当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.

BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus.

Abstract：

:The transition to pulmonary respiration after birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation. Two members of the TGFβ family, bone morphogenetic protein 9 (BMP9) and BMP10, have been recently involved in postnatal angiogenesis, both being necessary for remodeling of newly formed microvascular beds. The aim of the present work was to study whether BMP9 and BMP10 could be involved in closure of the DA. We found that Bmp9 knockout in mice led to an imperfect closure of the DA. Further, addition of a neutralizing anti-BMP10 antibody at postnatal day 1 (P1) and P3 in these pups exacerbated the remodeling defect and led to a reopening of the DA at P4. Transmission electron microscopy images and immunofluorescence stainings suggested that this effect could be due to a defect in intimal cell differentiation from endothelial to mesenchymal cells, associated with a lack of extracellular matrix deposition within the center of the DA. This result was supported by the identification of the regulation by BMP9 and BMP10 of several genes known to be involved in this process. The involvement of these BMPs was further supported by human genomic data because we could define a critical region in chromosome 2 encoding eight genes including BMP10 that correlated with the presence of a patent DA. Together, these data establish roles for BMP9 and BMP10 in DA closure.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Levet S,Ouarné M,Ciais D,Coutton C,Subileau M,Mallet C,Ricard N,Bidart M,Debillon T,Faravelli F,Rooryck C,Feige JJ,Tillet E,Bailly S

doi

10.1073/pnas.1508386112

subject

Has Abstract

pub_date

2015-06-23 00:00:00

pages

E3207-15

issue

25

eissn

0027-8424

issn

1091-6490

pii

1508386112

journal_volume

112

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.

    abstract：:Ribavirin is a nucleotide analog that can be incorporated by viral polymerases, causing mutations by allowing base mismatches. It is currently used therapeutically as an antiviral drug during hepatitis C virus infections. During the amplification of poliovirus genomic RNA or hepatitis C replicons, error frequency is k...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1232294100

    authors： Pfeiffer JK,Kirkegaard K

    更新日期：2003-06-10 00:00:00

  • Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives.

    abstract：:There has been much confusion recently about the relative merits of different approaches, osmotic stress, preferential interaction, and crowding, to describe the indirect effect of solutes on macromolecular conformations and reactions. To strengthen all interpretations of measurements and to forestall further unnecess...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.8.3987

    authors： Parsegian VA,Rand RP,Rau DC

    更新日期：2000-04-11 00:00:00

  • Cytosolic components of the respiratory burst oxidase: resolution of four components, two of which are missing in complementing types of chronic granulomatous disease.

    abstract：:The respiratory burst oxidase of neutrophils can be activated in a cell-free system in which plasma membranes, cytosol, Mg2+, and a membrane-perturbing detergent, such as arachidonate or sodium dodecyl sulfate, are all required. Using the technique of preparative isoelectric focusing, the cytosol factor required for o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.3.825

    authors： Curnutte JT,Scott PJ,Mayo LA

    更新日期：1989-02-01 00:00:00

  • Self/nonself recognition in ascidian fertilization: vitelline coat protein HrVC70 is a candidate allorecognition molecule.

    abstract：:Ascidians are hermaphrodites releasing sperm and eggs simultaneously, but many species are self-sterile because of a self/nonself-recognition system in spermegg interaction. Here, we show that a 70-kDa vitelline coat protein, HrVC70, consisting of 12 epidermal growth factor-like repeats, plays a key role in self/nonse...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0401928101

    authors： Sawada H,Tanaka E,Ban S,Yamasaki C,Fujino J,Ooura K,Abe Y,Matsumoto K,Yokosawa H

    更新日期：2004-11-02 00:00:00

  • Exploring monovalent copper compounds with oxygen and hydrogen.

    abstract：:New important applications of copper metal, e.g., in the areas of hydrogen production, fuel cell operation, and spent nuclear fuel disposal, require accurate knowledge of the physical and chemical properties of stable and metastable copper compounds. Among the copper(I) compounds with oxygen and hydrogen, cuprous oxid...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1115834109

    authors： Korzhavyi PA,Soroka IL,Isaev EI,Lilja C,Johansson B

    更新日期：2012-01-17 00:00:00

  • Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

    abstract：:In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in chromosomal segregation and that APC inactivation leads to chromosoma...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.012679099

    authors： Sieber OM,Heinimann K,Gorman P,Lamlum H,Crabtree M,Simpson CA,Davies D,Neale K,Hodgson SV,Roylance RR,Phillips RK,Bodmer WF,Tomlinson IP

    更新日期：2002-12-24 00:00:00

  • Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.

    abstract：:In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infec...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.1.367

    authors： Bukrinskaya AG,Ghorpade A,Heinzinger NK,Smithgall TE,Lewis RE,Stevenson M

    更新日期：1996-01-09 00:00:00

  • Phase identity of the maize leaf is determined after leaf initiation.

