当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.

Abstract：

:The Arabidopsis HYL1 gene encodes a nuclear double-stranded RNA-binding protein. A knockout mutation of the hyl1 gene is recessive and pleiotropic, causing developmental abnormalities, increasing sensitivity to abscisic acid, and reducing sensitivity to auxin and cytokinin. We report that levels of several microRNAs (miRNAs; miR159, -167, and -171) are reduced in homozygous mutant plants, and levels of two of three tested target mRNAs are elevated. Conversely, the miRNA levels are elevated in plants expressing a HYL1 cDNA from a strong promoter, and the corresponding target RNAs are reduced. These changes result from alterations in the stability of the target RNAs. However, double-stranded RNA-induced posttranscriptional gene silencing is unaffected by the hyl1 mutation. One-third to one-half of the cellular HYL1 protein is in a macromolecular complex, and a GFP-HYL1 fusion protein is found predominantly in the nucleus, although it is observed in both nucleus and cytoplasm in some cells. Within nuclei, HYL1 is associated with subnuclear bodies and ring-like structures. These observations provide evidence that the HYL1 protein is part of a nuclear macromolecular complex that is involved in miRNA-mediated gene regulation. Because hyl1 mutants show marked abnormalities in hormone responses, these results further suggest that miRNA-mediated changes in mRNA stability play a vital role in plant hormone signaling.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Han MH,Goud S,Song L,Fedoroff N

doi

10.1073/pnas.0307969100

keywords:

subject

Has Abstract

pub_date

2004-01-27 00:00:00

pages

1093-8

issue

4

eissn

0027-8424

issn

1091-6490

pii

0307969100

journal_volume

101

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Interior remodeling of the shell by a gastropod mollusc.

    abstract：:As the Conus shell grows by spiraling of the outer lip around the axis, profound internal shell dissolution thins the walls of the protected penultimate whorl from several millimeters to <50mum. Shell material is added to the inside of the spire and the anterior part of the columella. The resulting shell has a uniform...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.7.3406

    authors： Kohn AJ,Myers ER,Meenakshi VR

    更新日期：1979-07-01 00:00:00

  • How the Dorsal gradient works: insights from postgenome technologies.

    abstract：:Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,评审

    doi：10.1073/pnas.0806476105

    authors： Hong JW,Hendrix DA,Papatsenko D,Levine MS

    更新日期：2008-12-23 00:00:00

  • An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor.

    abstract：:Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with gp130. Here we present the crystal structure of a complex of mouse LIF receptor with human LIF at 4.0 A resolution. The str...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0705577104

    authors： Huyton T,Zhang JG,Luo CS,Lou MZ,Hilton DJ,Nicola NA,Garrett TP

    更新日期：2007-07-31 00:00:00

  • Reaction of glycolaldehyde with proteins: latent crosslinking potential of alpha-hydroxyaldehydes.

    abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.12.3590

    authors： Acharya AS,Manning JM

    更新日期：1983-06-01 00:00:00

  • Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains.

    abstract：:Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid compositi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1217611110

    authors： Volmer R,van der Ploeg K,Ron D

    更新日期：2013-03-19 00:00:00

  • Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes.

    abstract：:Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal vaccine with broadly protective activity against multiple influenza st...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2004783117

    authors： Liao HY,Wang SC,Ko YA,Lin KI,Ma C,Cheng TR,Wong CH

    更新日期：2020-07-28 00:00:00

  • Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates.

    abstract：:High-valent intermediates of binuclear nonheme iron enzymes are structurally unknown despite their importance for understanding enzyme reactivity. Nuclear resonance vibrational spectroscopy combined with density functional theory calculations has been applied to structurally well-characterized high-valent mono- and di...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1304238110

    authors： Park K,Bell CB 3rd,Liu LV,Wang D,Xue G,Kwak Y,Wong SD,Light KM,Zhao J,Alp EE,Yoda Y,Saito M,Kobayashi Y,Ohta T,Seto M,Que L Jr,Solomon EI

    更新日期：2013-04-16 00:00:00

  • Mapping membrane activity in undiscovered peptide sequence space using machine learning.

    abstract：:There are some ∼1,100 known antimicrobial peptides (AMPs), which permeabilize microbial membranes but have diverse sequences. Here, we develop a support vector machine (SVM)-based classifier to investigate ⍺-helical AMPs and the interrelated nature of their functional commonality and sequence homology. SVM is used to ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1609893113

    authors： Lee EY,Fulan BM,Wong GC,Ferguson AL

    更新日期：2016-11-29 00:00:00

  • Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.

