A large interspersed repeat found in mouse DNA contains a long open reading frame that evolves as if it encodes a protein.

abstract：:Overexpression of ErbB-2/Neu has been causally associated with mammary epithelial transformation. Here we report that blockade of the epidermal growth factor receptor (EGFR) kinase with AG-1478 markedly delays breast tumor formation in mouse mammary tumor virus (MMTV)/Neu + MMTV/transforming growth factor alpha bigeni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lenferink AE,Simpson JF,Shawver LK,Coffey RJ,Forbes JT,Arteaga CL

更新日期：2000-08-15 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00

abstract：:Restriction site variation in DNA that encodes rRNA (rDNA) was surveyed among 714 offspring within 31 lineages (26 genotypes) of obligate asexually reproducing Taraxacum officinale (dandelions). Although clonal offspring are expected, plants with nonparental rDNA were produced from two parents that were themselves sib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： King LM,Schaal BA

更新日期：1990-02-01 00:00:00

abstract：:Gene editing techniques have been extensively used to attempt to model recurrent genomic rearrangements found in tumor cells. These methods involve the induction of double-strand breaks at endogenous loci followed by the identification of breakpoint junctions within a population, which typically arise by nonhomologous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanoli F,Tomishima M,Feng W,Lamribet K,Babin L,Brunet E,Jasin M

更新日期：2017-04-04 00:00:00

abstract：:We have developed an efficient method to target lentivirus-mediated gene transduction to a desired cell type. It involves incorporation of antibody and fusogenic protein as two distinct molecules into the lentiviral surface. The fusogen is constructed by modifying viral envelope proteins, so that they lack the ability...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang L,Bailey L,Baltimore D,Wang P

更新日期：2006-08-01 00:00:00

abstract：:Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norton JJ,Lee DS,Lee JW,Lee W,Kwon O,Won P,Jung SY,Cheng H,Jeong JW,Akce A,Umunna S,Na I,Kwon YH,Wang XQ,Liu Z,Paik U,Huang Y,Bretl T,Yeo WH,Rogers JA

更新日期：2015-03-31 00:00:00

abstract：:The BAG6 complex was first identified as an upstream loading factor for tail-anchored membrane proteins entering the TRC40-dependent pathway for posttranslational delivery to the endoplasmic reticulum. Subsequently, BAG6 was shown to enhance the proteasomal degradation of mislocalized proteins by selectively promoting...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leznicki P,High S

更新日期：2012-11-20 00:00:00

abstract：:Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric proteins and studied the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Guidez F,Rousselot P,Agadir A,Chen SJ,Wang ZY,Degos L,Zelent A,Waxman S,Chomienne C

更新日期：1994-02-01 00:00:00

abstract：:Urate oxidase (UOxase; urate:oxygen oxidoreductase, EC 1.7.3.3), which catalyzes the oxidation of uric acid to allantoin, is present in most mammals but is absent in humans and certain primates. A cDNA clone for UOxase containing an insert of 1.3 kilobases (kb) was isolated from a lambda gt11 cDNA library prepared fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy PG,Nemali MR,Reddy MK,Reddy MN,Yuan PM,Yuen S,Laffler TG,Shiroza T,Kuramitsu HK,Usuda N

更新日期：1988-12-01 00:00:00

abstract：:Evolutionary transitions in individuality (ETIs) underlie the watershed events in the history of life on Earth, including the origins of cells, eukaryotes, plants, animals, and fungi. Each of these events constitutes an increase in the level of complexity, as groups of individuals become individuals in their own right...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herron MD,Hackett JD,Aylward FO,Michod RE

更新日期：2009-03-03 00:00:00

abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkley-Levenson E,Galván A

更新日期：2014-01-28 00:00:00

abstract：:Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochar DA,Savard J,Wang W,Lafleur DW,Moore P,Côté J,Shiekhattar R

更新日期：2000-02-01 00:00:00

abstract：:Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao W,Rovin BH,Friedman A

更新日期：2014-09-30 00:00:00

abstract：:A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Oth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimprich KA,Shin TB,Keith CT,Schreiber SL

更新日期：1996-04-02 00:00:00

abstract：:We describe here the successful establishment of a reverse genetics system for rotavirus (RV), a member of the Reoviridae family whose genome consists of 10-12 segmented dsRNA. The system is based on the recombinant vaccinia virus T7 RNA polymerase-driven procedure for supplying artificial viral mRNA in the cytoplasm....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komoto S,Sasaki J,Taniguchi K

更新日期：2006-03-21 00:00:00

abstract：:Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 --> Arg + Ser-117 --> Asn) s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsaeree P,Khongsuk P,Leartsakulpanich U,Chitnumsub P,Tarnchompoo B,Walkinshaw MD,Yuthavong Y

更新日期：2005-09-13 00:00:00

abstract：:Yawn contagion in humans has been proposed to be related to our capacity for empathy. It is presently unclear whether this capacity is uniquely human or shared with other primates, especially monkeys. Here, we show that in gelada baboons (Theropithecus gelada) yawning is contagious between individuals, especially thos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palagi E,Leone A,Mancini G,Ferrari PF

