Abstract:
:Previous findings of intact remote autobiographical memory in patients with medial temporal lobe damage have been questioned on the grounds that the narrative recollections were impoverished and fact-like and that the methods were not sufficiently sensitive to detect an impairment. We adopted a newer method, the Autobiographical Interview [Levine B, Svoboda E, Hay JF, Winocur G, Moscovitch M (2002) Psychol Aging 17:677-689], which uses extensive probing to elicit an average of 50 or more details per memory (in contrast to the approximately 20 details per memory elicited with previous methods). We found that autobiographical recollection was impaired in patients with medial temporal lobe damage when memories were drawn from the recent past but fully intact when memories were drawn from the remote past. Impaired remote autobiographical memory, which has sometimes been reported with this and other tests, is likely caused by significant damage outside the medial temporal lobe.
journal_name
Proc Natl Acad Sci U S Aauthors
Kirwan CB,Bayley PJ,Galván VV,Squire LRdoi
10.1073/pnas.0712155105subject
Has Abstractpub_date
2008-02-19 00:00:00pages
2676-80issue
7eissn
0027-8424issn
1091-6490pii
0712155105journal_volume
105pub_type
杂志文章abstract::The role of gene interactions in the evolutionary process has long been controversial. Although some argue that they are not of importance, because most variation is additive, others claim that their effect in the long term can be substantial. Here, we focus on the long-term effects of genetic interactions under direc...
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更新日期:2009-08-18 00:00:00
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更新日期:1990-04-01 00:00:00