Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation.

abstract：:Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to faci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muller AJ,Teresky AK,Levine AJ

更新日期：2000-07-18 00:00:00

abstract：:When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new eve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawarczyk D,Wahlheim CN,Etzel JA,Snyder AZ,Zacks JM

更新日期：2020-11-24 00:00:00

abstract：:Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellstrom A,Perruzzi C,Ju M,Engstrom E,Hard AL,Liu JL,Albertsson-Wikland K,Carlsson B,Niklasson A,Sjodell L,LeRoith D,Senger DR,Smith LE

更新日期：2001-05-08 00:00:00

abstract：:The ability of the radiomimetic anticancer enediyne C-1027 to induce ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR)-independent damage responses was discovered to reside in its unique ability to concurrently generate robust amounts of double-strand breaks (DSBs) and interstrand cross-links (ICLs) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kennedy DR,Ju J,Shen B,Beerman TA

更新日期：2007-11-06 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu T,Laidlaw TM,Katz HR,Boyce JA

更新日期：2013-10-15 00:00:00

abstract：:The transition to pulmonary respiration after birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation. Two memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levet S,Ouarné M,Ciais D,Coutton C,Subileau M,Mallet C,Ricard N,Bidart M,Debillon T,Faravelli F,Rooryck C,Feige JJ,Tillet E,Bailly S

更新日期：2015-06-23 00:00:00

abstract：:Pseudomonas fluorescens Pf-5, a rhizosphere-inhabiting bacterium that suppresses several soilborne pathogens of plants, produces the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol. A gene necessary for pyrrolnitrin production by Pf-5 was identified as rpoS, which encodes the stationary-phase sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarniguet A,Kraus J,Henkels MD,Muehlchen AM,Loper JE

更新日期：1995-12-19 00:00:00

abstract：:We use stable isotope ratios in feces of wild mountain gorillas (Gorilla beringei) to test the hypothesis that diet shifts within a single year, as measured by dry mass intake, can be recovered. Isotopic separation of staple foods indicates that intraannual changes in the isotopic composition of feces reflect shifts i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenthal SA,Chritz KL,Rothman JM,Cerling TE

更新日期：2012-12-26 00:00:00

abstract：:Our understanding of the molecular control of many disease pathologies requires the identification of direct substrates targeted by specific protein kinases. Here we describe an integrated proteomic strategy, termed kinase assay linked with phosphoproteomics, which combines a sensitive kinase reaction with endogenous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue L,Wang WH,Iliuk A,Hu L,Galan JA,Yu S,Hans M,Geahlen RL,Tao WA

更新日期：2012-04-10 00:00:00

abstract：:Specific [3H]retinoic acid (RA)-binding sites in nuclear and cytosolic extracts prepared from human myeloblastic leukemia HL-60 cells have been detected by sucrose density gradient sedimentation and size-exclusion high-performance liquid chromatography (HPLC) analyses. This RA-binding activity migrated as a single pea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nervi C,Grippo JF,Sherman MI,George MD,Jetten AM

更新日期：1989-08-01 00:00:00

abstract：:We have constructed yeast strains that secrete functional mouse-human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole antibody, cDNA copies of the chimeric light-chain and heavy-chain genes of an anti-tumor antibody were inserted into vectors containing the yeast phosphoglycerate kin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horwitz AH,Chang CP,Better M,Hellstrom KE,Robinson RR

更新日期：1988-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) play key roles in detecting pathogens and initiating inflammatory responses that, subsequently, prime specific adaptive responses. Several mechanisms control TLR activity to avoid excessive inflammation and consequent immunopathology, including the anti-inflammatory cytokine IL-10. Recently,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtale G,Mirolo M,Renzi TA,Rossato M,Bazzoni F,Locati M

更新日期：2013-07-09 00:00:00

abstract：:Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms ranging from yeast to mammals. Mutations affecting somatotropic, insulin, or homologous signaling pathways can increase life span in worms, flies, and mice, and there is considerable evidence that reduced secretion of insulin-like gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonkowski MS,Rocha JS,Masternak MM,Al Regaiey KA,Bartke A

更新日期：2006-05-16 00:00:00

abstract：:Chemokines and their receptors are key factors in the onset and progression of AIDS. Among them, accumulating evidence strongly indicates the involvement of IL-8 and its receptors, CXCR1 and CXCR2, in AIDS-related conditions. Through extensive investigation of genetic variations of the human CXCR1-CXCR2 locus, we iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasilescu A,Terashima Y,Enomoto M,Heath S,Poonpiriya V,Gatanaga H,Do H,Diop G,Hirtzig T,Auewarakul P,Lauhakirti D,Sura T,Charneau P,Marullo S,Therwath A,Oka S,Kanegasaki S,Lathrop M,Matsushima K,Zagury JF,Matsuda

更新日期：2007-02-27 00:00:00

abstract：:Inside-out erythrocyte membranes attached to polycationic beads manifested glutathione disulfide (GSSG)-stimulated ATPase activity. A Lineweaver-Burk plot of the ATPase activity as a function of GSSG concentration was biphasic and gave apparent Km values of 0.13 mM and 2.0 mM. These kinetics are similar to those repor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo T,Kawakami Y,Taniguchi N,Beutler E

