Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33.

abstract：:Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:Recent genome-wide nucleosome mappings along with bioinformatics studies have confirmed that the DNA sequence plays a more important role in the collective organization of nucleosomes in vivo than previously thought. Yet in living cells, this organization also results from the action of various external factors like D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milani P,Chevereau G,Vaillant C,Audit B,Haftek-Terreau Z,Marilley M,Bouvet P,Argoul F,Arneodo A

更新日期：2009-12-29 00:00:00

abstract：:G protein-coupled receptors mediate biological signals by stimulating nucleotide exchange in heterotrimeric G proteins (Galphabetagamma). Receptor dimers have been proposed as the functional unit responsible for catalytic interaction with Galphabetagamma. To investigate whether a G protein-coupled receptor monomer can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ernst OP,Gramse V,Kolbe M,Hofmann KP,Heck M

更新日期：2007-06-26 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:To explore the lethal, ataxic phenotype of complex I deficiency in Ndufs4 knockout (KO) mice, we inactivated Ndufs4 selectively in neurons and glia (NesKO mice). NesKO mice manifested the same symptoms as KO mice including retarded growth, loss of motor ability, breathing abnormalities, and death by approximately 7 wk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quintana A,Kruse SE,Kapur RP,Sanz E,Palmiter RD

更新日期：2010-06-15 00:00:00

abstract：:Nicotine exposure diminishes the protective breathing and arousal responses to stress (hypoxia). By exacerbating sleep-disordered breathing, this disturbance could underpin the well established association between smoking and the increased risk of sudden infant death syndrome. We show here that the protective response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen G,Han ZY,Grailhe R,Gallego J,Gaultier C,Changeux JP,Lagercrantz H

更新日期：2002-10-01 00:00:00

abstract：:Despite being a fundamental electronic component for over 70 years, it is still possible to develop different transistor designs, including the addition of a diode-like Schottky source electrode to thin-film transistors. The discovery of a dependence of the source barrier height on the semiconductor thickness and deri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,Wilson J,Auton G,Wang Y,Xu M,Xin Q,Song A

更新日期：2019-03-12 00:00:00

abstract：:Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that tetherin forms a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Wang J,Jia X,McNatt MW,Zang T,Pan B,Meng W,Wang HW,Bieniasz PD,Xiong Y

更新日期：2010-10-26 00:00:00

abstract：:Somatic LINE-1 (L1) retrotransposition has been detected in early embryos, adult brains, and the gastrointestinal (GI) tract, and many cancers, including epithelial GI tumors. We previously found numerous somatic L1 insertions in paired normal and GI cancerous tissues. Here, using a modified method of single-cell anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Soares AO,Goff LA,Talasila A,Choi JA,Ivenitsky D,Karma S,Brophy B,Devine SE,Meltzer SJ,Kazazian HH Jr

更新日期：2020-12-22 00:00:00

abstract：:Integration of viral DNA into the host nuclear genome, although not unusual in bacterial and animal systems, has surprisingly not been reported for plants. We have discovered geminvirus-related DNA (GRD) sequences, in the form of distinct sets of multiple direct repeats comprising three related repeat classes, situate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bejarano ER,Khashoggi A,Witty M,Lichtenstein C

更新日期：1996-01-23 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Integrating sulfanyl substituents into copper-bonded phenoxyls significantly alters their optical and redox properties and provides insight into the influence of cysteine modification of the tyrosine cofactor in the enzyme galactose oxidase. The model complexes [1(SR2)](+) are class II mixed-valent Cu(II)-phenoxyl-phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma P,Pratt RC,Storr T,Wasinger EC,Stack TD

更新日期：2011-11-15 00:00:00

abstract：:Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustained and sufficient oxygen and nutrient exchange during fat mass expansion, thereby improving adipose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun K,Wernstedt Asterholm I,Kusminski CM,Bueno AC,Wang ZV,Pollard JW,Brekken RA,Scherer PE

更新日期：2012-04-10 00:00:00

abstract：:Complement-stimulated granulocytes adhere to and induce significant 51Cr release from endothelial cells in vitro. Platelets were stimulated to undergo release, and these release products significantly enhanced granulocyte-endothelial cell adherence and granulocyte-induced 51Cr release from endothelial cells. Platelet ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boogaerts MA,Yamada O,Jacob HS,Moldow CF

更新日期：1982-11-01 00:00:00

abstract：:Obesity is a major health problem worldwide, given its growing incidence and its association with a variety of comorbidities. Weight gain results from an increase in energy intake without a concomitant increase in energy expenditure. To combat the obesity epidemic, many studies have focused on the pathways underlying ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaspari RR,Reyna-Neyra A,Jung L,Torres-Manzo AP,Hirabara SM,Carrasco N

更新日期：2020-09-08 00:00:00

abstract：:Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were crossed with Tspo-floxed mice t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Campioli E,Midzak A,Culty M,Papadopoulos V

