Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k gene.

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function. At excitatory synapses, NLGN1 mediates transsyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong J,Pandey S,Li Y,Badger JD 2nd,Lu W,Roche KW

更新日期：2019-06-11 00:00:00

abstract：:At the neuromuscular junction, two motor neuron-derived signals have been implicated in the regulation of synaptogenesis. Neuregulin-1 is thought to induce transcription of acetylcholine receptor (AChR) genes in subsynaptic muscle nuclei by activating ErbB receptors. Neural agrin aggregates AChRs by activating the rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore C,Leu M,Müller U,Brenner HR

更新日期：2001-12-04 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:We previously purified a 48-kDa protein (p48) that specifically reacts with an antiserum directed against the 12 carboxyl-terminal amino acids of the c-myc gene product. Using an antiserum directed against the purified p48, we have cloned a cDNA from a human expression library. This cDNA hybrid-selects an mRNA that tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giallongo A,Feo S,Moore R,Croce CM,Showe LC

更新日期：1986-09-01 00:00:00

abstract：:Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats. However, no changes in the amplitude or time course of spontaneous miniature endplate potentials or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albuquerque EX,Gage PW

更新日期：1978-03-01 00:00:00

abstract：:Loads on molecular motors regulate and coordinate their function. In a study that directly measures properties of internally strained myosin 2 heads bound to actin, we find that human nonmuscle myosins 2A and 2B show marked load-dependent changes in kinetics of ADP release but not in nucleotide binding. We show that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovács M,Thirumurugan K,Knight PJ,Sellers JR

更新日期：2007-06-12 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis and neuronal survival in humans. However, most studies on DHEA have been performed in rodents, and there is little direct evidence for biological effects on the human nervous system. Furthermore, the mechanism of its action is unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki M,Wright LS,Marwah P,Lardy HA,Svendsen CN

更新日期：2004-03-02 00:00:00

abstract：:In RBL-2H3 rat tumor mast cells, cross-linking the high-affinity IgE receptor Fc epsilon RI causes tyrosine phosphorylation of multiple proteins. These phosphoproteins include phospholipase C gamma 1, the beta and gamma subunits of the Fc epsilon RI, the Src family protein-tyrosine kinase Lyn, and a 72-kDa protein tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutchcroft JE,Geahlen RL,Deanin GG,Oliver JM

更新日期：1992-10-01 00:00:00

abstract：:Viruses are the most common biological entities in the oceans by an order of magnitude. However, very little is known about their diversity. Here we report a genomic analysis of two uncultured marine viral communities. Over 65% of the sequences were not significantly similar to previously reported sequences, suggestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breitbart M,Salamon P,Andresen B,Mahaffy JM,Segall AM,Mead D,Azam F,Rohwer F

更新日期：2002-10-29 00:00:00

abstract：:In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells are nearly completely opposite the corresponding changes in vascular endothelial cells (ECs) [Thi MM et al. (2004) Proc Natl Acad Sci USA 101:16483-16488]. Mouse prox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duan Y,Gotoh N,Yan Q,Du Z,Weinstein AM,Wang T,Weinbaum S

更新日期：2008-08-12 00:00:00

abstract：:The environments we humans encounter daily are sources of exposure to diverse microbial communities, some of potential concern to human health. In this study, we used culture-independent technology to investigate the microbial composition of biofilms inside showerheads as ecological assemblages in the human indoor env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feazel LM,Baumgartner LK,Peterson KL,Frank DN,Harris JK,Pace NR

更新日期：2009-09-22 00:00:00

abstract：:Developing tools for investigating the cellular activity of glycans will help to delineate the molecular basis for aberrant glycosylation in pathological processes such as cancer. Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu TL,Hanson SR,Kishikawa K,Wang SK,Sawa M,Wong CH

更新日期：2007-02-20 00:00:00

abstract：:The complete amino acid sequences of the variable regions of two human IgM anti-gamma globulins are reported. The two proteins, Sie and Wol, share idiotypic determinants that are distinct from those shared by the two previously sequenced IgM anti-gamma globulins, Lay and Pom [Capra, J. D. & Kehoe, J. M. (1974) Proc. N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrews DW,Capra JD

更新日期：1981-06-01 00:00:00

abstract：:We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of the induction of CO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masferrer JL,Zweifel BS,Manning PT,Hauser SD,Leahy KM,Smith WG,Isakson PC,Seibert K

更新日期：1994-04-12 00:00:00

abstract：:The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jörnvall H

更新日期：1973-08-01 00:00:00

abstract：:The association between nicotinic acetylcholine receptor (nAChR) dysfunction and cognitive decline in Alzheimer's disease (AD) has been widely exploited for its therapeutic potential. The effects of chronic nicotine exposure on Abeta accumulation have been studied in both humans and animal models, but its therapeutic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oddo S,Caccamo A,Green KN,Liang K,Tran L,Chen Y,Leslie FM,LaFerla FM