    abstract：:Substantial evidence from epidemiological, pathological, and clinical reports suggests that vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in blood flow are currently the most reliable indicators of the disease. We previously reported that older APP23 transgenic (tg) mice ha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0709788105

    authors： Meyer EP,Ulmann-Schuler A,Staufenbiel M,Krucker T

    更新日期：2008-03-04 00:00:00

  • Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.

    abstract：:The multifunctional Creb-binding protein (CBP) protein plays a pivotal role in many critical cellular processes. Here we demonstrate that the bromodomain of CBP binds to histone H3 acetylated on lysine 56 (K56Ac) with higher affinity than to its other monoacetylated binding partners. We show that autoacetylation of CB...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1319122111

    authors： Das C,Roy S,Namjoshi S,Malarkey CS,Jones DN,Kutateladze TG,Churchill ME,Tyler JK

    更新日期：2014-03-25 00:00:00

  • Inhibition of beta-catenin-mediated transactivation by cadherin derivatives.

    abstract：:We studied the effect of N-cadherin, and its free or membrane-anchored cytoplasmic domain, on the level and localization of beta-catenin and on its ability to induce lymphocyte enhancer-binding factor 1 (LEF-1)-responsive transactivation. These cadherin derivatives formed complexes with beta-catenin and protected it f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.26.15339

    authors： Sadot E,Simcha I,Shtutman M,Ben-Ze'ev A,Geiger B

    更新日期：1998-12-22 00:00:00

  • Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands.

    abstract：:Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adja...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.22.12890

    authors： Dickinson LA,Gulizia RJ,Trauger JW,Baird EE,Mosier DE,Gottesfeld JM,Dervan PB

    更新日期：1998-10-27 00:00:00

  • Stone tool production and utilization by bonobo-chimpanzees (Pan paniscus).

    abstract：:Using direct percussion, language-competent bonobo-chimpanzees Kanzi and Pan-Banisha produced a significantly wider variety of flint tool types than hitherto reported, and used them task-specifically to break wooden logs or to dig underground for food retrieval. For log breaking, small flakes were rotated drill-like o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212855109

    authors： Roffman I,Savage-Rumbaugh S,Rubert-Pugh E,Ronen A,Nevo E

    更新日期：2012-09-04 00:00:00

  • Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.

    abstract：:New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microsco...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0806658105

    authors： Faulkner RL,Jang MH,Liu XB,Duan X,Sailor KA,Kim JY,Ge S,Jones EG,Ming GL,Song H,Cheng HJ

    更新日期：2008-09-16 00:00:00

  • Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering.

    abstract：:Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-r...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1113193109

    authors： Lee SC,Park K,Han J,Lee JJ,Kim HJ,Hong S,Heu W,Kim YJ,Ha JS,Lee SG,Cheong HK,Jeon YH,Kim D,Kim HS

    更新日期：2012-02-28 00:00:00

  • Engineering adenylate cyclases regulated by near-infrared window light.

    abstract：:Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties make bacteriophytochromes particularly attractive for optogenetic applications. However, the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1324301111

    authors： Ryu MH,Kang IH,Nelson MD,Jensen TM,Lyuksyutova AI,Siltberg-Liberles J,Raizen DM,Gomelsky M

    更新日期：2014-07-15 00:00:00

  • Endocytosis in alveolar type II cells: effect of charge and size of tracers.

    abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.19.6054

    authors： Williams MC

    更新日期：1984-10-01 00:00:00

  • A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo.

    abstract：:2'-Deoxyadenosine 5'-O-(1-thiotriphosphate) (dATP[alpha S]) was introduced into the 3' ends of DNA restriction fragments with Escherichia coli DNA polymerase I to give phosphorothioate internucleotide linkages. Such "capped" 3' ends were found to be resistant to exonuclease III digestion. Moreover, the resistance to d...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.12.7350

    authors： Putney SD,Benkovic SJ,Schimmel PR

    更新日期：1981-12-01 00:00:00

  • Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis.

    abstract：:OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and endothelial cells by binding to vitronectin and proteoglycan cell-surface receptors. Here, we report the determination of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.062630899

    authors： Prince SM,Achtman M,Derrick JP

    更新日期：2002-03-19 00:00:00

  • Variable region genes for the immunoglobulin framework are assembled from small segments of DNA--a hypothesis.

    abstract：:Sequences of each of the four framework segments FR1, FR2, FR3, and FR4 of the variable regions (V-regions) of light and heavy chains of immunoglobulins were grouped into sets with identical sequences. Sets contained from 1 to 18 members. When each V-region was traced from one FR to the next, it was seen that members ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.5.2429

    authors： Kabat EA,Wu TT,Bilofsky H

    更新日期：1978-05-01 00:00:00

  • Fate of the replisome following arrest by UV-induced DNA damage in Escherichia coli.

