A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control.

abstract：:Fast axoplasmic transport was studied in dorsal root ganglion cells of the cat. Proteins carried in the fast axoplasmic flow were labeled after an intraganglionic injection of (L)-[4,5-(3)H]leucine. The rate of transport was 380 +/- 26 mm/day in both the central and peripheral branches of the bifurcating axons that ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson LE,McClure WO

更新日期：1973-05-01 00:00:00

abstract：:An elegant expression is obtained for the product of the inverse Weierstrass-Laguerre transforms of two functions in terms of their convolution. It is also shown how the main result can be extended to hold for the product of the inverse Weierstrass-Laguerre transforms of several functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava HM

更新日期：1971-03-01 00:00:00

abstract：:The size of virus-specific RNA synthesized in cultured mouse kidney cells infected with polyoma virus was estimated by electrophoresis and sedimentation analysis of RNA extracts from whole cells. Newly synthesized "late" polyoma-specific RNA appears as "giant" molecules of heterogeneous size, up to several times large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheson NH,Buetti E,Scherrer K,Weil R

更新日期：1971-09-01 00:00:00

abstract：:Seep sediments are dominated by intensive microbial sulfate reduction coupled to the anaerobic oxidation of methane (AOM). Through geochemical measurements of incubation experiments with methane seep sediments collected from Hydrate Ridge, we provide insight into the role of iron oxides in sulfate-driven AOM. Seep sed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivan O,Antler G,Turchyn AV,Marlow JJ,Orphan VJ

更新日期：2014-10-07 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:A protein that specifically binds leukemia inhibitory factor (LIF) has been isolated from normal mouse serum by using four successive fractionation steps: chromatography on a LIF affinity matrix, anion-exchange chromatography, size-exclusion chromatography, and preparative native gel electrophoresis. The purified LIF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Layton MJ,Cross BA,Metcalf D,Ward LD,Simpson RJ,Nicola NA

更新日期：1992-09-15 00:00:00

abstract：:We previously identified a stromal cell-derived inducing activity (SDIA), which induces differentiation of neural cells, including midbrain tyrosine hydroxylase-positive (TH(+)) dopaminergic neurons, from mouse embryonic stem cells. We report here that SDIA induces efficient neural differentiation also in primate embr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawasaki H,Suemori H,Mizuseki K,Watanabe K,Urano F,Ichinose H,Haruta M,Takahashi M,Yoshikawa K,Nishikawa S,Nakatsuji N,Sasai Y

更新日期：2002-02-05 00:00:00

abstract：:The reliability of (13)C NMR chemical shift correlations in the application of the "tool of increasing electron demand" to stable long-lived carbocationic systems is demonstrated by a comprehensive analysis of 22 stable aryl-substituted carbocationic systems. The observation of slopes of less than unity in such chemic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah GA,Berrier AL,Prakash GK

更新日期：1981-04-01 00:00:00

abstract：:CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4(+) T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,Zhu Y,Zhang G,Gao C,Zhong W,Zhang X

更新日期：2011-11-15 00:00:00

abstract：:We induced an essential fatty acid deficiency (EFAD) in human umbilical vein endothelial cells by culture in medium with 20% (vol/vol) delipidated fetal calf serum. EFAD, reflected by decreased cellular linoleic acid (18:2 omega 6) and arachidonic acid (20:4 omega 6) and emergence of the oleic acid derivative 5,8,11-e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner R,Lindström P,Berg A,Johansson E,Rosendahl K,Palmblad J

更新日期：1995-02-14 00:00:00

abstract：:The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1 expression in early human adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sposi NM,Zon LI,Carè A,Valtieri M,Testa U,Gabbianelli M,Mariani G,Bottero L,Mather C,Orkin SH

更新日期：1992-07-15 00:00:00

abstract：:The post-translational proteolytic conversion of somatostatin-14 precursors was studied to characterize the enzyme system responsible for the production of the tetradecapeptide either from its 15-kDa precursor protein or from its COOH-terminal fragment, somatostatin-28. A synthetic undecapeptide Pro-Arg-Glu-Arg-Lys-Al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gluschankof P,Morel A,Gomez S,Nicolas P,Fahy C,Cohen P

更新日期：1984-11-01 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:At least two kidney epithelial cell lines, the Madin-Darby canine kidney (MDCK) and the murine inner medullary collecting duct line mIMCD-3, can be induced to form branching tubular structures when cultured with hepatocyte growth factor (HGF) plus serum in collagen I gels. In our studies, whereas MDCK cells remained u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barros EJ,Santos OF,Matsumoto K,Nakamura T,Nigam SK

更新日期：1995-05-09 00:00:00

abstract：:We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA-protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding sites are identified by most methods, DiSEL uncovered nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhimsaria D,Rodríguez-Martínez JA,Pan J,Roston D,Korkmaz EN,Cui Q,Ramanathan P,Ansari AZ

更新日期：2018-11-06 00:00:00

abstract：:Tauopathies are a class of neurodegenerative diseases associated with pathological tau. Despite many advances in our understanding of these diseases, the direct mechanism through which tau contributes to neurodegeneration remains poorly understood. Previously, our laboratory implicated the histone demethylase LSD1 in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engstrom AK,Walker AC,Moudgal RA,Myrick DA,Kyle SM,Bai Y,Rowley MJ,Katz DJ

