Spontaneous activation of a human proto-oncogene.

abstract：:Incorporation and conversion of icosapentaenoic acid (20:5, n - 3) by human polymorphonuclear leukocytes were studied in volunteers (n = 6) ingesting a normal Western diet supplemented with icosapentaenoic acid (approximately equal to 4 g daily). Ingestion of icosapentaenoic acid leads to formation of biologically les...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strasser T,Fischer S,Weber PC

更新日期：1985-03-01 00:00:00

abstract：:We have shown that a scanning transmission electron microscope with a high brightness field emission source is capable of obtaining better than 3 A resolution using 30 to 40 keV electrons. Elastic dark field images of single atoms of uranium and mercury are shown which demonstrate this fact as determined by a modified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall J,Langmore J,Isaacson M,Crewe AV

更新日期：1974-01-01 00:00:00

abstract：:A decade ago, it seemed rational that our rapidly increasing knowledge of the molecular identities of tumor antigens and a deeper understanding of basic immunology would point the way to an effective therapeutic cancer vaccine. Significant progress has been made, but we do not yet have a cancer vaccine that can reliab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis JJ

更新日期：2004-10-05 00:00:00

abstract：:Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Komarova NL,Sengupta A,Jallepalli PV,Shih IeM,Vogelstein B,Lengauer C

更新日期：2002-12-10 00:00:00

abstract：:Homeobox 9 (HOXB9), a nontransforming transcription factor overexpressed in breast cancer, alters tumor cell fate and promotes tumor progression and metastasis. Here we show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In nonirradiated cells, HOXB9 induces spontaneous DNA damag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiba N,Comaills V,Shiotani B,Takahashi F,Shimada T,Tajima K,Winokur D,Hayashida T,Willers H,Brachtel E,Vivanco MD,Haber DA,Zou L,Maheswaran S

更新日期：2012-02-21 00:00:00

abstract：:Calcium signaling pathways control a variety of cellular events such as gene transcription, protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often involve a large number of calcium-binding proteins collectively known as the calmodulin or EF-hand protein superfamily. Many EF-hand protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikura M,Ames JB

更新日期：2006-01-31 00:00:00

abstract：:The visual (retinoid) cycle, the enzymatic pathway that regenerates chromophore after light absorption, is located primarily in the retinal pigment epithelium (RPE) and is essential for rod photoreceptor survival. Whether this pathway also is essential for cone photoreceptor survival is unknown, and there are no data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobson SG,Aleman TS,Cideciyan AV,Heon E,Golczak M,Beltran WA,Sumaroka A,Schwartz SB,Roman AJ,Windsor EA,Wilson JM,Aguirre GD,Stone EM,Palczewski K

更新日期：2007-09-18 00:00:00

abstract：:Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA. Six polyamides containing three to eight rings bind DNA sites 5-10 bp in length, respectively. Quantitative DNas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly JJ,Baird EE,Dervan PB

更新日期：1996-07-09 00:00:00

abstract：:The ability to control the placement of individual protein molecules on surfaces could enable advances in a wide range of areas, from the development of nanoscale biomolecular devices to fundamental studies in cell biology. Such control, however, remains a challenge in nanobiotechnology due to the limitations of curre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chai J,Wong LS,Giam L,Mirkin CA

更新日期：2011-12-06 00:00:00

abstract：:Protein-based hydrogels have emerged as promising alternatives to synthetic hydrogels for biomedical applications, owing to the precise control of structure and function enabled by protein engineering. Nevertheless, strategies for assembling 3D molecular networks that carry the biological information encoded in full-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun F,Zhang WB,Mahdavi A,Arnold FH,Tirrell DA

更新日期：2014-08-05 00:00:00

abstract：:Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buttke TM,Van Cleave S,Steelman L,McCubrey JA

更新日期：1989-08-01 00:00:00

abstract：:Fifteen tumor-containing specimens were obtained directly from patients with small cell carcinoma of the lung and tested for their ability to grow in serum-supplemented medium and in serum-free medium supplemented with hydrocortisone, insulin, transferrin, estrogen, and selenium (HITES). The tumor cells replicated in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carney DN,Bunn PA Jr,Gazdar AF,Pagan JA,Minna JD

更新日期：1981-05-01 00:00:00

abstract：:Habituation is a form of simple memory that suppresses neural activity in response to repeated, neutral stimuli. This process is critical in helping organisms guide attention toward the most salient and novel features in the environment. Here, we follow known circuit mechanisms in the fruit fly olfactory system to der...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen Y,Dasgupta S,Navlakha S

更新日期：2020-06-02 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Zhang X,Yuan P,Yang J,Xu Y,Grutzendler J,Shao Y,Moore A,Ran C

更新日期：2017-11-21 00:00:00

abstract：:To investigate the properties of metazoan replication origins, recent studies in cell culture have adopted the strategy of identifying origins using genome-wide approaches and assessing correlations with such features as transcription and histone modifications. Drosophila amplicon in follicle cells (DAFCs), genomic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JC,Orr-Weaver TL