更新日期：1987-11-01 00:00:00

abstract：:In this note the Weierstrass integral J is taken as L, the Riemann integral of length. Here M(n), n > 1, is a compact, connected manifold of class C(infinity) with a positive definite Riemann structure. Presentations (phi, U(phi)) in M(n) and geodesics (with the aid of the Euler-Riemann equations) are defined in Morse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse M

更新日期：1977-06-01 00:00:00

abstract：:Current understanding of the integration of cell division and expansion in the development of plant lateral organs such as leaves is limited. Cell number is established during a mitotic phase, and subsequent growth into a mature organ relies primarily on cell expansion accompanied by endocycles. Here we show that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dewitte W,Scofield S,Alcasabas AA,Maughan SC,Menges M,Braun N,Collins C,Nieuwland J,Prinsen E,Sundaresan V,Murray JA

更新日期：2007-09-04 00:00:00

abstract：:The virulent properties of the common human and livestock pathogen Clostridium perfringens are attributable to a formidable battery of toxins. Among these are a number of large and highly modular carbohydrate-active enzymes, including the mu-toxin and sialidases, whose catalytic properties are consistent with degradat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams JJ,Gregg K,Bayer EA,Boraston AB,Smith SP

更新日期：2008-08-26 00:00:00

abstract：:MyoD is a master regulatory gene for myogenesis. Its product, the MyoD protein, appears to act by binding to muscle-specific enhancer sequences. We show that MyoD binds cooperatively to two sites in the muscle-specific creatine kinase enhancer; this is dramatically reflected in dissociation-rate measurements. A deleti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weintraub H,Davis R,Lockshon D,Lassar A

更新日期：1990-08-01 00:00:00

abstract：:With threats to nature becoming increasingly prominent, in order for biodiversity levels to persist, there is a critical need to improve implementation of conservation measures. In the oceans, the surveillance of fisheries is complex and inadequate, such that quantifying and locating nondeclared and illegal fisheries ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weimerskirch H,Collet J,Corbeau A,Pajot A,Hoarau F,Marteau C,Filippi D,Patrick SC

更新日期：2020-02-11 00:00:00

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:The 2012-2015 drought has left California with severely reduced snowpack, soil moisture, ground water, and reservoir stocks, but the impact of this estimated millennial-scale event on forest health is unknown. We used airborne laser-guided spectroscopy and satellite-based models to assess losses in canopy water conten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Brodrick PG,Anderson CB,Vaughn N,Knapp DE,Martin RE

更新日期：2016-01-12 00:00:00

abstract：:A wide diversity of biological molecules are modified by the addition of sugar residues, and a large number of glycosyltransferases have been identified that are responsible for these reactions. Despite catalyzing closely related reactions, many of these transferases show little apparent sequence homology. By comparin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiggins CA,Munro S

更新日期：1998-07-07 00:00:00

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00

abstract：:We studied intracellular pH (pHi) regulation in the absence of HCO3- in single mesangial cells (MCs) with the pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(and -6)carboxyfluorescein. Our approach was to acid load the cells by an NH+4 prepulse and to monitor the subsequent pHi recovery. Previous work on MCs and other ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyarsky G,Ganz MB,Cragoe EJ Jr,Boron WF

更新日期：1990-08-01 00:00:00

abstract：:The solar system formed from interstellar dust and gas in a molecular cloud. Astronomical observations show that typical interstellar dust consists of amorphous (a-) silicate and organic carbon. Bona fide physical samples for laboratory studies would yield unprecedented insight about solar system formation, but they w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii HA,Bradley JP,Bechtel HA,Brownlee DE,Bustillo KC,Ciston J,Cuzzi JN,Floss C,Joswiak DJ

更新日期：2018-06-26 00:00:00

abstract：:Human apolipoprotein E (apoE) was produced in Escherichia coli by transforming cells with an expression vector containing a reconstructed apoE cDNA, a lambda PL promoter regulated by the thermolabile cI repressor, and a ribosomal binding site derived from the lambda cII or the E. coli beta-lactamase gene. Transformed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel T,Weisgraber KH,Zeevi MI,Ben-Artzi H,Levanon AZ,Rall SC Jr,Innerarity TL,Hui DY,Taylor JM,Kanner D

更新日期：1985-12-01 00:00:00

abstract：:Pristine meteoritic materials carry light element isotopic fractionations that constrain physiochemical conditions during solar system formation. Here we report the discovery of a unique xenolith in the metal-rich chondrite Isheyevo. Its fine-grained, highly pristine mineralogy has similarity with interplanetary dust ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briani G,Gounelle M,Marrocchi Y,Mostefaoui S,Leroux H,Quirico E,Meibom A

更新日期：2009-06-30 00:00:00

abstract：:Signaling lymphocytic activation molecule family 3 (SLAMF3/Ly9) is a coregulatory molecule implicated in T-cell activation and differentiation. Systemic lupus erythematosus (SLE) is characterized by aberrant T-cell activation and compromised IL-2 production, leading to abnormal regulatory T-cell (Treg) development/fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC

更新日期：2016-08-16 00:00:00

abstract：:Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hodakoski C,Hopkins BD,Barrows D,Mense SM,Keniry M,Anderson KE,Kern PA,Hawkins PT,Stephens LR,Parsons R

更新日期：2014-01-07 00:00:00