Immunologic evidence that the gene for L-gulono-gamma-lactone oxidase is not expressed in animals subject to scurvy.

abstract：:The transforming growth factor-beta (TGF-beta) superfamily of growth factors and cytokines has been implicated in a variety of physiological and developmental processes within the cardiovascular system. Smad proteins are a recently described family of intracellular signaling proteins that transduce signals in response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Topper JN,DiChiara MR,Brown JD,Williams AJ,Falb D,Collins T,Gimbrone MA Jr

更新日期：1998-08-04 00:00:00

abstract：:The actin cytoskeleton is an essential intracellular filamentous structure that underpins cellular transport and cytoplasmic streaming in plant cells. However, the system-level properties of actin-based cellular trafficking remain tenuous, largely due to the inability to quantify key features of the actin cytoskeleton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breuer D,Nowak J,Ivakov A,Somssich M,Persson S,Nikoloski Z

更新日期：2017-07-11 00:00:00

abstract：:We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mink S,Mutschler B,Weiskirchen R,Bister K,Klempnauer KH

更新日期：1996-06-25 00:00:00

abstract：:A recently described organ culture system for human thymocytes is shown to support the generation of a diverse T-cell receptor repertoire in vitro: thymocytes of the alpha beta lineage, including representatives of the V beta families 5.2/5.3, 6.7, and 8, accounted for the majority of T-cell receptor-positive cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merkenschlager M,Fisher AG

更新日期：1992-05-15 00:00:00

abstract：:Analysis of the mRNA capping apparatus of the malaria parasite Plasmodium falciparum illuminates an evolutionary connection to fungi rather than metazoans. We show that P. falciparum encodes separate RNA guanylyltransferase (Pgt1) and RNA triphosphatase (Prt1) enzymes and that the triphosphatase component is a member ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho CK,Shuman S

更新日期：2001-03-13 00:00:00

abstract：:Zn2+ is critical for the functional and structural integrity of cells and contributes to a number of important processes including gene expression. It has been shown that NO exogenously applied via NO donors resulting in nitrosative stress leads to cytoplasmic Zn2+ release from the zinc storing protein metallothionein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spahl DU,Berendji-Grün D,Suschek CV,Kolb-Bachofen V,Kröncke KD

更新日期：2003-11-25 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-like loci and a mechanism for silencing two of them. How this system originated is unknown, because the three-locus system is present throughout the family Saccharomycetace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanson SJ,Byrne KP,Wolfe KH

更新日期：2014-11-11 00:00:00

abstract：:The stimulatory activity of peptides from the alpha 1 domain of the major histocompatibility complex (MHC) class I antigen on adipose cell glucose transport was previously shown to require a preformed, ordered conformation of the peptide. The two peptides studied previously were Dk-(61-85) (ERETQIAKGNEQSFRVDLRTLLRYY) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagsted J,Mapelli C,Meyers C,Matthews BW,Anfinsen CB,Goldstein A,Olsson L

更新日期：1993-08-15 00:00:00

abstract：:Administration of epidermal growth factor (EGF) to neonatal mice resulted in rapid tyrosine phosphorylation of a number of specific substrates in liver, kidney, lung, bladder, skin, and brain as detected by Western blot analysis of tissue homogenates with anti-phosphotyrosine antibodies. In the liver, three prominent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson RW,Cohen S

更新日期：1992-09-15 00:00:00

abstract：:The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale. Toward this end, we have designed custom arrays that interrogate the expression of the vast majority of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su AI,Wiltshire T,Batalov S,Lapp H,Ching KA,Block D,Zhang J,Soden R,Hayakawa M,Kreiman G,Cooke MP,Walker JR,Hogenesch JB

更新日期：2004-04-20 00:00:00

abstract：:In skeletal muscle, transcription of the gene encoding the mouse type Ialpha (RIalpha) subunit of the cAMP-dependent protein kinase is initiated from the alternative noncoding first exons 1a and 1b. Here, we report that activity of the promoter upstream of exon 1a (Pa) depends on two adjacent E boxes (E1 and E2) in NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barradeau S,Imaizumi-Scherrer T,Weiss MC,Faust DM

更新日期：2001-04-24 00:00:00

abstract：:Mosquitoes are major disease vectors because most species must feed on blood from a vertebrate host to produce eggs. Blood feeding by the vector mosquito Aedes aegypti triggers the release of two neurohormones, ovary ecdysteroidogenic hormone (OEH) and insulin-like peptides (ILPs), which activate multiple processes re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogel KJ,Brown MR,Strand MR

更新日期：2015-04-21 00:00:00

abstract：:There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Akt1 deficiency in mice results in structural and functional abnormalities in prefrontal cortex (PFC). Exploratory transcriptional profiling revealed concerted alterations in the expression of PFC gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai WS,Xu B,Westphal KG,Paterlini M,Olivier B,Pavlidis P,Karayiorgou M,Gogos JA

更新日期：2006-11-07 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:E. coli cells treated with the bifunctional crosslinking reagents dimethyl malonimidate, succinimidate, adipimidate, suberimidate, and sebacinimidate served for the isolation of rod-shaped "ghosts." These ghosts proved to be crosslinked over their entire surface; i.e., a macromolecule (resistant to boiling 1% Na dodec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller I,Henning U

