Direct brain recordings reveal hippocampal rhythm underpinnings of language processing.

abstract：:Heparan sulfate regulates diverse cell-surface signaling events, and its roles in the development of the nervous system recently have been increasingly uncovered by studies using genetic models carrying mutations of genes encoding enzymes for its synthesis. On the other hand, the role of heparan sulfate in the physiol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irie F,Badie-Mahdavi H,Yamaguchi Y

更新日期：2012-03-27 00:00:00

abstract：:We used a family-based cluster detection approach designed to localize significant rare disease-risk variants clusters within a region of interest to systematically search for schizophrenia (SCZ) susceptibility genes within 49 genomic loci previously implicated by de novo copy number variants. Using two independent wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ionita-Laza I,Xu B,Makarov V,Buxbaum JD,Roos JL,Gogos JA,Karayiorgou M

更新日期：2014-01-07 00:00:00

abstract：:During exercise, increased energy demands are met by increased glucose production that occurs simultaneously with the increased glucose uptake. We had previously observed that, during exercise, metabolic clearance rate of glucose (MCR) increases markedly in normal, but only marginally in poorly controlled diabetic dog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles PD,Yamatani K,Lickley HL,Vranic M

更新日期：1991-02-15 00:00:00

abstract：:Decision-makers increasingly seek scientific guidance on investing in nature, but biodiversity remains difficult to estimate across diverse landscapes. Here, we develop empirically based models for quantifying biodiversity across space. We focus on agricultural lands in the tropical forest biome, wherein lies the grea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mendenhall CD,Shields-Estrada A,Krishnaswami AJ,Daily GC

更新日期：2016-12-20 00:00:00

abstract：:T4 polynucleotide ligase efficiently catalyzes the head-to-tail joining of the ribo-oligoadenylates, r-(pA)(8) and r-(pA)(10), in the presence of high molecular weight deoxypolythymidylate. The enzyme also catalyzes the joining of deoxy-oligothymidylates, e.g., d-(pT)(10), in the presence of ribopolyadenylate. The enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleppe K,Van de Sande JH,Khorana HG

更新日期：1970-09-01 00:00:00

abstract：:Associative memory of the mollusc Hermissenda crassicornis, previously correlated with changes of specific K+ currents, protein phosphorylation, and increased synthesis of mRNA and specific proteins, is here shown to be accompanied by macroscopic alteration in the structure of a single identified neuron, the medial ty...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkon DL,Ikeno H,Dworkin J,McPhie DL,Olds JL,Lederhendler I,Matzel L,Schreurs BG,Kuzirian A,Collin C

更新日期：1990-02-01 00:00:00

abstract：:The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa (SLP-76), to analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushar ND,Corbo E,Schmidt M,Maltzman JS,Farber DL

更新日期：2010-01-12 00:00:00

abstract：:Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cain SM,Bohnet B,LeDue J,Yung AC,Garcia E,Tyson JR,Alles SR,Han H,van den Maagdenberg AM,Kozlowski P,MacVicar BA,Snutch TP

更新日期：2017-02-28 00:00:00

abstract：:The biological roles of estrogen-responsive finger protein (efp) in vivo were evaluated in mice carrying a loss-of-function mutation in efp by gene-targeted mutagenesis. Although efp homozygous mice were viable and fertile in both sexes, the uterus that expressed abundant estrogen receptor alpha exhibited significant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orimo A,Inoue S,Minowa O,Tominaga N,Tomioka Y,Sato M,Kuno J,Hiroi H,Shimizu Y,Suzuki M,Noda T,Muramatsu M

更新日期：1999-10-12 00:00:00

abstract：:Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonèche V,Portetelle D,Kettmann R,Willems L,Limbach K,Paoletti E,Ruysschaert JM,Burny A,Brasseur R

更新日期：1992-05-01 00:00:00

abstract：:Summertime Arctic shipboard observations of oxygenated volatile organic compounds (OVOCs) such as organic acids, key precursors of climatically active secondary organic aerosol (SOA), are consistent with a novel source of OVOCs to the marine boundary layer via chemistry at the sea surface microlayer. Although this sou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mungall EL,Abbatt JPD,Wentzell JJB,Lee AKY,Thomas JL,Blais M,Gosselin M,Miller LA,Papakyriakou T,Willis MD,Liggio J

更新日期：2017-06-13 00:00:00

abstract：:Much of the success of Plasmodium falciparum in establishing persistent infections is attributed to immune evasion through antigenic variation. This process involves periodically exchanging variants of the major surface antigen PfEMP1, a protein also responsible for parasite cytoadherence. PfEMP1 is encoded by genes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ralph SA,Scheidig-Benatar C,Scherf A

更新日期：2005-04-12 00:00:00

abstract：:Many empirical studies throughout the social and biomedical sciences focus only on very narrow outcomes such as income, or a single specific disease state, or a measure of positive affect. Human well-being or flourishing, however, consists in a much broader range of states and outcomes, certainly including mental and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanderWeele TJ

更新日期：2017-08-01 00:00:00

abstract：:Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-alpha), fibroblast interferon (IFN-beta), or immune interferon (INF-gamma) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-alpha and IFN-beta genes to the sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trent JM,Olson S,Lawn RM

更新日期：1982-12-01 00:00:00

abstract：:Most human cancers are of monoclonal origin and display many genetic alterations. In an effort to determine whether clonal expansion itself could account for the large number of genetic alterations, we compared spontaneous transformation in cloned and uncloned populations of NIH 3T3 cells. We have reported that progre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow M,Rubin H