    abstract：:Accurate replication in the presence of DNA damage is essential to genome stability and viability in all cells. In Escherichia coli, DNA replication forks blocked by UV-induced damage undergo a partial resection and RecF-catalyzed regression before synthesis resumes. These processing events generate distinct structura...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1300624110

    authors： Jeiranian HA,Schalow BJ,Courcelle CT,Courcelle J

    更新日期：2013-07-09 00:00:00

  • The spectrum of NGC 7027 (367-650 nm).

    abstract：:NGC 7027 shows the richest spectrum of any known gaseous nebula. In the region of the spectrum surveyed we have measured lines of ions of H, He, C, N, O, F, Ne, Mg, Si, P, S, Cl, Ar, K, Ca, Mn, and Fe using the new Hamilton Echelle Spectrograph of Lick Observatory with a charge-coupled device (CCD) detector. Since a C...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.8.2417

    authors： Aller LH,Keyes CD

    更新日期：1988-04-01 00:00:00

  • Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I.

    abstract：:The Xlim-1 gene is activated in the late blastula stage of Xenopus embryogenesis in the mesoderm, and its RNA product becomes concentrated in the Spemann organizer at early gastrula stage. A major regulator of early expression of Xlim-1 is activin or an activin-like signal. We report experiments aiming to identify the...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.18.9717

    authors： Rebbert ML,Dawid IB

    更新日期：1997-09-02 00:00:00

  • Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer.

    abstract：:The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy number and expression of all genes within an amplified region of the genome have not been performed. Here we have used a c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.091582298

    authors： Monni O,Barlund M,Mousses S,Kononen J,Sauter G,Heiskanen M,Paavola P,Avela K,Chen Y,Bittner ML,Kallioniemi A

    更新日期：2001-05-08 00:00:00

  • Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus.

    abstract：:Positive-strand RNA viruses are the largest virus class and include many pathogens such as hepatitis C virus and the severe acute respiratory syndrome coronavirus (SARS). Brome mosaic virus (BMV) is a representative positive-strand RNA virus whose RNA replication, gene expression, and encapsidation have been reproduce...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2536857100

    authors： Kushner DB,Lindenbach BD,Grdzelishvili VZ,Noueiry AO,Paul SM,Ahlquist P

    更新日期：2003-12-23 00:00:00

  • Thermogenic methane release as a cause for the long duration of the PETM.

    abstract：:The Paleocene-Eocene Thermal Maximum (PETM) (∼56 Ma) was a ∼170,000-y (∼170-kyr) period of global warming associated with rapid and massive injections of 13C-depleted carbon into the ocean-atmosphere system, reflected in sedimentary components as a negative carbon isotope excursion (CIE). Carbon cycle modeling has ind...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1603348113

    authors： Frieling J,Svensen HH,Planke S,Cramwinckel MJ,Selnes H,Sluijs A

    更新日期：2016-10-25 00:00:00

  • Flexible and conductive MXene films and nanocomposites with high capacitance.

    abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1414215111

    authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

    更新日期：2014-11-25 00:00:00

  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

    abstract：:Transforming growth factor beta (TGF-beta) causes growth arrest in most cell types. TGF-beta induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase of the cell cycle, thereby leading to cell cycle arrest at G1. It is possible, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.10.4948

    authors： Li JM,Hu PP,Shen X,Yu Y,Wang XF

    更新日期：1997-05-13 00:00:00

  • Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.

    abstract：:The conservation of developmental functions exerted by Antp-class homeoproteins in protostomes and deuterostomes suggested that homologs with related functions are present in diploblastic animals. Our phylogenetic analyses showed that Antp-class homeodomains belong either to non-Hox or to Hox/paraHox families. Among t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.9.4493

    authors： Gauchat D,Mazet F,Berney C,Schummer M,Kreger S,Pawlowski J,Galliot B

    更新日期：2000-04-25 00:00:00

  • Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.

    abstract：:Obligate intracellular pathogens such as Leishmania specifically target host phagocytes for survival and replication. Phosphoinositide 3-kinase γ (PI3Kγ), a member of the class I PI3Ks that is highly expressed by leukocytes, controls cell migration by initiating actin polymerization and cytoskeletal reorganization, wh...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1110339109

    authors： Cummings HE,Barbi J,Reville P,Oghumu S,Zorko N,Sarkar A,Keiser TL,Lu B,Rückle T,Varikuti S,Lezama-Davila C,Wewers MD,Whitacre C,Radzioch D,Rommel C,Seveau S,Satoskar AR

    更新日期：2012-01-24 00:00:00