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Human sleep consolidates allergic responses conditioned to the environmental context of an allergen exposure.

Abstract：

:Allergies are highly prevalent, and allergic responses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cue. Here we show in humans suffering from allergic rhinitis that merely reencountering the environmental context in which an allergen was administered a week earlier is sufficient to trigger an allergic response-but only if participants had slept after allergen exposure. This context-conditioning effect was entirely absent when participants stayed awake the night after allergen exposure or were tested in a different context. Unlike in context conditioning, cue conditioning (to an odor stimulus) occurred independently of sleep, a differential pattern that is likewise observed for conditioning in the behavioral domain. Our findings provide evidence that allergic responses can be conditioned to contextual information alone, even after only a single-trial conditioning procedure, and that sleep is necessary to consolidate this rapidly acquired maladaptive response. The results unravel a mechanism that could explain part of the strong psychological impact on allergic responses.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Besedovsky L,Benischke M,Fischer J,Yazdi AS,Born J

doi

10.1073/pnas.1920564117

subject

Has Abstract

pub_date

2020-05-19 00:00:00

pages

10983-10988

issue

20

eissn

0027-8424

issn

1091-6490

pii

1920564117

journal_volume

117

pub_type

杂志文章

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