更新日期：2000-01-04 00:00:00

abstract：:The photoproduct of carbon monoxide myoglobin generated at 4 K and lower has a resonance Raman spectrum characteristic of a high-spin heme but in which the high-frequency core size-sensitive lines are at lower frequency than those in the deoxy preparation. Such differences are not detected in the photoproduct generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau DL,Argade PV

更新日期：1986-03-01 00:00:00

abstract：:The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schewe DM,Aguirre-Ghiso JA

更新日期：2008-07-29 00:00:00

abstract：:Energy-coupling factor (ECF) transporters are a recently discovered family of primary active transporters for micronutrients and vitamins, such as biotin, thiamine, and riboflavin. Found exclusively in archaea and bacteria, including the human pathogens Listeria, Streptococcus, and Staphylococcus, ECF transporters may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karpowich NK,Wang DN

更新日期：2013-02-12 00:00:00

abstract：:Molecular dynamics simulations of the response to oscillating electric field elicited from an altitudinal dipolar molecular rotor mounted on the Au(111) surface and previously studied experimentally in static fields show unidirectional rotation in one of the three pairs of conformational enantiomers. The simulations a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horinek D,Michl J

更新日期：2005-10-04 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has between 10(4) and 10(5) clones of HTLV-1-infected T lymphocytes, each clone distinguished by the genomic integration site of the single-copy HTLV-1 provirus. The HTL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR

更新日期：2016-03-15 00:00:00

abstract：:The effects of divalent ionophores (A23187 and ionomycin), Ca2+ channel agonist (BAY K 8644), and protein kinase C (C-kinase) activators [phorbol 12-myristate 13-acetate (PMA), mezerein] on bovine tracheal smooth muscle contraction were investigated. A23187 (5 microM) and ionomycin (0.5 microM) produced a prompt but t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Rasmussen H

更新日期：1985-12-01 00:00:00

abstract：:Serum RNase (ribonuclease) of normal persons and of patients with pancreatitis, carcinoma of pancreas, or other neoplasms was determined with poly(C) as substrate. Strikingly abnormal elevations occur in the serum RNase of patients with pancreatic cancer. There is no elevation in the serum RNase level of patients with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddi KK,Holland JF

更新日期：1976-07-01 00:00:00

abstract：:To improve the usefulness of in vivo mode for the investigation of the pathophysiology of human immunodeficiency virus (HIV) infection, we modified the construction of SCID mice implanted with human fetal thymus and liver (thy/liv-SCID-hu mice) so that the peripheral blood of the mice contained significant numbers of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kollmann TR,Pettoello-Mantovani M,Katopodis NF,Hachamovitch M,Rubinstein A,Kim A,Goldstein H

更新日期：1996-04-02 00:00:00

abstract：:Hepatitis C virus (HCV) infects nearly 3% of the population of the world and is a major cause of liver disease. However, the mechanism whereby the virus targets the liver for infection remains unknown, because none of the putative cellular receptors for HCV are both expressed specifically in the liver and capable of b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner JP,Durso RJ,Arrigale RR,Donovan GP,Maddon PJ,Dragic T,Olson WC

更新日期：2003-04-15 00:00:00

abstract：:Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl compounds. Spectrophotometric measurement of these moieties, after their reaction with 2,4-dinitrophenylhydrazine, is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Requena JR,Chao CC,Levine RL,Stadtman ER

更新日期：2001-01-02 00:00:00

abstract：:Widespread belief in misinformation circulating online is a critical challenge for modern societies. While research to date has focused on psychological and political antecedents to this phenomenon, few studies have explored the role of digital media literacy shortfalls. Using data from preregistered survey experiment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guess AM,Lerner M,Lyons B,Montgomery JM,Nyhan B,Reifler J,Sircar N

更新日期：2020-07-07 00:00:00

abstract：:ATP is copackaged and coreleased with adrenergic, serotonergic, and cholinergic neurotransmitters, suggesting a possible interaction between the signaling pathways for ATP and these coreleased neurotransmitters. Muscarinic m2 and m4, alpha 2-adrenergic, and D2-dopaminergic neurotransmitter receptors, which have in com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felder CC,Williams HL,Axelrod J

更新日期：1991-08-01 00:00:00

abstract：:For beta-D-glucosylisophosphoramide mustard (beta-D-Glc-IPM), a new alkylating drug in which isophosphoramide mustard is stabilized, a higher selectivity and lower myelotoxicity was observed than for the currently used cytostatic ifosfamide. Because beta-D-Glc-IPM is hydrophilic and does not diffuse passively through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veyhl M,Wagner K,Volk C,Gorboulev V,Baumgarten K,Weber WM,Schaper M,Bertram B,Wiessler M,Koepsell H

更新日期：1998-03-17 00:00:00

abstract：:Successful adaptation to changes in an animal's emotional and motivational environment depends on behavioral flexibility accompanied by changes in bodily responses, e.g., autonomic and endocrine, which support the change in behavior. Here, we identify the orbitofrontal cortex (OFC) as pivotal in the flexible regulatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reekie YL,Braesicke K,Man MS,Roberts AC

更新日期：2008-07-15 00:00:00

abstract：:Stable isotope values of carbon (delta13C) and nitrogen (delta15N) in blood, feathers, eggshell, and bone have been used in seabird studies since the 1980s, providing a valuable source of information on diet, foraging patterns, and migratory behavior in these birds. These techniques can also be applied to fossil mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emslie SD,Patterson WP

更新日期：2007-07-10 00:00:00