    abstract：:The vegetative development of the maize shoot can be divided into juvenile and adult phases based on the types of leaves produced at different times in shoot development. Models for the regulation of phase change make explicit predictions about when the identity of these types of leaves is determined. To test these mo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.180301597

    authors： Orkwiszewski JA,Poethig RS

    更新日期：2000-09-12 00:00:00

  • Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.

    abstract：:Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-terminal halves, each comp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.20.10594

    authors： Dey S,Ramachandra M,Pastan I,Gottesman MM,Ambudkar SV

    更新日期：1997-09-30 00:00:00

  • Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies.

    abstract：:The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we identified a clear correlatio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1416694112

    authors： Venetz D,Hess C,Lin CW,Aebi M,Neri D

    更新日期：2015-02-17 00:00:00

  • A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

    abstract：:We recently found that scatter factor (SF), a cell motility factor with a multimodular structure, is identical to hepatocyte growth factor (HGF), a potent mitogen of various cell types. SF/HGF is the ligand of the c-Met receptor tyrosine kinase. Here we used transient expression of naturally occurring and in vitro mut...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.23.11574

    authors： Hartmann G,Naldini L,Weidner KM,Sachs M,Vigna E,Comoglio PM,Birchmeier W

    更新日期：1992-12-01 00:00:00

  • Causes and consequences of asymmetric lateral plume flow during South Atlantic rifting.

    abstract：:Volcanic rifted margins are typically associated with a thick magmatic layer of seaward dipping reflectors and anomalous regional uplift. This is conventionally interpreted as due to melting of an arriving mantle plume head at the onset of rifting. However, seaward dipping reflectors and uplift are sometimes asymmetri...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2012246117

    authors： Morgan JP,Taramón JM,Araujo M,Hasenclever J,Perez-Gussinye M

    更新日期：2020-11-10 00:00:00

  • African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system.

    abstract：:Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs during an infection, in ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1905120116

    authors： Aresta-Branco F,Sanches-Vaz M,Bento F,Rodrigues JA,Figueiredo LM

    更新日期：2019-10-08 00:00:00

  • Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

    abstract：:During or immediately after synthesis in vertebrate cells, the oncogenic protein-tyrosine kinase pp60v-src associates with the approximately 90-kDa heat-shock protein (hsp90). In this complex, pp60v-src is not functional as a kinase. When pp60v-src is subsequently found inserted into the plasma membrane, it is active ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.15.7074

    authors： Xu Y,Lindquist S

    更新日期：1993-08-01 00:00:00

  • Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalry.

    abstract：:During sustained viewing of an ambiguous stimulus, an individual's perceptual experience will generally switch between the different possible alternatives rather than stay fixed on one interpretation (perceptual rivalry). Here, we measured pupil diameter while subjects viewed different ambiguous visual and auditory st...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0707727105

    authors： Einhäuser W,Stout J,Koch C,Carter O

    更新日期：2008-02-05 00:00:00

  • cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

    abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.252782799

    authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

    更新日期：2003-02-18 00:00:00

  • Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog.

    abstract：:African sleeping sickness is a fatal disease that is caused by the protozoan parasite Trypanosoma brucei. Polyamine biosynthesis is an essential pathway in the parasite and is a validated drug target for treatment of the disease. S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a key step in polyamine biosynthe...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0701111104

    authors： Willert EK,Fitzpatrick R,Phillips MA

    更新日期：2007-05-15 00:00:00

  • Radio frequency transmitter based on a laser frequency comb.

    abstract：:Since the days of Hertz, radio transmitters have evolved from rudimentary circuits emitting around 50 MHz to modern ubiquitous Wi-Fi devices operating at gigahertz radio bands. As wireless data traffic continues to increase, there is a need for new communication technologies capable of high-frequency operation for hig...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1903534116

    authors： Piccardo M,Tamagnone M,Schwarz B,Chevalier P,Rubin NA,Wang Y,Wang CA,Connors MK,McNulty D,Belyanin A,Capasso F

    更新日期：2019-05-07 00:00:00

  • Dichotomous effects of VEGF-A on adipose tissue dysfunction.

    abstract：:Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustained and sufficient oxygen and nutrient exchange during fat mass expansion, thereby improving adipose...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1200447109

    authors： Sun K,Wernstedt Asterholm I,Kusminski CM,Bueno AC,Wang ZV,Pollard JW,Brekken RA,Scherer PE

    更新日期：2012-04-10 00:00:00

  • Uncoupling of the DNA topoisomerase and replication activities of an initiator protein.

    abstract：:The replication initiator proteins encoded by the pT181 and related plasmids have sequence-specific DNA binding and topoisomerase activities. These proteins create a site-specific nick in one strand of the DNA at the origin of replication that serves as a primer for the initiation of replication. To define the regions...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.7.3083

    authors： Dempsey LA,Birch P,Khan SA

    更新日期：1992-04-01 00:00:00

  • A neuronal signature for monogamous reunion.

