Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

abstract：:The proapoptotic activity of the "BH3-only" molecule BAD can be differentially regulated by survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins proved viable, and most cell types appeared to develop normally. BAD did not exclusively account for cell death after withdrawal of surv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranger AM,Zha J,Harada H,Datta SR,Danial NN,Gilmore AP,Kutok JL,Le Beau MM,Greenberg ME,Korsmeyer SJ

更新日期：2003-08-05 00:00:00

abstract：:ES cells represent a valuable model for investigating early embryo development and hold promise for future regenerative medicine strategies. The self-renewal of pluripotent mouse ES cells has been shown to require extrinsic stimulation by the bone morphogenetic protein (BMP) and leukemia inhibitory factor signaling pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki A,Raya Á,Kawakami Y,Morita M,Matsui T,Nakashima K,Gage FH,Rodríguez-Esteban C,Izpisúa Belmonte JC

更新日期：2006-07-05 00:00:00

abstract：:Although much evidence suggests that the plasma membrane of eukaryotic cells is not homogenous, the precise architecture of this important structure has not been clear. Here we use transmission electron microscopy of plasma membrane sheets and specific probes to show that most or all plasma membrane-associated protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillemeier BF,Pfeiffer JR,Surviladze Z,Wilson BS,Davis MM

更新日期：2006-12-12 00:00:00

abstract：:Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou J,Renigunta A,Yang J,Waldegger S

更新日期：2010-10-19 00:00:00

abstract：:A form of two-dimensional (2D) vibrational spectroscopy, which uses two ultrafast IR laser pulses, is used to examine the structure of a cyclic penta-peptide in solution. Spectrally resolved cross peaks occur in the off-diagonal region of the 2D IR spectrum of the amide I region, analogous to those in 2D NMR spectrosc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamm P,Lim M,DeGrado WF,Hochstrasser RM

更新日期：1999-03-02 00:00:00

abstract：:Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP). However, the mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Han L,Shen H,Wang P,Lv C,Zhao G,Niu J,Xue L,Wang QJ,Tong T,Chen J

更新日期：2014-05-27 00:00:00

abstract：:2(S)-dihydroxypropanesulfonate (DHPS) is a microbial degradation product of 6-deoxy-6-sulfo-d-glucopyranose (sulfoquinovose), a component of plant sulfolipid with an estimated annual production of 1010 tons. DHPS is also at millimolar levels in highly abundant marine phytoplankton. Its degradation and sulfur recycling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Wei Y,Lin L,Teng L,Yin J,Lu Q,Chen J,Zheng Y,Li Y,Xu R,Zhai W,Liu Y,Liu Y,Cao P,Ang EL,Zhao H,Yuchi Z,Zhang Y

更新日期：2020-07-07 00:00:00

abstract：:The influence of the rare initiation triplet AUU on mRNA translation was investigated by comparing the activity of two pairs of model mRNAs that differ in the length of Shine-Dalgarno and spacer sequences. Irrespective of the initiation triplet (AUG or AUU), all mRNAs had similar template activity in vitro, but transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Teana A,Pon CL,Gualerzi CO

更新日期：1993-05-01 00:00:00

abstract：:Urea (200-400 milliosmolar) activates transcription, translation of, and trans-activation by the immediate-early gene transcription factor Egr-1 in a renal epithelial cell-specific fashion. The effect at the transcriptional level has been attributed to multiple serum response elements and their adjacent Ets motifs loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen DM

更新日期：1996-10-01 00:00:00

abstract：:Integrable models form pillars of theoretical physics because they allow for full analytical understanding. Despite being rare, many realistic systems can be described by models that are close to integrable. Therefore, an important question is how small perturbations influence the behavior of solvable models. This is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Žnidarič M,Ljubotina M

更新日期：2018-05-01 00:00:00

abstract：:The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B cells from normal lymph nodes, B2 was absent from approximately 50% of B cells from hyperplastic lymph nodes. When B cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stashenko P,Nadler LM,Hardy R,Schlossman SF

更新日期：1981-06-01 00:00:00

abstract：:Standard economic and evolutionary models assume that humans are fundamentally selfish. On this view, any acts of prosociality--such as cooperation, giving, and other forms of altruism--result from covert attempts to avoid social injunctions against selfishness. However, even in the absence of social pressure, individ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaki J,Mitchell JP

更新日期：2011-12-06 00:00:00

abstract：:Spermatogonia are the male germ stem cells that continuously produce sperm for the next generation. Spermatogenesis is a complicated process that proceeds through mitotic phase of stem cell renewal and differentiation, meiotic phase, and postmeiotic phase of spermiogenesis. Full recapitulation of spermatogenesis in vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong Y,Liu T,Zhao H,Xu H,Wang W,Liu R,Chen T,Deng J,Gui J

更新日期：2004-05-25 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. This positiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayashi Y,Hsiao EC,Sami S,Lancero M,Schlieve CR,Nguyen T,Yano K,Nagahashi A,Ikeya M,Matsumoto Y,Nishimura K,Fukuda A,Hisatake K,Tomoda K,Asaka I,Toguchida J,Conklin BR,Yamanaka S

更新日期：2016-11-15 00:00:00

abstract：:Animals capable of regenerating multiple tissue types, organs, and appendages after injury are common yet sporadic and include some sponge, hydra, planarian, and salamander (i.e., newt and axolotl) species, but notably such regenerative capacity is rare in mammals. The adult MRL mouse strain is a rare exception to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedelbaeva K,Snyder A,Gourevitch D,Clark L,Zhang XM,Leferovich J,Cheverud JM,Lieberman P,Heber-Katz E

