Curved DNA: design, synthesis, and circularization.

abstract：:Many materials phenomena are governed by the interaction between chemistry and mechanics. However, it was only in the second half of the 20th century that the theory of open system elasticity by Francis Larché and John W. Cahn concatenated the fields of solid mechanics and alloy chemistry. As the theory's central mate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi S,Markmann J,Weissmüller J

更新日期：2018-10-23 00:00:00

abstract：:C factor, an intercellular signaling protein, is required for aggregation and sporulation of the social bacterium, Myxococcus xanthus. We report that C factor, which normally is associated with the cell surface, provides input to the Frz signal transduction cascade. Elements of this cascade have sequence homology to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Søgaard-Andersen L,Kaiser D

更新日期：1996-04-02 00:00:00

abstract：:Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Runguphan W,Maresh JJ,O'Connor SE

更新日期：2009-08-18 00:00:00

abstract：:3-(4'-Benzoylphenyl)propionyl[3H] Phe-tRNA bound to the peptidyl site of the ribosome is photo-crosslinked exclusively to 23S RNA on irradiation at 320 nm. The site of reaction has been identified both by hybridization and primer-extension experiments as uridine-2584 and uridine-2585, located within the central loop o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barta A,Steiner G,Brosius J,Noller HF,Kuechler E

更新日期：1984-06-01 00:00:00

abstract：:The attachment of human polymorphonuclear leukocytes (PMN) to bovine endothelial monolayers is increased by pretreatment of the endothelial cells with leukotriene B4 (LTB4). The response is dose dependent with a maximum at 10(-6) M, requires no more than 1 min of preincubation for the maximal effect, and decays linear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoover RL,Karnovsky MJ,Austen KF,Corey EJ,Lewis RA

更新日期：1984-04-01 00:00:00

abstract：:Pregnant mothers often report a special awareness of and bonding with their unborn child. Little is known about this relationship although it may offer potential for the assessment of the fetal condition. Recently we found evidence of short epochs of fetal-maternal heart rate synchronization under uncontrolled conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Leeuwen P,Geue D,Thiel M,Cysarz D,Lange S,Romano MC,Wessel N,Kurths J,Grönemeyer DH

更新日期：2009-08-18 00:00:00

abstract：:Increased accumulation of lipofuscin in cells of the retinal pigment epithelium (RPE) is seen in several forms of macular degeneration, a common cause of blindness in humans. A major fluorophore of lipofuscin is the toxic bis-retinoid, N-retinylidene-N-retinylethanolamine (A2E). Previously, we generated mice with a kn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mata NL,Weng J,Travis GH

更新日期：2000-06-20 00:00:00

abstract：:Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C dimorphism, which is s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colonna M,Borsellino G,Falco M,Ferrara GB,Strominger JL

更新日期：1993-12-15 00:00:00

abstract：:The one-sided multipliers of an operator space X are a key to "latent operator algebraic structure" in X. We begin with a survey of these multipliers, together with several of the applications that they have had to operator algebras. We then describe several new results on one-sided multipliers, and new applications, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blecher DP,Zarikian V

更新日期：2004-01-20 00:00:00

abstract：:The posteromedial barrel subfield of the somatosensory cortex of mice was examined histochemically for cytochrome oxidase activity (cytochrome c oxidase; ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1). In normal mice a high enzymatic activity was found within the barrel hollows, rather than in the sides and sept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong-Riley MT,Welt C

更新日期：1980-04-01 00:00:00

abstract：:The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry for selection is well understood, how these nuclei evaluate the outcome of actions is unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates the habenula-projecting globus pallidus (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephenson-Jones M,Kardamakis AA,Robertson B,Grillner S

更新日期：2013-09-17 00:00:00

abstract：:A fraction obtained by gel filtration at neutral pH of the extracellular Hb of Lumbricus terrestris dissociated either at pH 9.8 or at pH 4.0, consisting of the three subunits D1 (31 kDa), D2 (37 kDa), and T (50 kDa), was found to produce two peaks when subjected to gel filtration on Superose 6 at pH 7. The first peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapp OH,Mainwaring MG,Vinogradov SN,Crewe AV

更新日期：1987-11-01 00:00:00

abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

更新日期：1994-04-26 00:00:00

abstract：:A 105-kilobase bacterial artificial chromosome (BAC) clone from the ovate-containing region of tomato chromosome 2 was sequenced and annotated. The tomato BAC sequence was then compared, gene by gene, with the sequenced portions of the Arabidopsis thaliana genome. Rather than matching a single portion of the Arabidops...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku HM,Vision T,Liu J,Tanksley SD

更新日期：2000-08-01 00:00:00

abstract：:The plasma membrane (PM) is composed of heterogeneous subdomains, characterized by differences in protein and lipid composition. PM receptors can be dynamically sorted into membrane domains to underpin signaling in response to extracellular stimuli. In plants, the plasmodesmal PM is a discrete microdomain that hosts s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheval C,Samwald S,Johnston MG,de Keijzer J,Breakspear A,Liu X,Bellandi A,Kadota Y,Zipfel C,Faulkner C

更新日期：2020-04-28 00:00:00

abstract：:In an era of large-scale science-related challenges and rapid advancements in groundbreaking science with major societal implications, communicating about science is critical. The profile of science communication has increased over the last few decades, with multiple sectors calling for such activities. As scientists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rose KM,Markowitz EM,Brossard D

