Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm.

abstract：:Signaling through beta-arrestins is a recently appreciated mechanism used by seven-transmembrane receptors. Because G protein-coupled receptor kinase (GRK) phosphorylation of such receptors is generally a prerequisite for beta-arrestin binding, we studied the roles of different GRKs in promoting beta-arrestin-mediated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ren XR,Reiter E,Ahn S,Kim J,Chen W,Lefkowitz RJ

更新日期：2005-02-01 00:00:00

abstract：:The interaction between the ribosomal-stalk protein L7/12 (L12) and initiation factor 2 (IF2) is essential for rapid subunit association, but the underlying mechanism is unknown. Here, we have characterized the L12-IF2 interaction on Escherichia coli ribosomes using site-directed mutagenesis, fast kinetics, and molecu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge X,Mandava CS,Lind C,Åqvist J,Sanyal S

更新日期：2018-05-01 00:00:00

abstract：:The NIFA protein of Klebsiella pneumoniae is required for transcription of all nif (nitrogen fixation) operons except the regulatory nifLA operon itself. NIFA activates transcription of nif operons by the alternative holoenzyme form of RNA polymerase, sigma 54-holoenzyme, in a nucleoside triphosphate (NTP)-dependent m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger DK,Narberhaus F,Kustu S

更新日期：1994-01-04 00:00:00

abstract：:The Toll/IL-1 receptor (TIR) domains are crucial signaling modules during innate immune responses involving the Toll-like receptors (TLRs) and IL-1 receptor (IL-1R). Myeloid differential factor 88 (MyD88) is a central TIR domain-containing adapter molecule responsible for nearly all TLR-mediated signaling and is targe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder GA,Cirl C,Jiang J,Chen K,Waldhuber A,Smith P,Römmler F,Snyder N,Fresquez T,Dürr S,Tjandra N,Miethke T,Xiao TS

更新日期：2013-04-23 00:00:00

abstract：:At least two kidney epithelial cell lines, the Madin-Darby canine kidney (MDCK) and the murine inner medullary collecting duct line mIMCD-3, can be induced to form branching tubular structures when cultured with hepatocyte growth factor (HGF) plus serum in collagen I gels. In our studies, whereas MDCK cells remained u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barros EJ,Santos OF,Matsumoto K,Nakamura T,Nigam SK

更新日期：1995-05-09 00:00:00

abstract：:The basic assumptions of van der Waals theory are contained in two well-known concepts: excluded volume (repulsive forces) and a homogeneous, isotropic field potential (attractive forces). We have superimposed on these, one more well-known concept: the existence of dimers, trimers, etc., at chemical equilibrium. With ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heidemann RA,Prausnitz JM

更新日期：1976-06-01 00:00:00

abstract：:Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

更新日期：1977-02-01 00:00:00

abstract：:The global configuration of individual, surface-adsorbed molecules of the giant muscle protein titin, labeled with rhodamine conjugates, was followed with confocal microscopy. Fluorescence-emission intensity was reduced because of self-quenching caused by the close spacing between rhodamine dye molecules that formed d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grama L,Somogyi B,Kellermayer MS

更新日期：2001-12-04 00:00:00

abstract：:RNAs 1 and 2 of the tripartite cowpea chlorotic mottle virus (CCMV) genome are sufficient for RNA replication in protoplasts, whereas systemic infection of cowpea plants additionally requires RNA3, which encodes the 3a noncapsid protein and coat protein. By using biologically active CCMV cDNA clones, we find that dele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allison R,Thompson C,Ahlquist P

更新日期：1990-03-01 00:00:00

abstract：:Heavy electronic states originating from the f atomic orbitals underlie a rich variety of quantum phases of matter. We use atomic scale imaging and spectroscopy with the scanning tunneling microscope to examine the novel electronic states that emerge from the uranium f states in URu(2)Si(2). We find that, as the tempe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aynajian P,da Silva Neto EH,Parker CV,Huang Y,Pasupathy A,Mydosh J,Yazdani A

更新日期：2010-06-08 00:00:00

abstract：:Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum, including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg A,Luth MR,Winzeler EA,Behnke M,Sibley LD

更新日期：2019-12-05 00:00:00

abstract：:Specific protein domains and amino acids responsible for the apparent capacity of P-glycoprotein (mdr) to recognize and transport a large group of structurally unrelated drugs have not been identified. We have introduced a single Ser----Phe substitution within the predicted TM11 domain of mdr1 (position 941) and mdr3 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gros P,Dhir R,Croop J,Talbot F

更新日期：1991-08-15 00:00:00

abstract：:Despite sharing a common architecture with archetypal voltage-gated ion channels (VGICs), hyperpolarization- and cAMP-activated ion (HCN) channels open upon hyperpolarization rather than depolarization. The basic motions of the voltage sensor and pore gates are conserved, implying that these domains are inversely coup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowgill J,Klenchin VA,Alvarez-Baron C,Tewari D,Blair A,Chanda B

更新日期：2019-01-08 00:00:00

abstract：:Campylobacter jejuni has a general N-linked glycosylation pathway (encoded by the pgl gene cluster), which culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac [where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover KJ,Weerapana E,Imperiali B

更新日期：2005-10-04 00:00:00

abstract：:Blood cells transplantation is largely replacing bone marrow transplantation because engraftment is more rapid. This accelerated engraftment is thought to be mediated by relatively mature committed hematopoietic progenitor cells. Herein, we have used a modified rhodamine (Rho) staining procedure to identify and purify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zijlmans JM,Visser JW,Laterveer L,Kleiverda K,Heemskerk DP,Kluin PM,Willemze R,Fibbe WE

