Model of anaphase chromosome movement based on polymer-guided diffusion.

abstract：:In the primary visual cortex, neurons with similar response preferences are grouped into domains forming continuous maps of stimulus orientation and direction of movement. These properties are widely believed to result from the combination of ascending and lateral interactions in the visual system. We have tested this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RA,Schmidt KE,Goebel R,Lomber SG,Payne BR

更新日期：2002-12-24 00:00:00

abstract：:The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garber ME,Troyanskaya OG,Schluens K,Petersen S,Thaesler Z,Pacyna-Gengelbach M,van de Rijn M,Rosen GD,Perou CM,Whyte RI,Altman RB,Brown PO,Botstein D,Petersen I

更新日期：2001-11-20 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm(-3), 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F(1), and (NZW x NZW)F(1) em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner RA,Jensen F,Kennel SJ,Dixon FJ,Des Roches G,Francke U

更新日期：1972-10-01 00:00:00

abstract：:Mitogen-stimulated scheduled DNA synthesis and DNA excision repair in human lymphocytes, as well as DNA polymerase a activity in a cell-free system, were inhibited by an electrophilic metabolite of benzo[a]pyrene. This metabolite, (+/-)-anti-(7r,8t)-dihydroxy-(9,10t)-epoxy-7,8,9,10-tetrahyd robenzo[a]pyrene (BPDE), co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busbee DL,Joe CO,Norman JO,Rankin PW

更新日期：1984-09-01 00:00:00

abstract：:A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JY,Clegg DO,Koshland DE Jr

更新日期：1981-08-01 00:00:00

abstract：:Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier--the glomerular basement membrane (GBM)--can disassemble cation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Choi CH,Han H,Davis ME

更新日期：2012-02-21 00:00:00

abstract：:Matching ATP:NADPH provision and consumption in the chloroplast is a prerequisite for efficient photosynthesis. In terms of ATP:NADPH ratio, the amount of ATP generated from the linear electron flow does not meet the demand of the Calvin-Benson-Bassham (CBB) cycle. Several different mechanisms to increase ATP availabi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voon CP,Guan X,Sun Y,Sahu A,Chan MN,Gardeström P,Wagner S,Fuchs P,Nietzel T,Versaw WK,Schwarzländer M,Lim BL

更新日期：2018-11-06 00:00:00

abstract：:Targeted gene disruption in the murine TOP3beta gene-encoding DNA topoisomerase IIIbeta was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIalpha, top3beta(-/-) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIbeta have a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwan KY,Wang JC

更新日期：2001-05-08 00:00:00

abstract：:We have recently identified a family of rhesus monkeys with members exhibiting a spontaneous hypercholesterolemia associated with a low density lipoprotein receptor (LDLR) deficiency. By using the polymerase chain reaction, we now show that the affected monkeys are heterozygous for a nonsense mutation in exon 6 of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummel M,Li ZG,Pfaffinger D,Neven L,Scanu AM

更新日期：1990-04-01 00:00:00

abstract：:Rat carbonic anhydrase (CA) IV was purified by affinity chromatography and used to produce a specific antiserum in rabbits for immunolocalization studies in rat kidney. CA IV was localized in apical plasma membranes of the proximal convoluted tubule and the thick ascending limb of Henle. Both of these segments are inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown D,Zhu XL,Sly WS

更新日期：1990-10-01 00:00:00

abstract：:Proceedings of the National Academy of Sciences Colloquium on the roles of homologous recombination in DNA replication are summarized. Current findings in experimental systems ranging from bacteriophages to mammalian cell lines substantiate the idea that homologous recombination is a system supporting DNA replication ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuzminov A

更新日期：2001-07-17 00:00:00

abstract：:Over the past years, family 18 chitinases have been validated as potential targets for the design of drugs against human pathogens that contain or interact with chitin during their normal life cycles. Thus far, only one potent chitinase inhibitor has been described in detail, the pseudotrisaccharide allosamidin. Recen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houston DR,Shiomi K,Arai N,Omura S,Peter MG,Turberg A,Synstad B,Eijsink VG,van Aalten DM

更新日期：2002-07-09 00:00:00

abstract：:The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkinshaw MD,Saenger W,Maelicke A

更新日期：1980-05-01 00:00:00

abstract：:Recent structural studies of the minimal core DNA-binding domain of p53 (p53DBD) complexed to a single consensus pentamer sequence and of the isolated p53 tetramerization domain have provided valuable insights into their functions, but many questions about their interacting roles and synergism remain unanswered. To be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balagurumoorthy P,Sakamoto H,Lewis MS,Zambrano N,Clore GM,Gronenborn AM,Appella E,Harrington RE

更新日期：1995-09-12 00:00:00

abstract：:We have used the newly engineered transposable element Dsg to tag a gene that gives rise to a defective kernel (dek) phenotype. Dsg requires the autonomous element Ac for transposition. Upon excision, it leaves a short DNA footprint that can create in-frame and frameshift insertions in coding sequences. Therefore, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia N,Li Y,Dooner HK,Messing J

