Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship.

abstract：:The last 2 decades have seen discoveries in highly excited states of atoms and molecules of phenomena that are qualitatively different from the "planetary" model of the atom, and the near-rigid model of molecules, characteristic of these systems in their low-energy states. A unified view is emerging in terms of approx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kellman ME

更新日期：1996-12-10 00:00:00

abstract：:Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly (LIS1), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique situation because most LIS1 mutati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cahana A,Escamez T,Nowakowski RS,Hayes NL,Giacobini M,von Holst A,Shmueli O,Sapir T,McConnell SK,Wurst W,Martinez S,Reiner O

更新日期：2001-05-22 00:00:00

abstract：:Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC responses in two populations of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ndungu FM,Olotu A,Mwacharo J,Nyonda M,Apfeld J,Mramba LK,Fegan GW,Bejon P,Marsh K

更新日期：2012-05-22 00:00:00

abstract：:Transfer RNA (tRNA) is essential for decoding the genome sequence into proteins. In Archaea, previous studies have revealed unique multiple intron-containing tRNAs and tRNAs that are encoded on 2 separate genes, so-called split tRNAs. Here, we discovered 10 fragmented tRNA genes in the complete genome of the hyperther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujishima K,Sugahara J,Kikuta K,Hirano R,Sato A,Tomita M,Kanai A

更新日期：2009-02-24 00:00:00

abstract：:Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1-Pms1 complex interaction properties of dominant mutant Msh2-Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mutant complexes, the mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess MT,Mendillo ML,Mazur DJ,Kolodner RD

更新日期：2006-01-17 00:00:00

abstract：:Among 21 human mammary tumors analyzed for transforming genes by transfection of NIH/3T3 cells, only DNA of a carcinosarcoma cell line, HS578T, registered as positive. A Harvey (H)-ras oncogene identified in this line was cloned in biologically active form and the activating lesion was identified as a single nucleotid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus MH,Yuasa Y,Aaronson SA

更新日期：1984-09-01 00:00:00

abstract：:Resequencing or reference-based assemblies reveal large parts of the small-scale sequence variation. However, they typically fail to separate such local variation into colinear and rearranged variation, because they usually do not recover the complement of large-scale rearrangements, including transpositions and inver...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapata L,Ding J,Willing EM,Hartwig B,Bezdan D,Jiao WB,Patel V,Velikkakam James G,Koornneef M,Ossowski S,Schneeberger K

更新日期：2016-07-12 00:00:00

abstract：:The Late Heavy Bombardment (LHB), a hypothesized impact spike at ∼3.9 Ga, is one of the major scientific concepts to emerge from Apollo-era lunar exploration. A significant portion of the evidence for the existence of the LHB comes from histograms of (40)Ar/(39)Ar "plateau" ages (i.e., regions selected on the basis of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Harrison TM

更新日期：2016-09-27 00:00:00

abstract：:cDNA array technology has proven to be a powerful way to monitor global changes in gene expression patterns. Here, we present an approach that extends the current utility of cDNA arrays to allow the evaluation of the relative roles of transcription and mRNA turnover in governing gene expression on a global basis, comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Yang X,Wang W,Wood WH 3rd,Becker KG,Gorospe M

更新日期：2002-08-06 00:00:00

abstract：:Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egger G,Jeong S,Escobar SG,Cortez CC,Li TW,Saito Y,Yoo CB,Jones PA,Liang G

更新日期：2006-09-19 00:00:00

abstract：:Antigen-induced activation of T cells can be specifically inhibited by antigen analogs that have been termed T-cell receptor peptide antagonists. These antagonists appear to act by inducing the formation of nonstimulatory or partially stimulatory complexes between T-cell receptors and the major histocompatibility comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Page DM,Alexander J,Snoke K,Appella E,Sette A,Hedrick SM,Grey HM

更新日期：1994-04-26 00:00:00

abstract：:The location of renin (EC 3.4.99.19) in rat pituitary was determined by the peroxidase-antiperoxidase immunohistochemical technique. By using antisera prepared with purified rat renal renin, an immunoreactive substance was localized within ovoid cells scattered throughout the anterior pituitary. These cells were shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naruse K,Takii Y,Inagami T

更新日期：1981-12-01 00:00:00

abstract：:Mammalian CLC proteins function as Cl(-) channels or as electrogenic Cl(-)/H(+) exchangers and are present in the plasma membrane and intracellular vesicles. We now show that the ClC-6 protein is almost exclusively expressed in neurons of the central and peripheral nervous systems, with a particularly high expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poët M,Kornak U,Schweizer M,Zdebik AA,Scheel O,Hoelter S,Wurst W,Schmitt A,Fuhrmann JC,Planells-Cases R,Mole SE,Hübner CA,Jentsch TJ

更新日期：2006-09-12 00:00:00

abstract：:We have cloned a member of the nuclear receptor superfamily. The cDNA was isolated from a rat liver library and encodes a protein of 446 aa with a predicted mass of 50 kDa. This clone (OR-1) shows no striking homology to any known member of the steroid/thyroid hormone receptor superfamily. The most related receptor is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teboul M,Enmark E,Li Q,Wikström AC,Pelto-Huikko M,Gustafsson JA

更新日期：1995-03-14 00:00:00

abstract：:The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be variable surface loops of the enzyme. The complete coding regions, the 5'- and 3'-flanking regions, and the exon-intron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyazaki H,Fukamizu A,Hirose S,Hayashi T,Hori H,Ohkubo H,Nakanishi S,Murakami K

