Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

abstract：:Glial cells are traditionally regarded as elements for structural support and ionic homeostasis, but have recently attracted attention as putative integral elements of the machinery involved in synaptic transmission and plasticity. Here, we demonstrate that calcium-binding protein S100B, which is synthesized in consid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishiyama H,Knopfel T,Endo S,Itohara S

更新日期：2002-03-19 00:00:00

abstract：:A recently described experimental system for analyzing the mode of action of a morphogen gradient involves the in situ hybridization of sectioned tissue constructs. In these constructs, a source of activin signaling induces the transcription of several mesodermal genes in blastula animal caps, according to the positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gurdon JB,Mitchell A,Ryan K

更新日期：1996-09-03 00:00:00

abstract：:Structural differences between dynein and kinesin suggest a unique molecular mechanism of dynein motility. Measuring the mechanical properties of a single molecule of dynein is crucial for revealing the mechanisms underlying its movement. We measured the step size and force produced by single molecules of active cytop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toba S,Watanabe TM,Yamaguchi-Okimoto L,Toyoshima YY,Higuchi H

更新日期：2006-04-11 00:00:00

abstract：:The highly polymorphic system of serologically defined genetic markers on human IgG heavy chains (Gm allotypes) is second only to the HLA complex in terms of the large number of determinants, alleles, and haplotypes that can be used for analyses of disease associations and other genetic studies. However, present typin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelaschi D,Newby C,Parsons M,van West B,Cavalli-Sforza LL,Herzenberg LA,Herzenberg LA

更新日期：1983-06-01 00:00:00

abstract：:The crystal structure of the decapeptide Boc-Aib-Glu(OBzl)-Leu-Aib-Ala-Leu-Aib-Ala-Lys(Z)-Aib-OMe (where Aib is alpha-aminoisobutyryl, Boc is t-butoxycarbonyl, OBzl is benzyl ester, and Z is benzyloxycarbonyl) illustrates a parallel zipper arrangement of interacting helical peptide columns. Head-to-tail NH...OC hydrog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karle IL,Flippen-Anderson JL,Uma K,Balaram P

更新日期：1990-10-01 00:00:00

abstract：:This report establishes that increasing the activity of cyclic AMP-dependent protein kinase (protein kinase A; PKA) potentiates glucocorticoid-mediated signaling in embryonic day 5.5 (E5.5) chicken retina. Expression of a glutamine synthetase-chloramphenicol acetyltransferase (CAT) fusion gene is not induced by treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Li YC,Young AP

更新日期：1993-05-01 00:00:00

abstract：:The apparatus of photosynthetic energy conversion in chloroplasts is quite well characterized with respect to structure and function. Light-driven electron transport in the thylakoid membrane is coupled to synthesis of ATP, used to drive energy-dependent metabolic processes in the stroma and the outer surface of the t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spetea C,Hundal T,Lundin B,Heddad M,Adamska I,Andersson B

更新日期：2004-02-03 00:00:00

abstract：:Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. An exponentially increasing number of channel structures captured in different conformational states are now being determined; however, these newly resolved structures are commonly classifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao S,Klesse G,Stansfeld PJ,Tucker SJ,Sansom MSP

更新日期：2019-07-09 00:00:00

abstract：:The hyperactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. We previously reported that in the murine brain, aminopeptidase A (APA) is involved in the conversion of angioten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fournie-Zaluski MC,Fassot C,Valentin B,Djordjijevic D,Reaux-Le Goazigo A,Corvol P,Roques BP,Llorens-Cortes C

更新日期：2004-05-18 00:00:00

abstract：:Stereotypical patterns of vascular and neuronal networks suggest that specific genetic programs tightly control path determination and, consequently, angiogenesis and axon-guidance mechanisms. Our study focuses on one member of the roundabout family of receptors, which traditionally mediate repulsion from the midline....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedell VM,Yeo SY,Park KW,Chung J,Seth P,Shivalingappa V,Zhao J,Obara T,Sukhatme VP,Drummond IA,Li DY,Ramchandran R

更新日期：2005-05-03 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw P,Eckstrand K,Sharp W,Blumenthal J,Lerch JP,Greenstein D,Clasen L,Evans A,Giedd J,Rapoport JL

更新日期：2007-12-04 00:00:00

abstract：:High-throughput screening (HTS) of chemical compounds to identify modulators of molecular targets is a mainstay of pharmaceutical development. Increasingly, HTS is being used to identify chemical probes of gene, pathway, and cell functions, with the ultimate goal of comprehensively delineating relationships between ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inglese J,Auld DS,Jadhav A,Johnson RL,Simeonov A,Yasgar A,Zheng W,Austin CP

更新日期：2006-08-01 00:00:00

abstract：:Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2 at 2.9 A, has about 37% molecular mass of the transmembrane portion not resolved. In this study, by applying a novel no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Wang Q,Ni F,Ma J

更新日期：2010-06-22 00:00:00

abstract：:Accurate and timely surface precipitation measurements are crucial for water resources management, agriculture, weather prediction, climate research, as well as ground validation of satellite-based precipitation estimates. However, the majority of the land surface of the earth lacks such data, and in many parts of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Overeem A,Leijnse H,Uijlenhoet R

