Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.

abstract：:High molecular weight proteins extracted from the walking nerves of the shore crab (Carcinus maenas) exhibit a cycle of phosphorylation-dephosphorylation that is influenced by neurotropic compounds and inorganic ions. The net phosphorylation state of the proteins is increased in the presence of K+ ions and decreased w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoffeniels E,Dandrifosse G

更新日期：1980-02-01 00:00:00

abstract：:Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ponmalar II,Cheerla R,Ayappa KG,Basu JK

更新日期：2019-06-25 00:00:00

abstract：:Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luft CDB,Zioga I,Thompson NM,Banissy MJ,Bhattacharya J

更新日期：2018-12-26 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) DNA was treated with four restriction endonucleases (EcoRI, HincIII, Bgl II, and Xba I) and eight fragments were purified and labeled with 32P in vitro. The kinetics of renaturation of each of the fragments was measured in the presence of DNA extracted from 333-8-9, a hamster cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galloway DA,Copple CD,McDougall JK

更新日期：1980-02-01 00:00:00

abstract：:The mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyckman AW,Horng S,Leamey CA,Tropea D,Watakabe A,Van Wart A,McCurry C,Yamamori T,Sur M

更新日期：2008-07-08 00:00:00

abstract：:Ferredoxin:NADP oxidoreductases (FNRs) constitute a family of flavoenzymes that catalyze the exchange of reducing equivalents between one-electron carriers and the two-electron-carrying NADP(H). The main role of FNRs in cyanobacteria and leaf plastids is to provide the NADPH for photoautotrophic metabolism. In root pl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas JC,Ughy B,Lagoutte B,Ajlani G

更新日期：2006-11-28 00:00:00

abstract：:The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer. We find that miR-182, member of a miRNA cluster in a chromosomal locus (7q31-34) frequently amplified in melanoma, is commonly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segura MF,Hanniford D,Menendez S,Reavie L,Zou X,Alvarez-Diaz S,Zakrzewski J,Blochin E,Rose A,Bogunovic D,Polsky D,Wei J,Lee P,Belitskaya-Levy I,Bhardwaj N,Osman I,Hernando E

更新日期：2009-02-10 00:00:00

abstract：:Cell cycle-controlled human histone genes are coordinately expressed during S phase, and transcriptional regulation involves a series of trans-acting factors (HiNFs). The proliferation-specific factor HiNF-D interacts with multiple recognition motifs in histone H4, H3, and H1 promoters. Using gel shift immunoassays, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Wijnen AJ,Aziz F,Graña X,De Luca A,Desai RK,Jaarsveld K,Last TJ,Soprano K,Giordano A,Lian JB

更新日期：1994-12-20 00:00:00

abstract：:The beta-globin locus control region (LCR) consists of four erythroid-specific DNase I-hypersensitive sites, which are necessary for high-level expression of the beta-like globin genes in erythroid tissues. One of these sites, designated 5'HS-2, functions as an erythroid-specific enhancer element in transfection and t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu D,Chang JC,Moi P,Liu W,Kan YW,Curtin PT

更新日期：1992-05-01 00:00:00

abstract：:In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maita N,Okada K,Hatakeyama K,Hakoshima T

更新日期：2002-02-05 00:00:00

abstract：:The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability neces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisman JE,Goldring MA

更新日期：1988-07-01 00:00:00

abstract：:Recently, the focus of network research shifted to network controllability, prompting us to determine proteins that are important for the control of the underlying interaction webs. In particular, we determined minimum dominating sets of proteins (MDSets) in human and yeast protein interaction networks. Such groups of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wuchty S

更新日期：2014-05-13 00:00:00

abstract：:Type VI secretion systems (T6SSs) are multiprotein complexes best studied in Gram-negative pathogens where they have been shown to inhibit or kill prokaryotic or eukaryotic cells and are often important for virulence. We recently showed that T6SS loci are also widespread in symbiotic human gut bacteria of the order Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatzidaki-Livanis M,Geva-Zatorsky N,Comstock LE

更新日期：2016-03-29 00:00:00

abstract：:The ribosome is one of the major targets for therapeutic antibiotics; however, the rise in multidrug resistance is a growing threat to the utility of our current arsenal. The orthosomycin antibiotics evernimicin (EVN) and avilamycin (AVI) target the ribosome and do not display cross-resistance with any other classes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arenz S,Juette MF,Graf M,Nguyen F,Huter P,Polikanov YS,Blanchard SC,Wilson DN

更新日期：2016-07-05 00:00:00

abstract：:In Salmonella typhimurium, the CobU, CobS, CobT, and CobC proteins have been proposed to catalyze the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. This paper reports the in vitro assembly of the nucleotide loop of adenosylcobalamin from its precursors adenosylcobinam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maggio-Hall LA,Escalante-Semerena JC

