Abstract:
:We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc downregulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings identify a new function for Myc and reveal a novel mechanism by which Myc affects the expression of other genes.
journal_name
Proc Natl Acad Sci U S Aauthors
Mink S,Mutschler B,Weiskirchen R,Bister K,Klempnauer KHdoi
10.1073/pnas.93.13.6635subject
Has Abstractpub_date
1996-06-25 00:00:00pages
6635-40issue
13eissn
0027-8424issn
1091-6490journal_volume
93pub_type
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