Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.

abstract：:At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heng HH,Chamberlain JW,Shi XM,Spyropoulos B,Tsui LC,Moens PB

更新日期：1996-04-02 00:00:00

abstract：:Various enzymatic derivatives of the murine myeloma protein IgA(MOPC-315) were subjected to hapten-binding quantitation and circular dichroic analysis in an attempt to ascertain the structural localization and functional definition of the immunoglobulin active site. The extrinsic Cotton effects observed with near satu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merz DC,Litman GW,Good RA

更新日期：1974-05-01 00:00:00

abstract：:Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that it might be an ideal agent for the prevention of intrahepatic islet allograft failure. This hypothesis was tested in MHC-mismatched rhesus monkeys. Transplantat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kenyon NS,Chatzipetrou M,Masetti M,Ranuncoli A,Oliveira M,Wagner JL,Kirk AD,Harlan DM,Burkly LC,Ricordi C

更新日期：1999-07-06 00:00:00

abstract：:Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Besedovsky L,Benischke M,Fischer J,Yazdi AS,Born J

更新日期：2020-05-19 00:00:00

abstract：:The mechanisms that cause aging are not well understood. The oxidative stress hypothesis proposes that the changes associated with aging are a consequence of random oxidative damage to biomolecules. We hypothesized that oxidation of specific proteins is critical in controlling the rate of the aging process. Utilizing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan LJ,Levine RL,Sohal RS

更新日期：1997-10-14 00:00:00

abstract：:The planarity of peptide bonds is an assumption that underlies decades of theoretical modeling of proteins. Peptide bonds strongly deviating from planarity are considered very rare features of protein structure that occur for functional reasons. Here, empirical analyses of atomic-resolution protein structures reveal t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berkholz DS,Driggers CM,Shapovalov MV,Dunbrack RL Jr,Karplus PA

更新日期：2012-01-10 00:00:00

abstract：:Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer's disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that amyloid-β peptide (Aβ) engages α7 nicotinic acetylcholine receptors to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Talantova M,Sanz-Blasco S,Zhang X,Xia P,Akhtar MW,Okamoto S,Dziewczapolski G,Nakamura T,Cao G,Pratt AE,Kang YJ,Tu S,Molokanova E,McKercher SR,Hires SA,Sason H,Stouffer DG,Buczynski MW,Solomon JP,Michael S,Powers E

更新日期：2013-07-02 00:00:00

abstract：:To investigate whether caveolin-1 (cav-1) may modulate inducible nitric oxide synthase (iNOS) function in intact cells, the human intestinal carcinoma cell lines HT29 and DLD1 that have low endogenous cav-1 levels were transfected with cav-1 cDNA. In nontransfected cells, iNOS mRNA and protein levels were increased by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felley-Bosco E,Bender FC,Courjault-Gautier F,Bron C,Quest AF

更新日期：2000-12-19 00:00:00

abstract：:Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle-tendon units of the leg to modulate the amount of mechanical power the limb absorbs and outputs in each step. How individual muscles adapt their behavior to modulate limb po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farris DJ,Sawicki GS

更新日期：2012-01-17 00:00:00

abstract：:The Tap protein mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element (CTE). Previously, the structures of individual Tap subdomains, including ribonucleoprotein and leucine-rich repeat domains, have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho DN,Coburn GA,Kang Y,Cullen BR,Georgiadis MM

更新日期：2002-02-19 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spirochetes must migrate through complex, polymeric environments such as the basement membrane of the tick...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harman MW,Dunham-Ems SM,Caimano MJ,Belperron AA,Bockenstedt LK,Fu HC,Radolf JD,Wolgemuth CW

更新日期：2012-02-21 00:00:00

abstract：:Mammalian thalamus is a critical site where early perception of sensorimotor signals is dynamically regulated by acetylcholine in a behavioral state-dependent manner. In this study, we examined how synaptic transmission is modulated by acetylcholine in auditory thalamus where sensory relay neurons form parallel lemnis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mooney DM,Zhang L,Basile C,Senatorov VV,Ngsee J,Omar A,Hu B

更新日期：2004-01-06 00:00:00

abstract：:In Arabidopsis, the two-dimensional expansion of leaves is regulated via the polarized elongation of cells. The ROTUNDIFOLIA3 (ROT3) protein, a member of the family of cytochromes P450, is involved in this process and regulates leaf length. Transgenic plants that overexpressed a wild-type ROT3 gene had longer leaves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim GT,Tsukaya H,Saito Y,Uchimiya H

更新日期：1999-08-03 00:00:00

abstract：:Membrane-integrated type II phosphatidic acid phosphatases (PAP2s) are important for numerous bacterial to human biological processes, including glucose transport, lipid metabolism, and signaling. Escherichia coli phosphatidylglycerol-phosphate phosphatase B (ecPgpB) catalyzes removing the terminal phosphate group fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Jiang D,Zhao Y,Liu J,Zhang XC

更新日期：2014-05-27 00:00:00

abstract：:The his4 region of yeast contains the information necessary for the catalysis of three steps in the histidine biosynthetic pathway. The three activities specified by this region remain physically associated during gel filtration and ultracentrifugation and after extensive purification. Nonsense mutations in the "opera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer B,Rytka J,Fink GR

更新日期：1969-08-01 00:00:00

abstract：:The role of global climate change in the decline of biodiversity and the emergence of infectious diseases remains controversial, and the effect of climatic variability, in particular, has largely been ignored. For instance, it was recently revealed that the proposed link between climate change and widespread amphibian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohr JR,Raffel TR