更新日期：2011-10-04 00:00:00

abstract：:Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting complex (APC), a 20S particle cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Townsley FM,Aristarkhov A,Beck S,Hershko A,Ruderman JV

更新日期：1997-03-18 00:00:00

abstract：:The structural and functional organization of the Cct complex was addressed by genetic analyses of subunit interactions and catalytic cooperativity among five of the eight different essential subunits, Cct1p-Cct8p, in the yeast Saccharomyces cerevisiae. The cct1-1, cct2-3, and cct3-1 alleles, containing mutations at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin P,Sherman F

更新日期：1997-09-30 00:00:00

abstract：:Secondary (i.e., heterotrophic or animal) production is a main pathway of energy flow through an ecosystem as it makes energy available to consumers, including humans. Its estimation can play a valuable role in the examination of linkages between ecosystem functions and services. We found that oil and gas platforms of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claisse JT,Pondella DJ 2nd,Love M,Zahn LA,Williams CM,Williams JP,Bull AS

更新日期：2014-10-28 00:00:00

abstract：:The core enzyme of Escherichia coli RNA polymerase acquires essential promoter recognition and transcription initiation activities by binding one of several sigma subunits. To characterize the proximity between sigma70, the major sigma for transcription of the growth-related genes, and the core enzyme subunits (alpha2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owens JT,Miyake R,Murakami K,Chmura AJ,Fujita N,Ishihama A,Meares CF

更新日期：1998-05-26 00:00:00

abstract：:Peptide nucleic acid (PNA) is a DNA mimic that has shown considerable promise as a lead compound for developing gene therapeutic drugs. We report that PNAs targeted to functional and accessible sites in ribosomal RNA can inhibit translation in an Escherichia coli cell-free transcription/translation system, with 50% re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Good L,Nielsen PE

更新日期：1998-03-03 00:00:00

abstract：:The anti-hapten responses to the dinitrophenyl (Dnp) conjugate of the random linear terpolymers poly(L-Glu,LLys,LPhe), GLphi, or poly(LGlu,LLys,LAla), GLA, are of highly restricted heterogeneity. Thus, individual mice of most responder strains express an average of two to four anti-Dnp clones to Dnp-GLphi or Dnp-GLA, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipps TJ,Benacerraf B,Dorf ME

更新日期：1978-06-01 00:00:00

abstract：:The Drosophila melanogaster urate oxidase (UO)-encoding gene is expressed in the third-instar larva and adult. In contrast, the Drosophila pseudoobscura UO gene is only expressed in the adult, whereas the Drosophila virilis UO gene is expressed only in the third-instar larva. UO activity in these three Drosophila spec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallrath LL,Friedman TB

更新日期：1991-07-01 00:00:00

abstract：:In a field study, we show that a young song sparrow (i) selects his songs from three or four older birds who have neighboring territories, (ii) preferentially learns song types that these tutor neighbors share, and (iii) ultimately sets up his territory next to, or replaces, one of these tutor neighbors. The consequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beecher MD,Campbell SE,Stoddard PK

更新日期：1994-02-15 00:00:00

abstract：:To examine the hypothesis that bone marrow consists of discrete stem cell regulatory volumes or domains, we studied spleen colony-forming unit (CFU-S) population growth kinetics in unirradiated WBB6F1-W/Wv mice receiving various doses of +/+ bone marrow cells. Assay of femoral marrow CFU-S content in the eight recipie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maloney MA,Lamela RA,Banda MJ,Patt HM

更新日期：1982-02-01 00:00:00

abstract：:Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao W,Bao C,Lowenstein CJ

更新日期：2003-06-24 00:00:00

abstract：:Saposin A, a heat-stable 16-kDa glycoprotein, was isolated from Gaucher disease spleen and purified to homogeneity. Chemical sequencing from its amino terminus and of peptides obtained by digestion with protease from Staphylococcus aureus strain V-8 demonstrated that saposin A is derived from proteolytic processing of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morimoto S,Martin BM,Yamamoto Y,Kretz KA,O'Brien JS,Kishimoto Y

更新日期：1989-05-01 00:00:00

abstract：:Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integrate visual information. Here we used in vivo two-photon calcium imagi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochefort NL,Garaschuk O,Milos RI,Narushima M,Marandi N,Pichler B,Kovalchuk Y,Konnerth A

更新日期：2009-09-01 00:00:00

abstract：:Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ros-Bernal F,Hunot S,Herrero MT,Parnadeau S,Corvol JC,Lu L,Alvarez-Fischer D,Carrillo-de Sauvage MA,Saurini F,Coussieu C,Kinugawa K,Prigent A,Höglinger G,Hamon M,Tronche F,Hirsch EC,Vyas S

更新日期：2011-04-19 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00