更新日期：2013-02-19 00:00:00

abstract：:The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit ferrochelatase, has been isolated and purified. The pigment has been resolved into one major, one minor, and two trace components, all of which appear to be isomeric porphyrins. The major fract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz de Montellano PR,Beilan HS,Kunze KL

更新日期：1981-03-01 00:00:00

abstract：:The utilization of the isoaccepting species of leucyl-tRNA in protein synthesis has been examined in E. coli. Two minor leucyl-tRNA species, isoacceptors tRNA3Leu and tRNA4Leu, are the predominant species found bound to ribosomes during exponential growth in minimal medium. In rich medium, an increased proportion of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes WM,Goldman E,Miner TA,Hatfield GW

更新日期：1977-04-01 00:00:00

abstract：:Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder. The increase occurs in the apical plasma membrane of granular cells that line the urinary surface of the bladder and is produced by the insertion of water permeability units that have been identified by freeze-fracture electron mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris HW Jr,Wade JB,Handler JS

更新日期：1988-03-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two mediators synthesized by immune cells, specially under inflammatory and antigen stimulation conditions. Reports have shown that neuropeptides attenuate the deleterious consequences of septic shock both by down-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez C,Abad C,Delgado M,Arranz A,Juarranz MG,Rodriguez-Henche N,Brabet P,Leceta J,Gomariz RP

更新日期：2002-01-22 00:00:00

abstract：:The opposite slopes of "Evolution Canyon" in Israel have served as a natural model system of adaptation to a microclimate contrast. Long-term studies of Drosophila melanogaster populations inhabiting the canyon have exhibited significant interslope divergence in thermal and drought stress resistance, candidate genes, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hübner S,Rashkovetsky E,Kim YB,Oh JH,Michalak K,Weiner D,Korol AB,Nevo E,Michalak P

更新日期：2013-12-24 00:00:00

abstract：:The selective alteration of the cellular genome by laser microbeam irradiation has been extensively applied in cell biology. We report here the use of the third harmonic (355 nm) of an yttrium-aluminum garnet laser to facilitate the direct transfer of the neo gene into cultured human HT1080-6TG cells. The resultant tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao W,Wilkinson J,Stanbridge EJ,Berns MW

更新日期：1987-06-01 00:00:00

abstract：:We introduce the concept of hybridization chain reaction (HCR), in which stable DNA monomers assemble only upon exposure to a target DNA fragment. In the simplest version of this process, two stable species of DNA hairpins coexist in solution until the introduction of initiator strands triggers a cascade of hybridizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dirks RM,Pierce NA

更新日期：2004-10-26 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:A recently determined set of 20 NMR-derived conformations of a 48-residue all-alpha-helical protein, (PDB ID code 2JVD), is validated here by comparing the observed (13)C(alpha) chemical shifts with those computed at the density functional level of theory. In addition, a recently introduced physics-based method, aimed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vila JA,Aramini JM,Rossi P,Kuzin A,Su M,Seetharaman J,Xiao R,Tong L,Montelione GT,Scheraga HA

更新日期：2008-09-23 00:00:00

abstract：:Two high molecular weight growth inhibitors have been isolated from the culture medium of BSC-1 cells, epithelial cells of African green monkey kidney. The purified kidney epithelial cell growth inhibitors, at ng/ml concentrations, reversibly arrest the growth of BSC-1 cells in the G1 phase of the cell cycle. Their ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Böhlen P,Fava R,Baldwin JH,Kleeman G,Armour R

更新日期：1980-10-01 00:00:00

abstract：:Myosin VI is a molecular motor implicated in many processes, and it likely associates with a variety of cargoes that specify its functions. Although it is critical to Drosophila development, little is known about its cellular roles. To reveal its involvement in specific pathways, we sought to identify the binding part...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finan D,Hartman MA,Spudich JA

更新日期：2011-04-05 00:00:00

abstract：:Zeatin is the most active and ubiquitous of the naturally occurring cytokinins. The O-glucoside of zeatin, found in all plants examined, is considered to be important in cytokinin transport, storage, and protection against cytokinin oxidases. The enzyme UDPglucose:zeatin O-glucosyltransferase (EC 2.4.1.203) was previo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin RC,Mok MC,Mok DW

更新日期：1999-01-05 00:00:00

abstract：:Aqueous gel sieving chromatography on Sephadex G-10 of the Group IA cations (Li+, Na+, K+, Rb+, Cs+) plus NH4+ as the Cl- salts, in combination with previous results for the halide anions (F-, Cl-, Br-, I-) as the Na+ salts [Washabaugh, M.W. & Collins, K.D. (1986) J. Biol. Chem. 261, 12477-12485], leads to the followi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins KD

更新日期：1995-06-06 00:00:00

abstract：:X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain. The IL-2R gamma chain is a common component of the IL-2, IL-4, and IL-7 receptor sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiSanto JP,Rieux-Laucat F,Dautry-Varsat A,Fischer A,de Saint Basile G

更新日期：1994-09-27 00:00:00

abstract：:It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus. However, it remains unknown how thymocyte development so favors CD4 lineage development. To identify the basis of this asymmetry, we analyzed dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinclair C,Bains I,Yates AJ,Seddon B

更新日期：2013-07-30 00:00:00