Direction of motion discrimination after early lesions of striate cortex (V1) of the macaque monkey.

abstract：:Alfalfa mosaic virus (AlMV) coat protein is involved in systemic infection of host plants, and a specific mutation in this gene prevents the virus from moving into the upper uninoculated leaves. The coat protein also is required for different viral functions during early and late infection. To study the role of the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitsin S,Steplewski K,Fleysh N,Belanger H,Mikheeva T,Shivprasad S,Dawson W,Koprowski H,Yusibov V

更新日期：1999-03-02 00:00:00

abstract：:The structure of the gene encoding human hexabrachion (tenascin) has been determined from overlapping clones isolated from a human genomic bacteriophage library. The genomic inserts were characterized by restriction mapping, Southern blot analysis, PCR, and DNA sequencing. The coding region of the hexabrachion gene sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulcher JR,Nies DE,Alexakos MJ,Ravikant NA,Sturgill ME,Marton LS,Stefansson K

更新日期：1991-11-01 00:00:00

abstract：:Timelapse video microscopy has been used to record the motility and dynamic interactions between an H-2Db-restricted murine cytotoxic T lymphocyte clone (F5) and Db-transfected L929 mouse fibroblasts (LDb) presenting normal or variant antigenic peptides from human influenza nucleoprotein. F5 cells will kill LDb target...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shotton DM,Attaran A

更新日期：1998-12-22 00:00:00

abstract：:Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes over mucosal wounds. High levels of ITF are frequently present in colorectal cancers and derived cell lines. Mucosal restitution requires the detachment of epithelium from substrate, which wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taupin DR,Kinoshita K,Podolsky DK

更新日期：2000-01-18 00:00:00

abstract：:Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile."...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strang CJ,Siegel RC,Phillips ML,Poon PH,Schumaker VN

更新日期：1982-01-01 00:00:00

abstract：:Agrin is a basal lamina molecule that directs key events in postsynaptic differentiation, most notably the aggregation of acetylcholine receptors (AChRs) on the muscle cell surface. Agrin's AChR clustering activity is regulated by alternative mRNA splicing. Agrin splice forms having inserts at two sites (y and z) in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Toole JJ,Deyst KA,Bowe MA,Nastuk MA,McKechnie BA,Fallon JR

更新日期：1996-07-09 00:00:00

abstract：:The biosynthesis of fibronectin during the in vivo development of matrix-induced endochondral bone was investigated by using [35S]methionine in rats. The dmineralized bone matrix that was implanted subcutaneously to induce local bone formation bound circulating fibronectin. This may be an important initial requirement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss RE,Reddi AH

更新日期：1980-04-01 00:00:00

abstract：:A cell separation technique was designed based on the interaction between cell-surface-bound IgG and protein A of Staphylococcus aureus. The density of lymphoid cells coated with IgG antibodies against one of the surface markers was increased by adherence of staphylococci. Cells with adhering bacteria were separated f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghetie V,Nilsson K,Sjöquist J

更新日期：1974-12-01 00:00:00

abstract：:Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. Many aberrantly methylated genes play important roles in development and are bivalently marked in ES...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproul D,Nestor C,Culley J,Dickson JH,Dixon JM,Harrison DJ,Meehan RR,Sims AH,Ramsahoye BH

更新日期：2011-03-15 00:00:00

abstract：:The phosphatidylinositol phosphate kinase (PIPK) family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates. As such, these kinases are central to many signaling and membrane trafficking processes in the eukaryotic cell. The th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muftuoglu Y,Xue Y,Gao X,Wu D,Ha Y

更新日期：2016-08-02 00:00:00

abstract：:The nanoscale distributions of electron density and electric fields in GaAs semiconductor devices are displayed with NMR experiments. The spectra are sensitive to the changes to the nuclear-spin Hamiltonian that are induced by perturbations delivered in synchrony with a line-narrowing pulse sequence. This POWER (pertu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempf JG,Miller MA,Weitekamp DP

更新日期：2008-12-23 00:00:00

abstract：:Most homeobox genes belonging to the Hox family are sequentially activated in embryonal carcinoma cells upon treatment with retinoic acid. Genes located at the 3' end of each one of the four Hox clusters are activated first, whereas upstream Hox genes are activated progressively later. This activation has been extensi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faiella A,Zappavigna V,Mavilio F,Boncinelli E

更新日期：1994-06-07 00:00:00

abstract：:As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin EJ,Cao Y,Enkavi G,Quick M,Pan Y,Tajkhorshid E,Zhou M

更新日期：2012-07-10 00:00:00

abstract：:Biological membranes are complex, self-organized structures that define boundaries and compartmentalize space in living matter. Composed of a wide variety of lipid and protein molecules, these responsive surfaces mediate transmembrane signaling and material transport within the cell and with its environment. It is wel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watkins EB,Miller CE,Majewski J,Kuhl TL

更新日期：2011-04-26 00:00:00

abstract：:Cellular and molecular signals involved in axon elongation versus collateral and arbor formation may be intrinsic to developing neurons, or they may derive from targets. To identify signals regulating axon growth modes, we have developed a culture system in which trigeminal ganglion cells are challenged by various tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erzurumlu RS,Jhaveri S,Takahashi H,McKay RD

