Cell fate determination in the vertebrate retina.

Abstract:

:In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

authors

Cepko CL,Austin CP,Yang X,Alexiades M,Ezzeddine D

doi

10.1073/pnas.93.2.589

subject

Has Abstract

pub_date

1996-01-23 00:00:00

pages

589-95

issue

2

eissn

0027-8424

issn

1091-6490

journal_volume

93

pub_type

杂志文章
  • SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.

    abstract::SIRT6 (sirtuin 6) is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and tumorigenesis. However, the role of SIRT6 deacetylase activity in its tumor-suppressor functions is not well understood. Here we report that SIRT6 binds to and deacetylat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1520045113

    authors: Bhardwaj A,Das S

    更新日期:2016-02-02 00:00:00

  • Chromosomal location targets different MYC family gene members for oncogenic translocations.

    abstract::The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations occur frequently in ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0812763106

    authors: Gostissa M,Ranganath S,Bianco JM,Alt FW

    更新日期:2009-02-17 00:00:00

  • The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences.

    abstract::We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated higher order organization of genes and noncoding sequences. All 15 X-linked genes, regardless of activity, position on the border of the XIST RNA territory, which ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0601069103

    authors: Clemson CM,Hall LL,Byron M,McNeil J,Lawrence JB

    更新日期:2006-05-16 00:00:00

  • Formation and evolution of molecular products in α-pinene secondary organic aerosol.

    abstract::Much of our understanding of atmospheric secondary organic aerosol (SOA) formation from volatile organic compounds derives from laboratory chamber measurements, including mass yield and elemental composition. These measurements alone are insufficient to identify the chemical mechanisms of SOA production. We present he...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1517742112

    authors: Zhang X,McVay RC,Huang DD,Dalleska NF,Aumont B,Flagan RC,Seinfeld JH

    更新日期:2015-11-17 00:00:00

  • Biologically inspired crack trapping for enhanced adhesion.

    abstract::We present a synthetic adaptation of the fibrillar adhesion surfaces found in nature. The structure consists of protruding fibrils topped by a thin plate and shows an experimentally measured enhancement in adhesion energy of up to a factor of 9 over a flat control. Additionally, this structure solves the robustness pr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0703762104

    authors: Glassmaker NJ,Jagota A,Hui CY,Noderer WL,Chaudhury MK

    更新日期:2007-06-26 00:00:00

  • Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets.

    abstract::The fluxes of arginine and citrulline through plasma and the rate of conversion of labeled citrulline to arginine were estimated in two pilot studies (with a total of six adult subjects) and in a dietary study with five healthy young men. These latter subjects received an L-amino acid-based diet that was arginine-rich...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.16.7749

    authors: Castillo L,Chapman TE,Sanchez M,Yu YM,Burke JF,Ajami AM,Vogt J,Young VR

    更新日期:1993-08-15 00:00:00

  • Structural diversity in social contagion.

    abstract::The concept of contagion has steadily expanded from its original grounding in epidemic disease to describe a vast array of processes that spread across networks, notably social phenomena such as fads, political opinions, the adoption of new technologies, and financial decisions. Traditional models of social contagion ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1116502109

    authors: Ugander J,Backstrom L,Marlow C,Kleinberg J

    更新日期:2012-04-17 00:00:00

  • Mycosporine-like amino acids are multifunctional molecules in sea hares and their marine community.

    abstract::Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential impor...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1103906108

    authors: Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

    更新日期:2011-07-12 00:00:00

  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.

    abstract::Frizzled polypeptides are integral membrane proteins that recently were shown to function as receptors for Wnt signaling molecules. Here, we report the identification of a novel, secreted 36-kDa protein that contains a region homologous to a putative Wnt-binding domain of Frizzleds. This protein, called Frizzled-relat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.13.6770

    authors: Finch PW,He X,Kelley MJ,Uren A,Schaudies RP,Popescu NC,Rudikoff S,Aaronson SA,Varmus HE,Rubin JS

    更新日期:1997-06-24 00:00:00

  • Mathematical model of chronic pancreatitis.

    abstract::Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1620264114

    authors: Hao W,Komar HM,Hart PA,Conwell DL,Lesinski GB,Friedman A

    更新日期:2017-05-09 00:00:00

  • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization.

