Significant liquid-structure theory of viscosity and self-diffusion of the alkali metals.

abstract：:Evolutionary processes leading to adaptive radiation regularly occur too fast to be accurately recorded in the fossil record but too slowly to be readily observed in living biota. The study of evolutionary radiations is thereby confronted with an epistemological gap between the timescales and approaches used by neonto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Bocxlaer B,Hunt G

更新日期：2013-08-20 00:00:00

abstract：:To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higuchi H,Muto E,Inoue Y,Yanagida T

更新日期：1997-04-29 00:00:00

abstract：:This study was undertaken to characterize bile acid metabolism in hereditary forms of hypertriglyceridemia. Ten hypertriglyceridemic patients (type IV phenotype) with familial combined hyperlipidemia and 7 patients with monogenic familial hypertriglyceridemia (FHTG) were compared with 18 healthy controls; all subjects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angelin B,Hershon KS,Brunzell JD

更新日期：1987-08-01 00:00:00

abstract：:A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Oth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimprich KA,Shin TB,Keith CT,Schreiber SL

更新日期：1996-04-02 00:00:00

abstract：:Drosophila melanogaster Polo kinase physically interacts with, and is repressed by, the Matrimony (Mtrm) protein during oogenesis. Females heterozygous for a deletion of the mtrm gene display defects in chromosome segregation at meiosis I. However, a complete absence of Mtrm results in both meiotic catastrophe and fem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonner AM,Hughes SE,Chisholm JA,Smith SK,Slaughter BD,Unruh JR,Collins KA,Friederichs JM,Florens L,Swanson SK,Pelot MC,Miller DE,Washburn MP,Jaspersen SL,Hawley RS

更新日期：2013-03-26 00:00:00

abstract：:Expression of the homeobox protein CDX1 is lost or reduced in a significant proportion of colorectal carcinomas (CRCs) but the underlying mechanism for this is unclear. We have demonstrated absence of CDX1 mRNA expression in 7 of 37 CRC cell lines and shown that all 7 cell lines have a methylated CDX1 promoter. Twenty...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong NA,Britton MP,Choi GS,Stanton TK,Bicknell DC,Wilding JL,Bodmer WF

更新日期：2004-01-13 00:00:00

abstract：:The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabra-Makke L,Maritan M,Planchais J,Boutant M,Pégorier JP,Even PC,Vasseur-Cognet M,Bossard P

更新日期：2013-03-12 00:00:00

abstract：:CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4(+) T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,Zhu Y,Zhang G,Gao C,Zhong W,Zhang X

更新日期：2011-11-15 00:00:00

abstract：:Before they even speak, infants become attuned to the sounds of the language(s) they hear, processing native phonetic contrasts more easily than nonnative ones. For example, between 6 to 8 mo and 10 to 12 mo, infants learning American English get better at distinguishing English and [l], as in "rock" vs. "lock," relat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schatz T,Feldman NH,Goldwater S,Cao XN,Dupoux E

更新日期：2021-02-09 00:00:00

abstract：:The distribution of wealth in the United States and countries around the world is highly skewed. How does visible economic inequality affect well-off individuals' support for redistribution? Using a placebo-controlled field experiment, I randomize the presence of poverty-stricken people in public spaces frequented by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sands ML

更新日期：2017-01-24 00:00:00

abstract：:Human diploid fibroblasts underwent lysis when resuspended in isotonic sucrose. After preparation of a granular fraction by differential centrifugation, lysosomes were almost completely purified by free-flow electrophoresis. Electron micrographs of the final fraction of fibroblast lysosomes (about 25-fold purified) sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harms E,Kern H,Schneider JA

更新日期：1980-10-01 00:00:00

abstract：:Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription. Here we report a systematic study of the oligomeric state of RXR in the absence of a DNA template. We have used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kersten S,Kelleher D,Chambon P,Gronemeyer H,Noy N

更新日期：1995-09-12 00:00:00

abstract：:Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Understanding the distinct genetic and epigenetic changes contributing to the establishment and growth of metastatic lesions is crucial for the development of novel therapeutic strategies. In a search for key regulators of col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rychahou PG,Kang J,Gulhati P,Doan HQ,Chen LA,Xiao SY,Chung DH,Evers BM

更新日期：2008-12-23 00:00:00

abstract：:Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharp DJ,Bonnelle V,De Boissezon X,Beckmann CF,James SG,Patel MC,Mehta MA

更新日期：2010-03-30 00:00:00

abstract：:All cell functions that involve membrane deformation or a change in cell shape (e.g., endocytosis, exocytosis, cell motility, and cytokinesis) are regulated by membrane tension. While molecular contacts between the plasma membrane and the underlying actin cytoskeleton are known to make significant contributions to mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nambiar R,McConnell RE,Tyska MJ

更新日期：2009-07-21 00:00:00

abstract：:To generate transgenic planarians we used a set of versatile vectors for animal transgenesis based on the promiscuous transposons, mariner, Hermes and piggyBac, and a universal enhanced GFP (EGFP) marker system with three Pax6 dimeric binding sites, the 3xP3-EGFP developed by Berghammer et al. [Berghammer, A. J., Klin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： González-Estévez C,Momose T,Gehring WJ,Saló E

