Abstract:
:Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC responses in two populations of children: (i) previously exposed children who had documented Pf infections several years ago, but minimal exposure since then; and (ii) persistently exposed children living in a separate but nearby endemic area. We found that although Pf-specific plasma Abs were lower in previously exposed children compared with persistently exposed children, their cognate MBCs were maintained at similar frequencies. We conclude that serological analysis by itself would greatly underestimate the true memory of Pf-specific Ab responses in previously exposed children living in areas where Pf transmission has been reduced or eliminated.
journal_name
Proc Natl Acad Sci U S Aauthors
Ndungu FM,Olotu A,Mwacharo J,Nyonda M,Apfeld J,Mramba LK,Fegan GW,Bejon P,Marsh Kdoi
10.1073/pnas.1200472109subject
Has Abstractpub_date
2012-05-22 00:00:00pages
8247-52issue
21eissn
0027-8424issn
1091-6490pii
1200472109journal_volume
109pub_type
杂志文章abstract::Primary cultures of differentiated liver cells from fetal rats respond to serum from partially hepatectomized rats by an increased uptake of [(3)H]thymidine and [(3)H]leucine as compared with cultures incubated with normal rat serum. These findings are discussed in relation to the mechanism of induction of DNA synthes...
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doi:10.1073/pnas.69.2.374
更新日期:1972-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:2013-05-07 00:00:00
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更新日期:2017-04-25 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:2017-05-23 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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更新日期:1979-08-01 00:00:00
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更新日期:1998-09-29 00:00:00
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更新日期:2014-04-15 00:00:00