Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative.

Abstract:

:The optical transitions of a chiral, three-substituted polythiophene with an amino acid function can be tuned by interactions with synthetic peptides. The addition of a positively charged peptide with a random-coil formation will force the polymer to adopt a nonplanar conformation, and the intensity of the emitted light is increased and blue-shifted. After the addition of a negatively charged peptide with a random-coil conformation, the backbone of the polymer adopts a planar conformation and an aggregation of the polymer chains occurs, seen as a red shift and a decrease of the intensity of the emitted light. By adding the positively charged peptide designed to form a four-helix bundle with the negatively charged peptide, the polymer aggregates are disrupted and the intensity of the emitted light is increased because of separation of the polymer chains. This technique could be used as a platform for making novel sensors and biomolecular switches.

authors

Nilsson KP,Rydberg J,Baltzer L,Inganäs O

doi

10.1073/pnas.1834422100

keywords:

subject

Has Abstract

pub_date

2003-09-02 00:00:00

pages

10170-4

issue

18

eissn

0027-8424

issn

1091-6490

pii

1834422100

journal_volume

100

pub_type

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