Early experience is associated with the development of categorical representations for facial expressions of emotion.

Abstract:

:A fundamental issue in human development concerns how the young infant's ability to recognize emotional signals is acquired through both biological programming and learning factors. This issue is extremely difficult to investigate because of the variety of sensory experiences to which humans are exposed immediately after birth. We examined the effects of emotional experience on emotion recognition by studying abused children, whose experiences violated cultural standards of care. We found that the aberrant social experience of abuse was associated with a change in children's perceptual preferences and also altered the discriminative abilities that influence how children categorize angry facial expressions. This study suggests that affective experiences can influence perceptual representations of basic emotions.

authors

Pollak SD,Kistler DJ

doi

10.1073/pnas.142165999

keywords:

subject

Has Abstract

pub_date

2002-06-25 00:00:00

pages

9072-6

issue

13

eissn

0027-8424

issn

1091-6490

pii

142165999

journal_volume

99

pub_type

杂志文章
  • The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.

    abstract::Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse. Heterozygotes carry...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0702846105

    authors: Ge C,Stanley P

    更新日期:2008-02-05 00:00:00

  • Low dielectric response in enzyme active site.

    abstract::The kinetics of charge transfer depend crucially on the dielectric reorganization of the medium. In enzymatic reactions that involve charge transfer, atomic dielectric response of the active site and of its surroundings determines the efficiency of the protein as a catalyst. We report direct spectroscopic measurements...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.050316997

    authors: Mertz EL,Krishtalik LI

    更新日期:2000-02-29 00:00:00

  • Cachectin alters anterior pituitary hormone release by a direct action in vitro.

    abstract::Cachectin (tumor necrosis factor) is a powerful macrophage hormone released during infection, which circulates in blood to produce diverse effects in the organism. We examined the effect of cachectin on release of anterior pituitary hormones from either hemipituitaries or dispersed pituitary cells incubated in vitro. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.7.2418

    authors: Milenkovic L,Rettori V,Snyder GD,Beutler B,McCann SM

    更新日期:1989-04-01 00:00:00

  • Infection of phytoplankton by aerosolized marine viruses.

    abstract::Marine viruses constitute a major ecological and evolutionary driving force in the marine ecosystems. However, their dispersal mechanisms remain underexplored. Here we follow the dynamics of Emiliania huxleyi viruses (EhV) that infect the ubiquitous, bloom-forming phytoplankton E. huxleyi and show that EhV are emitted...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1423667112

    authors: Sharoni S,Trainic M,Schatz D,Lehahn Y,Flores MJ,Bidle KD,Ben-Dor S,Rudich Y,Koren I,Vardi A

    更新日期:2015-05-26 00:00:00

  • Evolutionary dynamics of Clostridium difficile over short and long time scales.

    abstract::Clostridium difficile has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease, with the transcontinental spread of various PCR ribotypes, including 001, 017, 027 and 078. However, the genetic basis for the emergence of C. difficile as a human pathogen is unclear. Whole genome sequencing was...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0914322107

    authors: He M,Sebaihia M,Lawley TD,Stabler RA,Dawson LF,Martin MJ,Holt KE,Seth-Smith HM,Quail MA,Rance R,Brooks K,Churcher C,Harris D,Bentley SD,Burrows C,Clark L,Corton C,Murray V,Rose G,Thurston S,van Tonder A,Walker D

    更新日期:2010-04-20 00:00:00

  • Control of ColE1 DNA replication: the rop gene product negatively affects transcription from the replication primer promoter.

    abstract::A 600-base-pair region essential for ColE1 and pMBl plasmid replication contains two promoters responsible for the synthesis of two RNA molecules central to copy number control. One promoter directs synthesis of the primer RNA precursor. The second promoter directs the synthesis of a small RNA molecule, RNAl, which ac...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.79.20.6313

    authors: Cesareni G,Muesing MA,Polisky B

    更新日期:1982-10-01 00:00:00

  • Chromatin assembly in a yeast whole-cell extract.

    abstract::A simple in vitro system that supports chromatin assembly was developed for Saccharomyces cerevisiae. The assembly reaction is ATP-dependent, uses soluble histones and assembly factors, and generates physiologically spaced nucleosomes. We analyze the pathway of histone recruitment into nucleosomes, using this system i...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.17.9034

    authors: Schultz MC,Hockman DJ,Harkness TA,Garinther WI,Altheim BA

    更新日期:1997-08-19 00:00:00

  • Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones.