更新日期：2017-05-16 00:00:00

abstract：:Cellular factors tightly regulate the architecture of bundles of filamentous cytoskeletal proteins, giving rise to assemblies with distinct morphologies and physical properties, and a similar control of the supramolecular organization of nanotubes and nanorods in synthetic materials is highly desirable. However, it is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Needleman DJ,Ojeda-Lopez MA,Raviv U,Miller HP,Wilson L,Safinya CR

更新日期：2004-11-16 00:00:00

abstract：:Chronic, relapsing myelitis has been induced in golden Syrian hamsters by the intracerebral inoculation of measles virus when the animals were less than 1 day old. No acute illness was seen in animals that developed myelitis, and the onset of the myelitis was at 5 to 50 weeks after infection. In most animals the illne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrigan DR,Johnson KP

更新日期：1980-07-01 00:00:00

abstract：:Selenophosphate, an activated form of selenium that can serve as a selenium donor, is generated by the selD gene product, selenophosphate synthetase (SPS). Selenophosphate is required by several bacteria and by mammals for the specific synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. Although...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogasawara Y,Lacourciere GM,Ishii K,Stadtman TC

更新日期：2005-01-25 00:00:00

abstract：:Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs effective against all enzymes. Bisthiazolidines (BTZs) are carboxyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinchliffe P,González MM,Mojica MF,González JM,Castillo V,Saiz C,Kosmopoulou M,Tooke CL,Llarrull LI,Mahler G,Bonomo RA,Vila AJ,Spencer J

更新日期：2016-06-28 00:00:00

abstract：:Let G be a reductive algebraic group and let B be an affine variety with an algebraic action of G. Everything is defined over the field C of complex numbers. Consider the trivial G-vector bundle B x S = S over B where S is a G-module. From the endomorphism ring R of the G-vector bundle S a construction of G-vector bun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuda M,Petrie T

更新日期：1991-10-15 00:00:00

abstract：:When spores of the anaerobic bacterium Clostridium novyi-NT are systemically injected into animals, they germinate exclusively within the hypoxic regions of cancers. The germinated bacteria destroy adjacent tumor cells but spare a rim of well oxygenated tumor cells that subsequently expand. Surprisingly, we found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal N,Bettegowda C,Cheong I,Geschwind JF,Drake CG,Hipkiss EL,Tatsumi M,Dang LH,Diaz LA Jr,Pomper M,Abusedera M,Wahl RL,Kinzler KW,Zhou S,Huso DL,Vogelstein B

更新日期：2004-10-19 00:00:00

abstract：:Reversible biological electron transfer usually occurs between redox couples at standard redox potentials ranging from +0.8 to -0.5 V. Dearomatizing benzoyl-CoA reductases (BCRs), key enzymes of the globally relevant microbial degradation of aromatic compounds at anoxic sites, catalyze a biological Birch reduction bey...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huwiler SG,Löffler C,Anselmann SEL,Stärk HJ,von Bergen M,Flechsler J,Rachel R,Boll M

更新日期：2019-02-05 00:00:00

abstract：:Urea (200-400 milliosmolar) activates transcription, translation of, and trans-activation by the immediate-early gene transcription factor Egr-1 in a renal epithelial cell-specific fashion. The effect at the transcriptional level has been attributed to multiple serum response elements and their adjacent Ets motifs loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen DM

更新日期：1996-10-01 00:00:00

abstract：:Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores reflecting the difference between immediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albert MS

更新日期：1996-11-26 00:00:00

abstract：:A labile selenium donor compound monoselenophosphate is synthesized from selenide and ATP by selenophosphate synthetase (SPS). In the present study, Sps1 and Sps2 were cloned from a cDNA library prepared from human lung adenocarcinoma cells (NCIH441). The human lung Sps1 has been cloned as an ORF of 1,179 bp, identica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura T,Yamamoto S,Takahata M,Sakaguchi H,Tanaka H,Stadtman TC,Inagaki K

更新日期：2004-11-16 00:00:00

abstract：:The exceptional sensitivity of Mycobacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition. M. tuberculosis is a natural mutant in oxyR, a central regulator of peroxide stress response. The ahpC gene, which encodes a critical subunit of alkyl hydroperoxide reductase, is one of the tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Dhandayuthapani S,Deretic V

更新日期：1996-11-12 00:00:00

abstract：:Agrin is a basal lamina molecule that directs key events in postsynaptic differentiation, most notably the aggregation of acetylcholine receptors (AChRs) on the muscle cell surface. Agrin's AChR clustering activity is regulated by alternative mRNA splicing. Agrin splice forms having inserts at two sites (y and z) in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Toole JJ,Deyst KA,Bowe MA,Nastuk MA,McKechnie BA,Fallon JR

更新日期：1996-07-09 00:00:00

abstract：:Movement over and colonization of surfaces are important survival strategies for bacteria, and many find it advantageous to perform these activities as a group, using quorum sensing to sample population size and synchronize behavior. It is puzzling however, that swarming-proficient and virulent strains of Vibrio parah...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trimble MJ,McCarter LL

更新日期：2011-11-01 00:00:00

abstract：:The structural and functional organization of the cell nucleus has been investigated using three-dimensional reconstruction, immunoelectron microscopy, and high-resolution in situ autoradiography. Nuclear regions enriched in small nuclear ribonucleoprotein particles (snRNPs) form a reticular network within the nucleop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector DL

更新日期：1990-01-01 00:00:00