Abstract:
:Sulfolobus turreted icosahedral virus (STIV) was isolated in acidic hot springs where it infects the archeon Sulfolobus solfataricus. We determined the STIV structure using near-atomic resolution electron microscopy and X-ray crystallography allowing tracing of structural polypeptide chains and visualization of transmembrane proteins embedded in the viral membrane. We propose that the vertex complexes orchestrate virion assembly by coordinating interactions of the membrane and various protein components involved. STIV shares the same coat subunit and penton base protein folds as some eukaryotic and bacterial viruses, suggesting that they derive from a common ancestor predating the divergence of the three kingdoms of life. One architectural motif (β-jelly roll fold) forms virtually the entire capsid (distributed in three different gene products), indicating that a single ancestral protein module may have been at the origin of its evolution.
journal_name
Proc Natl Acad Sci U S Aauthors
Veesler D,Ng TS,Sendamarai AK,Eilers BJ,Lawrence CM,Lok SM,Young MJ,Johnson JE,Fu CYdoi
10.1073/pnas.1300601110subject
Has Abstractpub_date
2013-04-02 00:00:00pages
5504-9issue
14eissn
0027-8424issn
1091-6490pii
1300601110journal_volume
110pub_type
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