更新日期：2020-01-21 00:00:00

abstract：:A model for the chain melting phase transition in dilute aqueous phospholipid bilayer dispersions is presented. This model includes interactions between head groups, between hydrocarbon chains, and within the chains. The head groups are modeled as hard disks which are constrained to lie on a two-dimensional surface se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs RE,Hudson B,Andersen HC

更新日期：1975-10-01 00:00:00

abstract：:The total amount of noncoding sequences on chromosomes of contemporary organisms varies significantly from species to species. We propose a hypothesis for the origin of these noncoding sequences that assumes that (i) an approximately equal to 0.55-kilobase (kb)-long reading frame composed the primordial gene and (ii) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naora H,Miyahara K,Curnow RN

更新日期：1987-09-01 00:00:00

abstract：:Newborns are at increased risk of jaundice, a condition in which excess bilirubin accumulates in blood. Left untreated, jaundice can lead to neurological impairment and death. Jaundice resulting from unconjugated hyperbilirubinemia is easily treated with exposure to blue light, and phototherapy systems have been devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keahey PA,Simeral ML,Schroder KJ,Bond MM,Mtenthaonnga PJ,Miros RH,Dube Q,Richards-Kortum RR

更新日期：2017-12-19 00:00:00

abstract：:GABAergic dysfunction is present in the hippocampus in schizophrenia (SZ) and bipolar disorder (BD). The trisynaptic pathway was "deconstructed" into various layers of sectors CA3/2 and CA1 and gene expression profiling performed. Network association analysis was used to uncover genes that may be related to regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benes FM,Lim B,Matzilevich D,Walsh JP,Subburaju S,Minns M

更新日期：2007-06-12 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu T,Laidlaw TM,Katz HR,Boyce JA

更新日期：2013-10-15 00:00:00

abstract：:DNA from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (HPV) type 11 DNA only under nonstringent conditions. This DNA was molecularly cloned in lambda phage. Under stringent conditions of hybridization it cross-hybridized to a minor extent (less than 0.1%)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dürst M,Gissmann L,Ikenberg H,zur Hausen H

更新日期：1983-06-01 00:00:00

abstract：:It is shown that a stereochemical correspondence between two molecular systems can be represented by a commuting diagram of the point groups and permutation groups involved. The effect of the diagrammatic condition on the mappings of the cosets, double cosets, subgroup lattice, and double coset algebra determined for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nourse JG

更新日期：1975-06-01 00:00:00

abstract：:A number of recent studies have shown that iron dissolution in Fe-containing dust aerosol can be linked to source material (mineral or anthropogenic), mineralogy, and iron speciation. All of these factors need to be incorporated into atmospheric chemistry models if these models are to accurately predict the impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubasinghege G,Lentz RW,Scherer MM,Grassian VH

更新日期：2010-04-13 00:00:00

abstract：:We have analyzed ligand-receptor complexes resulting from (i) the incubation of canine hepatic plasma membranes with [125I]iodoglucagon and (ii) subsequent gentle solubilization of receptor-bound ligand with digitonin. The complexes (molecular weight approximately equal to 500,000) retain the radiolabeled ligand durin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason JC,Tager HS

更新日期：1985-10-01 00:00:00

abstract：:A densely packed granular system is an example of an out-of-equilibrium system in the jammed state. It has been a longstanding problem to determine whether this class of systems can be described by concepts arising from equilibrium statistical mechanics, such as an effective temperature and compactivity. The measureme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song C,Wang P,Makse HA

更新日期：2005-02-15 00:00:00

abstract：:Experimental systemic lupus erythematosus (SLE) can be induced in naive mice by immunization with a murine monoclonal anti-DNA antibody (mAb), 5G12, that bears a major idiotype designated 16/6 Id. Strain-dependent differences were observed in the proliferative responses of lymph node cells of mice immunized with two p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waisman A,Ruiz PJ,Israeli E,Eilat E,Könen-Waisman S,Zinger H,Dayan M,Mozes E

更新日期：1997-04-29 00:00:00

abstract：:Researchers have documented many cases in which individuals rationalize their regrettable actions. Four experiments examine situations in which people go beyond merely explaining away their misconduct to actively deceiving themselves. We find that those who exploit opportunities to cheat on tests are likely to engage ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance Z,Norton MI,Gino F,Ariely D

更新日期：2011-09-13 00:00:00

abstract：:Magnitudes of the larger Soviet underground nuclear weapons tests from the start of the Threshold Test Ban Treaty in 1976 through 1982 are determined for short- and long-period seismic waves. Yields are calculated from the surface wave magnitude for those explosions at the eastern Kazakh test site that triggered a sma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykes LR,Cifuentes IL

更新日期：1984-03-01 00:00:00

abstract：:The H2O2-requiring ligninase of the basidiomycete Phanerochaete chrysosporium oxidatively cleaves both lignin and lignin model compounds between C alpha and C beta (C-1 and C-2) of their aliphatic side chains. Previous work has demonstrated a reaction mechanism by which ligninase oxidizes aromatic substrates to their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammel KE,Kalyanaraman B,Kirk TK

更新日期：1986-06-01 00:00:00