更新日期：1984-10-01 00:00:00

abstract：:Von Willebrand protein is present in the extracellular matrix of endothelial cells where it codistributes with fibronectin and types IV and V collagen. Bacterial collagenase digestion of endothelial cells removed fibrillar collagen, but the pattern of fibronectin and of von Willebrand protein remained undisturbed. Exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner DD,Urban-Pickering M,Marder VJ

更新日期：1984-01-01 00:00:00

abstract：:A panel of 20 recombinant Fab fragments reactive with the surface glycoprotein gp120 of human type 1 immunodeficiency virus (HIV-1) were examined for their ability to neutralize MN and IIIB strains of the virus. Neutralization was determined as the ability of the Fab fragments to inhibit infection as measured in both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbas CF 3rd,Björling E,Chiodi F,Dunlop N,Cababa D,Jones TM,Zebedee SL,Persson MA,Nara PL,Norrby E

更新日期：1992-10-01 00:00:00

abstract：:Anatoxin-a, a bicyclic amine isolated from blue-green alga, binds to the nicotinic acetylcholine receptor of Torpedo electric tissue, thereby inducing conformational changes in the postsynaptic receptor--ion channel complex as evidenced by alterations in the binding of radiolabeled ligands to the complex. Anatoxin-a b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aronstam RS,Witkop B

更新日期：1981-07-01 00:00:00

abstract：:In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response to conserved pathogen-associated molecular patterns. In addition, immunity can be induced in tissues remote from infection sites by system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truman W,Bennett MH,Kubigsteltig I,Turnbull C,Grant M

更新日期：2007-01-16 00:00:00

abstract：:Golgi-associated cytoplasmic proteins, such as the coatomer protein complex, are required for vesicle budding and trafficking. We have previously described a cytoplasmic phosphoprotein, p200, which binds dynamically and specifically to Golgi membranes. The p200 protein is dissociated from Golgi membranes in the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narula N,Stow JL

更新日期：1995-03-28 00:00:00

abstract：:Insertion of the transposon Tn5 into the T-region of the octopine Ti plasmid of Agrobacterium tumefaciens gives rise to crown gall tumors having altered morphology. Three loci within the T-DNA that control tumor morphology have been detected [Garfinkel, D. J., Simpson, R. B., Ream, L. W., White, F. F., Gordon, M. P. &...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyoshi DE,Morris RO,Hinz R,Mischke BS,Kosuge T,Garfinkel DJ,Gordon MP,Nester EW

更新日期：1983-01-01 00:00:00

abstract：:Double-positive (DP) thymocytes respond to intrathymic T-cell receptor (TCR) signals by undergoing positive selection and lineage differentiation into single-positive (SP) mature cells. Concomitant with these well-characterized events is the acquisition of a mature T-cell gene expression program characterized by the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi LZ,Saravia J,Zeng H,Kalupahana NS,Guy CS,Neale G,Chi H

更新日期：2017-01-03 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone (GHRH) inhibit the proliferation of various human cancers in vitro and in vivo by mechanisms that include apparent direct effects through specific binding sites expressed on tumors and that differ from pituitary human GHRH (hGHRH) receptors. In this study, GHRH antagonis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halmos G,Schally AV,Varga JL,Plonowski A,Rekasi Z,Czompoly T

更新日期：2000-09-12 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:DNA extracted from Dane particles has been characterized by gel electrophoresis and restriction enzyme cleavage with endonuclease R-HaeIII (from Hemophilus aegyptius). Dane particle DNA is proposed to be a double-stranded circular DNA approximately 3600 nucleotides in length containing a single-stranded gap of 600-210...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Summers J,O'Connell A,Millman I

更新日期：1975-11-01 00:00:00

abstract：:We have made direct, quantitative measurements of the lateral motion and age-dependent distribution of acetylcholine receptors (AChR) on the surface of rat myotubes in primary culture. AChR were fluorescently marked with tetramethylrhodamine-labeled alpha-bungarotoxin and AChR lateral motion was measured by the fluore...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axelrod D,Ravdin P,Koppel DE,Schlessinger J,Webb WW,Elson EL,Podleski TR

更新日期：1976-12-01 00:00:00

abstract：:2'-Deoxyadenosine 5'-O-(1-thiotriphosphate) (dATP[alpha S]) was introduced into the 3' ends of DNA restriction fragments with Escherichia coli DNA polymerase I to give phosphorothioate internucleotide linkages. Such "capped" 3' ends were found to be resistant to exonuclease III digestion. Moreover, the resistance to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putney SD,Benkovic SJ,Schimmel PR

更新日期：1981-12-01 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00

abstract：:To create a universal system for the control of gene expression, we have studied methods for the construction of novel polydactyl zinc finger proteins that recognize extended DNA sequences. Elsewhere we have described the generation of zinc finger domains recognizing sequences of the 5'-GNN-3' subset of a 64-member zi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerli RR,Segal DJ,Dreier B,Barbas CF 3rd

更新日期：1998-12-08 00:00:00

abstract：:Communication about prescription drugs ought to be a paragon of public science communication. Unfortunately, it is not. Consumers see $4 billion of direct-to-consumer advertising annually, which typically fails to present data about how well drugs work. The professional label--the Food and Drug Administration's (FDA) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz LM,Woloshin S

更新日期：2013-08-20 00:00:00