更新日期：2003-11-25 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) obtained from human melanomas can specifically lyse autologous tumor in vitro and mediate tumor regression in vivo. To develop more effective therapeutic reagents and to further understand the T-cell response to tumors, the diversity of T-cell receptors (TCRs) involved in melanoma ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shilyansky J,Nishimura MI,Yannelli JR,Kawakami Y,Jacknin LS,Charmley P,Rosenberg SA

更新日期：1994-03-29 00:00:00

abstract：:Optimal flowering time is critical to the success of modern agriculture. Sorghum is a short-day tropical species that exhibits substantial photoperiod sensitivity and delayed flowering in long days. Genotypes with reduced photoperiod sensitivity enabled sorghum's utilization as a grain crop in temperate zones worldwid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RL,Klein RR,Morishige DT,Brady JA,Rooney WL,Miller FR,Dugas DV,Klein PE,Mullet JE

更新日期：2011-09-27 00:00:00

abstract：:Measurements of the effect of DNA on rates of bimolecular energy transfer between ions provide a direct indication of how cations cluster in regions near DNA and how anions are repelled from the same regions. Energy transfer from luminescent lanthanide ions (in the "rapid-diffusion" limit) probes collision frequencies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wensel TG,Meares CF,Vlachy V,Matthew JB

更新日期：1986-05-01 00:00:00

abstract：:Linkage disequilibrium between polymorphisms in a natural population may result from various evolutionary forces, including random genetic drift due to sampling of gametes during reproduction, restricted migration between subpopulations in a subdivided population, or epistatic selection. In this report, we present evi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirby DA,Muse SV,Stephan W

更新日期：1995-09-26 00:00:00

abstract：:A cDNA containing the full coding region of human cytochrome b5 was inserted into a vaccinia virus cDNA expression vector. Infection of human thymidine kinase-minus (TK-) 143 cells in culture with this recombinant virus resulted in production of 0.3 nmol of cytochrome b5 per mg of cell lysate protein. The expressed cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aoyama T,Nagata K,Yamazoe Y,Kato R,Matsunaga E,Gelboin HV,Gonzalez FJ

更新日期：1990-07-01 00:00:00

abstract：:We induced sublimation of suspended few-layer graphene by in situ Joule-heating inside a transmission electron microscope. The graphene sublimation fronts consisted of mostly {1100} zigzag edges. Under appropriate conditions, a fractal-like "coastline" morphology was observed. Extensive multiple-layer reconstructions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang JY,Ding F,Yakobson BI,Lu P,Qi L,Li J

更新日期：2009-06-23 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averyhart-Fullard V,Datta K,Marcus A

更新日期：1988-02-01 00:00:00

abstract：:From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern DL,Clemens J,Coen P,Calhoun AJ,Hogenesch JB,Arthur BJ,Murthy M

更新日期：2017-09-12 00:00:00

abstract：:We have evaluated two synthetic epothilone analogues lacking the 12,13-epoxide functionality, 12,13-desoxyepothilone B (dEpoB), and 12,13-desoxyepothilone F (dEpoF). The concentrations required for 50% growth inhibition (IC(50)) for a variety of anticancer agents were measured in CCRF-CEM/VBL1000 cells (2,048-fold res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou TC,O'Connor OA,Tong WP,Guan Y,Zhang ZG,Stachel SJ,Lee C,Danishefsky SJ

更新日期：2001-07-03 00:00:00

abstract：:Although soft devices (grippers, actuators, and elementary robots) are rapidly becoming an integral part of the broad field of robotics, autonomy for completely soft devices has only begun to be developed. Adaptation of conventional systems of control to soft devices requires hard valves and electronic controls. This ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preston DJ,Rothemund P,Jiang HJ,Nemitz MP,Rawson J,Suo Z,Whitesides GM

更新日期：2019-04-16 00:00:00

abstract：:The objective of this study was to determine whether the vascular smooth muscle contractile effect of NG-methyl-L-arginine (NMA) is endothelium dependent and attributed to a decline in smooth muscle levels of cyclic GMP. Vascular smooth muscle levels of cyclic GMP are severalfold greater in endothelium-intact than in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gold ME,Wood KS,Byrns RE,Fukuto J,Ignarro LJ

更新日期：1990-06-01 00:00:00

abstract：:Ankyrin-G (AnkG), a highly enriched scaffold protein in the axon initial segment (AIS) of neurons, functions to maintain axonal polarity and the integrity of the AIS. At the AIS, AnkG regulates selective intracellular cargo trafficking between soma and axons via interaction with the dynein regulator protein Ndel1, but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye J,Li J,Ye F,Zhang Y,Zhang M,Wang C

更新日期：2020-01-14 00:00:00

abstract：:We propose a motility mechanism that may result in the displacement of objects within the cell. The mechanism, which we call polymer-guided diffusion, involves a microscopic cycle of polymer association and dissociation from a lateral binding site. Reassociation occurs at the polymer subunit adjacent to that which has...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garel JR,Job D,Margolis RL

更新日期：1987-06-01 00:00:00