Regulation of p53 tetramerization and nuclear export by ARC.

abstract：:Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked mu, delta, and kappa opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon receptor activation. However, little is known about which of the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KS,Lee KW,Lee KW,Im JY,Yoo JY,Kim SW,Lee JK,Nestler EJ,Han PL

更新日期：2006-03-07 00:00:00

abstract：:Excited electronic states created by UV excitation of the diribonucleoside monophosphates ApA, ApG, ApC, ApU, and CpG were studied by the femtosecond transient-absorption technique. Bleach recovery signals recorded at 252 nm show that long-lived excited states are formed in all five dinucleosides. The lifetimes of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takaya T,Su C,de La Harpe K,Crespo-Hernández CE,Kohler B

更新日期：2008-07-29 00:00:00

abstract：:Retinoblastoma-related (RBR) proteins regulate cell division in higher eukaryotes by controlling the adenovirus E2 promoter binding factor (E2F)/dimerization partner (DP) family of transcription factors that regulate expression of many genes involved in cell-cycle progression. We identified a previously undescribed me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabelli PA,Dante RA,Leiva-Neto JT,Jung R,Gordon-Kamm WJ,Larkins BA

更新日期：2005-09-13 00:00:00

abstract：:Glycoprotein Ib is a surface membrane glycoprotein of platelets that functions as a receptor for von Willebrand factor. It is a heterodimer composed of an alpha and a beta chain linked by a disulfide bond(s). A phage lambda gt11 cDNA expression library prepared from mRNA from a human erythroleukemia cell line, HEL, wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez JA,Chung DW,Fujikawa K,Hagen FS,Papayannopoulou T,Roth GJ

更新日期：1987-08-01 00:00:00

abstract：:The binding of 125I-labeled wheat germ agglutinin (WGA) to parental and three distinct WGA-resistant Chinese hamster ovary cell lines possessing modified cell surface carbohydrate structures has been examined over a 10(6)-fold range of WGA concentrations. The Scatchard plot for WGA binding to parental cells was comple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanley P,Carver JP

更新日期：1977-11-01 00:00:00

abstract：:Access to robust and information-rich human cardiac tissue models would accelerate drug-based strategies for treating heart disease. Despite significant effort, the generation of high-fidelity adult-like human cardiac tissue analogs remains challenging. We used computational modeling of tissue contraction and assembly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thavandiran N,Dubois N,Mikryukov A,Massé S,Beca B,Simmons CA,Deshpande VS,McGarry JP,Chen CS,Nanthakumar K,Keller GM,Radisic M,Zandstra PW

更新日期：2013-12-03 00:00:00

abstract：:Histone methyltransferase G9a has critical roles in promoting cancer-cell growth and gene suppression, but whether it is also associated with the DNA damage response is rarely studied. Here, we report that loss of G9a impairs DNA damage repair and enhances the sensitivity of cancer cells to radiation and chemotherapeu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Q,Zhu Q,Lu X,Du Y,Cao L,Shen C,Hou T,Li M,Li Z,Liu C,Wu D,Xu X,Wang L,Wang H,Zhao Y,Yang Y,Zhu WG

更新日期：2017-07-25 00:00:00

abstract：:Studies of the accelerated aging disorder Hutchinson-Gilford progeria syndrome (HGPS) can potentially reveal cellular defects associated with physiological aging. HGPS results from expression and abnormal nuclear envelope association of a farnesylated, truncated variant of prelamin A called "progerin." We surveyed the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang W,Wang Y,Luxton GWG,Östlund C,Worman HJ,Gundersen GG

更新日期：2019-02-26 00:00:00

abstract：:The apoprotein corresponding to the mammalian photoreceptor rhodopsin has been expressed by using suspension cultures of HEK293S cells in defined media that contained 6-15N-lysine and 2-13C-glycine. Typical yields were 1.5-1.8 mg/liter. Incorporation of 6-15N-lysine was quantitative, whereas that of 2-13C-glycine was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eilers M,Reeves PJ,Ying W,Khorana HG,Smith SO