更新日期：2020-11-17 00:00:00

abstract：:The DNA end-joining protein Ku70 is one of several proteins that inhibit apoptosis by sequestering the proapoptotic factor Bax from the mitochondria. However, the molecular mechanism underlying Ku70-dependent inhibition of Bax is not fully understood. Here, we show that the absence of Ku70 results in the accumulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amsel AD,Rathaus M,Kronman N,Cohen HY

更新日期：2008-04-01 00:00:00

abstract：:The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to humans. Mutations of amino acid L13 within this domain rescue the essential function of the helicase protein Prp28p. Prp28p has been implicated in unwinding the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du H,Tardiff DF,Moore MJ,Rosbash M

更新日期：2004-10-12 00:00:00

abstract：:In neurotransmission synaptotagmin-1 tethers synaptic vesicles to the presynaptic plasma membrane by binding to acidic membrane lipids and SNAREs and promotes rapid SNARE-mediated fusion upon Ca(2+) triggering. However, recent studies suggested that upon membrane contact synaptotagmin may not only bind in trans to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vennekate W,Schröder S,Lin CC,van den Bogaart G,Grunwald M,Jahn R,Walla PJ

更新日期：2012-07-03 00:00:00

abstract：:We show that it is possible to direct particles entrained in a fluid along trajectories much like rays of light in classical optics. A microstructured, asymmetric post array forms the core hydrodynamic element and is used as a building block to construct microfluidic metamaterials and to demonstrate refractive, focusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton KJ,Loutherback K,Inglis DW,Tsui OK,Sturm JC,Chou SY,Austin RH

更新日期：2008-05-27 00:00:00

abstract：:The light-harvesting phycobilisome in cyanobacteria and red algae requires the lyase-catalyzed chromophorylation of phycobiliproteins. There are three functionally distinct lyase families known. The heterodimeric E/F type is specific for attaching bilins covalently to α-subunits of phycocyanins and phycoerythrins. Unl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Höppner A,Xu QZ,Gärtner W,Scheer H,Zhou M,Zhao KH

更新日期：2017-12-12 00:00:00

abstract：:A joint analysis of all-atom molecular dynamics (MD) calculations and picosecond time-resolved x-ray structures was performed to gain single-molecule insights into mechanisms of protein function. Ensemble-averaged MD simulations of the L29F mutant of myoglobin after ligand dissociation reproduce the direction, amplitu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Schotte F,Anfinrud PA

更新日期：2004-10-26 00:00:00

abstract：:We studied regional cerebral blood flow using the H2(15)O method while normal subjects performed four similar tasks involving three-letter word beginnings (stems). Prior to each task, subjects studied a list of words. Local blood flow was then monitored during a 40-sec period while subjects (i) silently viewed word st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Squire LR,Ojemann JG,Miezin FM,Petersen SE,Videen TO,Raichle ME

更新日期：1992-03-01 00:00:00

abstract：:Many empirical studies throughout the social and biomedical sciences focus only on very narrow outcomes such as income, or a single specific disease state, or a measure of positive affect. Human well-being or flourishing, however, consists in a much broader range of states and outcomes, certainly including mental and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanderWeele TJ

更新日期：2017-08-01 00:00:00

abstract：:If RNA editing could be rationally directed to mutated RNA sequences, genetic diseases caused by certain base substitutions could be treated. Here we use a synthetic complementary RNA oligonucleotide to direct the correction of a premature stop codon mutation in dystrophin RNA. The complementary RNA oligonucleotide wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woolf TM,Chase JM,Stinchcomb DT

更新日期：1995-08-29 00:00:00

abstract：:Valproic acid (VPA) is an anticonvulsant drug that is also used to treat migraines and bipolar disorder. Its proposed biological targets include human voltage-gated sodium channels, among other membrane proteins. We used the prokaryotic NavMs sodium channel, which has been shown to be a good exemplar for drug binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanatta G,Sula A,Miles AJ,Ng LCT,Torella R,Pryde DC,DeCaen PG,Wallace BA

更新日期：2019-12-10 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism that leads to excessive iron storage in the liver and other organs. Recently, between 83 and 100% of HH patients have been found to be homozygous for the same mutation in a novel major histocompatibility complex class I-like ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkkila S,Waheed A,Britton RS,Feder JN,Tsuchihashi Z,Schatzman RC,Bacon BR,Sly WS

更新日期：1997-03-18 00:00:00

abstract：:The canonical function of the human telomerase protein (hTERT) is to synthesize telomeric DNA, but it has other biological activities, including enhancing cell proliferation, decreasing apoptosis, regulating DNA damage responses, and increasing cellular proliferative lifespan. The mechanistic relationships among these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee S,Firpo EJ,Wang Y,Roberts JM

更新日期：2011-12-13 00:00:00

abstract：:Although introduced hemosporidian (malaria) parasites (Apicomplexa: Haemosporida) have hastened the extinction of endemic bird species in the Hawaiian Islands and perhaps elsewhere, little is known about the temporal dynamics of endemic malaria parasite populations. Haemosporidian parasites do not leave informative fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soares L,Latta SC,Ricklefs RE

更新日期：2017-06-20 00:00:00

abstract：:Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westin EH,Wong-Staal F,Gelmann EP,Dalla-Favera R,Papas TS,Lautenberger JA,Eva A,Reddy EP,Tronick SR,Aaronson SA,Gallo RC

更新日期：1982-04-01 00:00:00