更新日期：2009-11-17 00:00:00

abstract：:Effective gene therapy depends on the efficient transfer of therapeutic genes and their protein products to target cells. Lentiviral vectors appear promising for virus-mediated gene delivery and long-term expression in nondividing cells. The herpes simplex virus type 1 tegument protein VP22 has recently been shown to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Z,Han I,Zirzow G,Brady RO,Reiser J

更新日期：2000-10-10 00:00:00

abstract：:TCR-mediated recognition of beta-linked self-glycolipids bound to CD1d is poorly understood. Here, we have characterized the TCR repertoire of a CD1d-restricted type II NKT cell subset reactive to sulfatide involved in the regulation of autoimmunity and antitumor immunity. The sulfatide/CD1d-tetramer(+) cells isolated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arrenberg P,Halder R,Dai Y,Maricic I,Kumar V

更新日期：2010-06-15 00:00:00

abstract：:Immunoreactive and bioreactive corticotropin (ACTH-like) activities have been detected in the median eminence and remaining medial basal hypothalamus of both normal and hypophysectomized adult male rats: bioreactive ACTH (pg/100 mug of protein) 1028 in median eminence and 1289 in medial basal hypothalamus; immunoreact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger DT,Liotta A,Brownstein MJ

更新日期：1977-02-01 00:00:00

abstract：:Cell adhesion molecules (CAMs) may act as regulators of morphogenesis by constraining cell motion, forming borders, and controlling intercellular communications that lead to embryonic induction. This postulated causal role of CAMs in inductive events was tested here in an in vitro system of feather induction. In the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallin WJ,Chuong CM,Finkel LH,Edelman GM

更新日期：1986-11-01 00:00:00

abstract：:Serological expression cloning of antigens eliciting a humoral immune response to a syngeneic mouse sarcoma identified pem (mouse placenta and embryonic expression gene) as a new member of the cancer/testis family. To identify the human homologue of pem, mouse pem sequences and pem-related expressed sequence tags from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono T,Kurashige T,Harada N,Noguchi Y,Saika T,Niikawa N,Aoe M,Nakamura S,Higashi T,Hiraki A,Wada H,Kumon H,Old LJ,Nakayama E

更新日期：2001-03-13 00:00:00

abstract：:Seamless and minimally invasive integration of 3D electronic circuitry within host materials could enable the development of materials systems that are self-monitoring and allow for communication with external environments. Here, we report a general strategy for preparing ordered 3D interconnected and addressable macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Xie C,Dai X,Jin L,Zhou W,Lieber CM

更新日期：2013-04-23 00:00:00

abstract：:Voltage-gated channels maintain cellular resting potentials and generate neuronal action potentials by regulating ion flux. Here, we show that Ether-à-go-go (EAG) K+ channels also regulate intracellular signaling pathways by a mechanism that is independent of ion flux and depends on the position of the voltage sensor....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegle AP,Marble DD,Wilson GF

更新日期：2006-02-21 00:00:00

abstract：:Circadian rhythms in metazoan eukaryotes are controlled by an endogenous molecular clock. It functions in many locations, including subsets of brain neurons (clock neurons) within the central nervous system. Although the molecular clock relies on transcription/translation feedback loops, posttranscriptional regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Rosbash M

更新日期：2016-05-24 00:00:00

abstract：:What can be done to reduce unhealthy eating among adolescents? It was hypothesized that aligning healthy eating with important and widely shared adolescent values would produce the needed motivation. A double-blind, randomized, placebo-controlled experiment with eighth graders (total n = 536) evaluated the impact of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,Hinojosa CP,Chabot A,Bergen H,Kawamura M,Steubing F

更新日期：2016-09-27 00:00:00

abstract：:Neurons in macaque ventral premotor cortex and inferior parietal lobe discharge during both the observation and the execution of motor acts. It has been claimed that these so-called mirror neurons form the basis of action understanding by matching the visual input with the corresponding motor program (direct matching)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lingnau A,Gesierich B,Caramazza A

更新日期：2009-06-16 00:00:00

abstract：:Although heparin and low-molecular-weight heparins (LMWH) have been widely used clinically as anticoagulants, their broader use has been limited by the lack of noninvasive delivery methods for this class of molecules. In this study, we demonstrate an efficient, rapid, and reproducible delivery system for heparin throu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi Y,Zhao G,Liu D,Shriver Z,Sundaram M,Sengupta S,Venkataraman G,Langer R,Sasisekharan R

更新日期：2004-06-29 00:00:00

abstract：:Seed dormancy is a trait of considerable adaptive significance because it maximizes seedling survival by preventing premature germination under unfavorable conditions. Understanding how seeds break dormancy and initiate growth is also of great agricultural and biotechnological interest. Abscisic acid (ABA) plays prima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez-Molina L,Mongrand S,Chua NH

更新日期：2001-04-10 00:00:00

abstract：:To identify the metabolic pathway that generates choline (Cho) for acetylcholine (AcCho) from its storage pool in membrane phosphatidylcholine (PtdCho), human neuronal cells (LA-N-2) were radioisotopically labeled with 1-O-hexadecyl-2-hydroxy-sn-glycero(3)phospho[14C]choline. The compound was efficiently taken up by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee HC,Fellenz-Maloney MP,Liscovitch M,Blusztajn JK

更新日期：1993-11-01 00:00:00