更新日期：1999-01-19 00:00:00

abstract：:The basic helix-loop-helix transcriptional repressor Hairy-related transcription factor 2 (Hrt2) is expressed in ventricular, but not atrial, cardiomyocytes, and in endothelial and vascular smooth muscle cells. Mice homozygous for a null mutation of Hrt2 die perinatally from a spectrum of cardiac abnormalities, raisin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xin M,Small EM,van Rooij E,Qi X,Richardson JA,Srivastava D,Nakagawa O,Olson EN

更新日期：2007-05-08 00:00:00

abstract：:The suggested role of adenosine 3':5'-cyclic monophosphate as the "second messenger" in the neurite outgrowth from chick embryonic sensory ganglia mediated by nerve growth factor was examined. Although N(6),O(2)-dibutyryl adenosine 3':5'-cyclic monophosphate induces fiber outgrowth at concentrations of 1-5 mM, this re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frazier WA,Ohlendorf CE,Boyd LF,Aloe L,Johnson EM,Ferrendelli JA,Bradshaw RA

更新日期：1973-08-01 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate added to exponentially growing cells of Hemophilus influenzae strain Rd increases competence for transformation 100- to 10,000-fold. Cyclic AMP added to near-stationary or stationary cells does not increase competence over the high level normally found in the early stationary phase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Alexander SP,Powers M

更新日期：1973-02-01 00:00:00

abstract：:The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an otherwise hydrophobic core. This layer has an undetermined function; it consists of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scales SJ,Yoo BY,Scheller RH

更新日期：2001-12-04 00:00:00

abstract：:A pentapeptide open reading frame equipped with a canonical ribosome-binding site is present in the Escherichia coli 23S rRNA. Overexpression of 23S rRNA fragments containing the mini-gene renders cells resistant to the ribosome-inhibiting antibiotic erythromycin. Mutations that change either the initiator or stop cod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tenson T,DeBlasio A,Mankin A

更新日期：1996-05-28 00:00:00

abstract：:Monospecific antibodies were produced in vitro by fusing mouse myeloma cells with spleen cells from a BALB/c mouse immunized with rat skeletal myofibrils. After cloning 3 times on agarose, two stable clones were obtained and chosen for further characterization. The first clone, JLB1, produced an antibody that recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin JJ

更新日期：1981-04-01 00:00:00

abstract：:The ability of basic/leucine zipper transcription factors to form homo- and heterodimers potentially increases the diversity of signaling pathways that can impinge upon a single genetic element. The capacity of these proteins to dimerize in various combinations complicates the analysis of their functional properties, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loriaux MM,Rehfuss RP,Brennan RG,Goodman RH

更新日期：1993-10-01 00:00:00

abstract：:Exchange proteins directly activated by cAMP (Epac1 and Epac2) have been recently recognized as key players in β-adrenergic-dependent cardiac arrhythmias. Whereas Epac1 overexpression can lead to cardiac hypertrophy and Epac2 activation can be arrhythmogenic, it is unknown whether distinct subcellular distribution of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira L,Rehmann H,Lao DH,Erickson JR,Bossuyt J,Chen J,Bers DM

更新日期：2015-03-31 00:00:00

abstract：:Mismatch repair (MMR) is a major DNA repair pathway in cells from all branches of life that removes replication errors in a strand-specific manner, such that mismatched nucleotides are preferentially removed from the newly replicated strand of DNA. Here we demonstrate a role for MMR in helping create new phenotypes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez GP,Romanova NV,Bao G,Rouf NC,Kow YW,Crouse GF

更新日期：2012-04-17 00:00:00

abstract：:For the emergence of early life, the formation of biopolymers such as RNA is essential. However, the addition of nucleotide monomers to existing oligonucleotides requires millimolar concentrations. Even in such optimistic settings, no polymerization of RNA longer than about 20 bases could be demonstrated. How then cou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mast CB,Schink S,Gerland U,Braun D

