The sigma factor sigma s affects antibiotic production and biological control activity of Pseudomonas fluorescens Pf-5.

abstract：:The Mpemba effect occurs when a hot system cools faster than an initially colder one, when both are refrigerated in the same thermal reservoir. Using the custom-built supercomputer Janus II, we study the Mpemba effect in spin glasses and show that it is a nonequilibrium process, governed by the coherence length ξ of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baity-Jesi M,Calore E,Cruz A,Fernandez LA,Gil-Narvión JM,Gordillo-Guerrero A,Iñiguez D,Lasanta A,Maiorano A,Marinari E,Martin-Mayor V,Moreno-Gordo J,Muñoz Sudupe A,Navarro D,Parisi G,Perez-Gaviro S,Ricci-Tersenghi F,Rui

更新日期：2019-07-30 00:00:00

abstract：:During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Knaak T,Satkamp L,Humbert O,Falkow S,Ramakrishnan L

更新日期：2002-03-19 00:00:00

abstract：:Nitric oxide (NO) plays diverse and significant roles in biological processes despite its cytotoxicity, raising the question of how biological systems control the action of NO to minimize its cytotoxicity in cells. As a great example of such a system, we found a possibility that NO-generating nitrite reductase (NiR) f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasaka E,Yamada K,Wang PH,Hosokawa K,Yamagiwa R,Matsumoto K,Ishii S,Mori T,Yagi K,Sawai H,Arai H,Sugimoto H,Sugita Y,Shiro Y,Tosha T

更新日期：2017-09-12 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:Mutations in the DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome; NR0B1] gene cause X-linked AHC associated with hypogonadotropic hypogonadism. DAX-1 encodes an unusual orphan member of the nuclear hormone receptor superfamily, acting as a transcriptional rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann SG,Lalli E,Sassone-Corsi P

更新日期：2002-06-11 00:00:00

abstract：:The role of the renin-angiotensin system in blood pressure control and in the development of hypertension was investigated by generating transgenic mice carrying the rat renin or angiotensinogen gene or both genes under the control of the mouse metallothionein I promoter. The systolic blood pressure was significantly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohkubo H,Kawakami H,Kakehi Y,Takumi T,Arai H,Yokota Y,Iwai M,Tanabe Y,Masu M,Hata J

更新日期：1990-07-01 00:00:00

abstract：:Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

更新日期：2017-11-21 00:00:00

abstract：:The need to assess subtle, potentially exploitable changes in serial structure is paramount in the analysis of financial data. Herein, we demonstrate the utility of approximate entropy (ApEn), a model-independent measure of sequential irregularity, toward this goal, by several distinct applications. We consider both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus S,Kalman RE

更新日期：2004-09-21 00:00:00

abstract：:Apolipoprotein(a) [apo(a)] is the distinguishing protein component of lipoprotein(a), a major inherited risk factor for atherosclerosis. Human apo(a) is homologous to plasminogen. It contains from 15 to 50 repeated domains closely related to plasminogen kringle four, plus single kringle five-like and inactive protease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawn RM,Schwartz K,Patthy L

更新日期：1997-10-28 00:00:00

abstract：:MuB is an ATP-dependent nonspecific DNA-binding protein that regulates the activity of the MuA transposase and captures target DNA for transposition. Mechanistic understanding of MuB function has previously been hindered by MuB's poor solubility. Here we combine bioinformatic, mutagenic, biochemical, and electron micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizuno N,Dramićanin M,Mizuuchi M,Adam J,Wang Y,Han YW,Yang W,Steven AC,Mizuuchi K,Ramón-Maiques S

更新日期：2013-07-02 00:00:00

abstract：:It was proved that the protoplasts prepared from mesophyll of Nicotiana tabacum are infected by tobacco mosaic virus. The infection occurred when purified tobacco mosaic virus particles were added to a protoplast suspension in the presence of poly-L-ornithine. The virus multiplied in these protoplasts to a level of 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takebe I,Otsuki Y

更新日期：1969-11-01 00:00:00

abstract：:Although heparin and low-molecular-weight heparins (LMWH) have been widely used clinically as anticoagulants, their broader use has been limited by the lack of noninvasive delivery methods for this class of molecules. In this study, we demonstrate an efficient, rapid, and reproducible delivery system for heparin throu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi Y,Zhao G,Liu D,Shriver Z,Sundaram M,Sengupta S,Venkataraman G,Langer R,Sasisekharan R

更新日期：2004-06-29 00:00:00

abstract：:To specify when and where Ig class switch recombination (CSR) takes place, a good molecular marker closely associated with active CSR is required. CSR is accompanied by deletion of circular DNA from the Ig heavy chain locus. The circular DNA contains a DNA segment between Smu and a target S region including its I prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinoshita K,Harigai M,Fagarasan S,Muramatsu M,Honjo T

更新日期：2001-10-23 00:00:00

abstract：:Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling? Interneuron gap junctions enhance synchrony of gamma oscillations (25-70 Hz) in isolated interneuron networks and also in network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Traub RD,Pais I,Bibbig A,LeBeau FE,Buhl EH,Hormuzdi SG,Monyer H,Whittington MA

