Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription.

abstract：:Endoproteolytic processing of the human protein C (HPC) precursor to its mature form involves cleavage of the propeptide after amino acids Lys-2-Arg-1 and removal of a Lys156-Arg157 dipeptide connecting the light and heavy chains. This processing was inefficient in the mammary gland of transgenic mice and pigs. We hyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drews R,Paleyanda RK,Lee TK,Chang RR,Rehemtulla A,Kaufman RJ,Drohan WN,Luboń H

更新日期：1995-11-07 00:00:00

abstract：:Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a determinant of the clinical course of heart failure. The molecular mechanism of this process, however, remains to be elucidated. Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi O,Higuchi Y,Hirotani S,Kashiwase K,Nakayama H,Hikoso S,Takeda T,Watanabe T,Asahi M,Taniike M,Matsumura Y,Tsujimoto I,Hongo K,Kusakari Y,Kurihara S,Nishida K,Ichijo H,Hori M,Otsu K

更新日期：2003-12-23 00:00:00

abstract：:Particles composed of secondary organic material (SOM) are abundant in the lower troposphere. The viscosity of these particles is a fundamental property that is presently poorly quantified yet required for accurate modeling of their formation, growth, evaporation, and environmental impacts. Using two unique techniques...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renbaum-Wolff L,Grayson JW,Bateman AP,Kuwata M,Sellier M,Murray BJ,Shilling JE,Martin ST,Bertram AK

更新日期：2013-05-14 00:00:00

abstract：:Electron micrographs of replicating lambda DNA molecules, during the period of progeny-particle DNA formation, show single-tailed circular structures. The tails are, predominantly, shorter than one viral genome. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiger JA Jr,Sinsheimer RL

更新日期：1971-01-01 00:00:00

abstract：:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatt MA,Lohrenz T,Camerer CF,Montague PR

更新日期：2012-05-29 00:00:00

abstract：:Using an antiserum raised against a synthetic C-terminal peptide of porcine pancreastatin, we detected pancreastatin-like immunoreactivity (PLI) in human pancreatic islets, adrenal medulla, and endocrine tumors. From a carcinoid liver metastasis, human PLI was extracted and purified by HPLC. Two C-terminally amidated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt WE,Siegel EG,Kratzin H,Creutzfeldt W

更新日期：1988-11-01 00:00:00

abstract：:Nonsyndromic clefting of the lip and palate in humans has a highly complex etiology, with both multiple genetic loci and exposure to teratogens influencing susceptibility. Previous studies using mouse models have examined only very small portions of the genome. Here we report the findings of a genome-wide search for s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diehl SR,Erickson RP

更新日期：1997-05-13 00:00:00

abstract：:In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbertson LA,Stahl FW

更新日期：1994-12-06 00:00:00

abstract：:The crystal structure of raite was solved and refined from data collected at Beamline Insertion Device 13 at the European Synchrotron Radiation Facility, using a 3 x 3 x 65 microm single crystal. The refined lattice constants of the monoclinic unit cell are a = 15.1(1) A; b = 17.6(1) A; c = 5.290(4) A; beta = 100.5(2)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pluth JJ,Smith JV,Pushcharovsky DY,Semenov EI,Bram A,Riekel C,Weber HP,Broach RW

更新日期：1997-11-11 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustino TF,Fitzgerald PJ,Ressler RL,Maren S

更新日期：2019-04-23 00:00:00

abstract：:Pollen tubes are highly polarized plant cells specialized in delivering sperm for fertilization. Pollen tube growth is rapid, occurs exclusively at the tip, and can reach distances thousands of times the diameter of the pollen grain without cell division, thus representing an excellent model system for studying asymme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AY,Niroomand S,Zou Y,Wu HM

更新日期：2010-09-14 00:00:00

abstract：:Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson's disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lewy bodies and Lewy neurites is the histological hallmark of these diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao K,Lim YJ,Liu Z,Long H,Sun Y,Hu JJ,Zhao C,Tao Y,Zhang X,Li D,Li YM,Liu C

更新日期：2020-08-18 00:00:00

abstract：:A biological membrane is conceptualized as a system in which membrane proteins are naturally matched to the equilibrium thickness of the lipid bilayer. Cholesterol, in addition to lipid composition, has been suggested to be a major regulator of bilayer thickness in vivo because measurements in vitro have shown that ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra K,Ubarretxena-Belandia I,Taguchi T,Warren G,Engelman DM

更新日期：2004-03-23 00:00:00

abstract：:Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

更新日期：2017-01-03 00:00:00

abstract：:The bright ultrafast pulses of X-ray Free-Electron Lasers allow investigation into the structure of matter under extreme conditions. We have used single pulses to ionize and probe water as it undergoes a phase transition from liquid to plasma. We report changes in the structure of liquid water on a femtosecond time sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beyerlein KR,Jönsson HO,Alonso-Mori R,Aquila A,Bajt S,Barty A,Bean R,Koglin JE,Messerschmidt M,Ragazzon D,Sokaras D,Williams GJ,Hau-Riege S,Boutet S,Chapman HN,Tîmneanu N,Caleman C

