Kep1 interacts genetically with dredd/caspase-8, and kep1 mutants alter the balance of dredd isoforms.

abstract：:Plants have intercellular channels, plasmodesmata (PD), that span the cell wall to enable cell-to-cell transport of micro- and macromolecules. We identified an Arabidopsis thaliana embryo lethal mutant increased size exclusion limit 1 (ise1) that results in increased PD-mediated transport of fluorescent tracers. The i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stonebloom S,Burch-Smith T,Kim I,Meinke D,Mindrinos M,Zambryski P

更新日期：2009-10-06 00:00:00

abstract：:To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higuchi H,Muto E,Inoue Y,Yanagida T

更新日期：1997-04-29 00:00:00

abstract：:S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siddiquee K,Zhang S,Guida WC,Blaskovich MA,Greedy B,Lawrence HR,Yip ML,Jove R,McLaughlin MM,Lawrence NJ,Sebti SM,Turkson J

更新日期：2007-05-01 00:00:00

abstract：:Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype, is considered to play a causative role in the etiology of ischemic stroke and several neurodegenerative diseases. The NMDA receptor is therefore a target for the development of neuroprotective agents....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tai KK,Blondelle SE,Ostresh JM,Houghten RA,Montal M

更新日期：2001-03-13 00:00:00

abstract：:The development of osteoclastic cell lines would greatly facilitate analysis of the cellular and molecular biology of bone resorption. Several cell lines have previously been reported to be capable of osteoclastic differentiation. However, such cell lines form at best only occasional excavations, suggesting that osteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chambers TJ,Owens JM,Hattersley G,Jat PS,Noble MD

更新日期：1993-06-15 00:00:00

abstract：:The initial electron transfer steps in the photosynthetic reaction center of the purple bacterium Rhodobacter sphaeroides have been investigated by femtosecond time-resolved spectroscopy. The experimental data taken at various wavelengths demonstrate the existence of at least four intermediate states within the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holzapfel W,Finkele U,Kaiser W,Oesterhelt D,Scheer H,Stilz HU,Zinth W

更新日期：1990-07-01 00:00:00

abstract：:Developing tools for investigating the cellular activity of glycans will help to delineate the molecular basis for aberrant glycosylation in pathological processes such as cancer. Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu TL,Hanson SR,Kishikawa K,Wang SK,Sawa M,Wong CH

更新日期：2007-02-20 00:00:00

abstract：:Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over prolif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhandari D,Lopez-Sanchez I,To A,Lo IC,Aznar N,Leyme A,Gupta V,Niesman I,Maddox AL,Garcia-Marcos M,Farquhar MG,Ghosh P

更新日期：2015-09-01 00:00:00

abstract：:When a local mechanical perturbation is applied to the surface of a thin film of a mechanically interlocked molecule (a rotaxane), the molecules self-organize into periodic arrays of discrete dots or lines. The dimensionality of the nanostructures depends on whether the mechanical stimulus acts along a 1D line or over...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biscarini F,Cavallini M,Kshirsagar R,Bottari G,Leigh DA,León S,Zerbetto F

更新日期：2006-11-21 00:00:00

abstract：:Regulatory mechanisms for tissue repair and regeneration within damaged tissue have been extensively studied. However, the systemic regulation of tissue repair remains poorly understood. To elucidate tissue nonautonomous control of repair process, it is essential to induce local damage, independent of genetic manipula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kashio S,Obata F,Zhang L,Katsuyama T,Chihara T,Miura M

更新日期：2016-02-16 00:00:00

abstract：:Telomerase is a special reverse transcriptase that extends one strand of the telomere repeat by using a template embedded in an RNA subunit. Like other polymerases, telomerase is believed to use a pair of divalent metal ions (coordinated by a triad of aspartic acid residues) for catalyzing nucleotide addition. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lue NF,Bosoy D,Moriarty TJ,Autexier C,Altman B,Leng S

更新日期：2005-07-12 00:00:00

abstract：:Recent studies have highlighted the importance of peripheral induction of Foxp3-expressing regulatory T cells (Tregs) in the dominant control of immunological tolerance. However, Foxp3(+) Treg differentiation from naïve CD4(+) T cells occurs only under selective conditions, whereas the classical T helper (Th) 1 and 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei J,Duramad O,Perng OA,Reiner SL,Liu YJ,Qin FX

更新日期：2007-11-13 00:00:00

abstract：:These experiments investigate the capacity of thalamic and cortical structures in a sensory system to process information of a modality normally associated with another system. Retinal ganglion cells in newborn Syrian hamsters were made to project permanently to the main thalamic somatosensory (ventrobasal) nucleus. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Métin C,Frost DO

更新日期：1989-01-01 00:00:00

abstract：:A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roder JC,Rosén A,Fenyö EM,Troy FA

更新日期：1979-03-01 00:00:00

abstract：:The Caulobacter crescentus flagellum is formed at a specific time in the cell cycle and its assembly requires the ordered expression of a large number of genes. These genes are controlled in a positive trans-acting hierarchy that reflects the order of assembly of the flagellum. Using plasmids carrying transcriptional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu H,Dingwall A,Shapiro L