更新日期：2003-02-04 00:00:00

abstract：:A membrane-associated folate binding protein (FBP) and a soluble FBP, which is released into the culture medium, have been purified from human KB cells using affinity chromatography. By NaDodSO4/PAGE, both proteins have an apparent Mr of approximately 42,000. However, in the presence of Triton X-100, the soluble FBP e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luhrs CA,Pitiranggon P,da Costa M,Rothenberg SP,Slomiany BL,Brink L,Tous GI,Stein S

更新日期：1987-09-01 00:00:00

abstract：:We have studied the effect of the 3' terminal CCA sequence in precursors of tRNAs on catalysis by the RNase P RNA or the holoenzyme from the cyanobacterium Synechocystis sp. PCC 6803 in a completely homologous system. We have found that the absence of the 3' terminal CCA is not detrimental to activity, which is in sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pascual A,Vioque A

更新日期：1999-06-08 00:00:00

abstract：:Cell variants resistant to the cytotoxic effect of mycophenolic acid, an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC 1.2.1.14), were selected by a one-step procedure from Chinese hamster V79 cells. The frequency of these variants was increased in a dose-dependent manner after treatment with the mutagen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huberman E,McKeown CK,Friedman J

更新日期：1981-05-01 00:00:00

abstract：:The role of rising atmospheric CO2 in modulating estuarine carbonate system dynamics remains poorly characterized, likely due to myriad processes driving the complex chemistry in these habitats. We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pacella SR,Brown CA,Waldbusser GG,Labiosa RG,Hales B

更新日期：2018-04-10 00:00:00

abstract：:The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active I(-) uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na(+) per I(-). In the thyroid, NIS-mediated I(-) uptake is the first step in the biosynthesis of the iodine-containing thyroid ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dohán O,Portulano C,Basquin C,Reyna-Neyra A,Amzel LM,Carrasco N

更新日期：2007-12-18 00:00:00

abstract：:The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals. We present a model for signal integration by mixed clusters of interacting two-state chemoreceptors. Our model results compare favorably to the results obtained by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keymer JE,Endres RG,Skoge M,Meir Y,Wingreen NS

更新日期：2006-02-07 00:00:00

abstract：:A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roder JC,Rosén A,Fenyö EM,Troy FA

更新日期：1979-03-01 00:00:00

abstract：:Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which results in altered social behaviors of piglet offspring. These behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antonson AM,Lawson MA,Caputo MP,Matt SM,Leyshon BJ,Johnson RW

更新日期：2019-10-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Recent advances in understanding the role of neurotrophins on activity-dependent plasticity have provided insight into how behavior can affect specific aspects of neuronal biology. We present evidence that voluntary exercise can prime adult dorsal root ganglion neurons for increased axonal regeneration through a neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molteni R,Zheng JQ,Ying Z,Gómez-Pinilla F,Twiss JL

更新日期：2004-06-01 00:00:00

abstract：:In colloidal systems, the interplay between the short range attraction and long-range repulsion can lead to a low density associated state consisting of clusters of individual particles. Recently, such an equilibrium cluster phase was also reported for concentrated solutions of lysozyme at low ionic strength and close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla A,Mylonas E,Di Cola E,Finet S,Timmins P,Narayanan T,Svergun DI

更新日期：2008-04-01 00:00:00

abstract：:Taking advantage of a fluorescent Ca(2+) indicator selectively targeted to the trans-Golgi lumen, we here demonstrate that its Ca(2+) homeostatic mechanisms are distinct from those of the other Golgi subcompartments: (i) Ca(2+) uptake depends exclusively on the activity of the secretory pathway Ca(2+) ATPase1 (SPCA1),...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lissandron V,Podini P,Pizzo P,Pozzan T

更新日期：2010-05-18 00:00:00

abstract：:The emergence of multidrug-resistant (MDR) tuberculosis (TB) highlights the urgent need to understand the mechanisms of resistance to the drugs used to treat this disease. The aminoglycosides kanamycin and amikacin are important bactericidal drugs used to treat MDR TB, and resistance to one or both of these drugs is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaunbrecher MA,Sikes RD Jr,Metchock B,Shinnick TM,Posey JE

更新日期：2009-11-24 00:00:00

abstract：:The accuracy of dynamical models for reactive scattering of molecular hydrogen, H(2), from metal surfaces is relevant to the validation of first principles electronic structure methods for molecules interacting with metal surfaces. The ability to validate such methods is important to progress in modeling heterogeneous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroes GJ,Díaz C,Pijper E,Olsen RA,Auerbach DJ

更新日期：2010-12-07 00:00:00

abstract：:To identify the metabolic pathway that generates choline (Cho) for acetylcholine (AcCho) from its storage pool in membrane phosphatidylcholine (PtdCho), human neuronal cells (LA-N-2) were radioisotopically labeled with 1-O-hexadecyl-2-hydroxy-sn-glycero(3)phospho[14C]choline. The compound was efficiently taken up by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee HC,Fellenz-Maloney MP,Liscovitch M,Blusztajn JK

更新日期：1993-11-01 00:00:00

abstract：:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray JM,Hill JJ,Bargmann CI

更新日期：2005-03-01 00:00:00