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Structure of the human interleukin 2 gene.

Abstract：

:We have cloned two species of EcoRI-cleaved DNA segments that together cover the entire sequence for the human interleukin 2 gene and have determined the nucleotide sequence of the gene and its flanking regions. The gene contains three introns and the exon sequences can be aligned with the previously reported cDNA sequence almost perfectly except for a few nucleotides in the 3' nontranslated region. The promoter region contains a prototype "TATA" sequence as well as a notable palindromic sequence. Particularly interesting is the presence of sequences in this region that are homologous to the promoter region of the human interferon-gamma gene. In addition, a sequence that closely resembles the core sequence for the viral enhancer elements has been found in the second intron. Such sequences may play a role in the expression of the interleukin 2 gene in lectin- or antigen-stimulated T lymphocytes.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Fujita T,Takaoka C,Matsui H,Taniguchi T

doi

10.1073/pnas.80.24.7437

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

7437-41

issue

24

eissn

0027-8424

issn

1091-6490

journal_volume

80

pub_type

杂志文章

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