beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure.

abstract：:The human isoform 2 of pantothenate kinase (PanK2) is localized to the mitochondria, and mutations in this protein are associated with a progressive neurodegenerative disorder. PanK2 inhibition by acetyl-CoA is so stringent (IC50 < 1 microM) that it is unclear how the enzyme functions in the presence of intracellular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonardi R,Rock CO,Jackowski S,Zhang YM

更新日期：2007-01-30 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:Several mouse models have already proved valuable for investigating hypertrophic responses to cardiac stress. Here, we characterize one caused by a well defined single copy transgene, RenTgMK, that genetically clamps plasma renin and thence angiotensin II at high levels. All of the transgenic males develop concentric ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caron KM,James LR,Kim HS,Knowles J,Uhlir R,Mao L,Hagaman JR,Cascio W,Rockman H,Smithies O

更新日期：2004-03-02 00:00:00

abstract：:A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malins DC,Gilman NK,Green VM,Wheeler TM,Barker EA,Anderson KM

更新日期：2005-12-27 00:00:00

abstract：:To explore the basis for the template specificities of the bacteriophage T3 and T7 RNA polymerases (EC 2.7.7.6), we determined the nucleotide sequences of six promoters recognized by the T3 RNA polymerase and compared them with the previously determined promoter sequences recognized by the bacteriophage T7 RNA polymer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey JN,Klement JF,McAllister WT

更新日期：1983-05-01 00:00:00

abstract：:Argonaute (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interference (RNAi) in association with small RNAs. Although overall the mechanism of RNAi is well understood, many molecular details of this complex process are not. Here we report about in-depth steady-state and, in p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deerberg A,Willkomm S,Restle T

更新日期：2013-10-29 00:00:00

abstract：:Mutagen treatment of mouse P815 tumor cells produces tum- variants that are rejected by syngeneic mice because these variants express new surface antigens. These "tum- antigens" are recognized by cytolytic T lymphocytes but induce no detectable antibody response. Transfection of P815 cell line P1.HTR with DNA of tum- ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Plaen E,Lurquin C,Van Pel A,Mariamé B,Szikora JP,Wölfel T,Sibille C,Chomez P,Boon T

更新日期：1988-04-01 00:00:00

abstract：:CD4+ T cells recognize major histocompatibility complex (MHC) class II-bound peptides that are primarily obtained from extracellular sources. Endogenously synthesized proteins that readily enter the MHC class I presentation pathway are generally excluded from the MHC class II presentation pathway. We show here that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson S,Frauwirth K,Shastri N

更新日期：1995-08-01 00:00:00

abstract：:Adenosine, dibutyryl cyclic AMP, monobutyryl cyclic AMP, cyclic AMP, and 5'-AMP have a remarkable morphogenetic effect on cultured iris epithelial cells obtained from adult newt. They alter the broad undulating membrane of the cell into branching strands of cytoplasm, a configuration that has been named "stellate." Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz JR,Yamada T,Hsie AW

更新日期：1973-08-01 00:00:00

abstract：:Social ties are crucial for physical and mental health. However, psychiatric patients frequently encounter social rejection. Moreover, an increased reactivity to social exclusion influences the development, progression, and treatment of various psychiatric disorders. Nevertheless, the neuromodulatory substrates of rej...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preller KH,Pokorny T,Hock A,Kraehenmann R,Stämpfli P,Seifritz E,Scheidegger M,Vollenweider FX

更新日期：2016-05-03 00:00:00

abstract：:Plant germ cells develop in specialized haploid structures, termed gametophytes. The female gametophyte patterns of flowering plants are diverse, with often unknown adaptive value. Here we present the Arabidopsis fiona mutant, which forms a female gametophyte that is structurally and functionally reminiscent of a phyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kägi C,Baumann N,Nielsen N,Stierhof YD,Gross-Hardt R

更新日期：2010-12-21 00:00:00

abstract：:The Cu,Zn superoxide dismutase (SOD) was examined earlier and found to behave in a very unclock-like manner despite (accepted point mutation, or PAM) corrections for multiple replacements per site. Depending upon the time span involved, rates could differ 5-fold. We have sought to determine whether the data might be c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fitch WM,Ayala FJ

更新日期：1994-07-19 00:00:00

abstract：:The global demand for food could double in another 40 y owing to growth in the population and food consumption per capita. To meet the world's future food and sustainability needs for biofuels and renewable materials, the production of starch-rich cereals and cellulose-rich bioenergy plants must grow substantially whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You C,Chen H,Myung S,Sathitsuksanoh N,Ma H,Zhang XZ,Li J,Zhang YH

更新日期：2013-04-30 00:00:00

abstract：:Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llodrá J,Angeli V,Liu J,Trogan E,Fisher EA,Randolph GJ

更新日期：2004-08-10 00:00:00

abstract：:Alpha-Klotho (alpha-Kl) and its homolog, beta-Klotho (beta-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, members of the FGF19 subfamily, are believed to act as circulating metabolic regulators. Analyses of functional interactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomiyama K,Maeda R,Urakawa I,Yamazaki Y,Tanaka T,Ito S,Nabeshima Y,Tomita T,Odori S,Hosoda K,Nakao K,Imura A,Nabeshima Y

更新日期：2010-01-26 00:00:00

abstract：:Research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, Mycobacterium smegmatis. This transformation system was made possible by the successful isolation of a M. smegmatis mutant strain mc(2)155, whose efficient plasmid transformation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panas MW,Jain P,Yang H,Mitra S,Biswas D,Wattam AR,Letvin NL,Jacobs WR Jr

