当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.

Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.

Abstract：

:The extensive intratumor heterogeneity revealed by sequencing cancer genomes is an essential determinant of tumor progression, diagnosis, and treatment. What maintains heterogeneity remains an open question because competition within a tumor leads to a strong selection for the fittest subclone. Cancer cells also cooperate by sharing molecules with paracrine effects, such as growth factors, and heterogeneity can be maintained if subclones depend on each other for survival. Without strict interdependence between subclones, however, nonproducer cells can free-ride on the growth factors produced by neighboring producer cells, a collective action problem known in game theory as the "tragedy of the commons," which has been observed in microbial cell populations. Here, we report that similar dynamics occur in cancer cell populations. Neuroendocrine pancreatic cancer (insulinoma) cells that do not produce insulin-like growth factor II (IGF-II) grow slowly in pure cultures but have a proliferation advantage in mixed cultures, where they can use the IGF-II provided by producer cells. We show that, as predicted by evolutionary game theory, producer cells do not go extinct because IGF-II acts as a nonlinear public good, creating negative frequency-dependent selection that leads to a stable coexistence of the two cell types. Intratumor cell heterogeneity can therefore be maintained even without strict interdependence between cell subclones. Reducing the amount of growth factors available within a tumor may lead to a reduction in growth followed by a new equilibrium, which may explain relapse in therapies that target growth factors.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Archetti M,Ferraro DA,Christofori G

doi

10.1073/pnas.1414653112

subject

Has Abstract

pub_date

2015-02-10 00:00:00

pages

1833-8

issue

6

eissn

0027-8424

issn

1091-6490

pii

1414653112

journal_volume

112

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.

    abstract：:Pathologic ocular angiogenesis is a leading cause of blindness, influenced by both dysregulated lipid metabolism and inflammation. Retinoic-acid-receptor-related orphan receptor alpha (RORα) is a lipid-sensing nuclear receptor with diverse biologic function including regulation of lipid metabolism and inflammation; ho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1504387112

    authors： Sun Y,Liu CH,SanGiovanni JP,Evans LP,Tian KT,Zhang B,Stahl A,Pu WT,Kamenecka TM,Solt LA,Chen J

    更新日期：2015-08-18 00:00:00

  • Kinetic mechanism for HIV-1 neutralization by antibody 2G12 entails reversible glycan binding that slows cell entry.

    abstract：:Despite structural knowledge of broadly neutralizing monoclonal antibodies (NMAbs) complexed to HIV-1 gp120 and gp41 envelope glycoproteins, virus inactivation mechanisms have been difficult to prove, in part because neutralization assays are complex and were previously not understood. Concordant with recent evidence ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1109728109

    authors： Platt EJ,Gomes MM,Kabat D

    更新日期：2012-05-15 00:00:00

  • Expression of a desaturase gene, desat1, in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila.

    abstract：:Animals often use sex pheromones for mate choice and reproduction. As for other signals, the genetic control of the emission and perception of sex pheromones must be tightly coadapted, and yet we still have no worked-out example of how these two aspects interact. Most models suggest that emission and perception rely o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1109166108

    authors： Bousquet F,Nojima T,Houot B,Chauvel I,Chaudy S,Dupas S,Yamamoto D,Ferveur JF

    更新日期：2012-01-03 00:00:00

  • Atomic model of the human cardiac muscle myosin filament.

    abstract：:Of all the myosin filaments in muscle, the most important in terms of human health, and so far the least studied, are those in the human heart. Here we report a 3D single-particle analysis of electron micrograph images of negatively stained myosin filaments isolated from human cardiac muscle in the normal (undiseased)...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212708110

    authors： Al-Khayat HA,Kensler RW,Squire JM,Marston SB,Morris EP

    更新日期：2013-01-02 00:00:00

  • Economic and geographic drivers of wildlife consumption in rural Africa.

    abstract：:The harvest of wildlife for human consumption is valued at several billion dollars annually and provides an essential source of meat for hundreds of millions of rural people living in poverty. This harvest is also considered among the greatest threats to biodiversity throughout Africa, Asia, and Latin America. Economi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1011526108

    authors： Brashares JS,Golden CD,Weinbaum KZ,Barrett CB,Okello GV

    更新日期：2011-08-23 00:00:00

  • Recovery of taste organs and sensory function after severe loss from Hedgehog/Smoothened inhibition with cancer drug sonidegib.

    abstract：:Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1712881114

    authors： Kumari A,Ermilov AN,Grachtchouk M,Dlugosz AA,Allen BL,Bradley RM,Mistretta CM

    更新日期：2017-11-28 00:00:00

  • cDNA cloning of somatolactin, a pituitary protein related to growth hormone and prolactin.

    abstract：:From a flounder pituitary cDNA library, cDNA clones encoding a 28-kDa glycoprotein produced by the pars intermedia of the pituitary were isolated and characterized. Nucleotide sequencing demonstrated a precursor of the 28-kDa protein, which consisted of 231 amino acid residues, to be cleaved into a signal peptide (24 ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.11.4330

    authors： Ono M,Takayama Y,Rand-Weaver M,Sakata S,Yasunaga T,Noso T,Kawauchi H

    更新日期：1990-06-01 00:00:00

  • Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death.

