Abstract:
:In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked by the glucose-6-phosphate dehydrogenase and the color vision genes. CpG islands previously identified and mapped to distal Xq28 have helped in construction of a continuous contig of cosmids and in identification of cDNAs corresponding to eight transcripts. Thirteen to 16 small genes with CpG islands are clustered in a region of 250-300 kb. Many are highly expressed in muscle or brain and may be the genes responsible for muscle or neurological disorders mapped to distal Xq28. Our analysis indicates that, in this region of the genome, genes not related in sequence are organized in transcriptional domains of 100 kb and that this organization may be important for establishing and regulating gene expression in relation to tissue distribution and X chromosome inactivation.
journal_name
Proc Natl Acad Sci U S Aauthors
Bione S,Tamanini F,Maestrini E,Tribioli C,Poustka A,Torri G,Rivella S,Toniolo Ddoi
10.1073/pnas.90.23.10977subject
Has Abstractpub_date
1993-12-01 00:00:00pages
10977-81issue
23eissn
0027-8424issn
1091-6490journal_volume
90pub_type
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