更新日期：1999-10-12 00:00:00

abstract：:Degeneracy, the ability of elements that are structurally different to perform the same function or yield the same output, is a well known characteristic of the genetic code and immune systems. Here, we point out that degeneracy is a ubiquitous biological property and argue that it is a feature of complexity at geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman GM,Gally JA

更新日期：2001-11-20 00:00:00

abstract：:We study a simple antiplane fault of finite length embedded in a homogeneous isotropic elastic solid to understand the origin of seismic source heterogeneity in the presence of nonlinear rate- and state-dependent friction. All the mechanical properties of the medium and friction are assumed homogeneous. Friction inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madariaga R,Cochard A

更新日期：1996-04-30 00:00:00

abstract：:Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do not covalently mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl WE,Lalwani ND,Watanabe T,Goel SK,Reddy JK

更新日期：1984-12-01 00:00:00

abstract：:The induction of hemoglobin synthesis by dimethylsulfoxide in cells infected with Friend leukemia virus has been shown to depend on the number of cell divisions after the addition of the inducing agent. In asynchronous cultures the cells have a generation time of 24 hr, and hemoglobin synthesis occurs after 48 hr in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClintock PR,Papaconstantinou J

更新日期：1974-11-01 00:00:00

abstract：:Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that misexpression of Shh is a common requirement for generating extra digits. Here we identify a translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lettice LA,Horikoshi T,Heaney SJ,van Baren MJ,van der Linde HC,Breedveld GJ,Joosse M,Akarsu N,Oostra BA,Endo N,Shibata M,Suzuki M,Takahashi E,Shinka T,Nakahori Y,Ayusawa D,Nakabayashi K,Scherer SW,Heutink P,Hill RE

更新日期：2002-05-28 00:00:00

abstract：:Human craniofacial data were used to assess the similarities and differences between recent and prehistoric Old World samples, and between these samples and a similar representation of samples from the New World. The data were analyzed by the neighbor-joining clustering procedure, assisted by bootstrapping and by cano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brace CL,Nelson AR,Seguchi N,Oe H,Sering L,Qifeng P,Yongyi L,Tumen D

更新日期：2001-08-14 00:00:00

abstract：:Transport affects climate directly and indirectly through mechanisms that cause both warming and cooling of climate, and the effects operate on very different timescales. We calculate climate responses in terms of global mean temperature and find large differences between the transport sectors with respect to the size...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berntsen T,Fuglestvedt J

更新日期：2008-12-09 00:00:00

abstract：:This paper studies the cathodic corrosion of a spherical single crystal of platinum in an aqueous alkaline electrolyte, to map out the detailed facet dependence of the corrosion structures forming during this still largely unexplored electrochemical phenomenon. We find that anisotropic corrosion of the platinum electr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arulmozhi N,Hersbach TJP,Koper MTM

更新日期：2020-12-22 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:The lipid monogalactosyl diacylglycerol (MGD) is a major structural component of photosynthetic membranes in chloroplasts. Its formation is catalyzed by the enzyme MGD synthase. In many plants, MGD derives from two different biosynthetic pathways: the prokaryotic pathway, which operates entirely within the plastid, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis P,Dörmann P,Peto CA,Lutes J,Benning C,Chory J

更新日期：2000-07-05 00:00:00

abstract：:We have constructed an opal suppressor system in Escherichia coli to complement an existing amber suppressor system to study the structural basis of tRNA acceptor identity, particularly the role of middle anticodon nucleotide at position 35. The opal suppressor tRNA contains a UCA anticodon and the mRNA of the suppres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClain WH,Foss K,Jenkins RA,Schneider J

更新日期：1990-12-01 00:00:00

abstract：:The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Emu enhancer led to high PrP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raeber AJ,Sailer A,Hegyi I,Klein MA,Rülicke T,Fischer M,Brandner S,Aguzzi A,Weissmann C

更新日期：1999-03-30 00:00:00

abstract：:TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

更新日期：2018-04-10 00:00:00

abstract：:Cigarette smoke is the major cause of lung cancer, the leading cause of cancer death, and of chronic obstructive pulmonary disease, the fourth leading cause of death in the United States. Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spira A,Beane J,Shah V,Liu G,Schembri F,Yang X,Palma J,Brody JS

更新日期：2004-07-06 00:00:00

abstract：:The mammalian AML/CBFalpha runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most mammalian RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro). Using a yeast two-hybrid assay, in vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levanon D,Goldstein RE,Bernstein Y,Tang H,Goldenberg D,Stifani S,Paroush Z,Groner Y

更新日期：1998-09-29 00:00:00