    abstract::Recent advances in our understanding of the immune response are allowing for the logical design of new approaches to cancer immunization. One area of interest is the development of new immune adjuvants. Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can induce production of a wide variety o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.20.10833

    authors: Weiner GJ,Liu HM,Wooldridge JE,Dahle CE,Krieg AM

    更新日期:1997-09-30 00:00:00

  • Asymmetry and external noise-induced free energy transduction.

    abstract::The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties of the system can be analyzed analytically by using the usual master equation approach when the external parameter is f...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.3.729

    authors: Chen YD

    更新日期:1987-02-01 00:00:00

  • Mitochondrial localization of estrogen receptor beta.

    abstract::Estrogen receptors (ERs) are believed to be ligand-activated transcription factors belonging to the nuclear receptor superfamily, which on ligand binding translocate into the nucleus and activate gene transcription. To date, two ERs have been identified: ERalpha and ERbeta. ERalpha plays major role in the estrogen-med...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0306948101

    authors: Yang SH,Liu R,Perez EJ,Wen Y,Stevens SM Jr,Valencia T,Brun-Zinkernagel AM,Prokai L,Will Y,Dykens J,Koulen P,Simpkins JW

    更新日期:2004-03-23 00:00:00

  • Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts.

    abstract::If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.12.5413

    authors: Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

    更新日期:1992-06-15 00:00:00

  • Systemic administration of beta-endorphin: potent hypotensive effect involving a serotonergic pathway.

    abstract::In normal adult rats anesthetized with urethane, intravenous injections of beta-endorphin (30--150 micrograms kg-1) induced a transient fall of blood pressure followed by a small hypertension and a prolonged hypotension. Prior administration of naloxone completely blocked these effects, whereas naloxone, given 1 hr af...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.75.12.6240

    authors: Lemaire I,Tseng R,Lemaire S

    更新日期:1978-12-01 00:00:00

  • Development of vivo of genetic variability of simian immunodeficiency virus.

    abstract::Rapid development of genetic variability may contribute to the pathogenicity of lentiviruses as it may allow escape from immune surveillance and/or from suppression of virus replication. Although apathogenic in African green monkeys, simian immunodeficiency virus isolated from African green monkeys is shown to display...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.18.8126

    authors: Baier M,Dittmar MT,Cichutek K,Kurth R

    更新日期:1991-09-15 00:00:00

  • Variation in the sensitivity of organismal body temperature to climate change over local and geographic scales.

    abstract::Global climate change is expected to have broad ecological consequences for species and communities. Attempts to forecast these consequences usually assume that changes in air or water temperature will translate into equivalent changes in a species' organismal body temperature. This simple change is unlikely because a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0510992103

    authors: Gilman SE,Wethey DS,Helmuth B

    更新日期:2006-06-20 00:00:00

  • Spectrum and chemical composition of the remarkable planetary nebula NGC 6537.

    abstract::Observations with the image tube scanner at the Shane 3-m telescope are combined with data obtained with the International Ultraviolet Explorer to assess the spectrum of the remarkable high-excitation planetary nebula NGC 6537. We have analyzed the spectrum of this nitrogen-rich object with the aid of the theoretical ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.82.8.2202

    authors: Feibelman W,Aller LH,Keyes CD,Czyzak SJ

    更新日期:1985-04-01 00:00:00

  • Methyl-directed repair of frameshift mutations in heteroduplex DNA.

    abstract::DNA heteroduplexes with single unpaired bases of the four different kinds were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. Genetic analysis of the progeny phages obtained from transfected bacteria indicates that the E. coli mismatch repair system can reco...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.83.10.3395

    authors: Dohet C,Wagner R,Radman M

    更新日期:1986-05-01 00:00:00

  • Early rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.

    abstract::Immunoglobulin heavy-chain variable region (TH) gene segments located closest to the joining (JH) gene segments are preferentially rearranged during ontogeny, indicating that chromosomal position influences the frequency of rearrangement. In addition, certain VH gene segments are repeatedly rearranged, suggesting that...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.17.6744

    authors: Lawler AM,Kearney JF,Kuehl M,Gearhart PJ

    更新日期:1989-09-01 00:00:00

  • A randomized controlled design reveals barriers to citizenship for low-income immigrants.