更新日期：2010-05-04 00:00:00

abstract：:A four-factor cross between two strains of Phycomyces involving two auxotrophic, one color, and the mating type marker is described. Samples of 40 germspores from 84 individual fertile germsporangia were characterized. The results show: (i) The germspores of a germsporangium are derived from one meiosis in approximate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eslava AP,Alvarez MI,Delbrück M

更新日期：1975-10-01 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family has recently expanded by the identification and cloning of three additional members, namely VEGF-B, VEGF-C, and VEGF-D. In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1. This binding can be blocked by excess VEGF, indicating that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olofsson B,Korpelainen E,Pepper MS,Mandriota SJ,Aase K,Kumar V,Gunji Y,Jeltsch MM,Shibuya M,Alitalo K,Eriksson U

更新日期：1998-09-29 00:00:00

abstract：:H-2(q) mice (DBA/1) do not make an antibody response to a synthetic aminoacid polymer, (Glu, Ala,Tyr(10)), after an immunizing regimen that produces a good antibody response in mouse strains with other H-2 alleles. Their thymocytes, however, show evidence of recognizing this antigen since they synthesize DNA when they...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gershon RK,Maurer PH,Merryman CF

更新日期：1973-01-01 00:00:00

abstract：:Bipolar-cell axon terminals receive direct synaptic input from amacrine-cell processes, suggesting a possible pathway for modulation of transmitter release. In retinal slices, bath-applied baclofen, a gamma-aminobutyrate type B (GABAB) receptor agonist, reduced a patch-clamp-recorded L-type calcium channel current in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maguire G,Maple B,Lukasiewicz P,Werblin F

更新日期：1989-12-01 00:00:00

abstract：:Cardiac myosin-binding protein C (cMyBP-C) is an accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function. Its 4 N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influence actin and myosin interactions, the basic contractile proteins of muscle. Using neutron contrast variat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitten AE,Jeffries CM,Harris SP,Trewhella J

更新日期：2008-11-25 00:00:00

abstract：:In yeast, the mRNA encoded by the MAT alpha 1 gene is unstable (t1/2 = 5 min) and the mRNAs encoded by the ACT1 gene (t1/2 = 30 min) and the PGK1 gene (t1/2 = 45 min) are stable. To understand the RNA structural features that dictate mRNA decay rates in yeast, we have constructed PGK1/MAT alpha 1 and ACT1/MAT alpha 1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker R,Jacobson A

更新日期：1990-04-01 00:00:00

abstract：:The transcription factor cAMP response element (CRE)-binding protein (CREB) has been shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, an important part of the brain's reward pathways, and local manipulations of CREB activity have been shown to affect cocaine reward, suggestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrot M,Olivier JD,Perrotti LI,DiLeone RJ,Berton O,Eisch AJ,Impey S,Storm DR,Neve RL,Yin JC,Zachariou V,Nestler EJ

更新日期：2002-08-20 00:00:00

abstract：:Metallic nanoscale structures are capable of supporting surface plasmon polaritons (SPPs), propagating collective electron oscillations with tight spatial confinement at the metal surface. SPPs represent one of the most promising structures to beat the diffraction limit imposed by conventional dielectric optics. Ag na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Pausauskie P,Huang J,Yang P

更新日期：2009-12-15 00:00:00

abstract：:Mammalian visual systems are characterized by their ability to recognize stimuli invariant to various transformations. Here, we investigate the hypothesis that this ability is achieved by the temporal encoding of visual stimuli. By using a model of a cortical network, we show that this encoding is invariant to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wyss R,Konig P,Verschure PF

更新日期：2003-01-07 00:00:00

abstract：:The kinetics for hydrogen exchange at individual base pairs in self-complementary deoxydodecanucleotide duplexes have been estimated from NMR saturation recovery measurements on the resolved imino protons as a function of temperature. The imino protons of dA . dT base pairs in the center of the fully alternating d(C-G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Ikuta S,Kozlowski S,Itakura K

更新日期：1983-04-01 00:00:00

abstract：:Ribosomal signatures, idiosyncrasies in the ribosomal RNA (rRNA) and/or proteins, are characteristic of the individual domains of life. As such, insight into the early evolution of the domains can be gained from a comparative analysis of their respective signatures in the translational apparatus. In this work, we iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts E,Sethi A,Montoya J,Woese CR,Luthey-Schulten Z

更新日期：2008-09-16 00:00:00

abstract：:The floating water bridge phenomenon is a freestanding rope-shaped connection of pure liquid water, formed under the influence of a high potential difference (approximately 15 kV). Several recent spectroscopic, optical, and neutron scattering studies have suggested that the origin of the bridge is associated with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skinner LB,Benmore CJ,Shyam B,Weber JK,Parise JB

更新日期：2012-10-09 00:00:00

abstract：:The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although structurally dissimilar, both classes of molecules lead to the arrest of cell division and eventual cell death by stabilizing cellular microtubule assemblies. The epothilones differ in thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,Zhang XG,Harris CR,Kuduk SD,Balog A,Savin KA,Bertino JR,Danishefsky SJ

更新日期：1998-12-22 00:00:00

abstract：:The mechanism of contrast enhancement of tumors using magnetic resonance imaging was investigated in MCF7 human breast cancer implanted in nude mice. Dynamic contrast-enhanced images recorded at high spatial resolution were analyzed by an image analysis method based on a physiological model, which included the blood c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman-Haran E,Margalit R,Grobgeld D,Degani H

更新日期：1996-06-25 00:00:00