Aerial dispersal and drying of Peronospora tabacina conidia in tobacco shade tents.

abstract：:The calcium-dependent phosphatase calcineurin and its downstream transcriptional effector nuclear factor of activated T cells (NFAT) are important regulators of inducible gene expression in multiple cell types. In T cells, calcineurin-NFAT signaling represents a critical event for mediating cellular activation and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bueno OF,Brandt EB,Rothenberg ME,Molkentin JD

更新日期：2002-07-09 00:00:00

abstract：:Ca channel currents were studied in freshly dispersed bovine adrenal glomerulosa cells to better understand the control of aldosterone secretion by extracellular K concentration (Ko) and angiotensin II (AII). The whole-cell variation of the patch voltage clamp technique was used. Two types of Ca channels were found. O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen CJ,McCarthy RT,Barrett PQ,Rasmussen H

更新日期：1988-04-01 00:00:00

abstract：:Isolation and chromatography of collagen from chick cartilage revealed an excess of alpha1 relative to alpha2-chains. Characterization of the cyanogen bromide peptides from the alpha1 fraction indicated the presence of two homologous forms of alpha1. The results suggest that cartilage contains two collagens, one ident...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller EJ,Matukas VJ

更新日期：1969-12-01 00:00:00

abstract：:Figs (Ficus spp., Moraceae) and their pollinating wasps (Agaonidae, Chalcidoidea) constitute perhaps the most tightly integrated pollination mutualism that is known. Figs are characterized by extraordinarily high global and local species diversity. It has been proposed that the diversification of this mutualism has oc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machado CA,Robbins N,Gilbert MT,Herre EA

更新日期：2005-05-03 00:00:00

abstract：:The interaction of carboxylate ions (acetate, butyrate) with nucleic aicd bases and nucleosides has been investigated by proton magnetic resonance in dimethyl sulfoxide (d6)/H2O mixtures. Carboxylate ions interacted only with guanine derivatives and led to a large downfield shift of the NH2 resonance. A 1:1 stoichiome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot G,Hélène C

更新日期：1977-11-01 00:00:00

abstract：:Plants can recognize and resist invading pathogens by signaling the induction of rapid defense responses. Often these responses are mediated by single dominant resistance genes (R genes). The products of R genes have been postulated to recognize the pathogen and trigger rapid host defense responses. Here we describe i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinesh-Kumar SP,Whitham S,Choi D,Hehl R,Corr C,Baker B

更新日期：1995-05-09 00:00:00

abstract：:With current concerns of antibiotic-resistant bacteria and biodefense, it has become important to rapidly identify infectious bacteria. Traditional technologies involving isolation and amplification of the pathogenic bacteria are time-consuming. We report a rapid and simple method that combines in vivo biotinylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edgar R,McKinstry M,Hwang J,Oppenheim AB,Fekete RA,Giulian G,Merril C,Nagashima K,Adhya S

更新日期：2006-03-28 00:00:00

abstract：:A glycoprotein was isolated and purified to homogeneity from the serum of a patient with chronic non-A, non-B hepatitis. NaDodSO4/PAGE of the glycoprotein revealed a single major band at Mr approximately 77,000. Antibodies to this glycoprotein were shown to possess the following immunoreactivity: (i) they reacted by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto B,Gerety RJ

更新日期：1985-08-01 00:00:00

abstract：:Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain's striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma M,Rajendrarao S,Shahani N,Ramírez-Jarquín UN,Subramaniam S

更新日期：2020-07-07 00:00:00

abstract：:After prolonged exposure to ascorbate, collagen synthesis in cultured human skin fibroblasts increased approximately 8-fold with no significant change in synthesis of noncollagen protein. This effect of ascorbate appears to be unrelated to its cofactor function in collagen hydroxylation. The collagenous protein secret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murad S,Grove D,Lindberg KA,Reynolds G,Sivarajah A,Pinnell SR

更新日期：1981-05-01 00:00:00

abstract：:Transporters in the Golgi apparatus membrane translocate nucleotide sugars from the cytosol into the Golgi lumen before these can be substrates for the glycosylation of proteins, lipids, and proteoglycans. We have cloned the mammalian Golgi membrane transporter for uridine diphosphate-N-acetylglucosamine by phenotypic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guillen E,Abeijon C,Hirschberg CB

更新日期：1998-07-07 00:00:00

abstract：:The annual migration of ∼1.2 million wildebeest (Connochaetes taurinus) through the Serengeti Mara Ecosystem is the largest remaining overland migration in the world. One of the most iconic portions of their migration is crossing of the Mara River, during which thousands drown annually. These mass drownings have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subalusky AL,Dutton CL,Rosi EJ,Post DM

更新日期：2017-07-18 00:00:00

abstract：:Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Huang MT,Chang RL,Newmark HL,Lehr RE,Yagi H,Sayer JM,Jerina DM,Conney AH

更新日期：1982-09-01 00:00:00

abstract：:Ca deposition by isolated matrix vesicles from fetal calf growth plate cartilage and by a deoxycholate extract from matrix vesicles that included their phosphatase was studied under defined in vitro conditions. Electron microscopy showed that after removal of deoxycholate and lyophilization of the vesicle extract, new...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu HH,Anderson HC

更新日期：1978-08-01 00:00:00

abstract：:The pathophysiology of systemic inflammation and sepsis involves peripheral organs, causing gastrointestinal, renal, and cardiovascular alterations, as well as the central nervous system (CNS), affecting sleep, temperature regulation, behavior, and neuroendocrine function. The molecular basis of the CNS effects of sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong ML,Bongiorno PB,Rettori V,McCann SM,Licinio J