    abstract：:Autophagy is a cellular catabolic pathway by which long-lived proteins and damaged organelles are targeted for degradation. Activation of autophagy enhances cellular tolerance to various stresses. Recent studies indicate that a class of anticancer agents, histone deacetylase (HDAC) inhibitors, can induce autophagy. On...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1204429109

    authors： Gammoh N,Lam D,Puente C,Ganley I,Marks PA,Jiang X

    更新日期：2012-04-24 00:00:00

  • Remodeling of synaptic architecture during hippocampal "kindling".

    abstract：:The "kindling" phenomenon is associated with long-lasting facilitation of synaptic transmission. A possible mechanism of such facilitation could involve changes in the number of synaptic contacts. However, previous attempts to demonstrate a synaptic morphological alteration that could account for the long-term effects...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.9.3260

    authors： Geinisman Y,Morrell F,deToledo-Morrell L

    更新日期：1988-05-01 00:00:00

  • Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction.

    abstract：:Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links,...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1713135114

    authors： Gianoli F,Risler T,Kozlov AS

    更新日期：2017-12-19 00:00:00

  • Stereospecific binding of propranolol and catecholamines to the beta-adrenergic receptor.

    abstract：:The stereospecificity of the beta-adrenergic receptor of turkey erythrocyte ghosts was studied. Binding of the specific beta-adrenergic antagonist, propranolol, was found to occur exclusively with the l-stereoisomer. The stereospecificity of catecholamine binding was determined by assaying the ability of the catechola...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.71.10.4246

    authors： Atlas D,Steer ML,Levitzki A

    更新日期：1974-10-01 00:00:00

  • Autologous engineering of cartilage.

    abstract：:Treatment of full-thickness damage to hyaline cartilage is hampered by the limited availability of autologous healthy cartilage and the lengthy, cost-prohibitive cell isolation and expansion steps associated with autologous cartilage implantation (ACI). Here we report a strategy for de novo engineering of ectopic auto...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0907774107

    authors： Emans PJ,van Rhijn LW,Welting TJ,Cremers A,Wijnands N,Spaapen F,Voncken JW,Shastri VP

    更新日期：2010-02-23 00:00:00

  • Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla.

    abstract：:The effect of reflex splanchnic nerve stimulation on proenkephalin A biosynthesis was investigated in the rat adrenal medulla. Tissue levels of native [Met5]enkephalin-like immunoreactivity (IR) (measured by direct RIA of tissue extracts), cryptic [Met5]enkephalin-like IR (calculated as the increase in [Met5]enkephali...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.23.9245

    authors： Kanamatsu T,Unsworth CD,Diliberto EJ Jr,Viveros OH,Hong JS

    更新日期：1986-12-01 00:00:00

  • Dopa decarboxylase activity of the living human brain.

    abstract：:Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculate...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.7.2721

    authors： Gjedde A,Reith J,Dyve S,Léger G,Guttman M,Diksic M,Evans A,Kuwabara H

    更新日期：1991-04-01 00:00:00

  • Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells.

    abstract：:Using a proteomics screen, we have identified the methyltransferase G9a as an interacting partner of the hematopoietic activator NF-E2. We show that G9a is recruited to the beta-globin locus in a NF-E2-dependent manner and spreads over the entire locus. While G9a is often regarded as a corepressor, knocking down this ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0906769106

    authors： Chaturvedi CP,Hosey AM,Palii C,Perez-Iratxeta C,Nakatani Y,Ranish JA,Dilworth FJ,Brand M

    更新日期：2009-10-27 00:00:00

  • Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells.

    abstract：:Androgen receptor (AR) protein expression and function are critical for survival and proliferation of androgen-sensitive (AS) prostate cancer cells. Besides its ability to function as a transcription factor, experimental observations suggest that AR becomes a licensing factor for DNA replication in AS prostate cancer ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0603057103

    authors： Litvinov IV,Vander Griend DJ,Antony L,Dalrymple S,De Marzo AM,Drake CG,Isaacs JT

    更新日期：2006-10-10 00:00:00

  • A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait.

    abstract：:In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventory and seasonality s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1600039113

    authors： Zhang L,Hirano A,Hsu PK,Jones CR,Sakai N,Okuro M,McMahon T,Yamazaki M,Xu Y,Saigoh N,Saigoh K,Lin ST,Kaasik K,Nishino S,Ptáček LJ,Fu YH

    更新日期：2016-03-15 00:00:00

  • The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest.

    abstract：:Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a cyclin-dependent ki...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.23.12782

    authors： Yeh JR,Mohan R,Crews CM

    更新日期：2000-11-07 00:00:00

  • Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.

