-07-05 00:00:00

abstract：:Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groll M,Larionov OV,Huber R,de Meijere A

更新日期：2006-03-21 00:00:00

abstract：:Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance of oxidative stress. Cells lacking E2F1 are hypersensitive to oxidati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves JD,Lee YJ,Liu K,Li G,Lin FT,Lin WC

更新日期：2020-06-30 00:00:00

abstract：:Antibodies have been prepared to the core protein of cartilage chondroitin sulfate proteoglycan from clones isolated after fusion of rat spleen cells and mouse myeloma cell lines. Antibodies produced by five clones were studied in detail by a radioimmunoassay utilizing 35SO42-labeled hyaluronidase-digested chondroitin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorfman A,Hall T,Ho PL,Fitch F

更新日期：1980-07-01 00:00:00

abstract：:Many ecosystems, from vegetation to biofilms, are composed of territorial populations that compete for both nutrients and physical space. What are the implications of such spatial organization for biodiversity? To address this question, we developed and analyzed a model of territorial resource competition. In the mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner BG,Posfai A,Wingreen NS

更新日期：2019-09-03 00:00:00

abstract：:An interpretation is given of recent experiments by Brunori et al. on the binding of carbon monoxide by hemoglobin under photodissociating conditions. It is shown that their results follow directly from scalable models for hemoglobin in which the protein-modulated interactions are separable from the ligand binding. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabo A,Karplus M

更新日期：1973-03-01 00:00:00

abstract：:Across North America, human activities have been shown to cause river incision into unconsolidated alluvium. Human-caused erosion through bedrock, however, has only been observed in local and isolated outcrops. Here, we test whether splash-dam logging, which decreased in-stream alluvial cover by removing much of the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schanz SA,Montgomery DR,Collins BD

更新日期：2019-04-30 00:00:00

abstract：:Human speech comprehension is remarkable for its immediacy and rapidity. The listener interprets an incrementally delivered auditory input, millisecond by millisecond as it is heard, in terms of complex multilevel representations of relevant linguistic and nonlinguistic knowledge. Central to this process are the neura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyu B,Choi HS,Marslen-Wilson WD,Clarke A,Randall B,Tyler LK

更新日期：2019-10-15 00:00:00

abstract：:The molecular basis of pathogen clone emergence is relatively poorly understood. Acquisition of a bacteriophage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated in the rapid emergence in the mid-1980s of a new hypervirulent clone of serotype M3 group A Streptococcus. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sitkiewicz I,Nagiec MJ,Sumby P,Butler SD,Cywes-Bentley C,Musser JM

更新日期：2006-10-24 00:00:00

abstract：:Regulation of the sterol-synthesizing mevalonate pathway occurs in part through feedback-regulated endoplasmic reticulum degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R). In yeast, the Hmg2p isozyme of HMG-R is regulated in this manner. We have tested the involvement of ubiquitination in the regulated d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampton RY,Bhakta H

更新日期：1997-11-25 00:00:00

abstract：:A polypeptide was isolated from acid extracts of porcine hypothalami on the basis of its high ability to stimulate the release of corticotropin from superfused rat pituitary cells. After an initial separation by gel filtration on Sephadex G-25, further purification was carried out by reversed-phase HPLC. The isolated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patthy M,Horvath J,Mason-Garcia M,Szoke B,Schlesinger DH,Schally AV

更新日期：1985-12-01 00:00:00

abstract：:A brilliant, coarsely granular nuclear antigen was detected by anti-complement immunofluorescence in the nuclei of acute myeloid leukemia myeloblasts. Designated as LANA (leukemia-associated nuclear antigen), the reactivity differs from that of the Epstein-Barr-virus-determined nuclear antigen (EBNA) in immunological ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein G,Steiner M,Wiener F,Klein E

更新日期：1974-03-01 00:00:00

abstract：:Natural-abundance (13)C nuclear magnetic resonance spectra of ten common nucleotides in neutral, aqueous solutions have been determined and interpreted. The spectra of two of these substances were also determined in acidic solutions, and several of the carbon chemical shifts were found to depend markedly on pH. Within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman DE,Roberts JD

更新日期：1970-01-01 00:00:00

abstract：:We examined iron nitrosylation of non-heme protein and enzymatic activity of the Fe-S cluster protein, aconitase, in acute cardiac allograft rejection. Heterotopic transplantation of donor hearts was performed in histocompatibility matched (isografts: Lewis --> Lewis) and mismatched (allografts: Wistar-Furth --> Lewis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pieper GM,Halligan NL,Hilton G,Konorev EA,Felix CC,Roza AM,Adams MB,Griffith OW

更新日期：2003-03-18 00:00:00

abstract：:The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase activating protein (GAP) designated tuberin. Studies of the Eker rat model of hereditary cancer strongly support the role of Tsc2 as a tumor suppressor gene. In this s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin F,Wienecke R,Xiao GH,Maize JC Jr,DeClue JE,Yeung RS

更新日期：1996-08-20 00:00:00

abstract：:The rat brain increases >6x in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bandeira F,Lent R,Herculano-Houzel S

更新日期：2009-08-18 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:A 165-kilodalton (kDal) surface glycoprotein encoded by human chromosome 7 (SA-7) had been characterized by using antisera raised against human chromosome 7-containing somatic cell hybrids. We now present evidence that SA-7 is the human receptor for epidermal growth factor (EGF) and that these antisera recognize human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlin CR,Knowles BB

更新日期：1982-08-01 00:00:00

abstract：:Legionella pneumophila causes a potentially fatal form of pneumonia by replicating within macrophages in the Legionella-containing vacuole (LCV). Bacterial survival and proliferation within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy. The vacuolar membrane-localized Mav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christenson ET,Isaac DT,Yoshida K,Lipo E,Kim JS,Ghirlando R,Isberg RR,Banerjee A

更新日期：2019-09-03 00:00:00

abstract：:The recent completion of the deletion of essentially all of the ORFs in yeast is an important new resource for identifying the phenotypes of unknown genes. Each ORF is replaced with a cassette containing unique tag sequences that allow rapid parallel analysis of strains in a pool by using hybridization to a high-densi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birrell GW,Giaever G,Chu AM,Davis RW,Brown JM

更新日期：2001-10-23 00:00:00

abstract：:Keratins 14 and 5 are the structural hallmarks of the basal keratinocytes of the epidermis and outer root sheath (ORS) of the hair follicle. Their genes are controlled in a tissue-specific manner and thus serve as useful tools to elucidate the regulatory mechanisms involved in keratinocyte-specific transcription. Prev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha S,Fuchs E

更新日期：2001-02-27 00:00:00

abstract：:Artemis gene mutations are responsible for the development of a severe combined immunodeficiency [radiation-sensitive (RS) SCID] characterized by a severe B and T cell deficiency and a normal natural killer cell population. To establish the feasibility of a gene therapy approach to the treatment of RS-SCID, we generat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mostoslavsky G,Fabian AJ,Rooney S,Alt FW,Mulligan RC

更新日期：2006-10-31 00:00:00