更新日期：2018-05-29 00:00:00

abstract：:We used positron emission tomography (PET) to examine the role of the hippocampal formation in implicit and explicit memory. Human volunteers studied a list of familiar words, and then they either provided the first word that came to mind in response to three-letter cues (implicit memory) or tried to recall studied wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schacter DL,Alpert NM,Savage CR,Rauch SL,Albert MS

更新日期：1996-01-09 00:00:00

abstract：:Optogenetic methods have been highly effective for suppressing neural activity and modulating behavior in rodents, but effects have been much smaller in primates, which have much larger brains. Here, we present a suite of technologies to use optogenetics effectively in primates and apply these tools to a classic quest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acker L,Pino EN,Boyden ES,Desimone R

更新日期：2016-11-15 00:00:00

abstract：:Integrated single-crystal-like small and wide-angle X-ray diffraction images of a CdSe nanosheet under pressure provide direct experimental evidence for the detailed pathway of transformation of the CdSe from a wurtzite to a rock-salt structure. Two consecutive planar atomic slips [(001) {110} in parallel and (102) {1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Z,Wen XD,Hoffmann R,Son JS,Li R,Fang CC,Smilgies DM,Hyeon T

更新日期：2010-10-05 00:00:00

abstract：:Neonicotinoid insecticides control crop pests based on their action as agonists at the insect nicotinic acetylcholine receptor, which accepts chloropyridinyl- and chlorothiazolyl-analogs almost equally well. In some cases, these compounds have also been reported to enhance plant vigor and (a)biotic stress tolerance, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ford KA,Casida JE,Chandran D,Gulevich AG,Okrent RA,Durkin KA,Sarpong R,Bunnelle EM,Wildermuth MC

更新日期：2010-10-12 00:00:00

abstract：:We have studied the genetic interactions between mutant alleles in 12 genes, designated PER1-PER12, which are essential for peroxisome biogenesis in the yeast Hansenula polymorpha. Recessive mutations in any of these genes determined three different morphological phenotypes: (i) complete absence of peroxisomes (Per-);...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Titorenko VI,Waterham HR,Cregg JM,Harder W,Veenhuis M

更新日期：1993-08-15 00:00:00

abstract：:A 978-base-pair gene that encodes thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) from Lactobacillus casei has been synthesized and inserted into Escherichia coli expression vectors. The DNA sequence contains 35 unique restriction sites that are located an average of 28 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Climie S,Santi DV

更新日期：1990-01-01 00:00:00

abstract：:The C-C chemokine receptor 5 (CCR5) plays a crucial role in facilitating the entry of macrophage-tropic strains of the HIV-1 into cells, but the mechanism of this phenomenon is completely unknown. To explore the role of CCR5-derived signal transduction in viral entry, we introduced mutations into two cytoplasmic domai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gosling J,Monteclaro FS,Atchison RE,Arai H,Tsou CL,Goldsmith MA,Charo IF

更新日期：1997-05-13 00:00:00

abstract：:To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

更新日期：1989-12-01 00:00:00

abstract：:Hydra interstitial stem cells continuously give rise to daughter stem cells as well as precursors for nerve and nematocyte differentiation. Growth of the stem cell population is controlled by the self-renewal probability (Ps): Ps is the fraction of stem cell daughters that remain stem cells in each generation. We have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David CN,MacWilliams H

更新日期：1978-02-01 00:00:00

abstract：:Secondary organic aerosol (SOA) comprises a significant portion of atmospheric particular matter. The impact of particular matter on both human health and global climate has long been recognized. Despite its importance, there are still many unanswered questions regarding the formation and evolution of SOA in the atmos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WL,Griffin RJ,Dabdub D

更新日期：2010-04-13 00:00:00

abstract：:Results are reported showing that pituitary extracts stimulate growth of 3T3 cells, an established line of mouse fibroblast. Cells were cultured in medium containing an organic buffer (HEPES; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid), which increases the serum requirement for cell growth. The pituitary grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armelin HA

更新日期：1973-09-01 00:00:00

abstract：:Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can be grounded...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Der R,Martius G

更新日期：2015-11-10 00:00:00

abstract：:Protein stability is usually studied in simple buffered solutions, but most proteins function inside cells, where the heterogeneous and crowded environment presents a complex, nonideal system. Proteins are expected to behave differently under cellular crowding owing to two types of contacts: hard-core repulsions and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar M,Smith AE,Pielak GJ

更新日期：2013-11-26 00:00:00

abstract：:C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a beta-amino acid, and a benzoxazolinate moiety. We now show that the benzoxazolinate moiety is derived from chorismate by the sequential action of two enzymes-SgcD, a 2-amino-2-deoxyisochorismate (ADIC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Lanen SG,Lin S,Shen B

更新日期：2008-01-15 00:00:00

abstract：:J-domain chaperones are involved in the efficient handover of misfolded/partially folded proteins to Hsp70 but also function independently to protect against cell death. Due to their high flexibility, the mechanism by which they regulate the Hsp70 cycle and how specific substrate recognition is performed remains unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karamanos TK,Tugarinov V,Clore GM

更新日期：2019-10-22 00:00:00