更新日期：2005-02-22 00:00:00

abstract：:The stimulatory activity of peptides from the alpha 1 domain of the major histocompatibility complex (MHC) class I antigen on adipose cell glucose transport was previously shown to require a preformed, ordered conformation of the peptide. The two peptides studied previously were Dk-(61-85) (ERETQIAKGNEQSFRVDLRTLLRYY) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagsted J,Mapelli C,Meyers C,Matthews BW,Anfinsen CB,Goldstein A,Olsson L

更新日期：1993-08-15 00:00:00

abstract：:We have previously described how T and natural killer (NK) lineage commitment proceeds from common T/NK progenitors (p-T/NK) in the murine fetal thymus (FT), with the use of a clonal assay system capable of discriminating p-T/NK from unipotent T or NK lineage-committed progenitors (p-T and p-NK, respectively). The mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikawa T,Fujimoto S,Kawamoto H,Katsura Y,Yokota Y

更新日期：2001-04-24 00:00:00

abstract：:When deprived of D-glucose for 24 hr, chicken embryo fibroblasts exhibit a marked increase in hexose transport activity compared with that of control cells. Scatchard analysis of [3H]cytochalasin B binding to starved cell plasma membranes (46 pmol/mg) indicated a six-fold increase compared with fed cell plasma membran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pessin JE,Tillotson LG,Yamada K,Gitomer W,Carter-Su C,Mora R,Isselbacher KJ,Czech MP

更新日期：1982-04-01 00:00:00

abstract：:The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also coope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Archetti M,Ferraro DA,Christofori G

更新日期：2015-02-10 00:00:00

abstract：:Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels of lactogenic hormones fall. Four experimental models were used to define the role of local factors as compared with systemic hor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li M,Liu X,Robinson G,Bar-Peled U,Wagner KU,Young WS,Hennighausen L,Furth PA

更新日期：1997-04-01 00:00:00

abstract：:Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respirator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filoche M,Tai CF,Grotberg JB

更新日期：2015-07-28 00:00:00

abstract：:Tramadol, previously only known as a synthetic analgesic, has now been found in the bark and wood of roots of the African medicinal tree Nauclea latifolia. At present, no direct evidence is available as to the biosynthetic pathway of its unusual skeleton. To provide guidance as to possible biosynthetic precursors, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romek KM,Nun P,Remaud GS,Silvestre V,Taïwe GS,Lecerf-Schmidt F,Boumendjel A,De Waard M,Robins RJ

更新日期：2015-07-07 00:00:00

abstract：:The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset dia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louvet C,Szot GL,Lang J,Lee MR,Martinier N,Bollag G,Zhu S,Weiss A,Bluestone JA

更新日期：2008-12-02 00:00:00

abstract：:High-valent intermediates of binuclear nonheme iron enzymes are structurally unknown despite their importance for understanding enzyme reactivity. Nuclear resonance vibrational spectroscopy combined with density functional theory calculations has been applied to structurally well-characterized high-valent mono- and di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park K,Bell CB 3rd,Liu LV,Wang D,Xue G,Kwak Y,Wong SD,Light KM,Zhao J,Alp EE,Yoda Y,Saito M,Kobayashi Y,Ohta T,Seto M,Que L Jr,Solomon EI

更新日期：2013-04-16 00:00:00

abstract：:We have employed a combination of temperature-dependent UV absorption spectroscopy, circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a series of oligomeric DNA duplexes. We find the duplex [d(CGTCGACG)]2 to be unique in its ability to bind actinomycin D strongly despite the abs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JG,Hartman NG,D'Estantoit BL,Kennard O,Remeta DP,Breslauer KJ

更新日期：1989-06-01 00:00:00

abstract：:It is known from a variety of experimental systems that the ability of tumor cells to grow locally and metastasize can be affected by the presence of adjacent normal tissues and cells, particularly mesenchymally derived stromal cells such as fibroblasts. However, the comparative influence of such normal cell-tumor cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornil I,Theodorescu D,Man S,Herlyn M,Jambrosic J,Kerbel RS

更新日期：1991-07-15 00:00:00

abstract：:A recently discovered family of natural anion channelrhodopsins (ACRs) have the highest conductance among channelrhodopsins and exhibit exclusive anion selectivity, which make them efficient inhibitory tools for optogenetics. We report analysis of flash-induced absorption changes in purified wild-type and mutant ACRs,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sineshchekov OA,Li H,Govorunova EG,Spudich JL

更新日期：2016-04-05 00:00:00

abstract：:The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two electrons to the hemeprotein. In general these electrons are transferred from NADPH to the P450 via an FMN- and FAD-containing flavoprotein (NADPH-P450 reductase)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faulkner KM,Shet MS,Fisher CW,Estabrook RW

更新日期：1995-08-15 00:00:00