Abstract:
:For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous gamma-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and voltage-clamp experiments suggest that this synaptic transformation is due to a shift from a net increase of conductance to a net decrease of conductance in response to GABA. GABA-induced elevation of intracellular calcium is prolonged after the same stimulus pairing and may, therefore, contribute to this synaptic transformation via Ca(2+)-activated phosphorylation pathways. This synaptic transformation, which does not follow unpaired stimulus presentations, occurs in a neuronal compartment spatially separated from the soma, which also changes during stimulus pairing.
journal_name
Proc Natl Acad Sci U S Aauthors
Alkon DL,Sánchez-Andrés JV,Ito E,Oka K,Yoshioka T,Collin Cdoi
10.1073/pnas.89.24.11862keywords:
subject
Has Abstractpub_date
1992-12-15 00:00:00pages
11862-6issue
24eissn
0027-8424issn
1091-6490journal_volume
89pub_type
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