更新日期：2013-05-14 00:00:00

abstract：:Mitochondrial dysfunctions cause numerous human disorders. A platform technology based on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix could be of enormous potential benefit in treating mitochondrial diseases. Here we report a rationally designed mitochondria-targeted polymeric n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Dhar S

更新日期：2012-10-02 00:00:00

abstract：:The antigen recognition of a profoundly immunosuppressive mAb, mAb 2E1, in vivo was investigated. In addition to the 62-kDa effector cell protease receptor 1, mAb 2E1 bound the 32-kDa T cell adhesion receptor E2 (CD99) and the 86-kDa p80 subunit of the nuclear antigen complex Ku. These molecules share no overall seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothermel AL,Altieri DC

更新日期：1998-03-31 00:00:00

abstract：:Modern protein crystal structures are based nearly exclusively on X-ray data collected at cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little bias in the functional interpretation of structural results, because cryogenic temperatures minimally perturb the overall protein backbo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraser JS,van den Bedem H,Samelson AJ,Lang PT,Holton JM,Echols N,Alber T

更新日期：2011-09-27 00:00:00

abstract：:The adult repertoire of antibody specificities is acquired in a developmentally programmed fashion that, in mouse and man, parallels the ordered rearrangement of a limited number of germ-line heavy chain variable region (VH) gene segments during development. It has been hypothesized that this developmental bias is a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willems van Dijk K,Milner LA,Sasso EH,Milner EC

更新日期：1992-11-01 00:00:00

abstract：:Pseudomonas fluorescens Pf-5, a rhizosphere-inhabiting bacterium that suppresses several soilborne pathogens of plants, produces the antibiotics pyrrolnitrin, pyoluteorin, and 2,4-diacetylphloroglucinol. A gene necessary for pyrrolnitrin production by Pf-5 was identified as rpoS, which encodes the stationary-phase sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarniguet A,Kraus J,Henkels MD,Muehlchen AM,Loper JE

更新日期：1995-12-19 00:00:00

abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

更新日期：2015-12-08 00:00:00

abstract：:The murine-virus-infected erythroleukemia cell system provides an opportunity to examine regulatory mechanisms controlling cytodifferentiation. A cloned cell line (DR10c3) resistant to the erythropoiesis-inducing effect of dimethylsulfoxide (Me2SO) was isolated from the Me2SO-sensitive line DS19. DR10c3 is characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohta Y,Tanaka M,Terada M,Miller OJ,Bank A,Marks P,Rifkind RA

更新日期：1976-04-01 00:00:00

abstract：:Lethal factor, the principal virulence factor of Bacillus anthracis, inhibits mitogen-activated protein kinase (MAPK) signaling by proteolytically cleaving MAPK kinases. Edema factor, another component of anthrax toxin, is an adenylate cyclase, which increases intracellular cAMP. Inhibition of MAPK signaling with eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koo HM,VanBrocklin M,McWilliams MJ,Leppla SH,Duesbery NS,Vande Woude GF

更新日期：2002-03-05 00:00:00

abstract：:Use-dependent long-term changes of neuronal response properties must be gated to prevent irrelevant activity from inducing inappropriate modifications. Here we test the hypothesis that local network dynamics contribute to such gating. As synaptic modifications depend on temporal contiguity between presynaptic and post...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RAW,Munk MHJ,Singer W

更新日期：2019-11-12 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:We have analyzed the cell cycle regulation of human cyclin-dependent kinase 2 (CDK2), a protein closely related to the cell cycle-regulatory protein kinase CDC2. We find that CDK2 activity, like that of CDC2, oscillates during the cell cycle in cultured mammalian fibroblasts. Unlike CDC2 activity (which peaks during m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenblatt J,Gu Y,Morgan DO

更新日期：1992-04-01 00:00:00