更新日期：1974-05-01 00:00:00

abstract：:Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases. Indeed, humans deficient for DNA polymerase (pol) eta have decreased substitutions of A.T base pairs in variable and switch regions. To study the role of pol e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martomo SA,Yang WW,Wersto RP,Ohkumo T,Kondo Y,Yokoi M,Masutani C,Hanaoka F,Gearhart PJ

更新日期：2005-06-14 00:00:00

abstract：:While the general structure of immunoglobulin chains has remained relatively unchanged throughout evolution, the organization of the genes encoding these molecules differs substantially. To understand how the rearranging immunoglobulin system arose, it is necessary to examine living representatives of the most early v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohman VS,Schuchman DB,Schluter SF,Marchalonis JJ

更新日期：1993-11-01 00:00:00

abstract：:The neuropeptide galanin is expressed developmentally in the dorsal root ganglion (DRG) and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we report that adult mice carrying a loss-of-function mutation in the galanin gene have a 13% reduction in the number of cells in the DRG associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes FE,Mahoney S,King VR,Bacon A,Kerr NC,Pachnis V,Curtis R,Priestley JV,Wynick D

更新日期：2000-10-10 00:00:00

abstract：:Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of somatic point mutatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nekhaeva E,Bodyak ND,Kraytsberg Y,McGrath SB,Van Orsouw NJ,Pluzhnikov A,Wei JY,Vijg J,Khrapko K

更新日期：2002-04-16 00:00:00

abstract：:Semaphorin 4D (sema4D; CD100) is an integral membrane protein and the ligand for two receptors, CD72 and plexin-B1. Soluble sema4D has been shown to evoke angiogenic responses from endothelial cells and impair monocyte migration, but the origin of soluble sema4D, particularly at sites of vascular injury, has been uncl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Bergmeier W,Wu J,Jiang H,Stalker TJ,Cieslak M,Fan R,Boumsell L,Kumanogoh A,Kikutani H,Tamagnone L,Wagner DD,Milla ME,Brass LF

更新日期：2007-01-30 00:00:00

abstract：:Reducible compounds that participate in crosslinking were analyzed in hydroxylysine-deficient collagens of patients with a heritable disorder of connective tissue. After treatment with [(3)H]sodium borohydride, new compounds, as well as a totally different pattern of tritiated compounds, were found in hydroxylysine-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyre DR,Glimcher MJ

更新日期：1972-09-01 00:00:00

abstract：:Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP-17) is caused by mutations in the tau gene, and the signature lesions of FTDP-17 are filamentous tau inclusions. Tau mutations may be pathogenic either by altering protein function or gene regulation. Here we show that missense, silent, and intronic t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Souza I,Poorkaj P,Hong M,Nochlin D,Lee VM,Bird TD,Schellenberg GD

更新日期：1999-05-11 00:00:00

abstract：:Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accumulation of Man9GlcNAc2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagljar I,te Heesen S,Aebi M

更新日期：1994-06-21 00:00:00

abstract：:Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding elem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Nie F,Wang S,Li L

更新日期：2011-02-22 00:00:00

abstract：:Researchers have documented many cases in which individuals rationalize their regrettable actions. Four experiments examine situations in which people go beyond merely explaining away their misconduct to actively deceiving themselves. We find that those who exploit opportunities to cheat on tests are likely to engage ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance Z,Norton MI,Gino F,Ariely D

更新日期：2011-09-13 00:00:00

abstract：:Alternative ribosome subunit proteins are prevalent in the genomes of diverse bacterial species, but their functional significance is controversial. Attempts to study microbial ribosomal heterogeneity have mostly relied on comparing wild-type strains with mutants in which subunits have been deleted, but this approach ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YX,Xu ZY,Ge X,Sanyal S,Lu ZJ,Javid B

更新日期：2020-08-11 00:00:00

abstract：:Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve the performance of liquid biopsies so that they are highly predictive of cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) that uses 10 different methylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin S,Zhu D,Shao F,Chen S,Guo Y,Li K,Wang Y,Ding R,Gao L,Ma W,Lu T,Li D,Zhang Z,Cai S,Liang X,Song H,Ji L,Li J,Zheng Z,Jiang F,Wu X,Luan J,Zhang H,Yang Z,Cantor CR,Xu C,Ding C

更新日期：2021-02-02 00:00:00

abstract：:Almost all theoretical and experimental studies of the mechanisms underlying learning and memory focus on synaptic efficacy and make the implicit assumption that changes in synaptic efficacy are both necessary and sufficient to account for learning and memory. However, network dynamics depends on the complex interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E,Abbott LF,Turrigiano GG,Liu Z,Golowasch J

更新日期：1996-11-26 00:00:00

abstract：:Expansion of myeloid cells associated with solid tumor development is a key contributor to neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid cell production and activity in cancer remains poorly understood. Using a multistage mouse model of breast cancer, we show that product...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casbon AJ,Reynaud D,Park C,Khuc E,Gan DD,Schepers K,Passegué E,Werb Z

更新日期：2015-02-10 00:00:00