更新日期：1989-09-01 00:00:00

abstract：:d-alanine-d-lactate ligase from Enterococcus faecium BM4147 is directly responsible for the biosynthesis of alternate cell-wall precursors in bacteria, which are resistant to the glycopeptide antibiotic vancomycin. The crystal structure has been determined with data extending to 2.5-A resolution. This structure shows ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roper DI,Huyton T,Vagin A,Dodson G

更新日期：2000-08-01 00:00:00

abstract：:MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate measurements. A deleti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weintraub H,Davis R,Lockshon D,Lassar A

更新日期：1990-08-01 00:00:00

abstract：:Humans reason about the mental states of others; this capacity is called Theory of Mind (ToM). In typically developing adults, ToM is supported by a consistent group of brain regions: the bilateral temporoparietal junction (TPJ), medial prefrontal cortex (MPFC), precuneus (PC), and anterior temporal sulci (aSTS). How ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedny M,Pascual-Leone A,Saxe RR

更新日期：2009-07-07 00:00:00

abstract：:Regulation of the turnover of triglycerides in adipose tissue requires the continuous provision of 3-glycerophosphate, which may be supplied by the metabolism of glucose or by glyceroneogenesis, the de novo synthesis of 3-glycerophosphate from sources other than hexoses or glycerol. The importance of glyceroneogenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olswang Y,Cohen H,Papo O,Cassuto H,Croniger CM,Hakimi P,Tilghman SM,Hanson RW,Reshef L

更新日期：2002-01-22 00:00:00

abstract：:Glucocorticoids play a critical role in control of the cytokine response after immune challenge. Conversely, cytokines modulate glucocorticoid production by the hypothalamic-pituitary-adrenal axis. To define the potency and mechanism of interleukin-6 (IL-6) for augmentation of adrenal function, we exploited mice defic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bethin KE,Vogt SK,Muglia LJ

更新日期：2000-08-01 00:00:00

abstract：:Theoretical and experimental optical, redox, and paramagnetic results are presented for models of siroheme, the iron isobacteriochlorin prosthetic group of nitrite and sulfite reductases, and of sirohydrochlorin, the metal-free siroheme that is an intermediate in the biosynthetic pathway to vitamin B(12). The facile o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang CK,Hanson LK,Richardson PF,Young R,Fajer J

更新日期：1981-05-01 00:00:00

abstract：:A protein of 87 kilodaltons (87 kDa) was previously identified as a major specific substrate for protein kinase C in neuronal and other tissues. We have now studied the effect of protein kinase C-catalyzed phosphorylation of this protein on its association with membranes in isolated nerve terminals (synaptosomes) from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JK,Walaas SI,Sihra TS,Aderem A,Greengard P

更新日期：1989-04-01 00:00:00

abstract：:The term amyloid defines a group of proteins that aggregate into plaques or fibers. Amyloid fibers gained their fame mostly due to their relation with neurodegenerative diseases in humans. However, secreted by lower organisms, such as bacteria and fungi, amyloid fibers play a functional role: for example, when they se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lester-Zer N,Ghrayeb M,Chai L

更新日期：2019-11-05 00:00:00

abstract：:Cytokines often deliver simultaneous, yet distinct, cell growth and cell survival signals. The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate cell growth by inducing protein synthesis components. We purified membrane-based p70S6K as a kinase responsible for site-specific phosphorylation of BAD, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada H,Andersen JS,Mann M,Terada N,Korsmeyer SJ

更新日期：2001-08-14 00:00:00

abstract：:Recent studies investigating the relationship between crop genetic diversity and human cultural diversity patterns showed that seed exchanges are embedded in farmers' social organization. However, our understanding of the social processes involved remains limited. We investigated how farmers' membership in three major...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Labeyrie V,Thomas M,Muthamia ZK,Leclerc C

更新日期：2016-01-05 00:00:00

abstract：:Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steeves RA,Fjelde A,Mirand EA

更新日期：1971-10-01 00:00:00

abstract：:The earliest measurable parameter that shows density-dependent inhibition is the uptake of [(3)H]deoxyglucose by Balb 3T3 cells. The rate decreases even during the exponential phase of growth and reaches a minimum, about 8- to 10-times lower than maximum, as the culture approaches the saturation density. Cells transfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose SK,Zlotnick BJ

更新日期：1973-08-01 00:00:00

abstract：:Measurements of the water proton spinlattice relaxation (T(1)) in 106 human tumors confirms earlier results with animals [Damadian, R. (1971) Science 171, 1151-1153]. T(1) of all the tumors studied were significantly longer than T(1) of the corresponding normal tissues. Mean standard error and range were reported for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damadian R,Zaner K,Hor D,DiMaio T

更新日期：1974-04-01 00:00:00

abstract：:We advance a theory of resilience as it applies to the challenges of international development. The conceptualization we advance for development resilience focuses on the stochastic dynamics of individual and collective human well-being, especially on the avoidance of and escape from chronic poverty over time in the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CB,Constas MA

更新日期：2014-10-07 00:00:00

abstract：:The gamma-aminobutyrate-synthesizing enzyme glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) is a major target of autoantibodies associated with both early and late stages of pancreatic beta-cell destruction and development of type 1 diabetes. We have used five monoclonal anti-islet-cell antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter W,Shi Y,Baekkeskov S

更新日期：1993-04-01 00:00:00