更新日期：2015-06-09 00:00:00

abstract：:Markov chain Monte Carlo (MCMC) or the Metropolis-Hastings algorithm is a simulation algorithm that has made modern Bayesian statistical inference possible. Nevertheless, the efficiency of different Metropolis-Hastings proposal kernels has rarely been studied except for the Gaussian proposal. Here we propose a unique ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Rodríguez CE

更新日期：2013-11-26 00:00:00

abstract：:We recognize, understand, and interact with objects through both vision and touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons in macaque monkey intermediate visual (area V4) and somatosensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau JM,Pasupathy A,Fitzgerald PJ,Hsiao SS,Connor CE

更新日期：2009-09-22 00:00:00

abstract：:Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development. To elucidate the molecular basis for tetramer formation of the various family members, we solved the crystal structure of the human p73 tetramerizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joerger AC,Rajagopalan S,Natan E,Veprintsev DB,Robinson CV,Fersht AR

更新日期：2009-10-20 00:00:00

abstract：:Mutations induced by (+/-)trans-benzo-[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BaP-diol epoxide-1) were selected by using a recombinant plasmid vector system designed for the study of transcription termination signals. The plasmid contains a transcription terminator positioned between a promotor signal and the Escheric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizusawa H,Lee CH,Kakefuda T,McKenney K,Shimatake H,Rosenberg M

更新日期：1981-11-01 00:00:00

abstract：:The p2b domain of Rous sarcoma virus (RSV) Gag and the p6 domain of HIV-1 Gag contain late assembly (L) domains that engage the ESCRT membrane fission machinery and are essential for virus release. We now show that the PPXY-type RSV L domain specifically recruits the BAR domain protein PACSIN2 into virus-like particle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popov S,Popova E,Inoue M,Wu Y,Göttlinger H

更新日期：2018-07-03 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00

abstract：:Fast-atom bombardment mass spectrometry was used to follow the time course of disulfide bond formation during in vitro refolding of recombinant human macrophage-colony-stimulating factor. The content of iodoacetamide-alkylated half-cystines in proteolytic peptides of trapped refolding intermediates collected at 0, 6, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glocker MO,Arbogast B,Milley R,Cowgill C,Deinzer ML

更新日期：1994-06-21 00:00:00

abstract：:An immunoglobulin light chain protein was isolated from the urine of an individual (BRE) with systemic amyloidosis. Complete amino acid sequence of the variable region of the light chain (VL) protein established it as a kappa I, which when compared with other kappa I amyloid associated proteins had unique residues, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schormann N,Murrell JR,Liepnieks JJ,Benson MD

更新日期：1995-10-10 00:00:00

abstract：:Opportunistic infections are often polymicrobial. Two of the most important bacterial opportunistic pathogens of humans, Pseudomonas aeruginosa and Staphylococcus aureus, frequently are coisolated from infections of catheters, endotracheal tubes, skin, eyes, and the respiratory tract, including the airways of people w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman LR,Déziel E,D'Argenio DA,Lépine F,Emerson J,McNamara S,Gibson RL,Ramsey BW,Miller SI

更新日期：2006-12-26 00:00:00

abstract：:Setting aside high-quality large areas of habitat to protect threatened populations is becoming increasingly difficult as humans fragment and degrade the environment. Biologists and managers therefore must determine the best way to shepherd small populations through the dual challenges of reductions in both the number...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufbauer RA,Szűcs M,Kasyon E,Youngberg C,Koontz MJ,Richards C,Tuff T,Melbourne BA

更新日期：2015-08-18 00:00:00

abstract：:The initial electron transfer steps in the photosynthetic reaction center of the purple bacterium Rhodobacter sphaeroides have been investigated by femtosecond time-resolved spectroscopy. The experimental data taken at various wavelengths demonstrate the existence of at least four intermediate states within the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holzapfel W,Finkele U,Kaiser W,Oesterhelt D,Scheer H,Stilz HU,Zinth W

更新日期：1990-07-01 00:00:00

abstract：:The three most common methods of sterilization in use today are ethylene oxide exposure, gamma-irradiation, and steam sterilization. Each of these methods has serious limitations for the sterilization of some materials used in medicine, especially thermally and hydrolytically sensitive polymers by themselves and in co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dillow AK,Dehghani F,Hrkach JS,Foster NR,Langer R

更新日期：1999-08-31 00:00:00

abstract：:We have earlier reported conditions that support the axenic development in vitro of a complete asexual erythrocytic cycle of Plasmodium falciparum. Up to 30% of merozoites showed initial differentiation into trophic forms (rings) viable at 14 hr. However, only approximately 1% of the merozoites would develop further i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JH,Gill GS,Trager W

更新日期：1995-01-17 00:00:00

abstract：:Development of spatial patterns in multicellular organisms depends on gradients in the concentration of signaling molecules that control gene expression. In the Drosophila embryo, Bicoid (Bcd) morphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localized at the anterior pole....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor T,Bialek W,de Ruyter van Steveninck RR,Tank DW,Wieschaus EF

更新日期：2005-12-20 00:00:00