    abstract：:Pair-bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens, but the neuronal dynamics underlying this behavior remain unclear. Using 1-photon in vivo Ca2+ imaging in monogamous prairie voles, we found that pair bonding does not elicit differences in overall nucleus accumbens Ca2+ act...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1917287117

    authors： Scribner JL,Vance EA,Protter DSW,Sheeran WM,Saslow E,Cameron RT,Klein EM,Jimenez JC,Kheirbek MA,Donaldson ZR

    更新日期：2020-05-19 00:00:00

  • Absence of Jahn-Teller transition in the hexagonal Ba3CuSb2O9 single crystal.

    abstract：:With decreasing temperature, liquids generally freeze into a solid state, losing entropy in the process. However, exceptions to this trend exist, such as quantum liquids, which may remain unfrozen down to absolute zero owing to strong quantum entanglement effects that stabilize a disordered state with zero entropy. Ex...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1508941112

    authors： Katayama N,Kimura K,Han Y,Nasu J,Drichko N,Nakanishi Y,Halim M,Ishiguro Y,Satake R,Nishibori E,Yoshizawa M,Nakano T,Nozue Y,Wakabayashi Y,Ishihara S,Hagiwara M,Sawa H,Nakatsuji S

    更新日期：2015-07-28 00:00:00

  • Role of adenine functional groups in the recognition of the 3'-splice-site AG during the second step of pre-mRNA splicing.

    abstract：:The AG dinucleotide at the 3' splice sites of metazoan nuclear pre-mRNAs plays a critical role in catalytic step II of the splicing reaction. Previous studies have shown that replacement of the guanine by adenine in the AG (AG --> GG) inhibits this step. We find that the second step was even more severely inhibited by...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.1.115

    authors： Gaur RK,Beigelman L,Haeberli P,Maniatis T

    更新日期：2000-01-04 00:00:00

  • A single-stranded promoter for RNA polymerase III.

    abstract：:Single strands of DNA serve, in rare instances, as promoters for transcription; duplex DNA promoters with individual strands that also have a promoter capacityfunction have not been described. We show that the nontranscribed strand of the Saccharomyces cerevisiae U6 snRNA gene directs transcription initiation factor I...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.242735699

    authors： Schroder O,Geiduschek EP,Kassavetis GA

    更新日期：2003-02-04 00:00:00

  • Macroecological signals of species interactions in the Danish avifauna.

    abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0914089107

    authors： Gotelli NJ,Graves GR,Rahbek C

    更新日期：2010-03-16 00:00:00

  • Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.

    abstract：:A 32-base-pair (bp) DNA duplex with deletions in one strand, and thus extra bases in the opposing strand, was ligated head-to-tail to produce linear and circular multimers. The electrophoretic mobility of the linear multimers was analyzed in polyacrylamide gels and the size of the circular DNA was determined by electr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.13.4833

    authors： Hsieh CH,Griffith JD

    更新日期：1989-07-01 00:00:00

  • Species interactions limit the occurrence of urban-adapted birds in cities.

    abstract：:Urbanization represents an extreme transformation of more natural systems. Populations of most species decline or disappear with urbanization, and yet some species persist and even thrive in cities. What determines which species persist or thrive in urban habitats? Direct competitive interactions among species can inf...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1809317115

    authors： Martin PR,Bonier F

    更新日期：2018-12-04 00:00:00

  • Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner.

    abstract：:Several publications have attested to the ability of herpes simplex viruses to protect cells against apoptosis. We investigated the ability of the virus to protect cells in continuous cultivation from apoptosis induced by the virus itself, and by other known inducers such as exposure to the tumor necrosis factor alpha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.7.3931

    authors： Galvan V,Roizman B

    更新日期：1998-03-31 00:00:00

  • Targeted mutations induced by a single acetylaminofluorene DNA adduct in mammalian cells and bacteria.

    abstract：:Mutagenic specificity of 2-acetylaminofluorene (AAF) has been established in mammalian cells and several strains of bacteria by using a shuttle plasmid vector containing a single N-(deoxyguanosin-8-yl)acetylaminofluorene (C8-dG-AAF) adduct. The nucleotide sequence of the gene conferring tetracycline resistance was mod...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.5.1586

    authors： Moriya M,Takeshita M,Johnson F,Peden K,Will S,Grollman AP

    更新日期：1988-03-01 00:00:00

  • Global temperature responses to current emissions from the transport sectors.

    abstract：:Transport affects climate directly and indirectly through mechanisms that cause both warming and cooling of climate, and the effects operate on very different timescales. We calculate climate responses in terms of global mean temperature and find large differences between the transport sectors with respect to the size...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0804844105

    authors： Berntsen T,Fuglestvedt J

    更新日期：2008-12-09 00:00:00