    abstract：:Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. Although TACE achieves substantial necrosis of the tumor, complete tumor necrosis is uncommon, and the res...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1613466113

    authors： Lin WH,Yeh SH,Yeh KH,Chen KW,Cheng YW,Su TH,Jao P,Ni LC,Chen PJ,Chen DS

    更新日期：2016-10-18 00:00:00

  • The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog.

    abstract：:The het-s locus of Podospora anserina is a heterokaryon incompatibility locus. The coexpression of the antagonistic het-s and het-S alleles triggers a lethal reaction that prevents the formation of viable heterokaryons. Strains that contain the het-s allele can display two different phenotypes, [Het-s] or [Het-s*], ac...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.18.9773

    authors： Coustou V,Deleu C,Saupe S,Begueret J

    更新日期：1997-09-02 00:00:00

  • Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.

    abstract：:Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites responsible for DR re...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1604047113

    authors： Ogawa T,Tsubakiyama R,Kanai M,Koyama T,Fujii T,Iefuji H,Soga T,Kume K,Miyakawa T,Hirata D,Mizunuma M

    更新日期：2016-10-18 00:00:00

  • Recombinant DNA molecules of bacteriophage phi chi174.

    abstract：:Phi chi174 DNA structures containing two different parental genomes were detected genetically and examined by electron microscopy. These structures consisted of two monomeric double-stranded DNA molecules linked in a figure 8 configuration. Such DNA structures were observed to be formed preferentially in host recA+ ce...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.72.1.235

    authors： Benbow RM,Zuccarelli AJ,Sinsheimer RL

    更新日期：1975-01-01 00:00:00

  • Climate and infectious disease: use of remote sensing for detection of Vibrio cholerae by indirect measurement.

    abstract：:It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may dire...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.4.1438

    authors： Lobitz B,Beck L,Huq A,Wood B,Fuchs G,Faruque AS,Colwell R

    更新日期：2000-02-15 00:00:00

  • Translocation of phospholipids from the inner to the outer membrane of Escherichia coli.

    abstract：:The translocation of lipids from the inner to the outer membrane of Escherichia coli has been investigated by pulse-chase experiments. After a pulse with [2-3H]glycerol, the specific activity of the newly synthesized [3H]phosphatidylethanolamine was 5 times greater in the inner than in the outer membrane. During the c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.4.1867

    authors： Donohue-Rolfe AM,Schaechter M

    更新日期：1980-04-01 00:00:00

  • TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter.

    abstract：:Activator-dependent recruitment of TFIID initiates formation of the transcriptional preinitiation complex. TFIID binds core promoter DNA elements and directs the assembly of other general transcription factors, leading to binding of RNA polymerase II and activation of RNA synthesis. How TATA box-binding protein (TBP) ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0605499103

    authors： Wright KJ,Marr MT 2nd,Tjian R

    更新日期：2006-08-15 00:00:00

  • Adenovirus 2 early gene expression promotes susceptibility to effector cell lysis of hybrids formed between hamster cells transformed by adenovirus 2 and simian virus 40.

    abstract：:Weakly oncogenic adenovirus 2 (Ad2)-transformed LSH hamster cells are sensitive to lysis by spontaneously cytolytic lymphoid cells and activated macrophages, whereas highly oncogenic simian virus 40 (SV40)-transformed LSH cells are relatively resistant to these nonspecific effector cells. Somatic cell hybrids formed b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.19.5995

    authors： Cook JL,Hauser J,Patch CT,Lewis AM Jr,Levine AS

    更新日期：1983-10-01 00:00:00

  • Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.

    abstract：:In this report we examine the effects of chronic anaerobic exposure and subsequent reoxygenation on protein synthesis patterns in Chinese hamster ovary cells. It is observed by two-dimensional gel electrophoresis (isoelectric focusing/NaDodSO4/PAGE) that the transition from an atmospheric environment to an anaerobic s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.15.4843

    authors： Sciandra JJ,Subjeck JR,Hughes CS

    更新日期：1984-08-01 00:00:00

  • Effect of oil spills on infant mortality in Nigeria.

    abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1818303116

    authors： Bruederle A,Hodler R

    更新日期：2019-03-19 00:00:00

  • Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis.

    abstract：:EWS (Ewing sarcoma) encodes an RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosomal translocations. Physiologically, EWS has diverse and essential roles in various organ development and cellular processes. In this study, we uncovered a new role of EWS in mitochondrial...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1504391112

    authors： Park JH,Kang HJ,Lee YK,Kang H,Kim J,Chung JH,Chang JS,McPherron AC,Lee SB

    更新日期：2015-05-12 00:00:00

  • Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

    abstract：:A central problem in understanding enzyme regulation is to define the conformational states that account for allosteric changes in catalytic activity. For Escherichia coli aspartate transcarbamoylase (ATCase; EC) the active, relaxed (R state) holoenzyme is generally assumed to be represented by the crystal structure o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.090087197

    authors： Endrizzi JA,Beernink PT,Alber T,Schachman HK

    更新日期：2000-05-09 00:00:00