更新日期：1997-01-07 00:00:00

abstract：:Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells. At this time, however, the clinical and prognostic significance of HSF1 in cancer is un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Hu R,Lin NU,Mendillo ML,Collins LC,Hankinson SE,Schnitt SJ,Whitesell L,Tamimi RM,Lindquist S,Ince TA

更新日期：2011-11-08 00:00:00

abstract：:The roles of glycosylation and protein synthesis in the maintenance of insulin receptor levels and turnover rates in 3T3-L1 adipocytes were investigated. The heavy isotope density-shift technique was employed to determine the effects of inhibitors of these processes on the rates of synthesis and degradation of cellula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed BC,Ronnett GV,Lane MD

更新日期：1981-05-01 00:00:00

abstract：:Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin KM,Hu W,Troutman TD,Jennings M,Brewer T,Li X,Nanda S,Cohen P,Thomas JA,Pasare C

更新日期：2014-01-14 00:00:00

abstract：:Mutator activity associated with the common male recombination (MR) chromosomes in Drosophila melanogaster appears to be suppressed in natural populations. Crosses between geographically separated populations, however, lead to the release of mutator activity as measured by a significant increase in visible mutations. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JN Jr,Woodruff RC

更新日期：1980-02-01 00:00:00

abstract：:Treatment of human fibroblast cells with human fibroblast (beta)interferon for up to 8 hr resulted in the accumulation of at least four mRNAs. The mRNAs were isolated from cellular polysomes and characterized by stimulation of translation in a wheat germ cell-free protein synthesis system. The mRNAs appear as early as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colonno RJ

更新日期：1981-08-01 00:00:00

abstract：:E2A helix-loop-helix proteins are involved in the control of various developmental pathways. We show here by in situ hybridization that E2A transcripts are present in most embryonic and adult tissues. However, no E2A expression is detectable in heart and nonproliferative regions of the brain and spinal cord. Highest l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts VJ,Steenbergen R,Murre C

更新日期：1993-08-15 00:00:00

abstract：:Mosquitoes are major disease vectors because most species must feed on blood from a vertebrate host to produce eggs. Blood feeding by the vector mosquito Aedes aegypti triggers the release of two neurohormones, ovary ecdysteroidogenic hormone (OEH) and insulin-like peptides (ILPs), which activate multiple processes re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel KJ,Brown MR,Strand MR

更新日期：2015-04-21 00:00:00

abstract：:Ca(2+) is essential for physiological depolarization-evoked synchronous neurotransmitter release. But, whether Ca(2+) influx or another factor controls release initiation is still under debate. The time course of ACh release is controlled by a presynaptic inhibitory G protein-coupled autoreceptor (GPCR), whose agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kupchik YM,Rashkovan G,Ohana L,Keren-Raifman T,Dascal N,Parnas H,Parnas I

更新日期：2008-03-18 00:00:00

abstract：:The tat protein encoded by the human immunodeficiency virus type 1 is a potent trans-activator of gene expression from the viral long terminal repeat. The domains that are essential for trans-activation, a Pro-Xaa3-Pro triad, a cysteine-rich metal-binding sequence motif, and a cluster of basic residues, are present wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeyapaul J,Reddy MR,Khan SA

更新日期：1990-09-01 00:00:00

abstract：:The intracellular localization of phytochrome was seen in dark-grown oat (Avena sativa L., cv. Garry) and rice (Oryza sativa L., cv. unknown) shoots after various light treatments using an indirect peroxidase-antiperoxidase antibody labeling method. Phytochrome is generally distributed throughout the cytoplasm in cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackenzie JM Jr,Coleman RA,Briggs WR,Pratt LH

更新日期：1975-03-01 00:00:00

abstract：:Here we describe a strategy designed to identify RNAs that are actively transported to synapses during learning. Our approach is based on the characterization of RNA transport complexes carried by molecular motor kinesin. Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both codi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puthanveettil SV,Antonov I,Kalachikov S,Rajasethupathy P,Choi YB,Kohn AB,Citarella M,Yu F,Karl KA,Kinet M,Morozova I,Russo JJ,Ju J,Moroz LL,Kandel ER

更新日期：2013-04-30 00:00:00

abstract：:We have analyzed the spectra of UV-induced mutations in the lacI gene of a wild-type and an mfd strain of Escherichia coli. mfd strains have been recently proposed to be deficient in a factor coupling DNA repair and transcription. Analysis of UV-induced mutations occurring at adjacent pyrimidines showed that mutations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oller AR,Fijalkowska IJ,Dunn RL,Schaaper RM

更新日期：1992-11-15 00:00:00

abstract：:Foraminifera are unicellular organisms that inhabit the oceans in various ecosystems. The majority of the foraminifera precipitate calcitic shells and are among the major CaCO(3) producers in the oceans. They comprise an important component of the global carbon cycle and also provide valuable paleoceanographic informa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bentov S,Brownlee C,Erez J

更新日期：2009-12-22 00:00:00

abstract：:For more than a century we have understood that our brain's left hemisphere is the primary site for processing language, yet why this is so has remained more elusive. Using positron emission tomography, we report cerebral blood flow activity in profoundly deaf signers processing specific aspects of sign language in ke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petitto LA,Zatorre RJ,Gauna K,Nikelski EJ,Dostie D,Evans AC

更新日期：2000-12-05 00:00:00

abstract：:This work describes a multifunctional phage lambda expression vector system, lambda YES, designed to facilitate gene isolation from eukaryotes by complementation of Escherichia coli and Saccharomyces cerevisiae mutations. lambda YES vectors have a selection for cDNA inserts using an oligo adaptor strategy and are capa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elledge SJ,Mulligan JT,Ramer SW,Spottswood M,Davis RW

更新日期：1991-03-01 00:00:00