更新日期：1998-01-20 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Airway disease is the major source of morbidity and mortality. Successful implementation of gene- and cell-based therapies for CF airway disease requires knowledge of relations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah VS,Ernst S,Tang XX,Karp PH,Parker CP,Ostedgaard LS,Welsh MJ

更新日期：2016-05-10 00:00:00

abstract：:Despite the widespread use of silicon in modern technology, its peculiar thermal expansion is not well understood. Adapting harmonic phonons to the specific volume at temperature, the quasiharmonic approximation, has become accepted for simulating the thermal expansion, but has given ambiguous interpretations for micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DS,Hellman O,Herriman J,Smith HL,Lin JYY,Shulumba N,Niedziela JL,Li CW,Abernathy DL,Fultz B

更新日期：2018-02-27 00:00:00

abstract：:Two mouse monoclonal anti-anti-idiotopic antibodies (anti-anti-Id, Ab3), AF14 and AF52, were prepared by immunizing BALB/c mice with rabbit polyclonal anti-idiotypic antibodies (anti-Id, Ab2) raised against antibody D1.3 (Ab1) specific for the antigen hen egg lysozyme. AF14 and AF52 react with an "internal image" mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldbaum FA,Velikovsky CA,Dall'Acqua W,Fossati CA,Fields BA,Braden BC,Poljak RJ,Mariuzza RA

更新日期：1997-08-05 00:00:00

abstract：:CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the beta-globin locus and flanking olfactory receptor genes. Although CTCF occup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou C,Dale R,Dean A

更新日期：2010-02-23 00:00:00

abstract：:Bacterial proteins often localize to distinct sites within the cell, but the primary cues that dictate localization are largely unknown. Recent evidence has shown that positive membrane curvature can serve as a cue for localization of a peripheral membrane protein. Here we report that localization of the peripheral me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramamurthi KS,Losick R

更新日期：2009-08-11 00:00:00

abstract：:Modern protein crystal structures are based nearly exclusively on X-ray data collected at cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little bias in the functional interpretation of structural results, because cryogenic temperatures minimally perturb the overall protein backbo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraser JS,van den Bedem H,Samelson AJ,Lang PT,Holton JM,Echols N,Alber T

更新日期：2011-09-27 00:00:00

abstract：:We investigated the ultrafast structural transitions of the heme induced by nitric oxide (NO) binding for several heme proteins by subpicosecond time-resolved resonance Raman and femtosecond transient absorption spectroscopy. We probed the heme iron motion by the evolution of the iron-histidine Raman band intensity af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruglik SG,Yoo BK,Franzen S,Vos MH,Martin JL,Negrerie M

更新日期：2010-08-03 00:00:00

abstract：:The Hippo signaling pathway is a master regulator of organ growth, tissue homeostasis, and tumorigenesis. The activity of the Hippo pathway is controlled by various upstream components, including Expanded (Ex), but the precise molecular mechanism of how Ex is regulated remains poorly understood. Here we identify Plent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma X,Guo X,Richardson HE,Xu T,Xue L

更新日期：2018-02-27 00:00:00

abstract：:Neurons in the mammalian suprachiasmatic nuclei (SCN) generate daily rhythms in physiology and behavior, but it is unclear how they maintain and synchronize these rhythms in vivo. We hypothesized that parallel signaling pathways in the SCN are required to synchronize rhythms in these neurons for coherent output. We re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aton SJ,Huettner JE,Straume M,Herzog ED

更新日期：2006-12-12 00:00:00

abstract：:A type of chromosome-free cell called SimCells (simple cells) has been generated from Escherichia coli, Pseudomonas putida, and Ralstonia eutropha. The removal of the native chromosomes of these bacteria was achieved by double-stranded breaks made by heterologous I-CeuI endonuclease and the degradation activity of end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Davison PA,Habgood R,Zeng H,Decker CM,Gesell Salazar M,Lueangwattanapong K,Townley HE,Yang A,Thompson IP,Ye H,Cui Z,Schmidt F,Hunter CN,Huang WE

更新日期：2020-03-24 00:00:00

abstract：:Bone morphogenetic protein 9 (BMP9) promotes the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons (BFCN) during development and protects these neurons from cholinergic dedifferentiation following axotomy when administered in vivo. A decline in BFCN function occurs in patients with Alzhei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burke RM,Norman TA,Haydar TF,Slack BE,Leeman SE,Blusztajn JK,Mellott TJ

更新日期：2013-11-26 00:00:00

abstract：:The expression of a number of genes encoding products involved in copper ion uptake in yeast is specifically inhibited by copper ions. We show here that copper metalloregulation occurs through Cu-dependent repression of the transactivation activity of Mac1p. A segment of the yeast transcription factor Mac1p was identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graden JA,Winge DR

更新日期：1997-05-27 00:00:00

abstract：:Which network structures favor the rapid spread of new ideas, behaviors, or technologies? This question has been studied extensively using epidemic models. Here we consider a complementary point of view and consider scenarios where the individuals' behavior is the result of a strategic choice among competing alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montanari A,Saberi A

更新日期：2010-11-23 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:The Arabidopsis HYL1 gene encodes a nuclear double-stranded RNA-binding protein. A knockout mutation of the hyl1 gene is recessive and pleiotropic, causing developmental abnormalities, increasing sensitivity to abscisic acid, and reducing sensitivity to auxin and cytokinin. We report that levels of several microRNAs (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han MH,Goud S,Song L,Fedoroff N

更新日期：2004-01-27 00:00:00