    abstract::The expression of interleukin 2 receptors (IL-2R) is a critical step leading to normal lymphocyte proliferation. Since thymosin fraction 5 (TF5), a thymic hormone preparation, enhances lymphoproliferative responses of human cells, we examined the effects of TF5 on the expression of IL-2R on mitogen-stimulated human ly...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.83.16.6107

    authors: Sztein MB,Serrate SA,Goldstein AL

    更新日期:1986-08-01 00:00:00

  • Copper economy in Chlamydomonas: prioritized allocation and reallocation of copper to respiration vs. photosynthesis.

    abstract::Inorganic elements, although required only in trace amounts, permit life and primary productivity because of their functions in catalysis. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce th...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1422492112

    authors: Kropat J,Gallaher SD,Urzica EI,Nakamoto SS,Strenkert D,Tottey S,Mason AZ,Merchant SS

    更新日期:2015-03-03 00:00:00

  • A generation at risk: young investigators and the future of the biomedical workforce.

    abstract::A number of distressing trends, including a decline in the share of key research grants going to younger scientists, as well as a steady rise in the age at which investigators receive their first funding, are now a decades-long feature of the US biomedical research workforce. Working committees have proposed recommend...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1418761112

    authors: Daniels RJ

    更新日期:2015-01-13 00:00:00

  • Transfer of information across repeated decisions in general and in obsessive-compulsive disorder.

    abstract::Real-life decisions are often repeated. Whether considering taking a job in a new city, or doing something mundane like checking if the stove is off, decisions are frequently revisited even if no new information is available. This mode of behavior takes a particularly pathological form in obsessive-compulsive disorder...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2014271117

    authors: Solway A,Lin Z,Vinaik E

    更新日期:2021-01-05 00:00:00

  • Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

    abstract::NIH 3T3 mouse cells were transfected with plasmids that induce efficient expression of either (i) the Rous sarcoma virus v-src gene, (ii) the chicken c-src gene, or (iii) a recombinant gene combining the 5' portion of c-src with the 3' end of v-src. Focus formation in tissue culture and formation of large colonies in ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.22.7071

    authors: Shalloway D,Coussens PM,Yaciuk P

    更新日期:1984-11-01 00:00:00

  • Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases.

    abstract::A rapid method for quantitating products of the oligodeoxynucleotide processing reaction in vitro has been developed to facilitate enzymatic studies of the retroviral integrases. Unlike earlier procedures, this assay does not depend on polyacrylamide gel electrphoresis but separates products by batch adsorption to PEI...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.24.11633

    authors: Müller B,Jones KS,Merkel GW,Skalka AM

    更新日期:1993-12-15 00:00:00

  • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.

    abstract::Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that it might be an ideal agent for the prevention of intrahepatic islet allograft failure. This hypothesis was tested in MHC-mismatched rhesus monkeys. Transplantat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.14.8132

    authors: Kenyon NS,Chatzipetrou M,Masetti M,Ranuncoli A,Oliveira M,Wagner JL,Kirk AD,Harlan DM,Burkly LC,Ricordi C

    更新日期:1999-07-06 00:00:00

  • Operant matching is a generic outcome of synaptic plasticity based on the covariance between reward and neural activity.

    abstract::The probability of choosing an alternative in a long sequence of repeated choices is proportional to the total reward derived from that alternative, a phenomenon known as Herrnstein's matching law. This behavior is remarkably conserved across species and experimental conditions, but its underlying neural mechanisms st...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0505220103

    authors: Loewenstein Y,Seung HS

    更新日期:2006-10-10 00:00:00

  • Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma.

    abstract::Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.97.1.228

    authors: Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

    更新日期:2000-01-04 00:00:00

  • Ras activity regulates cyclin E degradation by the Fbw7 pathway.

    abstract::The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis. Fbw7 is a human tumor suppressor that is targeted for mutation in primary cancers. However, mechanisms other than mutat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0503677102

    authors: Minella AC,Welcker M,Clurman BE

    更新日期:2005-07-05 00:00:00

  • Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.

    abstract::In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human beta-globin LCRs are homologous, indicating conservation of an essential function in beta-globin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.9.5129

    authors: Bulger M,van Doorninck JH,Saitoh N,Telling A,Farrell C,Bender MA,Felsenfeld G,Axel R,Groudine M

    更新日期:1999-04-27 00:00:00

  • A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

    abstract::Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1611431114

    authors: Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

    更新日期:2017-01-03 00:00:00

  • Monoclonal antibodies against the rat liver glucocorticoid receptor.