    abstract::Citizenship endows legal protections and is associated with economic and social gains for immigrants and their communities. In the United States, however, naturalization rates are relatively low. Yet we lack reliable knowledge as to what constrains immigrants from applying. Drawing on data from a public/private natura...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1714254115

    authors: Hainmueller J,Lawrence D,Gest J,Hotard M,Koslowski R,Laitin DD

    更新日期:2018-01-30 00:00:00

  • Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment.

    abstract::Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function on targeting the fibrotic microenvironment. Starting from a murine HCC model, we identi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1909145117

    authors: Winkler I,Bitter C,Winkler S,Weichenhan D,Thavamani A,Hengstler JG,Borkham-Kamphorst E,Kohlbacher O,Plass C,Geffers R,Weiskirchen R,Nordheim A

    更新日期:2020-01-07 00:00:00

  • Growth-and density-dependent inhibition of deoxyglucose transport in Balb 3T3 cells and its absence in cells transformed by murine sarcoma virus.

    abstract::The earliest measurable parameter that shows density-dependent inhibition is the uptake of [(3)H]deoxyglucose by Balb 3T3 cells. The rate decreases even during the exponential phase of growth and reaches a minimum, about 8- to 10-times lower than maximum, as the culture approaches the saturation density. Cells transfo...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.8.2374

    authors: Bose SK,Zlotnick BJ

    更新日期:1973-08-01 00:00:00

  • Meiosis in Phycomyces.

    abstract::A four-factor cross between two strains of Phycomyces involving two auxotrophic, one color, and the mating type marker is described. Samples of 40 germspores from 84 individual fertile germsporangia were characterized. The results show: (i) The germspores of a germsporangium are derived from one meiosis in approximate...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.72.10.4076

    authors: Eslava AP,Alvarez MI,Delbrück M

    更新日期:1975-10-01 00:00:00

  • Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis.

    abstract::The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognized to play a crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we demonstrate an unexpected role of H2S in Mycobacterium tuberculosis (Mtb) pathogenesis. We showed that Mtb-infected CSE-/- mice survive longer than WT m...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1919211117

    authors: Rahman MA,Cumming BM,Addicott KW,Pacl HT,Russell SL,Nargan K,Naidoo T,Ramdial PK,Adamson JH,Wang R,Steyn AJC

    更新日期:2020-03-24 00:00:00

  • The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.

    abstract::Expression of glucokinase in hepatocytes and pancreatic 6-cells is of major physiologic importance to mammalian glucose homeostasis. Liver glucokinase catalyzes the first committed step in the disposal of glucose, and beta-cell glucokinase catalyzes a rate-limiting step required for glucose-regulated insulin release. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.14.7036

    authors: Heimberg H,De Vos A,Moens K,Quartier E,Bouwens L,Pipeleers D,Van Schaftingen E,Madsen O,Schuit F

    更新日期:1996-07-09 00:00:00

  • The serum response element can mediate induction of c-fos by growth hormone.

    abstract::The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.14.6721

    authors: Meyer DJ,Stephenson EW,Johnson L,Cochran BH,Schwartz J

    更新日期:1993-07-15 00:00:00

  • Active cargo positioning in antiparallel transport networks.

    abstract::Cytoskeletal filaments assemble into dense parallel, antiparallel, or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and intrinsic motor properties clearly affects transport properties but remains poorl...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1900416116

    authors: Richard M,Blanch-Mercader C,Ennomani H,Cao W,De La Cruz EM,Joanny JF,Jülicher F,Blanchoin L,Martin P

    更新日期:2019-07-23 00:00:00

  • Developmental and hormonal regulation of alpha 2u-globulin gene transcription.

    abstract::Hepatic alpha 2u-globulin protein and RNA levels are under developmental and complex multihormonal control. The present studies directly evaluate the degree to which this regulation is transcriptional. alpha 2u-Globulin transcription was determined by measuring nuclear runoff RNA in vitro, and tissue alpha 2u-globulin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.82.9.2579

    authors: Kulkarni AB,Gubits RM,Feigelson P

    更新日期:1985-05-01 00:00:00

  • Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion.

    abstract::Levels and subcellular distribution of connexin 43 (Cx43), a gap junction protein, were studied in hamster leukocytes before and after activation with endotoxin (lipopolysaccharide, LPS) both in vitro and in vivo. Untreated leukocytes did not express Cx43. However, Cx43 was clearly detectable by indirect immunofluores...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.15.7011

    authors: Jara PI,Boric MP,Sáez JC

    更新日期:1995-07-18 00:00:00