更新日期：1993-08-01 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:Evolution of new enzymatic activities is believed to require a period of gene sharing in which a single enzyme must serve both its original function and a new function that has become advantageous to the organism. Subsequent gene duplication allows one copy to maintain the original function, while the other diverges t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLoughlin SY,Copley SD

更新日期：2008-09-09 00:00:00

abstract：:Following proteolytic conversion of fibrinogen to fibrin, clot assembly commences with formation of double-stranded fibrils that subsequently branch extensively in forming a three-dimensional network. Plasmin digests of fibrin clots that had first been covalently crosslinked by plasma transglutaminase (factor XIIIa) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosesson MW,Siebenlist KR,Amrani DL,DiOrio JP

更新日期：1989-02-01 00:00:00

abstract：:Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermosura MC,Nayakanti H,Dorovkov MV,Calderon FR,Ryazanov AG,Haymer DS,Garruto RM

更新日期：2005-08-09 00:00:00

abstract：:Closed and pH-tight membrane vesicles prepared from hypocotyls of 5-day-old dark-grown seedlings of Cucurbita pepo accumulate the plant growth hormone indole-3-acetic acid along an imposed proton gradient (pH low outside, high inside). The use of electron paramagnetic spin probes permitted quantitation both of apparen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomax TL,Mehlhorn RJ,Briggs WR

更新日期：1985-10-01 00:00:00

abstract：:A loss-of-function mutation in the APC gene initiates colorectal carcinogenesis. Although the molecular mechanism of tumor initiation is complex, several modifier genes have been identified using mouse models, including the ApcMin mouse. Among the familial adenomatous polyposis mouse lines carrying a truncation mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibata H,Takano H,Ito M,Shioya H,Hirota M,Matsumoto H,Kakudo Y,Ishioka C,Akiyama T,Kanegae Y,Saito I,Noda T

更新日期：2007-11-13 00:00:00

abstract：:The mammalian retina contains an endogenous circadian pacemaker that broadly regulates retinal physiology and function, yet the cellular origin and organization of the mammalian retinal circadian clock remains unclear. Circadian clock neurons generate daily rhythms via cell-autonomous autoregulatory clock gene network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan GX,Zhang DQ,Zhou T,Yamazaki S,McMahon DG

更新日期：2006-06-20 00:00:00

abstract：:The total amount of noncoding sequences on chromosomes of contemporary organisms varies significantly from species to species. We propose a hypothesis for the origin of these noncoding sequences that assumes that (i) an approximately equal to 0.55-kilobase (kb)-long reading frame composed the primordial gene and (ii) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naora H,Miyahara K,Curnow RN

更新日期：1987-09-01 00:00:00

abstract：:DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure. We used random sequence substitutions to gain structure-function inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christians FC,Loeb LA

更新日期：1996-06-11 00:00:00

abstract：:To gain further insight into the mode of action of S-locus receptor kinase (SRK), a receptor-like kinase involved in the self-incompatibility response in Brassica, different recombinant SRK proteins have been expressed in a membranous environment using the insect cell/baculovirus system. Recombinant SRK proteins exhib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giranton JL,Dumas C,Cock JM,Gaude T

更新日期：2000-03-28 00:00:00

abstract：:The subdivision of all the experimental days of the Whitetop project into two approximately equal groups, group W with predominantly westerly winds aloft and group E with frequent easterly winds, shows a remarkable difference in the apparent effect of seeding. On W days there was no detectable effect of seeding on rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovasich JL,Neyman J,Scott EL,Smith JA

更新日期：1969-11-01 00:00:00

abstract：:Squalene and sterol carrier protein of liver plays a general role as a vehicle for cholesterol and its water-insoluble precursors; the carrier protein is essential for enzymic cholesterol synthesis. Liver microsomal enzymes contain a small amount of endogenous carrier protein, which is readily removed by washing or pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritter MC,Dempsey ME

更新日期：1973-01-01 00:00:00

abstract：:The amphiphilic fluorescent styryl pyridinium dyes FM1-43 and FM4-64 are used to probe activity-dependent synaptic vesicle cycling in neurons. Cultured astrocytes can internalize FM1-43 and FM4-64 inside vesicles but their uptake is insensitive to the elevation of cytosolic calcium (Ca(2+)) concentration and the under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li D,Hérault K,Oheim M,Ropert N

更新日期：2009-12-22 00:00:00

abstract：:The results of previous preclinical and clinical studies have identified angiogenin (ANG) as a potentially important target for anticancer therapy. Here we report the design and implementation of a high-throughput screening assay to identify small molecules that bind to the ribonucleolytic active site of ANG, which is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kao RY,Jenkins JL,Olson KA,Key ME,Fett JW,Shapiro R

更新日期：2002-07-23 00:00:00

abstract：:For almost a century, alcohols have been thought to produce their effects by actions on the membrane lipids of central nervous system neurons--the well known "lipid theory" of alcohol action. The rationale for this theory is the correlation of potency with oil/water or membrane/buffer partition coefficient. Although a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Peoples RW,Weight FF

更新日期：1994-08-16 00:00:00