    abstract::Splenic cells from one BALB/c mouse and one C57/BL mouse, immunized with purified rat liver glucocorticoid receptor (GR), were fused with the mouse myeloma cell line Sp 2/0-Ag 14. Screening for production of anti-GR-antibodies by the hybridomas was carried out with an enzyme-linked immunosorbent assay, using partially...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.6.1609

    authors: Okret S,Wikström AC,Wrange O,Andersson B,Gustafsson JA

    更新日期:1984-03-01 00:00:00

  • DNA polymerases of tumor virus: specific effect of ethidium bromide on the use of different synthetic templates.

    abstract::The DNA polymerase enzymes from avian, murine, and feline RNA tumor viruses can be distinguished by their ability to read specific, synthetic primertemplates. The copying of templates containing adenylic and thymidylic acids by all these DNA polymerases is inhibited by ethidium bromide, though this compound affects th...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.68.12.3116

    authors: Fridlender B,Weissbach A

    更新日期:1971-12-01 00:00:00

  • Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production.

    abstract::cGMP is a key regulatory molecule in visual transduction, integration of neuronal response to excitatory neurotransmitters, relaxation of smooth muscle, intestinal secretion of water and salt, and reabsorption of sodium and water in the distal tubules of the nephron. Some of these cellular functions are associated wit...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.7.2623

    authors: Ruth P,Wang GX,Boekhoff I,May B,Pfeifer A,Penner R,Korth M,Breer H,Hofmann F

    更新日期:1993-04-01 00:00:00

  • Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

    abstract::Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1203789109

    authors: Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

    更新日期:2012-07-17 00:00:00

  • Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

    abstract::Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production of the toxic effector molecule nitric oxide (NO). In this study, the mechanism of IL-10 action was identified as inhibition of endogenous tu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.18.8676

    authors: Oswald IP,Wynn TA,Sher A,James SL

    更新日期:1992-09-15 00:00:00

  • A SNARE complex containing SGR3/AtVAM3 and ZIG/VTI11 in gravity-sensing cells is important for Arabidopsis shoot gravitropism.

    abstract::Plants can sense the direction of gravity and change the growth orientation of their organs. The molecular mechanisms of gravity sensing and signal transduction during gravitropism are not well known. We have isolated several shoot gravitropism (sgr) mutants of Arabidopsis. The sgr3-1 mutant exhibits a reduced gravitr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1430749100

    authors: Yano D,Sato M,Saito C,Sato MH,Morita MT,Tasaka M

    更新日期:2003-07-08 00:00:00

  • Co-clustering of denatured hemoglobin with band 3: its role in binding of autoantibodies against band 3 to abnormal and aged erythrocytes.

    abstract::Precipitates of hemoglobin, termed Heinz bodies, occur in a fraction of erythrocytes after removal of the spleen and are also observed in aged erythrocytes. This implies that precipitates of hemoglobin might play a particular role in senescent cell recognition. By using immunofluorescence microscopy, evidence is prese...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.83.16.6137

    authors: Schlüter K,Drenckhahn D

    更新日期:1986-08-01 00:00:00

  • Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments.

    abstract::To explore the pathogenic mechanism of dominant mutations affecting the carboxyl terminus of rhodopsin that cause retinitis pigmentosa, we generated five lines of transgenic mice carrying the proline-347 to serine (P347S) mutation. The severity of photoreceptor degeneration correlated with the levels of transgene expr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.24.14176

    authors: Li T,Snyder WK,Olsson JE,Dryja TP

    更新日期:1996-11-26 00:00:00

  • Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae.

    abstract::By using the maximum likelihood method, we made a genome-wide comparison of the evolutionary rates in the lineages leading to the laboratory strain (S288c) and a wild strain (YJM789) of Saccharomyces cerevisiae and found that genes in the laboratory strain tend to evolve faster than in the wild strain. The pattern of ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0409159102

    authors: Gu Z,David L,Petrov D,Jones T,Davis RW,Steinmetz LM

    更新日期:2005-01-25 00:00:00

  • Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.

    abstract::Although x-ray crystallography is the most widely used method for macromolecular structure determination, it does not provide dynamical information, and either experimental tricks or complementary experiments must be used to overcome the inherently static nature of crystallographic structures. Here we used specific x-...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0804828105

    authors: Colletier JP,Bourgeois D,Sanson B,Fournier D,Sussman JL,Silman I,Weik M

    更新日期:2008-08-19 00:00:00

  • Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.

    abstract::Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells an...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0607062104

    authors: Yeo SY,Chitnis AB

    更新日期:2007-04-03 00:00:00