更新日期：2010-03-30 00:00:00

abstract：:dAn.dTn sequences, otherwise known as A tracts, are hotspots for cis-syn thymine dimer formation and deletion mutations induced by UV light. Such A tracts are also known to bend DNA, suggesting that some biological effects of UV light might be related to the distinctive structure and properties of cis-syn dimer-contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang CI,Taylor JS

更新日期：1991-10-15 00:00:00

abstract：:Cell-mediated immunity is critical for host resistance to tuberculosis. T lymphocytes recognizing antigens presented by the major histocompatibility complex (MHC) class I and class II molecules have been found to be necessary for control of mycobacterial infection. Mice genetically deficient in the generation of MHC c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teitelbaum R,Cammer M,Maitland ML,Freitag NE,Condeelis J,Bloom BR

更新日期：1999-12-21 00:00:00

abstract：:It is generally accepted that healthy cells degrade their own mitochondria. Here, we report that retinal ganglion cell axons of WT mice shed mitochondria at the optic nerve head (ONH), and that these mitochondria are internalized and degraded by adjacent astrocytes. EM demonstrates that mitochondria are shed through f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis CH,Kim KY,Bushong EA,Mills EA,Boassa D,Shih T,Kinebuchi M,Phan S,Zhou Y,Bihlmeyer NA,Nguyen JV,Jin Y,Ellisman MH,Marsh-Armstrong N

更新日期：2014-07-01 00:00:00

abstract：:Initiation of X chromosome inactivation requires the presence, in cis, of the X inactivation center (XIC). The Xist gene, which lies within the XIC region in both human and mouse and has the unique property of being expressed only from the inactive X chromosome in female somatic cells, is known to be essential for X i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heard E,Mongelard F,Arnaud D,Chureau C,Vourc'h C,Avner P

更新日期：1999-06-08 00:00:00

abstract：:Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it a target for leukemia, autoimmune disorders, and gout. Four generations of ribocation transition-state mimics bound to PNP are structurally characterized. Immucillin-H (K*i(1/4)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MC,Shi W,Rinaldo-Matthis A,Tyler PC,Evans GB,Clinch K,Almo SC,Schramm VL

更新日期：2010-03-16 00:00:00

abstract：:A "supermarket revolution" has occurred in developing countries in the past 2 decades. We focus on three specific issues that reflect the impact of this revolution, particularly in Asia: continuity in transformation, innovation in transformation, and unique development strategies. First, the record shows that the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reardon T,Timmer CP,Minten B

更新日期：2012-07-31 00:00:00

abstract：:Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively. Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and have iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi YH,Westfield GH,Oleskie AN,Trievel RC,Shilatifard A,Skiniotis G

更新日期：2011-12-20 00:00:00

abstract：:Plant soil specialists contribute greatly to global diversity; however, the ecoevolutionary forces responsible for generating this diversity are poorly understood. We integrate molecular phylogenies with descriptive and experimental ecological data, creating a powerful framework with which to elucidate forces driving ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cacho NI,Strauss SY

更新日期：2014-10-21 00:00:00

abstract：:The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive. The paramedian lobule is activated during limb movements used in both acrobatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black JE,Isaacs KR,Anderson BJ,Alcantara AA,Greenough WT

更新日期：1990-07-01 00:00:00

abstract：:In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fedoroff NV

更新日期：2012-12-11 00:00:00

abstract：:Virus-specific or group-specific antibody probes to potyviruses can be produced by targeting the immune response to the virus-specific, N-terminal region of the capsid protein (29-95 amino acids depending on the virus) or to the conserved core region (216 amino acids) of the capsid protein, respectively. Immunochemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla DD,Tribbick G,Mason TJ,Hewish DR,Geysen HM,Ward CW

更新日期：1989-11-01 00:00:00

abstract：:Cytochromes P450 play key roles in drug metabolism and disease by oxidizing a wide variety of natural and xenobiotic compounds. High-resolution crystal structures of P450cam bound to ruthenium sensitizer-linked substrates reveal an open conformation of the enzyme that allows substrates to access the active center via ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn AR,Dmochowski IJ,Bilwes AM,Gray HB,Crane BR

更新日期：2001-10-23 00:00:00

abstract：:Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurabielle C,Link VM,Bouladoux N,Han SJ,Merrill ED,Lightfoot YL,Seto N,Bleck CKE,Smelkinson M,Harrison OJ,Linehan JL,Tamoutounour S,Lionakis MS,Kaplan MJ,Nakajima S,Belkaid Y

更新日期：2020-07-14 00:00:00

abstract：:An RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) has been purified from phage-SP01-infected Bacillus subtilis that copies RNA almost exclusively from the heavy strand of native SP01 DNA, the DNA strand from which "middle" and "late" classes of RNA are copied in vivo. Hybridization-com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pero J,Nelson J,Fox TD

更新日期：1975-04-01 00:00:00

abstract：:Many infectious viruses coevolved with the vertebrate immune system. During the assembly of enveloped viruses, lipid ordered domains of the host cell plasma membrane, called lipid rafts, frequently function as a natural meeting point for viral proteins. The role of lipid rafts in the organization of complex combinatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Derdak SV,Kueng HJ,Leb VM,Neunkirchner A,Schmetterer KG,Bielek E,Majdic O,Knapp W,Seed B,Pickl WF

更新日期：2006-08-29 00:00:00