更新日期：2014-09-16 00:00:00

abstract：:The DNA sequences of wheat Acc-1 and Acc-2 loci, encoding the plastid and cytosolic forms of the enzyme acetyl-CoA carboxylase, were analyzed with a view to understanding the evolution of these genes and the origin of the three genomes in modern hexaploid wheat. Acc-1 and Acc-2 loci from each of the wheats Triticum ur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chalupska D,Lee HY,Faris JD,Evrard A,Chalhoub B,Haselkorn R,Gornicki P

更新日期：2008-07-15 00:00:00

abstract：:We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OHase deficiency and always carries a null allele at the locus encodi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,New MI,Dupont B

更新日期：1984-12-01 00:00:00

abstract：:The T-cell antigen receptor alpha-chain genes of an alloreactive, H-2Db-specific cytotoxic T-cell clone (3F9) are described. This study and our work on the 3F9 beta-chain genes reveal that the variable region gene segments for the alpha and beta chains expressed in 3F9 are identical to the ones used by a chicken eryth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupp F,Brecher J,Giedlin MA,Mosmann T,Zinkernagel RM,Hengartner H,Joho RH

更新日期：1987-01-01 00:00:00

abstract：:Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roschke AV,Lababidi S,Tonon G,Gehlhaus KS,Bussey K,Weinstein JN,Kirsch IR

更新日期：2005-02-22 00:00:00

abstract：:Working memory (WM) is the ability to retain and associate information over brief time intervals. Functional imaging studies demonstrate that WM is mediated by a distributed network including frontal and posterior cortices, hippocampus, and cerebellum. In rodents, the presentation of stimuli in a WM task is followed b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tesche CD,Karhu J

更新日期：2000-01-18 00:00:00

abstract：:Despite the importance of valuing another person's welfare for prosocial behavior, currently we have only a limited understanding of how these values are represented in the brain and, more importantly, how they give rise to individual variability in prosociality. In the present study, participants underwent functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sul S,Tobler PN,Hein G,Leiberg S,Jung D,Fehr E,Kim H

更新日期：2015-06-23 00:00:00

abstract：:The conformational effects of different amino acid substitutions (lysine, serine, proline, and D-valine) for glycine at position 12 in the p21 oncogene-encoded proteins have been investigated by using conformational energy calculations. The normal cellular gene codes for a glycine at position 12 in the amino acid sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Brandt-Rauf PW

更新日期：1985-06-01 00:00:00

abstract：:We describe retroviral expression vectors containing cDNAs encoding part of fibronectin preceded by the signal and "pro" sequences of parathyroid hormone. The recombinant retroviruses were used to generate NIH 3T3 cell lines stably producing functionally active fragments of fibronectin. The recombinant fibronectins (d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarzbauer JE,Mulligan RC,Hynes RO

更新日期：1987-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T. (1998) Proc. Natl. Acad. Sci. USA 95, 14470-14475]. By using high-density cDNA microarrays, we show that the HCMV-regulated gene expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simmen KA,Singh J,Luukkonen BG,Lopper M,Bittner A,Miller NE,Jackson MR,Compton T,Früh K

更新日期：2001-06-19 00:00:00

abstract：:Excitation-evoked Ca(2+) influx is the fastest and most ubiquitous chemical trigger for cellular processes, including neurotransmitter release, muscle contraction, and gene expression. The voltage dependence and timing of Ca(2+) entry are thought to be functions of voltage-gated calcium (CaV) channels composed of a ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis A,Savalli N,Sigg D,Neely A,Olcese R

更新日期：2014-12-23 00:00:00

abstract：:These studies sought to determine if neurons in the estrogen receptor-alpha knockout (ERalphaKO) mouse brain concentrated 16alpha-[125I]iodo-11beta-methoxy-17beta-estradiol (125I-estrogen), and if so, whether estrogen binding augmented the expression of progesterone receptor (PR) mRNA. Mice were injected with 125I-est...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shughrue PJ,Lubahn DB,Negro-Vilar A,Korach KS,Merchenthaler I

更新日期：1997-09-30 00:00:00

abstract：:Gold nanoparticles (NPs) wrapped in a membrane can be utilized as artificial virus nanoparticles (AVNs) that combine the large nonblinking or bleaching optical cross-section of the NP core with the biological surface properties and functionalities provided by a self-assembled lipid membrane. We used these hybrid nanom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM

更新日期：2018-09-25 00:00:00

abstract：:Seven antigenic variants obtained from a single field isolate of foot-and-mouth disease virus, serotype A12, differ only at residues 148 and 153 in the immunodominant loop of viral protein VP1. Synthetic peptides corresponding to the region 141-160 are highly immunogenic. UV circular dichroism shows that (i) in aqueou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： France LL,Piatti PG,Newman JF,Toth I,Gibbons WA,Brown F

更新日期：1994-08-30 00:00:00

abstract：:The motility of cilia and flagella is powered by dynein ATPases associated with outer doublet microtubules. However, a flagellar kinesin-like protein that may function as a motor associates with the central pair complex. We determined that Chlamydomonas reinhardtii central pair kinesin Klp1 is a phosphoprotein and, li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokoyama R,O'toole E,Ghosh S,Mitchell DR

更新日期：2004-12-14 00:00:00